Early-response biomarkers for assessment of radiation exposure in a mouse total-body irradiation model

Health Physics

Volumn 106, Issue 6, 2014, Pages 772-786

  Ossetrova, Natalia I ^b   Condliffe, Donald P ^b   Ney, Patrick H ^b   Krasnopolsky, Katya ^b   Hieber, Kevin P ^b   Rahman, Arifur ^b   Sandgren, David J ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b NONE

Author keywords

Bioassay; Biological indicators; Radiobiology; Whole body irradiation

Indexed keywords

BIOLOGICAL MARKER; COBALT; CYTOKINE;

ANIMAL; BLOOD; CONFERENCE PAPER; CYTOLOGY; GAMMA RADIATION; HEMATOPOIESIS; LYMPHOCYTE COUNT; MALE; METHODOLOGY; MOUSE; NEUTROPHIL; RADIATION EXPOSURE; RADIATION MONITORING; TIME; WHOLE BODY RADIATION;

ANIMALS; BIOLOGICAL MARKERS; COBALT RADIOISOTOPES; CYTOKINES; GAMMA RAYS; HEMATOPOIESIS; LYMPHOCYTE COUNT; MALE; MICE; NEUTROPHILS; RADIATION MONITORING; TIME FACTORS; WHOLE-BODY IRRADIATION;

EID: 84899861255     PISSN: 00179078     EISSN: 15385159     Source Type: Journal    
DOI: 10.1097/HP.0000000000000094     Document Type: Conference Paper

References (71)

1. Agay D CY, Herodin F, Mathieu J, Multon E, Van Uye A, Mestries JC. The inflammatory response plays a major role in the acute radiation syndrome induced by fission radiation. Radioprotection 32:C47-C49; 1997
2. Bachmann S, Le Hir M, Eckardt KU. Co-localization of erythropoietin m-RNA and ecto 5' nucleotidase immunoreactivity in peritubular cells in rat renal cortex indicate that fibroblasts produce erythropoietin. J Histochm Cytochem 41: 335-341; 1993
3. Baiocchi G, Scambia G, Benedetti P, Menichella G, Testa U, Pierelli L, Martucci R, Foddai ML, Bizzi B, Mancuso S, Peschie C. Autologous stem cell transplantation: sequential production of hematopoietic cytokines underlying granulocyte recovery. Cancer Res 53:1297-1303; 1993
4. Baumann H, Gauldie J. Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Molecular Biol Medicine 7:147-159; 1990
5. Baranov AE, Guskova AK, Nadejina NM, Nugis VY. Chernobyl experience: biological indicators of exposure to ionizing radiation. Stem Cells 13(Suppl 1):69-77; 1995
6. Barshishat-Kupper M, Mungunsukh O, Tipton A, McCart E, Panganiban R, Davis T, Landauer M, Day R. Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation. Experimental Hematol 39:293-304; 2011
7. Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Chang MS, Samal B, Nichol JL, Swift S. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor mpl. Cell 77:1117-1124; 1994
8. Bertho JM, Demarquay C, Frick J, Joubert C, Arenales S, Jacquet N, Sorokine-Durm I, Chau Q, Lopez M, Aigueperse J, Gorin NC, Gourmelon P. Level of Flt3 ligand in plasma: a possible new bio-indicator for radiation-induced aplasia. International J Radiat Biol 77:703-712; 2001
9. Bertho JM, Roy L, Souidi M, Benderitter M, Gueguen Y, Lataillade JJ, Prat M, Fagot T, De Revel T, Gourmelon P. New biological indicators to evaluate and monitor radiationinduced damage: an accident case report. Radiat Research 169:543-550; 2008
10. Blakely WF, Ossetrova NI, Manglapus GL, Salter CA, Levine IH, Jackson WE, Grace MB, Prasanna PGS, Sandgren DJ, Ledney GD. Amylase and blood cell-count hematological radiation-injury biomarkers in a rhesus monkey radiation model-use of multiparameter and integrated biological dosimetry. Radiat Meas 42:1164-1170; 2007
11. Blakely WF, Ossetrova NI, Whitnall MH, Sandgren DJ, Krivokrysenko VI, Shakhov A, Feinstein E.Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applications. Health Phys 98:153-159; 2010
12. Bronchud MH, Potter MR, Morgenstern G, BlascoMJ, Scarffe JH, Thatcher N, Crowther D, Souza LM, Alton NK, Testa NG. In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients. Br J Cancer 58:64-69; 1988
13. Broudy VC, Kaushansky K. Thrombopoietin, the C-MPL ligand, is a major regulator of platelet production. J Leukoc Biol 57: 719-725; 1995
14. Dainiak N. Hematologic consequences of exposure to ionizing radiation. Exp Hematol 30:513-528; 2002
15. Dainiak N,Waselenko JK, Armitage JO,MacVittie TJ, Farese AM. The hematologist and radiation casualties. Hematology. 1:473-496; 2003
16. Elliott S, Pham E, Macdougall IC. Erythropoietins: a common mechanism of action. Exp Hematol 36:1573-1584; 2008
17. Fliedner TM, Friesecke I, Beyrer K. Medical management of radiation accidents-manual on the acute radiation syndrome. London: The British Institute of Radiology; 2001
18. Fliedner TM, Graessle D, Paulsen C, Reimers K. Structure and function of bone marrow hemopoiesis:mechanisms of response to ionizing radiation exposure. Cancer Biother Radiopharm 17:405-426; 2002
19. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. New England J Med 340: 448-454; 1999
20. Goans RE, Holloway EC, Berger ME, Ricks RC. Early dose assessment following severe radiation accidents. Health Phys 72:513-518; 1997
21. Guipaud O, Holler V, Buard V, Tarlet G, Royer N, Vinh J, BenderitterM. Time-course analysis of mouse serum proteome changes following exposure of the skin to ionizing radiation. Proteomics 7:3992-4002; 2007
22. Hameed JM, Haley TJ. Plasma and adrenal gland corticosterone levels after x-ray exposure in rats. Radiat Res 23: 620-629; 1964
23. Harker LA, Hunt P, Marzec UM, Kelly AB, Tomer A, Hanson SR, Stead RB. Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 87:1833-1844; 1996
24. Hokom MM, Lacey D, Kinstler OB, Choi E, Kaufman S, Faust J, Rowan C, Dwyer E, Nichol JL, Grasel T, Wilson J, Steinbrink R, Hecht R, Winters D, Boone T, Hunt P. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 86:4486-4492; 1995
25. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC. Promotion of megakaryocyte progenitor expansion and differentiation by the C-MPL ligand thrombopoietin. Nature 369:568-571; 1994
26. Koc M, Taysi S, Sezen O, Bakan N. Levels of some acute-phase proteins in the serum of patients with cancer during radiotherapy. Biol Pharmaceutical Bulletin 26:1494-1497; 2003
27. Kovalev EE, Smirnova OA. Estimation of radiation risk based on the concept of individual variability of radiosensitivity. Bethesda, MD: Armed Forces Radiobiology Research Institute; Contract Report CR961, ADA310666; 1996
28. Levine SJ, Larivee P, Logun C, Angus CW, Shelhamer JH. Corticosteroids differentially regulate secretion of IL 6, IL 8, and G CSF by a human bronchial epithelial cell line. Am J Physiol 265:L360-L368; 1993
29. Li B, Pan H, Winkelmann JC, Dai W. Thrombopoietin and its alternatively spliced form are expressed in human amygdala and hippocampus. Blood 87:5382-5384; 1996
30. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Balley MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369: 565-568; 1994
31. Lord BI, Bronchud MH, Owens S, Chang J, Howell A, Souza L, Dexter TM. The kinetics of human granulopoiesis following treatment with granulocyte colony stimulating factor in vivo. Proc Natl Acad Sci USA 86:9499-9503; 1989
32. Lushbaugh CC. Reflections on some recent progress in human radiobiology. In: Augenstein LC, Mason R, Zelle M, eds. Advances in radiation biology. New York: Academic Press; 1969: 277-314
33. Lutgens LC HW, Deutz NEP, Gueulette J, Cleutjens JPM, Berger MPF, Wouters BG, Von Meyenfeldt MF, Lambin P. Citrulline: A physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage. Int J Radiat Oncol Biol Phys 57:1067-1074; 2003
34. MacVittie TJ, Monroy RL, Patchen ML, Souza LM. Therapeutic use of recombinant human G-CSF in a canine model of sublethal and lethal whole-body irradiation. Int J Radiat Biol 57:723; 1990
35. MacVittie TJ, Farese AM, Patchen ML, Myers LA. Therapeutic efficacy of recombinant interleukin 6 (IL 6) alone and combined with recombinant human IL 3 in a non-human primate model of high-dose, sublethal radiation-induced marrow aplasia. Blood 84:2515-2522; 1994
36. McIntosh JK, Jablons DM, Mule JJ, Nordan RP, Rudikoff S, LotzeMT. Rosenberg SA: In vivo induction of IL 6 by administration of exogenous cytokines and detection of de novo serum levels of IL 6 in tumor-bearing mice. J Immunol 143:162-167; 1989
37. Mal'tsev VN, Strel'nikov VA, Ivanov AA. C-reactive protein in the blood serum as an indicator of the severity of radiation lesion. Doklady Akademii Nauk SSR 239: 750-752; 1978
38. Mal'tsev VN, Ivanov AA, Mikhailov VF, Mazurik VK. The individual prognosis of the gravity of the outcome of radiation disease on immunological indexes. J Radiat Biol 46: 152-158; 2006
39. Marchetti F, Coleman MA, Jones IM, Wyrobek AJ. Candidate protein biodosimeters of human exposure to ionizing radiation. International J Radiat Biol 82:605-639; 2006
40. Mayer P, Schutze E, Lam C, Kricek F, Liehl E. Recombinant murine granulocyte macrophage colony-stimulating factor augments recovery and enhances resistance to infections in myelosuppressed mice. J Infect Dis 163:584-590; 1991
41. Metcalf D. The granulocyte-macrophage colony-stimulating factors. Science 229:16-22; 1985
42. Monroy RL, Skelly RR, MacVittie TJ, Davis TA, Sauber JJ, Clark SC, Donahue RE. The effect of recombinant GM-CSF on the recovery of monkeys transplanted with autologous bone marrow. Blood 70:1696; 1987
43. Neta R, Perlstein R, Vagel SN, Ledney GD, Abrams J. Role of interleukin 6 (IL 6) in protection from lethal irradiation and in endocrine response to IL 1 and tumor necrosis factor. J Exp Med 175:689-694; 1992
44. Nunia V, Goyal PK. Prevention of gamma radiation induced anaemia in mice by diltiazem. J Radiat Res 45:11-17; 2004
45. Ogilvie M, Yu X, Nicolas-Metral V, Pulido SM, Liu C, Ruegg UT, Noguchi CT. Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts. J Biol Chem 15:275 (50), 39754-39761; 2000
46. Ossetrova NI, Farese AM, MacVittie TJ, Manglapus GL, Blakely WF. The use of discriminant analysis for evaluation of early-response multiple biomarkers of radiation exposure using non-human primate 6 Gy whole-body radiation model. Radiat Meas 42:1158-1163; 2007
47. Ossetrova NI, Blakely WF. Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model. International J Radiat Biol 85: 837-850; 2009
48. Ossetrova NI, Sandgren DJ, Gallego S, Blakely WF. Combined approach of hematological biomarkers and plasma protein SAA for improvement of radiation dose assessment in triage biodosimetry applications. Health Phys 98:204-208; 2010
49. Ossetrova NI, Sandgren DJ. Biomarkers for early-response assessment of radiation exposure. In: Proceedings of the Third International Symposium on Radiation Emergency Medicine. Japan: Hirosaki University; 2011: 105-115
50. Ossetrova NI, Sandgren DJ, Blakely WF. C-reactive protein and serum amyloid A as early-phase and prognostic indicators of acute radiation exposure in nonhuman primate total-body irradiation model. Radiat Meas 46:1019-1024; 2011
51. Paschos N, Lykissas MG, Beris AE. The role of erythropoietin as an inhibitor of tissue ischemia. Int J Biol Sci 4:161-168; 2008
52. Petrov R. Immunology of acute radiation injury. Arlington, VA: Joint Publications Research Service; 1963
53. Sachs L. The molecular control of haematopoiesis: from cell cultures to the clinic. In: Molograstim GM-CSF: Possibilities and perspectives. London: Royal Society of Medicine Services; 1992: 311
54. Safwat A, Bentzen SM, Nielsen OS, Overgaard J. Time course of the hazard of murine nephropathy induced by total body irradiation. Int J Radiat Biol 76:979-983; 2000
55. Saito S, Kawano Y, Watanabe T, Okamoto Y, Abe T, Kurada Y, Takaue Y. Serum granulocyte colony-stimulating factor kinetics in children receiving intense chemotherapy with or without stem cell support. J Hematother 8:291-297; 1999
56. Satyamitra M, Lombardini E, Graves J, Mullaney C, Ney P, Hunter J, Johnson K, Tamburini P, Wang Y, Springhorn JP, Srinivasan V. A TPO receptor agonist, ALXN4100TPO, mitigates radiation-induced lethality and stimulates hematopoiesis in CD2F1 mice. Radiat Res 175:746-758; 2011
57. Schooley JC, Haves JM, Cantor LN, Harens VW. Studies in the behaviour of erythropoietic sensitive cells in the mouse during recovery from 200 Roentgens of whole body irradiation. Radiat Res 32:875-883; 1967
58. Singh VK, Fatanmi OO, Singh PK, Whitnall MH. Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation. Cytokine 58:406-414; 2012
59. Srinivasan V, Doctrow S, Singh VK, Whitnall MH. Evaluation of EUK 189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol 30:271-290; 2008
60. Stoffel RA, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 87: 567; 1996
61. Thomas J, Liu F, Link DC. Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol 9:183-189; 2002
62. Tukachinski SE, Moiseeva VP. Cx-reactive protein in radiation injury. Bulletin Experimental Biol Medicine 52:48-52; 1961
63. Ulich TR, del Castillo J, Yin S, Swift S, Padilla D, Senaldi G, LBenet L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WT, Hunt P. Megakaryocyte growth and developmental factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 86: 971; 1995
64. Vriesendorp HM, van Bekkum DW. Role of total body irradiation in conditioning for bone marrow transplantation. Haematol Blood Transfusion 25:349-364; 1980
65. Wang GG, Clark SC. Multiple action of interleukin 6 within a cytokine network. Immunol Today 9:137-139; 1988
66. Weisbart RH, Gasson JC, Golde DW. Colony-stimulating factors and host defense. Ann Intern Med 110:297-303; 1989
67. Welte K, Bonilla MA, Gillio AP, Boone TC, Potter GK, Gabrilove JL, Moore MAS, OReilly RJ, Souza LM. Recombinant human granulocyte colony-stimulating factor. Effects on hemopoiesis in normal and cyclophosphamide-treated primates. J Exp Med 165:941; 1987
68. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W. C-MPL ligand is a humoral regulator of megakaryopoiesis. Nature 369:571; 1994
69. Wood HF, Anderle S, Hammond CW, Miller CP. Studies on the Cx-reactive protein. The effect of irradiation on the acute phase protein system. J Experimental Medicine 111: 601-609; 1960
70. Xia J, Broadhurst DI, Wilson M, Wishart DS. Translational biomarker discovery in clinical metabolomics: an introductory tutorial. Metabolomics 9:280-299; 2013
71. Zhang A, Azizova TV, Wald N, Day R. Changes of ratio of peripheral neutrophils and lymphocytes after radiation exposure may serve as a prognostic indicator of accident severity. In: Final Program, 49th Annual Meeting of the Health Physics Society. McLean, VA: Health Physics Society; 2004: P8, 17.