메뉴 건너뛰기




Volumn 109, Issue 3, 2014, Pages 175-181

Tissue penetration of antibiotics: Does the treatment reach the target site?;Gewebepenetration von Antibiotika: Erreicht die Behandlung den Zielort?

Author keywords

Criticall illness; Microdialysis; Pharmacodynamics; Pharmacokinetics; Target site penetration

Indexed keywords

ANTIBIOTIC AGENT; LEVOFLOXACIN; MEROPENEM; ANTIINFECTIVE AGENT;

EID: 84899922436     PISSN: 21936218     EISSN: 21936226     Source Type: Journal    
DOI: 10.1007/s00063-013-0309-0     Document Type: Article
Times cited : (7)

References (41)
  • 1
    • 0030666474 scopus 로고    scopus 로고
    • Concentrations of levofloxacin (HR 355) in the respiratory tract following a single oral dose in patients undergoing fibre-optic bronchoscopy
    • Andrews JM, Honeybourne D, Jevons G et al (1997) Concentrations of levofloxacin (HR 355) in the respiratory tract following a single oral dose in patients undergoing fibre-optic bronchoscopy. J Antimicrob Chemother 40: 573-577.
    • (1997) J Antimicrob Chemother , vol.40 , pp. 573-577
    • Andrews, J.M.1    Honeybourne, D.2    Jevons, G.3
  • 2
    • 0028158707 scopus 로고
    • Concentration of meropenem in serum and in bronchial secretions in patients undergoing fibreoptic bronchoscopy
    • Bergogne-Berezin E, Muller-Serieys C, Aubier M et al (1994) Concentration of meropenem in serum and in bronchial secretions in patients undergoing fibreoptic bronchoscopy. Eur J Clin Pharmacol 46: 87-88.
    • (1994) Eur J Clin Pharmacol , vol.46 , pp. 87-88
    • Bergogne-Berezin, E.1    Muller-Serieys, C.2    Aubier, M.3
  • 3
    • 1942500845 scopus 로고    scopus 로고
    • EPISEPSIS: A reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units
    • Brun-Buisson C, Meshaka P, Pinton P et al (2004) EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 30: 580-588.
    • (2004) Intensive Care Med , vol.30 , pp. 580-588
    • Brun-Buisson, C.1    Meshaka, P.2    Pinton, P.3
  • 4
    • 33646061674 scopus 로고    scopus 로고
    • Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution
    • Brunner M, Langer O (2006) Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution. AAPS J 8: E263-E271.
    • (2006) AAPS J , vol.8
    • Brunner, M.1    Langer, O.2
  • 5
    • 0033933014 scopus 로고    scopus 로고
    • Surgery and intensive care procedures affect the target site distribution of piperacillin
    • Brunner M, Pernerstorfer T, Mayer BX et al (2000) Surgery and intensive care procedures affect the target site distribution of piperacillin. Crit Care Med 28: 1754-1759.
    • (2000) Crit Care Med , vol.28 , pp. 1754-1759
    • Brunner, M.1    Pernerstorfer, T.2    Mayer, B.X.3
  • 6
    • 0033011811 scopus 로고    scopus 로고
    • Penetration of meropenem in lung, bronchial mucosa, and pleural tissues
    • Byl B, Jacobs F, Roucloux I et al (1999) Penetration of meropenem in lung, bronchial mucosa, and pleural tissues. Antimicrob Agents Chemother 43: 681-682.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 681-682
    • Byl, B.1    Jacobs, F.2    Roucloux, I.3
  • 7
    • 1642362414 scopus 로고    scopus 로고
    • Steady-state intrapulmonary concentrations of moxifloxacin, levofloxacin, and azithromycin in older adults
    • Capitano B, Mattoes HM, Shore E et al (2004) Steady-state intrapulmonary concentrations of moxifloxacin, levofloxacin, and azithromycin in older adults. Chest 125: 965-973.
    • (2004) Chest , vol.125 , pp. 965-973
    • Capitano, B.1    Mattoes, H.M.2    Shore, E.3
  • 8
    • 0031952586 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic parameters: Rationale for antibacterial dosing of mice and men
    • quiz 11-12
    • Craig WA (1998) Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis 26: 1-10 (quiz 11-12).
    • (1998) Clin Infect Dis , vol.26 , pp. 1-10
    • Craig, W.A.1
  • 9
    • 0027935736 scopus 로고
    • Penetration of meropenem into the cerebrospinal fluid of patients with inflamed meninges
    • Dagan R, Velghe L, Rodda JL et al (1994) Penetration of meropenem into the cerebrospinal fluid of patients with inflamed meninges. J Antimicrob Chemother 34: 175-179.
    • (1994) J Antimicrob Chemother , vol.34 , pp. 175-179
    • Dagan, R.1    Velghe, L.2    Rodda, J.L.3
  • 10
    • 0028266514 scopus 로고
    • Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy
    • Davis R, Bryson HM (1994) Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy. Drugs 47: 677-700.
    • (1994) Drugs , vol.47 , pp. 677-700
    • Davis, R.1    Bryson, H.M.2
  • 11
    • 0030942858 scopus 로고    scopus 로고
    • Application of microdialysis in pharmacokinetic studies
    • Elmquist WF, Sawchuk RJ (1997) Application of microdialysis in pharmacokinetic studies. Pharm Res 14: 267-288.
    • (1997) Pharm Res , vol.14 , pp. 267-288
    • Elmquist, W.F.1    Sawchuk, R.J.2
  • 13
    • 84873159108 scopus 로고    scopus 로고
    • Guidance for Industry
    • FDA, Zugegriffen: 17. März 2014
    • FDA (1998) Guidance for Industry. Developing antimicrobial drugs - general considerations for clinical trials. http://www. fda. gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070983. pdf. Zugegriffen: 17. März 2014.
    • (1998) Developing antimicrobial drugs - general considerations for clinical trials
  • 14
    • 0031055732 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of levofloxacin
    • Fish DN, Chow AT (1997) The clinical pharmacokinetics of levofloxacin. Clin Pharmacokinet 32: 101-119.
    • (1997) Clin Pharmacokinet , vol.32 , pp. 101-119
    • Fish, D.N.1    Chow, A.T.2
  • 15
    • 1542644427 scopus 로고    scopus 로고
    • How predictive is PK/PD for antibacterial agents?
    • Frimodt-Moller N (2002) How predictive is PK/PD for antibacterial agents? Int J Antimicrob Agents 19: 333-339.
    • (2002) Int J Antimicrob Agents , vol.19 , pp. 333-339
    • Frimodt-Moller, N.1
  • 16
    • 0032793359 scopus 로고    scopus 로고
    • Levofloxacin concentrations in serum, sputum and lung tissue: Evaluation of its efficacy according to breakpoint
    • Fujita A, Miya T, Tanaka R et al (1999) Levofloxacin concentrations in serum, sputum and lung tissue: evaluation of its efficacy according to breakpoint. Jpn J Antibiot 52: 661-666.
    • (1999) Jpn J Antibiot , vol.52 , pp. 661-666
    • Fujita, A.1    Miya, T.2    Tanaka, R.3
  • 17
    • 80052672933 scopus 로고    scopus 로고
    • Antibiotics in critically ill patients: A systematic review of the pharmacokinetics of beta-lactams
    • Goncalves-Pereira J, Povoa P (2011) Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of beta-lactams. Crit Care 15: R206.
    • (2011) Crit Care , vol.15
    • Goncalves-Pereira, J.1    Povoa, P.2
  • 18
    • 0034917313 scopus 로고    scopus 로고
    • Steady-state plasma and intrapulmonary concentrations of levofloxacin and ciprofloxacin in healthy adult subjects
    • Gotfried MH, Danziger LH, Rodvold KA (2001) Steady-state plasma and intrapulmonary concentrations of levofloxacin and ciprofloxacin in healthy adult subjects. Chest 119: 1114-1122.
    • (2001) Chest , vol.119 , pp. 1114-1122
    • Gotfried, M.H.1    Danziger, L.H.2    Rodvold, K.A.3
  • 19
    • 0026522606 scopus 로고
    • A study on the concentrations of levofloxacin in the gallbladder tissue and bile of patients
    • Hukagawa H, Noga K (1992) A study on the concentrations of levofloxacin in the gallbladder tissue and bile of patients. Jpn J Antibiot 45: 253-257.
    • (1992) Jpn J Antibiot , vol.45 , pp. 253-257
    • Hukagawa, H.1    Noga, K.2
  • 20
    • 0035112931 scopus 로고    scopus 로고
    • Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock
    • Joukhadar C, Frossard M, Mayer BX et al (2001) Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock. Crit Care Med 29: 385-391.
    • (2001) Crit Care Med , vol.29 , pp. 385-391
    • Joukhadar, C.1    Frossard, M.2    Mayer, B.X.3
  • 21
    • 0036313816 scopus 로고    scopus 로고
    • Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis
    • Joukhadar C, Klein N, Mayer BX et al (2002) Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis. Crit Care Med 30: 1478-1482.
    • (2002) Crit Care Med , vol.30 , pp. 1478-1482
    • Joukhadar, C.1    Klein, N.2    Mayer, B.X.3
  • 22
    • 39449096286 scopus 로고    scopus 로고
    • Pharmacokinetics of meropenem determined by microdialysis in the peritoneal fluid of patients with severe peritonitis associated with septic shock
    • Karjagin J, Lefeuvre S, Oselin K et al (2008) Pharmacokinetics of meropenem determined by microdialysis in the peritoneal fluid of patients with severe peritonitis associated with septic shock. Clin Pharmacol Ther 83: 452-459.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 452-459
    • Karjagin, J.1    Lefeuvre, S.2    Oselin, K.3
  • 23
    • 0032723696 scopus 로고    scopus 로고
    • The penetration of anti-infectives into the central nervous system
    • Kearney BP, Aweeka FT (1999) The penetration of anti-infectives into the central nervous system. Neurol Clin 17: 883-900.
    • (1999) Neurol Clin , vol.17 , pp. 883-900
    • Kearney, B.P.1    Aweeka, F.T.2
  • 24
    • 0036177106 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of meropenem in critically ill patients
    • Kitzes-Cohen R, Farin D, Piva G et al (2002) Pharmacokinetics and pharmacodynamics of meropenem in critically ill patients. Int J Antimicrob Agents 19: 105-110.
    • (2002) Int J Antimicrob Agents , vol.19 , pp. 105-110
    • Kitzes-Cohen, R.1    Farin, D.2    Piva, G.3
  • 25
    • 0023637097 scopus 로고
    • Limitations of using urea to quantify epithelial lining fluid recovered by bronchoalveolar lavage
    • Marcy TW, Merrill WW, Rankin JA et al (1987) Limitations of using urea to quantify epithelial lining fluid recovered by bronchoalveolar lavage. Am Rev Respir Dis135: 1276-1280.
    • (1987) Am Rev Respir Dis135 , pp. 1276-1280
    • Marcy, T.W.1    Merrill, W.W.2    Rankin, J.A.3
  • 26
    • 84872907127 scopus 로고    scopus 로고
    • Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on a site-specific pharmacokinetic/pharmacodynamic evaluation
    • Nishikawa G, Ikawa K, Nakamura K et al (2013) Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on a site-specific pharmacokinetic/pharmacodynamic evaluation. Int J Antimicrob Agents 41: 267-271.
    • (2013) Int J Antimicrob Agents , vol.41 , pp. 267-271
    • Nishikawa, G.1    Ikawa, K.2    Nakamura, K.3
  • 27
    • 0141994726 scopus 로고    scopus 로고
    • Levofloxacin disposition in cerebrospinal fluid in patients with external ventriculostomy
    • Pea F, Pavan F, Nascimben E et al (2003) Levofloxacin disposition in cerebrospinal fluid in patients with external ventriculostomy. Antimicrob Agents Chemother 47: 3104-3108.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3104-3108
    • Pea, F.1    Pavan, F.2    Nascimben, E.3
  • 28
    • 0022204452 scopus 로고
    • Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution
    • Rennard SI, Basset G, Lecossier D et al (1986) Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J Appl Physiol 60: 532-538.
    • (1986) J Appl Physiol , vol.60 , pp. 532-538
    • Rennard, S.I.1    Basset, G.2    Lecossier, D.3
  • 29
    • 0242552660 scopus 로고    scopus 로고
    • Pharmacokinetics and dosage adaptation of meropenem during continuous venovenous hemodiafiltration in critically ill patients
    • Robatel C, Decosterd LA, Biollaz J et al (2003) Pharmacokinetics and dosage adaptation of meropenem during continuous venovenous hemodiafiltration in critically ill patients. J Clin Pharmacol 43: 1329-1340.
    • (2003) J Clin Pharmacol , vol.43 , pp. 1329-1340
    • Robatel, C.1    Decosterd, L.A.2    Biollaz, J.3
  • 30
    • 67449090359 scopus 로고    scopus 로고
    • Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: Intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution
    • Roberts JA, Kirkpatrick CM, Roberts MS et al (2009) Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution. J Antimicrob Chemother 64: 142-150.
    • (2009) J Antimicrob Chemother , vol.64 , pp. 142-150
    • Roberts, J.A.1    Kirkpatrick, C.M.2    Roberts, M.S.3
  • 31
    • 0027151885 scopus 로고
    • Pharmacokinetics of antibiotics in natural and experimental superficial compartments in animals and humans
    • Ryan DM (1993) Pharmacokinetics of antibiotics in natural and experimental superficial compartments in animals and humans. J Antimicrob Chemother 31(Suppl D): 1-16.
    • (1993) J Antimicrob Chemother , vol.31 , Issue.SUPPL. D , pp. 1-16
    • Ryan, D.M.1
  • 32
    • 12944255780 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of cefpirome in subcutaneous adipose tissue of septic patients
    • Sauermann R, Delle-Karth G, Marsik C et al (2005) Pharmacokinetics and pharmacodynamics of cefpirome in subcutaneous adipose tissue of septic patients. Antimicrob Agents Chemother 49: 650-655.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 650-655
    • Sauermann, R.1    Delle-Karth, G.2    Marsik, C.3
  • 33
    • 2542443541 scopus 로고    scopus 로고
    • Penetration of meropenem into pneumonic human lung tissue as measured by in vivo microdialysis
    • Tomaselli F, Maier A, Matzi V et al (2004) Penetration of meropenem into pneumonic human lung tissue as measured by in vivo microdialysis. Antimicrob Agents Chemother 48: 2228-2232.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2228-2232
    • Tomaselli, F.1    Maier, A.2    Matzi, V.3
  • 34
    • 0023697158 scopus 로고
    • Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model
    • Vogelman B, Gudmundsson S, Leggett J et al (1988) Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model. J Infect Dis 158: 831-847.
    • (1988) J Infect Dis , vol.158 , pp. 831-847
    • Vogelman, B.1    Gudmundsson, S.2    Leggett, J.3
  • 35
    • 33846140848 scopus 로고    scopus 로고
    • Clinical scoring system for the prediction of target site penetration of antimicrobials in patients with sepsis
    • Zeitlinger BS, Zeitlinger M, Leitner I et al (2007) Clinical scoring system for the prediction of target site penetration of antimicrobials in patients with sepsis. Clin Pharmacokinet 46: 75-83.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 75-83
    • Zeitlinger, B.S.1    Zeitlinger, M.2    Leitner, I.3
  • 36
    • 33644815680 scopus 로고    scopus 로고
    • Lung microdialysis - a powerful tool for the determination of exogenous and endogenous compounds in the lower respiratory tract (mini-review)
    • Zeitlinger M, Muller M, Joukhadar C (2005) Lung microdialysis - a powerful tool for the determination of exogenous and endogenous compounds in the lower respiratory tract (mini-review). Aaps J 7: E600-E608.
    • (2005) Aaps J , vol.7
    • Zeitlinger, M.1    Muller, M.2    Joukhadar, C.3
  • 37
    • 0242385488 scopus 로고    scopus 로고
    • Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis
    • Zeitlinger MA, Dehghanyar P, Mayer BX et al (2003) Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis. Antimicrob Agents Chemother 47: 3548-3553.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3548-3553
    • Zeitlinger, M.A.1    Dehghanyar, P.2    Mayer, B.X.3
  • 38
    • 27144536833 scopus 로고    scopus 로고
    • Plasma concentrations might lead to overestimation of target site activity of piperacillin in patients with sepsis
    • Zeitlinger MA, Erovic BM, Sauermann R et al (2005) Plasma concentrations might lead to overestimation of target site activity of piperacillin in patients with sepsis. J Antimicrob Chemother 56: 703-708.
    • (2005) J Antimicrob Chemother , vol.56 , pp. 703-708
    • Zeitlinger, M.A.1    Erovic, B.M.2    Sauermann, R.3
  • 39
    • 33845618523 scopus 로고    scopus 로고
    • A pilot study testing whether concentrations of levofloxacin in interstitial space fluid of soft tissues may serve as a surrogate for predicting its pharmacokinetics in lung
    • Zeitlinger MA, Traunmuller F, Abrahim A et al (2007) A pilot study testing whether concentrations of levofloxacin in interstitial space fluid of soft tissues may serve as a surrogate for predicting its pharmacokinetics in lung. Int J Antimicrob Agents 29: 44-50.
    • (2007) Int J Antimicrob Agents , vol.29 , pp. 44-50
    • Zeitlinger, M.A.1    Traunmuller, F.2    Abrahim, A.3
  • 40
    • 0035059952 scopus 로고    scopus 로고
    • Review of macrolides and ketolides: Focus on respiratory tract infections
    • Zhanel GG, Dueck M, Hoban DJ et al (2001) Review of macrolides and ketolides: focus on respiratory tract infections. Drugs 61: 443-498.
    • (2001) Drugs , vol.61 , pp. 443-498
    • Zhanel, G.G.1    Dueck, M.2    Hoban, D.J.3
  • 41
    • 84899942678 scopus 로고    scopus 로고
    • Zugegriffen: 17. März
    • http://en. wikipedia. org/wiki/File: Schematic_illustration_of_a_microdialysis_probe. png#metadata. Zugegriffen: 17. März 2014.
    • (2014)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.