Altered matrix metalloproteinase-2 and -9 expression/activity links placental ischemia and anti-angiogenic sFlt-1 to uteroplacental and vascular remodeling and collagen deposition in hypertensive pregnancy

Biochemical Pharmacology

Volumn 89, Issue 3, 2014, Pages 370-385

  Li, Wei ^a   Mata, Karina M ^a   Mazzuca, Marc Q ^a   Khalil, Raouf A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Blood vessels; Myometrium; Placenta; Preeclampsia

Indexed keywords

ANGIOGENESIS INHIBITOR; COLLAGEN; ELASTIN; GELATIN; GELATINASE; GELATINASE A; GELATINASE B; SFLT 1; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; AORTA MEDIA; ARTICLE; BIRTH WEIGHT; BLOOD PRESSURE; BLOOD VESSEL WALL; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; INTRAUTERINE GROWTH RETARDATION; ISCHEMIA; KIDNEY MASS; LITTER SIZE; MATERNAL BLOOD; MATERNAL HYPERTENSION; NONHUMAN; PERFUSION PRESSURE; PLACENTA CIRCULATION; PLACENTA ISCHEMIA; PLACENTA WEIGHT; PREGNANCY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; THORACIC AORTA; TISSUE HOMOGENATE; TISSUE STRUCTURE; UPREGULATION; UTERUS WEIGHT; VASCULAR DISEASE; VASCULAR TISSUE; VASCULAR TISSUE REMODELING; WESTERN BLOTTING; ZYMOGRAPHY;

BLOOD VESSELS; MYOMETRIUM; PLACENTA; PREECLAMPSIA;

ANIMALS; BLOOD PRESSURE; COLLAGEN; FEMALE; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERTENSION; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOVASCULARIZATION, PHYSIOLOGIC; PLACENTA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; UTERUS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84899914151     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.03.017     Document Type: Article

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