Up-regulation of striatal adenosine A2A receptors with iron deficiency in rats. Effects on locomotion and cortico-striatal neurotransmission.

Experimental Neurology

Volumn 224, Issue 1, 2010, Pages 292-298

  Quiroz, César ^a   Pearson, Virginia ^b   Gulyani, Seema ^c   Allen, Richard ^b   Earley, Christopher ^b   Ferré, Sergi ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Adenosine; Adenosine A2A receptor; Brain iron deficiency; Cortico striatal neurotransmission; Restless Legs Syndrome

Indexed keywords

ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MSX 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CONTROLLED STUDY; CORPUS STRIATUM; DENDRITE; ELECTROSTIMULATION; ENZYME PHOSPHORYLATION; GABAERGIC SYSTEM; IRON DEFICIENCY; LOCOMOTION; MALE; MOTOR PERFORMANCE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; RECEPTOR DENSITY; RECEPTOR UPREGULATION; RESTLESS LEGS SYNDROME; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CEREBRAL CORTEX; CORPUS STRIATUM; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; EXPLORATORY BEHAVIOR; IRON; MALE; MOTOR ACTIVITY; NEURAL PATHWAYS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A2A; RECEPTORS, TRANSFERRIN; SYNAPTIC TRANSMISSION; UP-REGULATION; XANTHINES;

EID: 77953728218     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2010.04.004     Document Type: Article

References (35)

1. Allen R. Dopamine and iron in the pathophysiology of restless legs syndrome (RLS). Sleep Med. 2004, 5:385-391.
2. Allen R.P., Picchietti D., Hening W.A., Trenkwalder C., Walters A.S., Montplaisir J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003, 4:101-119.
3. Allen R.P., Walter A.S., Montplaisir J., Hening W., Myers A., Bell T.J., Ferini-Strambi L. Restless legs syndrome prevalence and impact: REST general population study. Arch. Intern. Med. 2005, 165:1286-1292.
4. Angulo-Kinzler R.M., Peirano P., Lin E., Algarin C., Garrido M., Lozoff B. Twenty-four-hour motor activity in human infants with and without iron deficiency anemia. Early Hum. Dev. 2002, 70:85-101.
5. Azdad K., Gall D., Woods A.S., Ledent C., Ferré S., Schiffmann S.N. Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization. Neuropsychopharmacology 2008, 34:972-986.
6. Beard J.L. Iron deficiency alters brain development and functioning. J. Nutr. 2003, 133:1468S-1472S.
7. Beard J.L., Connor J.R. Iron status and neural functioning. Ann. Rev. Nutr. 2003, 23:41-58.
8. Boyer P.J., Ondo W.G., Allen R.P., Earley C.J., Menzies S.L., Chen X.L., Dellinger B.B., Connor J.R. Neuropathologic evaluation of the central nervous system in restless legs syndrome: case report and review of literature. Society for Neuroscience Annual Meeting. New Orleans, LA 2000.
9. Ciruela F., Casadó V., Rodrigues R.J., Luján R., Burgueño J., Canals M., Borycz J., Rebola N., Goldberg S.R., Mallol J., Cortés A., Canela E.I., López-Giménez J.F., Milligan G., Lluis C., Cunha R.A., Ferré S., Franco R. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. J. Neurosci. 2006, 26:2080-2087.
10. Connor J.R., Wang X.S., Patton S.M., Menzies S.L., Troncoso J.C., Earley C.J., Allen R.P. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology 2004, 62:1563-1567.
11. Connor J.R., Wang X.S., Allen R.P., Beard J.L., Wiesinger J.A., Felt B.T., Earley C.J. Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain 2009, 132:2403-2412.
12. Earley C.J., Connor J.R., Beard J.L., Malecki E.A., Epstein D.K., Allen R.P. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 2000, 54:1698-1700.
13. Earley C.J., Barker P.B., Horska A., Allen R.P. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep Med. 2006, 7:459-461.
14. Erikson K.M., Jones B.C., Beard J.L. Iron deficiency alters dopamine transporter functioning in rat striatum. J. Nutr. 2000, 130:2831-2837.
15. Erikson K.M., Jones B.C., Hess E.J., Zhang Q., Beard J.L. Iron deficiency decreases dopamine D1 and D2 receptors in rat brain. Pharmacol. Biochem. Behav. 2001, 69:409-418.
16. Ferré S., Fredholm B.B., Morelli M., Popoli P., Fuxe K. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 1997, 20:482-487.
17. Ferré S., Ciruela F., Canals M., Marcellino D., Burgueno J., Casadó V., Hillion J., Torvinen M., Fanelli F., Benedetti P.P., Goldberg S.R., Bouvier M., Fuxe K., Agnati L.F., Lluis C., Franco R., Woods A. Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders. Parkinsonism Relat. Disord. 2004, 10:265-271.
18. Ferré S., Agnati L.F., Ciruela F., Lluis C., Woods A.S., Fuxe K., Franco R. Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module. Brain Res. Rev. 2007, 55:55-67.
19. Ferré S., Quiroz C., Woods A.S., Cunha R., Popoli P., Ciruela F., Lluis C., Franco R., Azdad K., Schiffmann S.N. An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors. Curr. Pharm. Des. 2008, 14:1468-1474.
20. Fredholm B.B., IJzerman A.P., Jacobson K.A., Klotz K.N., Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 2001, 53:527-552.
21. Gerfen C.R., Miyachi S., Paletzki R., Brown P. D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase. J. Neurosci. 2002, 22:5042-5054.
22. Gulyani S., Earley C.J., Camandola S., Maudsley S., Ferré S., Mughal M.R., Martin B., Cheng A., Gleichmann M., Jones B.C., Allen R.P., Mattson M.P. Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells. Exp. Neurol. 2009, 215:236-242.
23. Karcz-Kubicha M., Antoniou K., Terasmaa A., Quarta D., Solinas M., Justinova Z., Pezzola A., Reggio R., Müller C.E., Fuxe K., Goldberg S.R., Popoli P., Ferré S. Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration. Neuropsychopharmacology 2003, 28:1281-1291.
24. Lok C.N., Loh T.T. Regulation of transferrin function and expression: review and update. Biol. Signals Recept. 1998, 7:157-178.
25. Lozoff B., Georgieff M.K. Iron deficiency and brain development. Semin. Pediatr. Neurol. 2006, 13:158-165.
26. Nelson C., Erikson K., Piñero D.J., Beard J.L. In vivo dopamine metabolism is altered in iron-deficient anemic rats. J. Nutr. 1997, 127:2282-2288.
27. Nordlander N.B. Restless legs. Brit. J. Phys. Med. 1954, 17:160-162.
28. Quiroz C., Gomes C., Pak A.C., Ribeiro J.A., Goldberg S.R., Hope B.T., Ferré S. Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation. J. Neurosci. 2006, 26:10808-10812.
29. Quiroz C., Lujan R., Uchigashima M., Simoes A.P., Lerner T.N., Borycz J., Kachroo A., Canas P.M., Orru M., Schwarzschild M.A., Rosin D.L., Kreitzer A.C., Cunha R.A., Watanabe M., Ferré S. Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway. Sci. World J. 2009, 9:1321-1344.
30. Rosin D.L., Robeva A., Woodard R.L., Guyenet P.G., Linden J. Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system. J. Comp. Neurol. 1998, 401:163-186.
31. Schiffmann S.N., Fisone G., Moresco R., Cunha R.A., Ferré S. Adenosine A2A receptors and basal ganglia physiology. Prog. Neurobiol. 2007, 83:277-292.
32. Tergau F., Wische S., Paulus W. Motor system excitability in patients with restless legs syndrome. Neurology 1999, 52:1060-1063.
33. Unger E.L., Wiesinger J.A., Hao L., Beard J.L. Dopamine D2 receptor expression is altered by changes in cellular iron levels in PC12 cells and rat brain tissue. J. Nutr. 2008, 2008(138):2487-2494.
34. Weinberg J., Dallman P.R., Levine S. Iron deficiency during early development in the rat: behavioral and physiological consequences. Pharmacol. Biochem. Behav. 1980, 12:493-502.
35. Youdim M.B., Ben-Shachar D., Ashkenazi R., Yehuda S. Brain iron and dopamine receptor function. Adv. Biochem. Psychopharmacol. 1983, 37:309-321.