Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement

Behavioural Brain Research

Volumn 269, Issue , 2014, Pages 61-65

  Uslaner, Jason M ^a   Winrow, Christopher J ^a   Gotter, Anthony L ^a   Roecker, Anthony J ^a   Coleman, Paul J ^a   Hutson, Pete H ^a   Le, Anh D ^b   Renger, John J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Addiction; Antagonist; Nicotine; Orexin; Reinstatement

Indexed keywords

2 SORA 18; NICOTINE; OREXIN 2 RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; CENTRAL NERVOUS SYSTEM AGENTS; NICOTINIC AGENT; OREXIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; COGNITION; CONDITIONING; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABUSE; DRUG DOSE COMPARISON; DRUG POTENCY; MALE; MOTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REINSTATEMENT; RELAPSE; REWARD; TOBACCO DEPENDENCE; TREATMENT OUTCOME; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; DRUG SEEKING BEHAVIOR; DRUG SELF ADMINISTRATION; EATING; INSTRUMENTAL CONDITIONING; LONG EVANS RAT; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; REINFORCEMENT;

ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; CONDITIONING, OPERANT; CUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-SEEKING BEHAVIOR; EATING; MALE; MOTIVATION; MOTOR ACTIVITY; NICOTINE; NICOTINIC AGONISTS; OREXIN RECEPTORS; RATS, LONG-EVANS; REINFORCEMENT SCHEDULE; REWARD; SELF ADMINISTRATION; TOBACCO USE DISORDER;

EID: 84899840129     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2014.04.012     Document Type: Article

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