Differential effects of presynaptic versus postsynaptic adenosine A2A receptor blockade on Δ9-tetrahydrocannabinol (THC) self-administration in squirrel monkeys

Journal of Neuroscience

Volumn 34, Issue 19, 2014, Pages 6480-6484

  Justinová, Zuzana ^a   Redhi, Godfrey H ^a   Goldberg, Steven R ^a   Ferré, Sergi ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Adenosine A2A receptor; Cannabinoids; Drug abuse; Monkey; Self administration; THC

Indexed keywords

1,3 DIETHYL 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 2 (2 FURANYL) 7 [3 (4 METHOXYPHENYL)PROPYL] 7H PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 5 AMINE; 3,7 DIHYDRO 8 [(1E) 2 (3 ETHOXYPHENYL)ETHENYL] 7 METHYL 3 [3 (PHOSPHOOXY)PROPYL 1 (2 PROPYNIL) 1H PURINE 2,6 DIONE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CANNABIS ADDICTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG SELF ADMINISTRATION; MALE; NEUROTRANSMISSION; NONHUMAN; POSTSYNAPTIC INHIBITION; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; RECEPTOR BLOCKING; SQUIRREL MONKEY;

ADENOSINE A2A RECEPTOR; CANNABINOIDS; DRUG ABUSE; MONKEY; SELF-ADMINISTRATION; THC;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRONABINOL; MALE; MARIJUANA ABUSE; PURINES; PYRAZOLES; PYRIMIDINES; RECEPTOR, ADENOSINE A2A; RECEPTORS, PRESYNAPTIC; REINFORCEMENT (PSYCHOLOGY); REWARD; SAIMIRI; SELF ADMINISTRATION; SYNAPSES; XANTHINES;

EID: 84899873549     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5073-13.2014     Document Type: Article

References (21)

1. 2A-D2 receptor heteromerization. Neuropsychopharmacology 34: 972-986. CrossRef Medline
2. 2A receptor heteromers. J Neurosci 26: 2080-2087. CrossRef Medline
3. 2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors. Curr Pharm Des 14: 1468-1474. CrossRef Medline
4. Gardner EL (2005) Endocannabinoid signaling system and brain reward: emphasis on dopamine. Pharmacol Biochem Behav 81: 263-284. CrossRef Medline
5. Goldberg SR (1973) Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey. J Pharmacol Exp Ther 186: 18-30. Medline
6. Jones IW, Wonnacott S (2004) Precise localization of alpha7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area. J Neurosci 24: 11244-11252. CrossRef Medline
7. Justinová Z, Tanda G, Redhi GH, Goldberg SR (2003) Self-administration of delta9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys. Psychopharmacology 169: 135-140. CrossRef
8. 2A receptor antagonist. Addict Biol 16: 405-415. CrossRef Medline
9. Justinová Z, Mascia P, Wu HQ, Secci ME, Redhi GH, Panlilio LV, Scherma M, Barnes C, Parashos A, Zara T, Fratta W, Solinas M, Pistis M, Bergman J, Kangas BD, Ferré S, Tanda G, Schwarcz R, Goldberg SR (2013) Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid. Nat Neurosci 16: 1652-1661. CrossRef Medline
10. Kaiser S, Wonnacott S (2000) alpha-bungarotoxin-sensitive nicotinic receptors indirectly modulate [(3)H]dopamine release in rat striatal slices via glutamate release. Mol Pharmacol 58: 312-318. CrossRef Medline
11. Orru M, Bakešová J, Brugarolas M, Quiroz C, Beaumont V, Goldberg SR, Lluís C, Cortés A, Franco R, Casadó V, Canela EI, Ferré S (2011) Striatal pre-and postsynaptic profile of adenosine A(2A) receptor antagonists. PLoS One 6: e16088. CrossRef Medline
12. 2A receptors in cortical neurotransmission to the striatal direct pathway. Scientific World Journal 9: 1321-1344. CrossRef Medline
13. Quiroz C, Pearson V, Gulyani S, Allen R, Earley C, Ferré S (2010) Upregulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmission. Exp Neurol 224: 292-298. CrossRef Medline
14. Rassoulpour A, Wu HQ, Ferre S, Schwarcz R (2005) Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum. J Neurochem 93: 762-765. CrossRef Medline
15. Schilström B, Svensson HM, Svensson TH, Nomikos GG (1998) Nicotine and food induced dopamine release in the nucleus accumbens of the rat: putative role of alpha7 nicotinic receptors in the ventral tegmental area. Neuroscience 85: 1005-1009. CrossRef Medline
16. Schmitt KC, Reith ME (2010) Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse. Ann N Y Acad Sci 1187: 316-340. CrossRef Medline
17. Shippenberg TS, Elmer GI (1998) The neurobiology of opiate reinforcement. Crit Rev Neurobiol 12: 267-303. CrossRef Medline
18. Solinas M, Scherma M, Fattore L, Stroik J, Wertheim C, Tanda G, Fratta W, Goldberg SR (2007) Nicotinic α7 receptors as a new target for treatment of cannabis abuse. J Neurosci 27: 5615-5620. CrossRef Medline
19. Tanda G, Pontieri FE, Di Chiara G (1997) Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism. Science 276: 2048-2050. CrossRef Medline
20. Tanda G, Munzar P, Goldberg SR (2000) Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys. Nat Neurosci 3: 1073-1074. CrossRef Medline
21. Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M (2013) Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Proc Natl Acad Sci U S A110: 12078-12083. CrossRef Medline