Differential expression of inflammationrelated genes in the ovarian stroma and granulosa cells of PCOS women

Molecular Human Reproduction

Volumn 20, Issue 1, 2014, Pages 49-58

  Schmidt, Johanna ^a   Weijdegård, Birgitta ^a   Mikkelsen, Anne Lis ^b,c   Lindenberg, Svend ^d   Nilsson, Lars ^a   Brännström, Mats ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b HOLBÆK HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Section for Human Reproduction   (Denmark)

Author keywords

Gene expression; Granulosa cells; Ovary; Polycystic ovary syndrome; Stroma

Indexed keywords

AMPHIREGULIN; BONE MORPHOGENETIC PROTEIN 6; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 12; PLACENTA PROTEIN 5; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHEMOKINE LIGAND 2 GENE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLICULAR PHASE; GENE; GENE EXPRESSION; GRANULOSA CELL; HUMAN; HUMAN TISSUE; INFLAMMATION; INTERLEUKIN 1 RECEPTOR TYPE I GENE; INTERLEUKIN 8 GENE; NITRIC OXIDE SYNTHASE 2 GENE; OUTCOME ASSESSMENT; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; OVARY STROMA; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE STUDY; STROMA; TISSUE INHIBITOR OF METALLOPROTEINASE 1 GENE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; OVARY; STROMA CELL; YOUNG ADULT;

GENE EXPRESSION; GRANULOSA CELLS; OVARY; POLYCYSTIC OVARY SYNDROME; STROMA;

ADULT; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GRANULOSA CELLS; HUMANS; INFLAMMATION; POLYCYSTIC OVARY SYNDROME; STROMAL CELLS; YOUNG ADULT;

EID: 84899854307     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gat051     Document Type: Article

References (41)

1. Abramov Y, Schenker JG, Lewin A, Friedler S, Nisman B, Barak V. Plasma inflammatory cytokines correlate to the ovarian hyperstimulation syndrome. Hum Reprod 1996;11:1381-1386.
2. Agrawal R, Sladkevicius P,Engmann L,Conway GS, PayneNN,Bekis J, TanSL, Campbell S, Jacobs HS. Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries. Hum Reprod 1998;13:651-655.
3. Andersen AG, Als-Nielsen B, Hornnes PJ, Franch Andersen L. Time interval from human chorionic gonadotrophin (HCG) injection to follicular rupture. Hum Reprod 1995;10:3202-3205.
4. BrännströmM. The potential role of cytokines in ovarian physiology: the case for interleukin-1. In: Leung PCK, Adashi EY (eds). The Ovary, Vol. 1. San Diego: Elsevier Academic Press, 2004, 261-268.
5. Brännström M, Runesson E. White blood cells: active participants in the ovulation cascade. In: Adashi EY (ed.). Ovulation. New York, USA: Springer-Varlag, 2000, 221-242.
6. Das SK, Chu WS, Hale TC, Wang X, Craig RL, Wang H, Shuldiner AR, Froguel P, Deloukas P, McCarthy MI et al. Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. Diabetes 2006;55:2631-2639.
7. Delvigne A, Rozenberg S. Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review. Hum Reprod Update 2002;8:559-577.
8. Diao FY, Xu M, Hu Y, Li J, Xu Z, Lin M,Wang L, Zhou Y, Zhou Z, Liu J et al. The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray. J Mol Endocrinol 2004; 33:59-72.
9. Ewens KG, Stewart DR, Ankener W, Urbanek M, McAllister JM, Chen C, Baig KM, Parker SC, Margulies EH, Legro RS et al. Family-based analysis of candidate genes for polycystic ovary syndrome. J Clin Endocrinol Metab 2010;95:2306-2315.
10. Garside SA, Harlow CR, Hillier SG, Fraser HM, Thomas FH. Thrombospondin-1 inhibits angiogenesis and promotes follicular atresia in a novel in vitro angiogenesis assay. Endocrinology 2010;151:1280-1289.
11. GeneCards. GeneCards version 3. Retrieved 110620, 2011.www.genecards. org.
12. Gilbert J, Lekstrom-Himes J, Donaldson D, Lee Y, Hu M, Xu J, Wyant T, Davidson M. Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region. Am J Cardiol 2011;107:906-911.
13. Gjonnaess H. Polycystic ovarian syndrome treated by ovarian electrocautery through the laparoscope. Fertil Steril 1984;41:20-25.
14. Glister C, Richards SL, Knight PG. Bone morphogenetic proteins (BMP) -4, -6, and -7 potently suppress basal and luteinizing hormone-induced androgen production by bovine theca interna cells in primary culture: could ovarian hyperandrogenic dysfunction be caused by a defect in thecal BMP signaling? Endocrinology 2005;146:1883-1892.
15. Govind A, Obhrai MS, Clayton RN. Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families. J Clin Endocrinol Metab 1999;84:38-43.
16. Hanna MD, Chizen DR, Pierson RA. Characteristics of follicular evacuation during human ovulation. Ultrasound Obstet Gynecol 1994;4:488-493.
17. Hsueh AJ. Ovarian kaleidoscope database, 1999. http://ovary.stanford. edu/.
18. Hurwitz A, PayneDW, Packman JN,AndreaniCL,ResnickCE,HernandezER, Adashi EY. Cytokine-mediated regulation of ovarian function: interleukin-1 inhibits gonadotropin-induced androgen biosynthesis. Endocrinology 1991; 129:1250-1256.
19. Jansen E, Laven JS, Dommerholt HB, Polman J, van Rijt C, van den Hurk C, Westland J, Mosselman S, Fauser BC. Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients. Mol Endocrinol 2004;18:3050-3063.
20. Junqueira LC, Carneiro J. The female reproductive system. In: Junqueira LC, Carneiro J (eds). Basic histology, 10th edn. New York, USA: Lange, 2003, 449.
21. Kenigsberg S, Bentov Y, Chalifa-Caspi V, Potashnik G, Ofir RBirk OS. Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients. Mol Hum Reprod 2009; 15:89-103.
22. Legro RS, Strauss JF. Molecular progress in infertility: polycystic ovary syndrome. Fertil Steril 2002;78:569-576.
23. Legro RS, Spielman R, Urbanek M, Driscoll D, Strauss JF III, Dunaif A. Phenotype and genotype in polycystic ovary syndrome. Recent Prog Horm Res 1998;53:217-256.
24. Legro RS, Kunselman AR, DodsonWC,Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 1999;84:165-169.
25. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
26. Mason HD, Willis DS, Beard RW, Winston RM, Margara R, Franks S. Estradiol production by granulosa cells of normal and polycystic ovaries: relationship to menstrual cycle history and concentrations of gonadotropins and sex steroids in follicular fluid. J Clin Endocrinol Metab 1994;79:1355-1360.
27. Nelson VL, Qin KN, Rosenfield RL, Wood JR, Penning TM, Legro RS, Strauss JF III, McAllister JM. The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome. J Clin Endocrinol Metab 2001;86:5925-5933.
28. Oksjoki S, Soderstrom M, Inki P, Vuorio E, Anttila L. Molecular profiling of polycystic ovaries for markers of cell invasion and matrix turnover. Fertil Steril 2005;83:937-944.
29. Park ES, Lind AK, Dahm-Kahler P, Brannstrom M, Carletti MZ, Christenson LK, Curry TE Jr, Jo M. RUNX2 transcription factor regulates gene expression in luteinizing granulosa cells of rat ovaries. Mol Endocrinol 2010;24:846-858.
30. Runesson E, Ivarsson K, Janson PO, Brannstrom M. Gonadotropin- and cytokine-regulated expression of the chemokine interleukin 8 in the human preovulatory follicle of the menstrual cycle. J Clin Endocrinol Metab 2000;85:4387-4395.
31. Schmidt J, Landin-Wilhelmsen K, BrannstromM, Dahlgren E. Cardiovascular disease and risk factors in PCOSwomen of postmenopausal age: a 21-year controlled follow-up study. J Clin Endocrinol Metab 2011;96:3794-3803.
32. Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, Gassmann M, Lightfoot S, Menzel W, Granzow M, Ragg T. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 2006;7:3.
33. Shi J, Yoshino O, Osuga Y, Koga K, Hirota Y, Hirata T, Yano T, Nishii O, Taketani Y. Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Mullerian hormone in human granulosa cells. Fertil Steril 2009; 92:1794-1798.
34. The Rotterdam Consensus, ESHRE/ASRM-Sponsored, PCOS, Consensus, WorkshopGroup. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
35. Thoroddsen A, Dahm-Kahler P, Lind AK, Weijdegard B, Lindenthal B, Muller J, Brannstrom M. The water permeability channels aquaporins 1-4 are differentially expressed in granulosa and theca cells of the preovulatory follicle during precise stages of human ovulation. J Clin Endocrinol Metab 2011;96:1021-1028.
36. Wang LJ, Brannstrom M, Pascoe V, Norman RJ. Cellular composition of primary cultures of human granulosa-lutein cells and the effect of cytokines on cell proliferation. Reprod Fertil Dev 1995;7:21-26.
37. Wood JR, Nelson VL, Ho C, Jansen E,Wang CY, Urbanek M, McAllister JM, Mosselman SStrauss JF III. The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis. J Biol Chem 2003;278:26380-26390.
38. Wood JR, Ho CK, Nelson-Degrave VL, McAllister JM, Strauss JF III. The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling. J Reprod Immunol 2004; 63:51-60.
39. Wood JR, Dumesic DA, Abbott DH, Strauss JF III. Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab 2007;92:705-713.
40. Wu R, Fujii S, Ryan NK, Van der Hoek KH, Jasper MJ, Sini I, Robertson SA, Robker RL, Norman RJ. Ovarian leukocyte distribution and cytokine/ chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome. Hum Reprod 2007;22:527-535.
41. Zamah AM, Hsieh M, Chen J, Vigne JL, Rosen MP, Cedars MI, Conti M. Human oocyte maturation is dependent on LH-stimulated accumulation of the epidermal growth factor-like growth factor, amphiregulin. Hum Reprod 2010;25:2569-2578.