Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome

Human Genetics

Volumn 129, Issue 6, 2011, Pages 663-673

  Wu, Chih Chieh ^a   Krahe, Ralf ^b   Lozano, Guillermina ^b   Zhang, Baili ^b   Wilson, Charmaine D ^b   Jo, Eun Ji ^a,c   Amos, Christopher I ^a   Shete, Sanjay ^a   Strong, Louise C ^b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

ADOLESCENT; ADRENAL CORTEX TUMOR; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BRAIN TUMOR; BREAST CANCER; CANCER INCIDENCE; CANCER RISK; CHILD; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; FAMILIAL CANCER; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GERM LINE; HEMATOLOGIC MALIGNANCY; HETEROZYGOTE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MOUTH CANCER; NEWBORN; NUCLEOTIDE SEQUENCE; ONSET AGE; OSTEOSARCOMA; PEDIGREE ANALYSIS; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY TRACT CANCER; RISK ASSESSMENT; SCHOOL CHILD; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOFT TISSUE SARCOMA; UROGENITAL TRACT CANCER; WILD TYPE;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; INFANT; INFANT, NEWBORN; LI-FRAUMENI SYNDROME; MALE; MIDDLE AGED; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79959733533     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-011-0957-1     Document Type: Article

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