Association between HLA variations and chronic hepatitis B virus infection in Saudi Arabian patients

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Al Qahtani, Ahmed A ^a,d   Al Anazi, Mashael R ^a   Abdo, Ayman A ^b,d   Sanai, Faisal M ^c,d   Al Hamoudi, Waleed ^b,d   Alswat, Khalid A ^b,d   Al Ashgar, Hamad I ^a   Khalaf, Nisreen Z ^a   Eldali, Abdelmoneim M ^a   Viswan, Nisha A ^a   Al Ahdal, Mohammed N ^a  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; HLA DP ANTIGEN; HLA DQ ANTIGEN;

ADULT; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HEPATITIS B; HLA GENE; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; SAUDI ARABIA; SINGLE NUCLEOTIDE POLYMORPHISM; VIRAL CLEARANCE; AGED; ALLELE; CARCINOMA, HEPATOCELLULAR; CASE CONTROL STUDY; EPIDEMIOLOGY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; HEPATITIS B, CHRONIC; LIVER NEOPLASMS; MIDDLE AGED; YOUNG ADULT;

ADULT; AGED; ALLELES; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENOTYPE; HAPLOTYPES; HEPATITIS B, CHRONIC; HLA ANTIGENS; HLA-DP ANTIGENS; HLA-DQ ANTIGENS; HUMANS; LINKAGE DISEQUILIBRIUM; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SAUDI ARABIA; YOUNG ADULT;

EID: 84899856630     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080445     Document Type: Article

References (30)

1. Lavanchy D (2004) Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 11: 97-107.
2. Purcell RH (1993) The discovery of the hepatitis viruses. Gastroenterology 104: 955-963.
3. Araujo NM, Waizbort R, Kay A (2011) Hepatitis B virus infection from an evolutionary point of view: how viral, host, and environmental factors shape genotypes and subgenotypes. Infect Genet Evol 11: 1199-1207.
4. Ahn SH, Han KH, Park JY, Lee CK, Kang SW, et al. (2000) Association between hepatitis B virus infection and HLA-DR type in Korea. Hepatology 31: 1371-1373. (Pubitemid 30351301)
5. Thio CL, Thomas DL, Karacki P, Gao X, Marti D, et al. (2003) Comprehensive analysis of class I and class II HLA antigens and chronic hepatitis B virus infection. J Virol 77: 12083-12087. (Pubitemid 37345173)
6. Wu YF, Wang LY, Lee TD, Lin HH, Hu CT, et al. (2004) HLA phenotypes and outcomes of hepatitis B virus infection in Taiwan. J Med Virol 72: 17-25.
7. Accolla RS, De Lerma Barbaro A, Mazza S, Casoli C, De Maria A, et al. (2001) The MHC class II transactivator: prey and hunter in infectious diseases. Trends Immunol 22: 560-563. (Pubitemid 33016403)
8. Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, et al. (2005) Nomenclature for factors of the HLA system, 2004. Tissue Antigens 65: 301-369. (Pubitemid 40470607)
9. Blackwell JM, Jamieson SE, Burgner D (2009) HLA and infectious diseases. Clin Microbiol Rev 22: 370-385, Table of Contents.
10. Lu LP, Li XW, Liu Y, Sun GC, Chen ZH, et al. (2006) [Association of haplotype formed on HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23: 427-430.
11. Thio CL, Carrington M, Marti D, O'Brien SJ, Vlahov D, et al. (1999) Class II HLA alleles and hepatitis B virus persistence in African Americans. J Infect Dis 179: 1004-1006. (Pubitemid 29159348)
12. Jiang YG, Wang YM, Liu TH, Liu J (2003) Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B. World J Gastroenterol 9: 2221-2225.
13. Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, et al. (2009) A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 41: 591-595.
14. Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, et al. (2011) A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum Mol Genet 20: 3884-3892.
15. Yan Z, Tan S, Dan Y, Sun X, Deng G, et al. (2012) Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: case-control study and meta-analysis. Infect Genet Evol 12: 1222-1228.
16. An P, Winkler C, Guan L, O'Brien SJ, Zeng Z (2011) A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese. J Infect Dis 203: 943-947.
17. Guo X, Zhang Y, Li J, Ma J, Wei Z, et al. (2011) Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. Hepatology 53: 422-428.
18. Hu L, Zhai X, Liu J, Chu M, Pan S, et al. (2012) Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development. Hepatology 55: 1426-1431.
19. Lau KC, Lam CW, Law CY, Lai ST, Tsang TY, et al. (2011) Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment. Clin Chim Acta 412: 952-957.
20. Abdo AA, Karim HA, Al Fuhaid T, Sanai FM, Kabbani M, et al. (2006) Saudi Gastroenterology Association guidelines for the diagnosis and management of hepatocellular carcinoma: summary of recommendations. Ann Saudi Med 26: 261-265. (Pubitemid 44679984)
21. Li J, Yang D, He Y, Wang M, Wen Z, et al. (2011) Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. PLoS One 6: e24221.
22. Wang L, Wu XP, Zhang W, Zhu DH, Wang Y, et al. (2011) Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies. PLoS One 6: e17608.
23. Vermehren J, Lotsch J, Susser S, Wicker S, Berger A, et al. (2012) A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers. PLoS One 7: e32605.
24. Nishida N, Sawai H, Matsuura K, Sugiyama M, Ahn SH, et al. (2012) Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. PLoS One 7: e39175.
25. Katsuyama Y, Inoko H, Imanishi T, Mizuki N, Gojobori T, et al. (1998) Genetic relationships among Japanese, northern Han, Hui, Uygur, Kazakh, Greek, Saudi Arabian, and Italian populations based on allelic frequencies at four VNTR (D1S80, D4S43, COL2A1, D17S5) and one STR (ACTBP2) loci. Hum Hered 48: 126-137. (Pubitemid 28220759)
26. Tseng TC, Yu ML, Liu CJ, Lin CL, Huang YW, et al. (2011) Effect of host and viral factors on hepatitis B e antigen-positive chronic hepatitis B patients receiving pegylated interferon-alpha-2a therapy. Antivir Ther 16: 629-637.
27. Thomas R, Thio CL, Apps R, Qi Y, Gao X, et al. (2012) A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection. J Virol 86: 6979-6985.
28. Kumar V, Kato N, Urabe Y, Takahashi A, Muroyama R, et al. (2011) Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. Nat Genet 43: 455-458.
29. Li S, Qian J, Yang Y, Zhao W, Dai J, et al. (2012) GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet 8: e1002791.
30. O'Brien TR, Kohaar I, Pfeiffer RM, Maeder D, Yeager M, et al. (2011) Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. Genes Immun 12: 428-433.