Nanoemulsions for delivery of flavonoids: Formulation and in vitro release of rutin as model drug

Pharmaceutical Development and Technology

Volumn 19, Issue 6, 2014, Pages 677-680

  Macedo, Ana S ^a   Quelhas, Sara ^a   Silva, Amélia M ^b,c   Souto, Eliana B ^a,b  

^a UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^b UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^c UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

Author keywords

Flavonoids; In vitro release; Nanoemulsion; Nanoencapsulation; Poorly water soluble drugs; Rutin

Indexed keywords

FLAVONOID; RUTOSIDE;

ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; ENCAPSULATION; IN VITRO STUDY; NANOEMULSION; PARTICLE SIZE; PRIORITY JOURNAL; STEADY STATE; SUSTAINED DRUG RELEASE; ZETA POTENTIAL;

CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; EMULSIONS; FLAVONOIDS; NANOPARTICLES; PARTICLE SIZE; SOLUBILITY; WATER;

EID: 84899862640     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2013.823989     Document Type: Article

References (29)

1. Nijveldt RJ, van Nood E, van Hoorn DE, et al. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001;74:418-425.
2. Han Y. Rutin has therapeutic effect on septic arthritis caused by Candida albicans. Int Immunopharmacol 2009;9:207-211.
3. Almeida JS, Lima F, Ros SD, et al. Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies. Nanoscale Res Lett 2010;5:1603-1610.
4. Mauludin R, Müller RH, Keck CM. Kinetic solubility and dissolution velocity of rutin nanocrystals. Eur J Pharm Sci 2009;36: 502-510.
5. Robbins RC, Hammer RH, Simpson CF. Methoxylated phenyl benzo-g-pyrone derivatives (flavonoids) that highly inhibit erythrocyte aggregation. Clin Chem 1971;17:1110-1113.
6. Yang J, Guo J, Yuan J. In vitro antioxidant properties of rutin. LWT 2008;41:1060-1066.
7. Jiménez-Aliaga K, Bermejo-Bescós P, Benedí J, Martín-Aragón S. Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells. Life Sci 2011;89:939-945.
8. Iacopini P, Baldi M, Storchi P, Sebastiani L. Catechin, epicatechin, quercetin, rutin and resveratrol in red grape: content, in vitro antioxidant activity and interactions. J Food Compost Anal 2008;21: 589-598.
9. Chat OA, Najar MH, Mir MA, et al. Effects of surfactant micelles on solubilization and DPPH radical scavenging activity of rutin. J Colloid Interface Sci 2011;355:140-149.
10. Mauludin R, Müller RH, Keck CM. Development of an oral rutin nanocrystal formulation. Int J Pharm 2009;370:202-209.
11. Kazlowska K, Hsu T, Hou CC, et al. Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata. J Ethnopharmacol 2010;128:123-130.
12. Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Il Farmaco 2001;56:683-687.
13. Dall'Acqua S, Bolego C, Cignarella A, et al. Vasoprotective activity of standardized Achillea millefolium extract. Phytomedicine 2011; 18:1031-1036.
14. Tian X, Li F, Zhu L, Ye B. Study on the electrochemical behavior of anticancer herbal drug rutin and its interaction with DNA. J Electroanal Chem 2008;621:1-6.
15. Orhan DD, Özçelik B, Özgen S, Ergun F. Antibacterial, antifungal, and antiviral activities of some flavonoids. Microbiol Res 2010;165: 496-504.
16. Lin YJ, Chang YC, Hsiao NW, et al. Fisetin and rutin as 3C protease inhibitors of enterovirus A71. J Virol Methods 2012;182:93-98.
17. Müller RH, Schmidt S, Buttle I, et al. SolEmuls - novel technology for the formulation of i.v. emulsions with poorly soluble drugs. Int J Pharm 2004;269:293-302.
18. Akkar A, Müller RH. Intravenous itraconazole emulsions produced by SolEmuls technology. Eur J Pharm Biopharm 2003;56:29-36.
19. Hoeller S, Sperger A, Valenta C. Lecithin based nanoemulsions: a comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation. Int J Pharm 2009;370:181-186.
20. Anton N, Vandamme TF. Nano-emulsions and micro-emulsions: clarifications of the critical differences. Pharm Res 2011;28: 978-985.
21. Li Y, Zheng J, Xiao H, McClements DJ. Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: influence of formulation parameters on polymethoxyflavone crystallization. Food Hydrocoll 2012;27:517-528.
22. Kong M, Park HJ. Stability investigation of hyaluronic acid based nanoemulsion and its potential as transdermal carrier. Carbohydr Polym 2011;83:1303-1310.
23. Silva HD, Cerqueira MA, Souza BWS, et al. Nanoemulsions of b-carotene using a high-energy emulsification-evaporation technique. J Food Eng 2011;102:130-135.
24. Bouchemal K, Briançon S, Perrier E, Fessi H. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. Int J Pharm 2004;280:241-251.
25. Gao F, Zhang Z, Bu H, et al. Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: performance and mechanism. J Control Release 2011;149:168-174.
26. Doktorovova S, Shegokar R, Rakovsky E, et al. Cationic solid lipid nanoparticles (cSLN): structure, stability and DNA binding capacity correlation studies. Int J Pharm 2011;420:341-349.
27. Kelmann RG, Kuminek G, Teixeira HF, Koester LS. Carbamazepine parenteral nanoemulsions prepared by spontaneous emulsification process. Int J Pharm 2007;342:231-239.
28. Li H, Zhao X, Ma Y, et al. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J Control Release 2009;133:238-244.
29. Araújo FA, Kelmann RG, Araújo BV, et al. Development and characterization of parenteral nanoemulsions containing thalidomide. Eur J Pharm Sci 2011;42:238-245.