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Volumn 139, Issue 1, 2014, Pages 162-173

Catechol-O-methyltransferase and 3,4-(±)-methylenedioxymethamphetamine toxicity

Author keywords

3,4 ( ) methylenedioxymethamphetamine; Catechol O methyltransferase; Hyperthermia

Indexed keywords

2' FLUORO 3,4 DIHYDROXY 5 NITROBENZOPHENONE; 3,4 DIHYDROXYPHENYLACETIC ACID; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; CATECHOL METHYLTRANSFERASE; NORADRENALIN; SEROTONIN; 3,4 METHYLENEDIOXYAMPHETAMINE; BENZOPHENONE DERIVATIVE; PRIMER DNA; RO 41-0960;

EID: 84899837459     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu035     Document Type: Article
Times cited : (7)

References (49)
  • 2
    • 0034933347 scopus 로고    scopus 로고
    • Serotonergic neurotoxicity of 3,4-(+/-)-methylenedioxyamphetamine and 3,4-(+/-)- methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase
    • Bai, F., Jones, D. C., Lau, S. S., and Monks, T. J. (2001). Serotonergic neurotoxicity of 3,4-(+/-)-methylenedioxyamphetamine and 3,4-(+/-)- methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase. Chem. Res. Toxicol. 14, 863-870.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 863-870
    • Bai, F.1    Jones, D.C.2    Lau, S.S.3    Monks, T.J.4
  • 3
    • 0033386744 scopus 로고    scopus 로고
    • Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: Possible role inmethylenedioxyamphetamine-mediated neurotoxicity
    • Bai, F., Lau, S. S., and Monks, T. J. (1999). Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: Possible role inmethylenedioxyamphetamine-mediated neurotoxicity. Chem. Res. Toxicol. 12, 1150-1157.
    • (1999) Chem. Res. Toxicol. , vol.12 , pp. 1150-1157
    • Bai, F.1    Lau, S.S.2    Monks, T.J.3
  • 4
    • 0024159060 scopus 로고
    • MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons
    • Battaglia, G., Yeh, S. Y., and De Souza, E. B. (1988). MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons. Pharmacol. Biochem. Behav. 29, 269-274.
    • (1988) Pharmacol. Biochem. Behav. , vol.29 , pp. 269-274
    • Battaglia, G.1    Yeh, S.Y.2    De Souza, E.B.3
  • 5
    • 53049107185 scopus 로고    scopus 로고
    • A new brain area affected by 3,4-methylenedioxymethamphetamine: A microdialysisbiotelemetry study
    • Benamar, K., Geller, E. B., and Adler, M. W. (2008). A new brain area affected by 3,4-methylenedioxymethamphetamine: A microdialysisbiotelemetry study. Eur. J. Pharmacol. 596, 84-88.
    • (2008) Eur. J. Pharmacol. , vol.596 , pp. 84-88
    • Benamar, K.1    Geller, E.B.2    Adler, M.W.3
  • 6
    • 69249211020 scopus 로고    scopus 로고
    • Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse
    • Bexis, S., and Docherty, J. R. (2009). Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. Br. J. Pharmacol. 158, 259-266.
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 259-266
    • Bexis, S.1    Docherty, J.R.2
  • 7
    • 0027978346 scopus 로고
    • CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine (MDMA)
    • Cadet, J. L., Ladenheim, B., Baum, I., Carlson, E., and Epstein, C. (1994). CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine (MDMA). Brain Res. 655, 259-262.
    • (1994) Brain Res. , vol.655 , pp. 259-262
    • Cadet, J.L.1    Ladenheim, B.2    Baum, I.3    Carlson, E.4    Epstein, C.5
  • 8
    • 69449095628 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: An overview
    • Capela, J. P., Carmo, H., Remiao, F., Bastos, M. L., Meisel, A., and Carvalho, F. (2009).Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: An overview. Mol. Neurobiol. 39, 210-271.
    • (2009) Mol. Neurobiol. , vol.39 , pp. 210-271
    • Capela, J.P.1    Carmo, H.2    Remiao, F.3    Bastos, M.L.4    Meisel, A.5    Carvalho, F.6
  • 11
    • 6344265879 scopus 로고    scopus 로고
    • Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain
    • Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T.M., Herman, M.M., Apud, J., et al. (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. Am. J. Hum. Genet. 75, 807-821.
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 807-821
    • Chen, J.1    Lipska, B.K.2    Halim, N.3    Ma, Q.D.4    Matsumoto, M.5    Melhem, S.6    Kolachana, B.S.7    Hyde, T.M.8    Herman, M.M.9    Apud, J.10
  • 12
    • 0032962796 scopus 로고    scopus 로고
    • Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4- methylenedioxymethamphetamine (MDMA or 'ecstasy') administration
    • Colado, M. I., O'Shea, E., Granados, R., Esteban, B., Martin, A. B., and Green, A. R. (1999). Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4- methylenedioxymethamphetamine (MDMA or 'ecstasy') administration. Br. J. Pharmacol. 126, 911-924.
    • (1999) Br. J. Pharmacol. , vol.126 , pp. 911-924
    • Colado, M.I.1    O'Shea, E.2    Granados, R.3    Esteban, B.4    Martin, A.B.5    Green, A.R.6
  • 13
    • 0029112473 scopus 로고
    • The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4- methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype
    • Colado, M. I., Williams, J. L., and Green, A. R. (1995). The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4- methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. Br. J. Pharmacol. 115, 1281- 1289.
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 1281-1289
    • Colado, M.I.1    Williams, J.L.2    Green, A.R.3
  • 15
    • 77149147425 scopus 로고    scopus 로고
    • Effects of estradiol on the thermoneutral zone and core temperature in ovariectomized rats
    • Dacks, P. A., and Rance, N. E. (2010). Effects of estradiol on the thermoneutral zone and core temperature in ovariectomized rats. Endocrinology 151, 1187- 1193.
    • (2010) Endocrinology , vol.151 , pp. 1187-1193
    • Dacks, P.A.1    Rance, N.E.2
  • 16
    • 4544314351 scopus 로고    scopus 로고
    • Neurotoxicity of MDMA (ecstasy): The limitations of scaling from animals to humans
    • de la Torre, R., and Farre, M. (2004). Neurotoxicity of MDMA (ecstasy): The limitations of scaling from animals to humans. Trends Pharmacol. Sci. 25, 505-508.
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 505-508
    • de la Torre, R.1    Farre, M.2
  • 19
    • 0029874309 scopus 로고    scopus 로고
    • Mesenteric organ production, hepatic metabolism, and renal elimination of norepinephrine and its metabolites in humans
    • Eisenhofer, G., Aneman, A., Hooper, D., Rundqvist, B., and Friberg, P. (1996). Mesenteric organ production, hepatic metabolism, and renal elimination of norepinephrine and its metabolites in humans. J. Neurochem. 66, 1565-1573.
    • (1996) J. Neurochem. , vol.66 , pp. 1565-1573
    • Eisenhofer, G.1    Aneman, A.2    Hooper, D.3    Rundqvist, B.4    Friberg, P.5
  • 20
    • 37349127647 scopus 로고    scopus 로고
    • Accumulation of neurotoxic thioether metabolites of 3,4-(+/-)-methylenedioxymethamphetamine in rat brain
    • Erives, G. V., Lau, S. S., and Monks, T. J. (2008). Accumulation of neurotoxic thioether metabolites of 3,4-(+/-)-methylenedioxymethamphetamine in rat brain. J. Pharmacol. Exp. Ther. 324, 284-291.
    • (2008) J. Pharmacol. Exp. Ther. , vol.324 , pp. 284-291
    • Erives, G.V.1    Lau, S.S.2    Monks, T.J.3
  • 21
    • 13444269027 scopus 로고    scopus 로고
    • A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice
    • Escobedo, I., O'Shea, E., Orio, L., Sanchez, V., Segura, M., de la Torre, R., Farre, M., Green, A. R., and Colado, M. I. (2005). A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice. Br. J. Pharmacol. 144, 231-241.
    • (2005) Br. J. Pharmacol. , vol.144 , pp. 231-241
    • Escobedo, I.1    O'Shea, E.2    Orio, L.3    Sanchez, V.4    Segura, M.5    de la Torre, R.6    Farre, M.7    Green, A.R.8    Colado, M.I.9
  • 22
    • 0035084704 scopus 로고    scopus 로고
    • 3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose
    • Esteban, B., O'Shea, E., Camarero, J., Sanchez, V., Green, A. R., and Colado, M. I. (2001). 3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose. Psychopharmacology (Berl.) 154, 251-260.
    • (2001) Psychopharmacology (Berl.) , vol.154 , pp. 251-260
    • Esteban, B.1    O'Shea, E.2    Camarero, J.3    Sanchez, V.4    Green, A.R.5    Colado, M.I.6
  • 24
    • 44649189106 scopus 로고    scopus 로고
    • Sprague-Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4- methylenedioxymethamphetamine (MDMA, ecstasy)
    • Fonsart, J., Menet, M. C., Decleves, X., Galons, H., Crete, D., Debray, M., Scherrmann, J. M., and Noble, F. (2008). Sprague-Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4- methylenedioxymethamphetamine (MDMA, ecstasy). Toxicol. Appl. Pharmacol. 230, 117-125.
    • (2008) Toxicol. Appl. Pharmacol. , vol.230 , pp. 117-125
    • Fonsart, J.1    Menet, M.C.2    Decleves, X.3    Galons, H.4    Crete, D.5    Debray, M.6    Scherrmann, J.7    Noble, F.8
  • 25
    • 40949119918 scopus 로고    scopus 로고
    • The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: Implications for neurotoxicity
    • Goni-Allo, B., B, O. M., Segura, M., Puerta, E., Lasheras, B., de la Torre, R., and Aguirre, N. (2008a). The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: Implications for neurotoxicity. Psychopharmacology (Berl.) 197, 263-278.
    • (2008) Psychopharmacology (Berl.) , vol.197 , pp. 263-278
    • Goni-Allo, B.1    Segura, M.2    Puerta, E.3    Lasheras, B.4    de la Torre, R.5    Aguirre, N.6
  • 26
    • 40849129898 scopus 로고    scopus 로고
    • On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats
    • Goni-Allo, B., Puerta, E., Mathuna, B. O., Hervias, I., Lasheras, B., de la Torre, R., and Aguirre, N. (2008b). On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats. Neuropharmacology 54, 885-900.
    • (2008) Neuropharmacology , vol.54 , pp. 885-900
    • Goni-Allo, B.1    Puerta, E.2    Mathuna, B.O.3    Hervias, I.4    Lasheras, B.5    de la Torre, R.6    Aguirre, N.7
  • 27
    • 0026081849 scopus 로고
    • Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat
    • Gordon, C. J., Watkinson, W. P., O'Callaghan, J. P., and Miller, D. B. (1991). Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat. Pharmacol. Biochem. Behav. 38, 339-344.
    • (1991) Pharmacol. Biochem. Behav. , vol.38 , pp. 339-344
    • Gordon, C.J.1    Watkinson, W.P.2    O'Callaghan, J.P.3    Miller, D.B.4
  • 29
    • 25644436223 scopus 로고    scopus 로고
    • Inhibitory effects of catechin gallates on o-methyltranslation of protocatechuic acid in rat liver cytosolic preparations and cultured hepatocytes
    • Kadowaki, M., Ootani, E., Sugihara, N., and Furuno, K. (2005). Inhibitory effects of catechin gallates on o-methyltranslation of protocatechuic acid in rat liver cytosolic preparations and cultured hepatocytes. Biol. Pharm. Bull. 28, 1509-1513.
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 1509-1513
    • Kadowaki, M.1    Ootani, E.2    Sugihara, N.3    Furuno, K.4
  • 30
    • 0027056441 scopus 로고
    • Comparative investigation of disposition of 3,4-(methylenedioxy)methamphetamine (MDMA) in the rat and the mouse by a capillary gas chromatography-mass spectrometry assay based on perfluorotributylamine-enhanced ammonia positive ion chemical ionization
    • Lim, H. K., Zeng, S., Chei, D. M., and Foltz, R. L. (1992). Comparative investigation of disposition of 3,4-(methylenedioxy)methamphetamine (MDMA) in the rat and the mouse by a capillary gas chromatography-mass spectrometry assay based on perfluorotributylamine-enhanced ammonia positive ion chemical ionization. J. Pharm. Biomed. Anal. 10, 657-665.
    • (1992) J. Pharm. Biomed. Anal. , vol.10 , pp. 657-665
    • Lim, H.K.1    Zeng, S.2    Chei, D.M.3    Foltz, R.L.4
  • 31
    • 0029884986 scopus 로고    scopus 로고
    • Effects of intracerebroventricular administration of 5-(glutathion-S-yl)-alpha-methyldopamine on brain dopamine, serotonin, and norepinephrine concentrations in male Sprague- Dawley rats
    • Miller, R. T., Lau, S. S., and Monks, T. J. (1996). Effects of intracerebroventricular administration of 5-(glutathion-S-yl)-alpha-methyldopamine on brain dopamine, serotonin, and norepinephrine concentrations in male Sprague- Dawley rats. Chem. Res. Toxicol. 9, 457-465.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 457-465
    • Miller, R.T.1    Lau, S.S.2    Monks, T.J.3
  • 32
    • 0030951385 scopus 로고    scopus 로고
    • 2,5-Bis-(glutathion- S-yl)-alpha-methyldopamine, a putative metabolite of (+/-)-3,4- methylenedioxyamphetamine, decreases brain serotonin concentrations
    • Miller, R. T., Lau, S. S., and Monks, T. J. (1997). 2,5-Bis-(glutathion- S-yl)-alpha-methyldopamine, a putative metabolite of (+/-)-3,4- methylenedioxyamphetamine, decreases brain serotonin concentrations. Eur. J. Pharmacol. 323, 173-180.
    • (1997) Eur. J. Pharmacol. , vol.323 , pp. 173-180
    • Miller, R.T.1    Lau, S.S.2    Monks, T.J.3
  • 33
    • 12444322029 scopus 로고    scopus 로고
    • The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine
    • Mills, E.M., Rusyniak, D. E., and Sprague, J. E. (2004). The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine. J. Mol. Med. (Berl.) 82, 787-799.
    • (2004) J. Mol. Med. (Berl.) , vol.82 , pp. 787-799
    • Mills, E.M.1    Rusyniak, D.E.2    Sprague, J.E.3
  • 34
    • 79960939959 scopus 로고    scopus 로고
    • Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: Implications for mechanisms of neurotoxicity
    • Mueller, M., Yuan, J., Maldonado Adrian, C., McCann, U. D., and Ricaurte, G.A. (2011). Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: Implications for mechanisms of neurotoxicity. Synapse 65, 983-990.
    • (2011) Synapse , vol.65 , pp. 983-990
    • Mueller, M.1    Yuan, J.2    Maldonado Adrian, C.3    McCann, U.D.4    Ricaurte, G.A.5
  • 35
    • 0027931499 scopus 로고
    • Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse
    • O'Callaghan, J. P., and Miller, D. B. (1994). Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse. J. Pharmacol. Exp. Ther. 270, 741-751.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 741-751
    • O'Callaghan, J.P.1    Miller, D.B.2
  • 36
    • 0023735752 scopus 로고
    • Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity
    • O'Hearn, E., Battaglia, G., De Souza, E. B., Kuhar, M. J., and Molliver, M. E. (1988). Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity. J. Neurosci. 8, 2788-2803.
    • (1988) J. Neurosci. , vol.8 , pp. 2788-2803
    • O'Hearn, E.1    Battaglia, G.2    De Souza, E.B.3    Kuhar, M.J.4    Molliver, M.E.5
  • 39
    • 0042872651 scopus 로고    scopus 로고
    • The organum vasculosum laminae terminalis in immune-to-brain febrigenic signaling: A reappraisal of lesion experiments
    • Romanovsky, A. A., Sugimoto, N., Simons, C. T., and Hunter, W. S. (2003). The organum vasculosum laminae terminalis in immune-to-brain febrigenic signaling: A reappraisal of lesion experiments. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R420-R428.
    • (2003) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.285
    • Romanovsky, A.A.1    Sugimoto, N.2    Simons, C.T.3    Hunter, W.S.4
  • 40
    • 0037333409 scopus 로고    scopus 로고
    • Differential effect of dietary selenium on the long-term neurotoxicity induced by MDMA in mice and rats
    • Sanchez, V., Camarero, J., O'Shea, E., Green, A. R., and Colado, M. I. (2003). Differential effect of dietary selenium on the long-term neurotoxicity induced by MDMA in mice and rats. Neuropharmacology 44, 449-461.
    • (2003) Neuropharmacology , vol.44 , pp. 449-461
    • Sanchez, V.1    Camarero, J.2    O'Shea, E.3    Green, A.R.4    Colado, M.I.5
  • 42
    • 56249103752 scopus 로고    scopus 로고
    • Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats
    • Shioda, K., Nisijima, K., Yoshino, T., Kuboshima, K., Iwamura, T., Yui, K., and Kato, S. (2008). Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. Neurotoxicology 29, 1030-1036.
    • (2008) Neurotoxicology , vol.29 , pp. 1030-1036
    • Shioda, K.1    Nisijima, K.2    Yoshino, T.3    Kuboshima, K.4    Iwamura, T.5    Yui, K.6    Kato, S.7
  • 43
    • 0023811368 scopus 로고
    • Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA)
    • Slikker, W., Jr, Ali, S. F., Scallet, A. C., Frith, C. H., Newport, G. D., and Bailey, J. R. (1988). Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA). Toxicol. Appl. Pharmacol. 94, 448-457.
    • (1988) Toxicol. Appl. Pharmacol. , vol.94 , pp. 448-457
    • Slikker, W.1    Jr Ali, S.F.2    Scallet, A.C.3    Frith, C.H.4    Newport, G.D.5    Bailey, J.R.6
  • 44
    • 20444456277 scopus 로고    scopus 로고
    • Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model
    • Sprague, J. E., Moze, P., Caden, D., Rusyniak, D. E., Holmes, C., Goldstein, D.S., and Mills, E. M. (2005). Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model. Crit. Care Med. 33, 1311-1316.
    • (2005) Crit. Care Med. , vol.33 , pp. 1311-1316
    • Sprague, J.E.1    Moze, P.2    Caden, D.3    Rusyniak, D.E.4    Holmes, C.5    Goldstein, D.S.6    Mills, E.M.7
  • 45
    • 0023522125 scopus 로고
    • Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats
    • Stone, D.M., Hanson, G. R., and Gibb, J. W. (1987a). Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats. Neuropharmacology 26, 1657-1661.
    • (1987) Neuropharmacology , vol.26 , pp. 1657-1661
    • Stone, D.M.1    Hanson, G.R.2    Gibb, J.W.3
  • 46
    • 0023154112 scopus 로고
    • A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives
    • Stone, D. M., Johnson, M., Hanson, G. R., and Gibb, J. W. (1987b). A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives. Eur. J. Pharmacol. 134, 245-248.
    • (1987) Eur. J. Pharmacol. , vol.134 , pp. 245-248
    • Stone, D.M.1    Johnson, M.2    Hanson, G.R.3    Gibb, J.W.4
  • 47
    • 78549252708 scopus 로고    scopus 로고
    • Are genetic variants of COMT associated with addiction? Pharmacogenet
    • Tammimaki, A. E., and Mannisto, P. T. (2010). Are genetic variants of COMT associated with addiction? Pharmacogenet. Genomics 20, 717-741.
    • (2010) Genomics , vol.20 , pp. 717-741
    • Tammimaki, A.E.1    Mannisto, P.T.2
  • 48
    • 78649374556 scopus 로고    scopus 로고
    • The catechol-O-methyltransferase gene: Its regulation and polymorphisms
    • Tunbridge, E.M. (2010). The catechol-O-methyltransferase gene: Its regulation and polymorphisms. Int. Rev. Neurobiol. 95, 7-27.
    • (2010) Int. Rev. Neurobiol. , vol.95 , pp. 7-27
    • Tunbridge, E.M.1
  • 49
    • 59149100910 scopus 로고    scopus 로고
    • The hyperthermia mediated by 3,4- methylenedioxymethamphetamine (MDMA, Ecstasy) is sensitive to sex differences
    • Wyeth, R. P., Mills, E. M., Ullman, A., Kenaston, M. A., Burwell, J., and Sprague, J. E. (2009). The hyperthermia mediated by 3,4- methylenedioxymethamphetamine (MDMA, Ecstasy) is sensitive to sex differences. Toxicol. Appl. Pharmacol. 235, 33-38.
    • (2009) Toxicol. Appl. Pharmacol. , vol.235 , pp. 33-38
    • Wyeth, R.P.1    Mills, E.M.2    Ullman, A.3    Kenaston, M.A.4    Burwell, J.5    Sprague, J.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.