Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Madala, Satish K ^a   Edukulla, Ramakrishna ^a   Phatak, Mukta ^b   Schmidt, Stephanie ^a   Davidson, Cynthia ^a   Acciani, Thomas H ^a   Korfhagen, Thomas R ^a   Medvedovic, Mario ^b   LeCras, Timothy D ^a   Wagner, Kimberly ^a   Hardie, William D ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 DIALLYLAMINOMETHYLENE 1,3,4,7,10,11,12,13,14,15,16,17 DODECAHYDRO 6 HYDROXY 1 METHOXYMETHYL 10,13 DIMETHYL 3,7,17 TRIOXO 2 OXACYCLOPENTA[A]PHENANTHREN 11 YL ACETATE; COLLAGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SELUMETINIB; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG POTENTIATION; DRUG TARGETING; ENZYME INHIBITION; LUNG FIBROSIS; LUNG WEIGHT; MOUSE; NONHUMAN; PLEURA; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; BENZIMIDAZOLES; BLOTTING, WESTERN; DRUG THERAPY, COMBINATION; GONANES; IMMUNOHISTOCHEMISTRY; LUNG; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; PHOSPHATIDYLINOSITOL 3-KINASES; PULMONARY FIBROSIS; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, RNA; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 84899907420     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086536     Document Type: Article

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