MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation

American Journal of Respiratory Cell and Molecular Biology

Volumn 46, Issue 3, 2012, Pages 380-388

  Madala, Satish K ^a   Schmidt, Stephanie ^a   Davidson, Cynthia ^a   Ikegami, Machiko ^a   Wert, Susan ^a   Hardie, William D ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

ARRY 142886; Epidermal growth factor receptor; Mitogen activated protein kinase mitogenactivated protein kinase kinase extracellular signal regulated kinase; Pulmonary fibrosis; Transforming growth factor

Indexed keywords

COLLAGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; SELUMETINIB; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; EXTRACELLULAR MATRIX; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LUNG FUNCTION; LUNG MECHANICS; MESENCHYME CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; BENZIMIDAZOLES; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; LUNG; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PULMONARY FIBROSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

MUS; MUS MUSCULUS;

EID: 84857739552     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0237OC     Document Type: Article

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