MicroRNA-31 contributes to colorectal cancer development by targeting factor inhibiting HIF-1α (FIH-1)

Cancer Biology and Therapy

Volumn 15, Issue 5, 2014, Pages 516-523

  Chen, Tao ^a   Yao, Li Qing ^a   Shi, Qiang ^a   Ren, Zhong ^a   Ye, Le Chi ^a   Xu, Jian Min ^a   Zhou, Ping Hong ^a   Zhong, Yun Shi ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Colorectal cancer; FIH 1; MiRNA 31; Regulatory circuit; Tumorigenesis

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MICRORNA 31; HIF1AN PROTEIN, HUMAN; MICRORNA; MIRN31 MICRORNA, HUMAN; MIXED FUNCTION OXIDASE; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER TISSUE; CELL MIGRATION; CELL PROLIFERATION; CLINICAL FEATURE; COLON CARCINOGENESIS; COLORECTAL CANCER; COMPUTER MODEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; MOUSE; NONHUMAN; PROTEIN CONTENT; PROTEIN FUNCTION; TISSUE LEVEL; TUMOR INVASION; ADULT; AGED; ANIMAL; CANCER STAGING; CARCINOGENESIS; CELL MOTION; COLORECTAL NEOPLASMS; DISEASE COURSE; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; NUDE MOUSE; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE; VERY ELDERLY; XENOGRAFT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CARCINOGENESIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; HETEROGRAFTS; HUMANS; MALE; MICE, NUDE; MICRORNAS; MIDDLE AGED; MIXED FUNCTION OXYGENASES; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; REPRESSOR PROTEINS;

EID: 84899891202     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.28017     Document Type: Article

References (25)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11-30; PMID:23335087; http://dx.doi.org/10.3322/caac.21166
2. Sakamoto T, Niiya D, Seiki M. Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase. J Biol Chem 2011; 286:14691-704; PMID:21372132; http://dx.doi.org/10.1074/jbc.M110.188714
3. Semenza GL. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 2010; 20:51-6; PMID:19942427; http://dx.doi.org/10.1016/j.gde. 2009.10.009
4. Kuwai T, Kitadai Y, Tanaka S, Onogawa S, Matsutani N, Kaio E, Ito M, Chayama K. Expression of hypoxiainducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer 2003; 105:176-81; PMID:12673675; http://dx.doi.org/10.1002/ijc.11068 (Pubitemid 36505317)
5. Furlan D, Sahnane N, Carnevali I, Cerutti R, Uccella S, Bertolini V, Chiaravalli AM, Capella C. Up-regulation and stabilization of HIF-1alpha in colorectal carcinomas. Surg Oncol 2007; 16(Suppl 1):S25-7; PMID:18023174; http://dx.doi.org/10.1016/j.suronc.2007.10.014
6. Harris AL. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2:38-47; PMID:11902584; http://dx.doi.org/10.1038/nrc704 (Pubitemid 37328806)
7. Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 2001; 15:2675-86; PMID:11641274; http://dx.doi.org/10.1101/gad.924501 (Pubitemid 32988878)
8. Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, et al. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A 2006; 103:14767-72; PMID:17003112; http://dx.doi.org/10.1073/pnas.0606877103 (Pubitemid 44527803)
9. Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, et al. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem 2007; 282:24027-38; PMID:17573339; http://dx.doi.org/10. 1074/jbc.M704102200 (Pubitemid 47328043)
10. Couvelard A, Deschamps L, Rebours V, Sauvanet A, Gatter K, Pezzella F, Ruszniewski P, Bedossa P. Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors. Clin Cancer Res 2008; 14:6634-9; PMID:18927305; http://dx.doi.org/10. 1158/1078-0432.CCR-07-5258
11. Giatromanolaki A, Koukourakis MI, Pezzella F, Turley H, Sivridis E, Bouros D, Bougioukas G, Harris AL, Gatter KC. Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway. Cancer Lett 2008; 262:87-93; PMID:18187257; http://dx.doi.org/10.1016/j.canlet.2007.11.041
12. Liu CJ, Tsai MM, Hung PS, Kao SY, Liu TY, Wu KJ, Chiou SH, Lin SC, Chang KW. miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma. Cancer Res 2010; 70:1635-44; PMID:20145132; http://dx.doi.org/10.1158/0008-5472.CAN-09-2291
13. Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M, Nenutil R, Vyzula R. Altered expression of miR-21, miR-31, miR- 143 and miR-145 is related to clinicopathologic features of colorectal cancer. Oncology 2007; 72:397-402; PMID:18196926; http://dx.doi.org/10.1159/000113489 (Pubitemid 351238155)
14. Wang CJ, Zhou ZG, Wang L, Yang L, Zhou B, Gu J, Chen HY, Sun XF. Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer. Dis Markers 2009; 26:27-34; PMID:19242066; http://dx.doi.org/10.1155/2009/921907
15. Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487:330-7; PMID:22810696; http://dx.doi.org/10.1038/nature11252
16. Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The expression and distribution of the hypoxia-inducible factors HIF- 1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157:411-21; PMID:10934146; http://dx.doi.org/10. 1016/S0002-9440(10)64554-3 (Pubitemid 30626905)
17. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW. Overexpression of hypoxiainducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999; 59:5830-5; PMID:10582706
18. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 2009; 69:1221-9; PMID:19141645; http://dx.doi.org/10.1158/0008-5472.CAN-08-2516
19. Pocock R. Invited review: decoding the microRNA response to hypoxia. Pflugers Arch 2011; 461:307-15; PMID:21207057; http://dx.doi.org/10.1007/s00424- 010-0910-5
20. Oberg AL, French AJ, Sarver AL, Subramanian S, Morlan BW, Riska SM, Borralho PM, Cunningham JM, Boardman LA, Wang L, et al. miRNA expression in colon polyps provides evidence for a multihit model of colon cancer. PLoS One 2011; 6:e20465; PMID:21694772; http://dx.doi.org/10.1371/journal.pone.0020465
21. Cekaite L, Rantala JK, Bruun J, Guriby M, Agesen TH, Danielsen SA, Lind GE, Nesbakken A, Kallioniemi O, Lothe RA, et al. MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer. Neoplasia 2012; 14:868-79; PMID:23019418
22. Cekaite L, Rantala JK, Bruun J, Guriby M, Agesen TH, Danielsen SA, Lind GE, Nesbakken A, Kallioniemi O, Lothe RA, et al. MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer. Neoplasia 2012; 14:868-79; PMID:23019418
23. Peng H, Hamanaka RB, Katsnelson J, Hao LL, Yang W, Chandel NS, Lavker RM. MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism. FASEB J 2012; 26:3140-7; PMID:22532441; http://dx.doi.org/10.1096/ fj.11-198515
24. Sun D, Yu F, Ma Y, Zhao R, Chen X, Zhu J, Zhang CY, Chen J, Zhang J. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). J Biol Chem 2013; 288:9508-18; PMID:23322774; http://dx.doi.org/10. 1074/jbc.M112.367763
25. Yu J, Ryan DG, Getsios S, Oliveira-Fernandes M, Fatima A, Lavker RM. MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proc Natl Acad Sci U S A 2008; 105:19300-5; PMID:19033458; http://dx.doi.org/10. 1073/pnas.0803992105