Survival according to BRAF-V600 tumor mutations - An analysis of 437 patients with primary melanoma

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Meckbach, Diana ^a   Bauer, Jürgen ^a   Pflugfelder, Annette ^a   Meier, Friedegund ^a   Busch, Christian ^a   Eigentler, Thomas K ^a   Capper, David ^b,c   Von Deimling, Andreas ^b,c   Mittelbronn, Michel ^d   Perner, Sven ^e   Ikenberg, Kristian ^f   Hantschke, Markus ^g   Büttner, Petra ^h   Garbe, Claus ^a   Weide, Benjamin ^a,b  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d GOETHE UNIVERSITY   (Germany)

^e UNIVERSITY HOSPITAL BONN   (Germany)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^g Dermatopathologische Gemeinschaftspraxis   (Germany)

^h JAMES COOK UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; VALINE;

ADULT; AGE; AGED; ARTICLE; BRAF GENE; CANCER CLASSIFICATION; CANCER PROGNOSIS; CANCER SURVIVAL; CONTROLLED STUDY; DISTANT METASTASIS; DISTANT METASTASIS FREE SURVIVAL; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MELANOMA; MITOSIS RATE; MUTANT; MUTATION RATE; OVERALL SURVIVAL; TUMOR VOLUME; ULCER; WILD TYPE;

AGED; FEMALE; HUMANS; MALE; MELANOMA; MIDDLE AGED; MUTATION; NEOPLASM STAGING; PROGNOSIS; PROTO-ONCOGENE PROTEINS B-RAF; REGISTRIES;

EID: 84899892975     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086194     Document Type: Article

References (31)

1. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417: 949-954. (Pubitemid 34716871)
2. Satyamoorthy K, Li G, Gerrero MR, Brose MS, Volpe P, et al. (2003) Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res 63: 756-759. (Pubitemid 36231971)
3. Flaherty KT, Robert C, Hersey P, Nathan P, Garbe C, et al. (2012) Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 367: 107-114.
4. Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, et al. (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364: 2507-2516.
5. Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, et al. (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363: 809-819.
6. Si L, Kong Y, Xu X, Flaherty KT, Sheng X, et al. (2012) Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohort. Eur J Cancer 48: 94-100.
7. Long GV, Menzies AM, Nagrial AM, Haydu LE, Hamilton AL, et al. (2011) Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol 29: 1239-1246.
8. Menzies AM, Haydu LE, Visintin L, Carlino MS, Howle JR, et al. (2012) Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. Clin Cancer Res 18: 3242-3249.
9. Jakob JA, Bassett RL, Jr., Ng CS, Curry JL, Joseph RW, et al. (2012) NRAS mutation status is an independent prognostic factor in metastatic melanoma. Cancer 118: 4014-4023.
10. Houben R, Becker JC, Kappel A, Terheyden P, Brocker EB, et al. (2004) Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J Carcinog 3: 6.
11. von Moos R, Seifert B, Simcock M, Goldinger SM, Gillessen S, et al. (2012) First-line temozolomide combined with bevacizumab in metastatic melanoma: a multicentre phase II trial (SAKK 50/07). Ann Oncol 23: 531-536.
12. Edlundh-Rose E, Egyhazi S, Omholt K, Mansson-Brahme E, Platz A, et al. (2006) NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing. Melanoma Res 16: 471-478. (Pubitemid 44934704)
13. Mann GJ, Pupo GM, Campain AE, Carter CD, Schramm SJ, et al. (2013) BRAF Mutation, NRAS Mutation, and the Absence of an Immune-Related Expressed Gene Profile Predict Poor Outcome in Patients with Stage III Melanoma. J Invest Dermatol 133: 509-517.
14. Moreau S, Saiag P, Aegerter P, Bosset D, Longvert C, et al. (2012) Prognostic value of BRAF(V(6)(0)(0)) mutations in melanoma patients after resection of metastatic lymph nodes. Ann Surg Oncol 19: 4314-4321.
15. Ellerhorst JA, Greene VR, Ekmekcioglu S, Warneke CL, Johnson MM, et al. (2011) Clinical correlates of NRAS and BRAF mutations in primary human melanoma. Clin Cancer Res 17: 229-235.
16. Maldonado JL, Fridlyand J, Patel H, Jain AN, Busam K, et al. (2003) Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst 95: 1878-1890.
17. Shinozaki M, Fujimoto A, Morton DL, Hoon DS (2004) Incidence of BRAF oncogene mutation and clinical relevance for primary cutaneous melanomas. Clin Cancer Res 10: 1753-1757. (Pubitemid 38435567)
18. Akslen LA, Angelini S, Straume O, Bachmann IM, Molven A, et al. (2005) BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. J Invest Dermatol 125: 312-317. (Pubitemid 41648165)
19. Chang DZ, Panageas KS, Osman I, Polsky D, Busam K, et al. (2004) Clinical significance of BRAF mutations in metastatic melanoma. J Transl Med 2: 46.
20. Kumar R, Angelini S, Czene K, Sauroja I, Hahka-Kemppinen M, et al. (2003) BRAF mutations in metastatic melanoma: a possible association with clinical outcome. Clin Cancer Res 9: 3362-3368. (Pubitemid 37082731)
21. Safaee Ardekani G, Jafarnejad SM, Tan L, Saeedi A, Li G (2012) The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis. PLoS One 7: e47054.
22. Lasithiotakis KG, Petrakis IE, Garbe C (2010) Cutaneous melanoma in the elderly: epidemiology, prognosis and treatment. Melanoma Res 20: 163-170.
23. Thompson JF, Soong SJ, Balch CM, Gershenwald JE, Ding S, et al. (2011) Prognostic significance of mitotic rate in localized primary cutaneous melanoma: an analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging database. J Clin Oncol 29: 2199-2205.
24. Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Reintgen DS, et al. (2001) Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 19: 3622-3634. (Pubitemid 32786275)
25. Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, et al. (2001) Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 19: 3635-3648. (Pubitemid 32786276)
26. Lee JH, Choi JW, Kim YS (2011) Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis. Br J Dermatol 164: 776-784.
27. Thomas NE, Edmiston SN, Alexander A, Millikan RC, Groben PA, et al. (2007) Number of nevi and early-life ambient UV exposure are associated with BRAFmutant melanoma. Cancer Epidemiol Biomarkers Prev 16: 991-997. (Pubitemid 46910102)
28. Greaves WO, Verma S, Patel KP, Davies MA, Barkoh BA, et al. (2013) Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma. J Mol Diagn 15: 220-226.
29. Colombino M, Capone M, Lissia A, Cossu A, Rubino C, et al. (2012) BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. J Clin Oncol 30: 2522-2529.
30. Capper D, Berghoff AS, Magerle M, Ilhan A, Wohrer A, et al. (2012) Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases. Acta Neuropathol 123: 223-233.
31. Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, et al. (2009) Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 27: 6199-6206.