A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection

Journal of Virology

Volumn 86, Issue 12, 2012, Pages 6979-6985

  Thomas, Rasmi ^a,b,i   Thio, Chloe L ^c   Apps, Richard ^a   Qi, Ying ^a   Gao, Xiaojiang ^a   Marti, Darlene ^a   Stein, Judy L ^d   Soderberg, Kelly A ^d   Moody, M Anthony ^d   Goedert, James J ^e   Kirk, Gregory D ^f   Hoots, W Keith ^g   Wolinsky, Steven ^h   Carrington, Mary ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b SAIC FREDERICK INC   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^g NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^h NORTHWESTERN UNIVERSITY   (United States)

ⁱ WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DPB1 ANTIGEN;

3' UNTRANSLATED REGION; AFRICAN AMERICAN; ALLELE; ALLOTYPE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; EUROPEAN AMERICAN; EXON; GENE; GENE EXPRESSION REGULATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEPATITIS B; HUMAN; HUMAN LEUKOCYTE ANTIGEN DPA1 GENE; HUMAN LEUKOCYTE ANTIGEN DPB1 GENE; INFECTION RISK; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

COHORT STUDIES; CONTINENTAL POPULATION GROUPS; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HEPATITIS B; HEPATITIS B VIRUS; HLA-DP ALPHA-CHAINS; HLA-DP BETA-CHAINS; HUMANS;

HEPATITIS B VIRUS;

EID: 84864000906     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00406-12     Document Type: Article

References (33)

1. Apps R, et al. 2009. Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies. Immunology 127:26 -39.
2. Edwards JA, Durant BM, Jones DB, Evans PR, Smith JL. 1986. Differential expression of HLA class II antigens in fetal human spleen: relationship of HLA-DP, DQ, and DR to immunoglobulin expression. J. Immunol. 137:490-497.
3. Goedert JJ, et al. 1989. A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia. N. Engl. J. Med. 321:1141-1148.
4. Guo X, et al. 2011. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. Hepatology 53:422- 428.
5. Hilgartner MW, et al. 1993. Hemophilia growth and development study. Design, methods, and entry data. Am. J. Pediatr. Hematol. Oncol. 15:208- 218.
6. Horejsi V, et al. 1988. Characterization of a new murine monoclonal antibody against human DP antigens. Tissue Antigens 32:6 -11.
7. Hyams KC. 1995. Risks of chronicity following acute hepatitis B virus infection: a review. Clin. Infect. Dis. 20:992-1000.
8. Kamatani Y, et al. 2009. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat. Genet. 41:591-595.
9. Klohe EP, et al. 1988. Analysis of the molecular specificities of anti-class II monoclonal antibodies by using L cell transfectants expressing HLA class II molecules. J. Immunol. 141:2158 -2164.
10. Kulkarni S, et al. 2011. Differential microRNA regulation of HLA-C expression and its association with HIV control. Nature 472:495- 498.
11. Lee WM. 1997. Hepatitis B virus infection. New Engl. J. Med. 337:1733- 1745.
12. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402- 408.
13. Locarnini S. 2004. Molecular virology of hepatitis B virus. Semin. Liver Dis. 24(Suppl 1):3-10.
14. Mbarek H, et al. 2011. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum. Mol. Genet. 20:3884 -3892.
15. O'Brien TR, et al. 2011. Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. Genes Immun. 12:428-433.
16. Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45. doi:10.1093/nar/29.9.e45.
17. Phair J, et al. 1992. Acquired immune deficiency syndrome occurring within 5 years of infection with human immunodeficiency virus type-1: the Multicenter AIDS Cohort Study. J. Acquir. Immune Defic. Syndr. 5:490-496.
18. Png E, et al. 2011. A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. Hum. Mol. Genet. 20:3893-3898.
19. Raychaudhuri S, et al. 2012. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat. Genet. 44:291-296.
20. Robbins PA, Evans EL, Ding AH, Warner NL, Brodsky FM. 1987. Monoclonal antibodies that distinguish between class II antigens (HLADP, DQ, and DR) in 14 haplotypes. Hum. Immunol. 18:301-313.
21. Rozemuller EH, van der Zwan A, Tilanus MGJ. 2006. Sequence based typing for HLA-DPA1, p 372-373. In Hansen JA (ed), Immunology of the human MHC, Proceedings of the 13th International Histocompatibility Workshop aand Conference, vol II. IHWC Press, Seattle, WA.
22. Sidney J, et al. 2010. Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity. J. Immunol. 184:2492-2503.
23. Singh R, Kaul R, Kaul A, Khan K. 2007. A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J. Gastroenterol. 13:1770 -1787.
24. Thio CL, et al. 2007. Genetic protection against hepatitis B virus conferred by CCR5Delta32: evidence that CCR5 contributes to viral persistence. J. Virol. 81:441- 445.
25. Thio CL, et al. 2008. Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. J. Immunol. 181:7944- 7947.
26. Thio CL, et al. 1999. Class II HLA alleles and hepatitis B virus persistence in African-Americans. J. Infect. Dis. 179:1004 -1006.
27. Thio CL, et al. 2003. Comprehensive analysis of class I and class II HLA antigens and chronic hepatitis B virus infection. J. Virol. 77:12083-12087.
28. Thomas R, et al. 2009. HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nat. Genet. 41: 1290-1294.
29. Thursz M, Yee L, Khakoo S. 2011. Understanding the host genetics of chronic hepatitis B and C. Semin. Liver Dis. 31:115-127.
30. van Roon JA, Bijlsma JW. 2002. Th2 mediated regulation in RA and the spondyloarthropathies. Ann. Rheum. Dis. 61:951-954.
31. Vlahov D, et al. 1998. Prognostic indicators for AIDS and infectious disease death in HIV-infected injection drug users: plasma viral load and CD4+ cell count. JAMA 279:35- 40.
32. Vooter CE, Kik MC, van den Berg-Loonen EM. 2006. Sequence based typing for HLA-DPB1, p 376-379. In Hansen JA (ed), Immunology of the human MHC, Proceedings of the 13th International Histocompatibility Workshop and Conference, vol II. IHWC Press, Seattle, WA.
33. Watson AJ, DeMars R, Trowbridge IS, Bach FH. 1983. Detection of a novel human class II HLA antigen. Nature 304:358 -361.