Human hepatocellular carcinoma-infiltrating CD4+CD69 +Foxp3- regulatory T cell suppresses T cell response via membrane-bound TGF-β1

Journal of Molecular Medicine

Volumn 92, Issue 5, 2014, Pages 539-550

  Han, Yanmei ^a   Yang, Yuan ^b   Chen, Zhubo ^a   Jiang, Zhengping ^a   Gu, Yan ^a   Liu, Yanfang ^a   Xu, Sheng ^a   Lin, Chuan ^b   Pan, Zeya ^b   Zhou, Weiping ^b   Cao, Xuetao ^a,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Eastern Hepatobiliary Surgery Hospital   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

CD69; Hepatocellular carcinoma; Regulatory T cells; Transforming growth factor 1; Tumor immune escape

Indexed keywords

CD45RO ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; CD4 ANTIGEN; CD69 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; LECTIN; LEUKOCYTE ANTIGEN; T LYMPHOCYTE ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CD4+ CD69+ FOXP3+ REGULATORY T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; LIVER CELL CARCINOMA; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MIXED LYMPHOCYTE REACTION; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TUMOR GROWTH; ANIMAL; CELL CULTURE; GENE DELETION; GENETICS; IMMUNOLOGY; LIVER; LIVER TUMOR; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED; MOUSE; PATHOLOGY; TUMOR ASSOCIATED LEUKOCYTE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CARCINOMA, HEPATOCELLULAR; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE DELETION; HUMANS; LECTINS, C-TYPE; LIVER; LIVER NEOPLASMS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICE; MIDDLE AGED; TRANSFORMING GROWTH FACTOR BETA1; YOUNG ADULT;

EID: 84899900047     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-014-1143-4     Document Type: Article

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