Mesenteric organ production, hepatic metabolism, and renal elimination of norepinephrine and its metabolites in humans

Journal of Neurochemistry

Volumn 66, Issue 4, 1996, Pages 1565-1573

  Eisenhofer, Graeme ^a,c   Åneman, Anders ^b   Hooper, Douglas ^a   Rundqvist, Bengt ^b   Friberg, Peter ^b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Kidneys; Liver; Metabolism; Norepinephrine; Sympathetic nerves

Indexed keywords

3,4 DIHYDROXYPHENYLETHYLENE GLYCOL; 4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL SULFATE; NORADRENALIN; VANILMANDELIC ACID;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG ELIMINATION; DRUG METABOLISM; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER METABOLISM; MALE; MESENTERY BLOOD FLOW; NORADRENALIN RELEASE; NORADRENALIN URINE LEVEL; PRIORITY JOURNAL; URINARY EXCRETION;

EID: 0029874309     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66041565.x     Document Type: Article

References (32)

1. Åneman A. (1995) Catecholamine release and hemodynamic regulation in hepatomesenteric organs of pigs and humans. Thesis, University of Göteborg, Göteborg, Sweden.
2. Aneman A., Eisenhofer G., Fändriks L., and Friberg P. (1995) Hepatomesenteric release and removal of norepinephrine in swine. Am. J. Physiol. 268, R924-R930.
3. Blombery P. A., Kopin I. J., Gordon E. K., and Markey S. P. (1980) Conversion of MHPG to vanillylmandelic acid: implications for the importance of urinary MHPG. Arch. Gen. Psychiatry 37, 1095-1098.
4. Brown R. T., Polinsky R. J., and Kopin I. J. (1987) Interconversion of O-methylated norepinephrine metabolites in humans. J. Lab. Clin. Med. 110, 119-124.
5. Cuche J. L., Brochier P., Klioua N., Poirer M. F., Cuche H., Benmiloud M., Loo H., and Safar M. (1990) Conjugated catecholamines in human plasma: where are they coming from? J. Lab. Clin. Med. 116, 681-686.
6. Eisenhofer G., Goldstein D. S., Stull R., Keiser H. R., Sunderland T., Murphy D. L., and Kopin I. J. (1986) Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase. Clin. Chem. 32, 2030-2033.
7. Eisenhofer G., Esler M. D., Meredith I. T., Dart A., Cannon R. O., Quyyumi A. A., Lambert G., Chin J., Jennings G. L., and Goldstein D. S. (1992) Sympathetic nervous function in the human heart as assessed by cardiac spillovers of dihydroxyphenylglycol and norepinephrine. Circulation 85, 1775-1785.
8. Eisenhofer G., Percorella W., Pacak K., Hooper D., Kopin I. J., and Goldstein D. S. (1994) The neuronal and extraneuronal origins of plasma 3-methoxy-4-hydroxyphenylglycol in rats. J. Auton. Nerv. Syst. 50, 93-107.
9. Eisenhofer G., Åneman A., Hooper D., Holmes C., Goldstein D S., and Friberg P. (1995a) Production and metabolism of dopamine and norepinephrine in mesenteric organs and liver of swine. Am. J. Physiol. 268, G641-G649.
10. Eisenhofer G., Rundquist B., Åneman A., Friberg P., Dakak N., Kopin I. J., Jacobs M. C., and Lenders J. W. M. (1995b) Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines. J. Clin. Endocrinol. Metab 80, 3009-3017.
11. Eriksson B. M. and Persson B. A. (1987) Liquid chromatographic method for the determination of 3,4-dihydroxyphenylethyleneglycol and 3,4-dihydroxymandelic acid in plasma. J. Chromatogr. 386, 1-9.
12. Graefe K.-H. and Henseling M. (1983) Neuronal and extraneuronal uptake and metabolism of catecholamines. Gen. Pharmacol. 14, 27-33.
13. Hashizume K., Yamatodani A., Yamamoto T., Ogihara T., Kumahara Y., and Wada H. (1987) Effects of oral and intravenous administrations of dopamine and L-DOPA on plasma levels of two isomers of dopamine sulfate in man. Life Sci. 41, 2697-2704.
14. 3-epinephrine in the rat. J. Biol. Chem. 237, 2291-2295.
15. Hoeldtke R. D. and Cilmi K. M. (1985) Effects of aging on catecholamine metabolism. J. Clin. Endocrinol. Metab. 60, 479-484.
16. Hoeldtke R. D., Cilmi K. M., Reichard G. A., Boden G., and Owen O. E. (1983) Assessment of norepinephrine secretion and production. J. Lab. Clin. Med. 101, 772-782.
17. Karoum F. (1983) Mass fragmentography in the analysis of biogenic amines: a clinical, physiological, and pharmacological evaluation, in Methods in Biogenic Amine Research (Parvez S., Nagatsu T., Nagatsu L, and Parvez H., eds), pp. 237-255. Elsevier, New York.
18. Kopin I. J. (1985) Catecholamine metabolism: basic aspects and clinical significance. Pharmacol. Rev. 37, 333-364.
19. Kuchel O. (1994) Clinical implications of genetic and acquired defects in catecholamine synthesis and metabolism. Clin. Invest. Med. 17, 354-373.
20. Kuchel O., Buu N. T., and Neemeh J. (1985) The platelet phenosulfotransferase is not indispensable for the sulfoconjugation of plasma catecholamines. Endocr. Res. 11, 225-232.
21. Lambert G. W., Kaye D. M., Lefkovits J., Jennings G. L., Turner A. G., Cox H. S., and Esler M. D. (1995) Increased central nervous system monoamine neurotransmitter turnover and its association with sympathetic nervous activity in treated heart failure patients. Circulation 92, 1813-1818.
22. Lenders J. W. M., Eisenhofer G., Armando I., Keiser H. R., Goldstein D. S., and Kopin I. J. (1993) Determination of plasma metanephrines by liquid chromatography with electrochemical detection. Clin. Chem. 39, 97-103.
23. Lenders J. W. M., Keiser H. R., Goldstein D. S., Willemsen J. J., Friberg P., Jacobs M. C., Kloppenborg P. W. C., Thien T., and Eisenhofer G. (1995) Plasma metanephrines in the diagnosis of pheochromocytoma. Ann. Intern. Med. 23, 101-109.
24. Maas J., Benensohn H., and Landis D. H. (1970) A kinetic study of the disposition of circulating norepinephrine in normal male subjects. J. Pharmacol Exp. Ther. 174, 381-387.
25. Mårdh G. and Änggård E. (1984) Norepinephrine metabolism in man using deuterium labelling: origin of 4-hydroxy-3-methoxymandelic acid. J. Neurochem. 42, 43-46.
26. Mårdh G., Sjöquist B., and Änggård E. (1981) Norepinephrine metabolism in man using deuterium labelling: the conversion of 4-hydroxy-3-methoxyphenylglycol to 4-hydroxy-3-methoxymandelic acid. J. Neurochem. 36, 1181-1185.
27. Sellgren J., Pontén J., and Wallin B. G. (1990) Percutaneous recording of muscle nerve sympathetic activity during propofol, nitrous oxide, and isoflurane anesthesia in humans. Anesthesiology 73, 20-27.
28. Strobel G., Friedmann B., Jost J., and Bärtsch P. (1994) Plasma and platelet catecholamine and catecholamine sulfate response to various exercise tests. Am. J. Physiol. 267, E537-B543.
29. Tyce G. M., Van Dyke R. A., Rettke S. R., Atchison S. R., Wiesner R. H., Dickson E. R., and Krom R. A. (1987) Human liver and conjugation of catecholamines. J. Lab. Clin. Med. 109, 532-537.
30. Tyce G. M., Banwart B., Chinnow S. L., Chritton S. L., Dousa M. K., Hunter L. W., Kristensen E. W., and Rorie D. K. (1992) Sources of DOPA and sulfated catecholamines in plasma, in Stress: Neuroendocrine and Molecular Approaches (Kvetnansky R., McCarty R., and Axelrod J., eds), pp. 159-169. Gordon and Breach Science, New York.
31. Tyce G. M., Hunter L. W., Ward L. E., and Rorie D. K. (1995) Effluxes of 3,4-dihydroxyphenylalanine, 3,4-dihydroxyphenylglycol, and norepinephrine from four blood vessels during basal conditions and during nerve stimulation. J. Neurochem. 64, 833-841.
32. Zimon R. P., Tyce G. M., Flock E. V., Sheps S. G., and Owen C. A. Jr. (1967) Effect of monoamine oxidase inhibition on biliary excretion of metabolites of norepinephrine by isolated rat liver. J. Pharmacol. Exp. Ther. 157, 89-95.