The hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is sensitive to sex differences

Toxicology and Applied Pharmacology

Volumn 235, Issue 1, 2009, Pages 33-38

  Wyeth, Richard P ^a   Mills, Edward M ^b   Ullman, Alison ^a   Kenaston, M Alexander ^b   Burwell, Johanna ^b   Sprague, Jon E ^a,c  

^a EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c OHIO NORTHERN UNIVERSITY   (United States)

Author keywords

Female; Hyperthermia; Male; MDMA

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALPHA 1 ADRENERGIC RECEPTOR; ESTROGEN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NORADRENALIN; PHENYLEPHRINE; TESTOSTERONE; UNCOUPLING PROTEIN 3;

ALPHA ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY CONSTRICTION; ARTICLE; CASTRATION; CONTROLLED STUDY; FEMALE; GASTROCNEMIUS MUSCLE; HYPERTHERMIA; INTOXICATION; MALE; NONHUMAN; NORADRENALIN BLOOD LEVEL; OVARIECTOMY; RAT; SEX DIFFERENCE; THERMOGENESIS;

ANIMALS; AORTA; FEMALE; FEVER; GENE EXPRESSION REGULATION; HALLUCINOGENS; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NITRIC OXIDE; NOREPINEPHRINE; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; SEX CHARACTERISTICS;

RATTUS;

EID: 59149100910     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.12.003     Document Type: Article

References (44)

1. Astrup A., Bulow J., Madsen J., and Christensen N.J. Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man. Am. J. Physiol. 248 (1985) E507-E515
2. Binko J., and Majewski H. 17 β-Estradiol reduces vasoconstriction in endothelium-denuded rat aortas through inducible NOS. Am. J. Physiol, Heart Circ. Physiol. 274 (1998) H853-H859
3. Blessing W.W., Zilm A., and Ootsuka Y. Clozapine reverses increased brown adipose tissue thermogenesis induced by 3,4-methylenedioxymethamphetamine and by cold exposure in conscious rats. Neuroscience 141 (2006) 2067-2073
4. Colado M.I., Williams J.L., and Green A.R. The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4-methylenedixoyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. Br. J. Pharmacol. 115 (1995) 1281-1289
5. Coore J.R. A fatal trip with ecstasy: a case of 3,4-methylenedioxymethamphetamine/3,4-methylenedioxyamphetamine toxicity. J. R. Soc. Med. 89 (1996) 51P-52P
6. Dar K.J., and McBrien M.E. MDMA induced hyperthermia: report of a fatality and review of current therapy. Intensive Care Med. 22 (1996) 995-996
7. de Miguel R., Fernandez-Ruiz J.J., Hernandez M.L., and Ramos J.A. Role of ovarian steroids on the catecholamine synthesis and release in female rat adrenal: in vivo and in vitro studies. Life Sci. 44 (1989) 1979-1986
8. Echtay K.S., Roussel D., St-Pierre J., Jekabsons M.B., Cadenas S., Stuart J.A., et al. Superoxide activates mitochondrial uncoupling proteins. Nature 415 (2002) 96-99
9. Fonsart J., Menet M.C., Decleves X., Galons H., Crete D., Debray M., Scherrmann J.M., and Noble F. Sprague-Dawley rats display metabolism-mediated sex differences in acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). Tox. Appl. Pharmacol. 230 (2008) 117-125
10. Gahlinger P.M. Club drugs: MDMA, gamma-hydroxybutyrate (GHB), rohypnol, and ketamine. Am. Fam. Phys. 69 (2004) 2619-2626
11. Gong D.W., He Y., Karas M., and Reitman M. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J. Biol. Chem. 272 (1997) 24129-24132
12. Hinojosa-Laborde C., Chapa I., Lange D., and Haywood J.R. Gender differences in sympathetic nervous system regulation. Clin. Exp. Pharmacol. Physiol. 26 (1999) 122-126
13. Hishikawa K., Nakaki T., Marumo T., Suzuki H., Kato R., and Saruta T. Up-regulation of nitric oxide synthase by estradiol in human aortic endothelial cells. FEBS Lett. 360 (1995) 291-293
14. Holmes C., Eisenhofer G., and Goldstein D.S. Improved assay for plasma dihydroxyphenylacetic acid and other catechols using high-performance liquid chromatography with electrochemical detection. J. Chromatogr., B, Biomed. Appl. 653 (1994) 131-138
15. Kauser K., and Rubanyi G.M. Gender difference in bioassayable endothelium-derived nitric oxide from isolated rat aortae. Am. J. Physiol. 267 (1997) H2311-H2317
16. Koenig J., Lazarus C., Jeltsch H., Hamida S.B., Riegert C., and Kelche C. MDMA (ecstasy) effects in pubescent rats: males are more sensitive than females. Pharmacol. Biochem. Behav. 81 (2005) 635-644
17. Larkin S., Mull E., Miao W., Pittner R., Albrandt K., and Moore C. Regulation of the third member of the uncoupling protein family, UCP3, by cold and thyroid hormone. Biochem. Biophys. Res. Commun. 240 (1997) 222-227
18. Liechti M.E., Gamma A., and Vollenweider F.X. Gender differences in the subjective effects of MDMA. Psychopharmacology. (Berl) 154 (2001) 161-168
19. Lin C., and Klingenberg M. Isolation of the uncoupling protein from brown adipose tissue mitochondria. FEBS Lett. 113 (1980) 299-303
20. Lombardi A., Silvestri E., Moreno M., De Lange P., Farina P., Goglia F., and Lanni A. Skeletal muscle mitochondrial free-fatty-acid content and membrane potential sensitivity in different thyroid states: involvement of uncoupling protein-3 and adenine nucleotide translocase. FEBS Lett. 532 (2002) 12-16
21. Mallick A., and Bodenham A.R. MDMA induced hyperthermia: a survivor with an initial body temperature of 42.9 degrees C. J. Accid. Emerg. Med. 14 (1997) 336-338
22. McDaid J., and Docherty J.R. Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat. Br. J. Pharmacol. 133 (2001) 429-437
23. McNamara M.G., Kelly J.P., and Leonard B.E. The effect of acute MDMA administration on body-temperature, serum corticosterone and neurotransmitter concentrations in male and female rats. Hum. Psychopharmacol. 10 (1995) 373-383
24. McNamara M.G., Kelly J.P., and Leonard B.E. Thermoregulatory and locomotor activity responses of 3,4-methylenedioxymethamphetamine (MDMA) in male and female rats. Journal Serotonin Res. 4 (1995) 275-282
25. Mills E.M., Banks M.L., Sprague J.E., and Finkel T. Pharmacology: uncoupling the agony from ecstasy. Nature 426 (2003) 403-404
26. Mills E.M., Rusyniak D.E., and Sprague J.E. The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine. J. Mol. Med. 82 (2004) 787-799
27. Milroy C.M., Clark J.C., and Forrest A.R. Pathology of deaths associated with "ecstasy" and "eve" misuse. J. Clin. Pathol. 49 (1996) 149-153
28. Moon K., Upreti V.V., Yu L.J., Lee I.J., Ye X., Eddington N.D., Timothy D., Veenstra T.D., and Song B. Mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated mitochondrial dysfunction in rat liver. Proteomics 8 (2008) 3906-3918
29. Nicholls D.G. Hamster brown-adipose-tissue mitochondria. The control of respiration and the proton electrochemical potential gradient by possible physiological effectors of the proton conductance of the inner membrane. Eur. J. Biochem. 49 (1974) 573-583
30. Orshal J.M., and Khalil R.A. Gender, sex hormones, and vascular tone. Am. J. Physiol., Regul. Integr. Comp. Physiol. 286 (2004) R233-R249
31. Pass D., and Freeth G. The rat. ANZCCART News 6 4 (1993) 1-4
32. Pedersen N.P., and Blessing W.W. Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits. J. Neurosci. 21 (2001) 8648-8654
33. Ribeiro M.O., Lebrun F.L., Christoffolete M.A., Branco M., Crescenzi A., and Carvalho S.D. Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat. Am. J. Physiol., Endocrinol. Metabol. 279 (2000) E314-E322
34. Rodriguez A.M., Roca P., Bonet M.L., Pico C., Oliver P., and Palou A. Positive correlation of skeletal muscle UCP3 mRNA levels with overweight in male, but not in female, rats. Am. J. Physiol., Regul. Integr. Comp. Physiol. 285 (2003) R880-R888
35. Rose R., West A., Ye J., McCormick G., and Colquhoun E. Nonshivering thermogenesis in a marsupial (the tasmanian bettong Bettongia gaimardi) is not attributable to brown adipose tissue. Physiol. Biochem. Zool. 72 (1999) 699-704
36. Simonyan R.A., Jimenez M., Ceddia R.B., Giacobino J.P., Muzzin P., and Skulachev V.P. Cold-induced changes in the energy coupling and the UCP3 level in rodent skeletal muscles. Biochim. Biophys. Acta 1505 (2001) 271-279
37. Sprague J.E., Banks M.L., Cook V.J., and Mills E.M. Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy). J. Pharmacol. Exp. Ther. 305 (2003) 159-166
38. Sprague J.E., Moze P., Caden D., Rusyniak D.E., Holmes C., Goldstein D.S., and Mills E.M. Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model. Crit. Care Med. 33 (2005) 1311-1316
39. Sprague J.E., Yang X., Sommers J., Gilman T.L., and Mills E.M. Roles of norepinephrine, free Fatty acids, thyroid status, and skeletal muscle uncoupling protein 3 expression in sympathomimetic-induced thermogenesis. J. Pharmacol. Exp. Ther. 320 (2007) 274-280
40. Skarsgard P., Van Breemen C., and Laher I. Estrogen regulates myogenic tone in pressurized cerebral arteries by enhanced basal release of nitric oxide. Am. J. Physiol., Heart Circ. Physiol. 273 (1997) H2248-H2256
41. Stirone C., Duckles S.P., Krause D.N., and Procaccio V. Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels. Mol. Pharmacol. 68 (2005) 959-965
42. Walker Q., Williams C.N., Jotwani R.P., Waller S.T., Francis R., and Kuhn C.M. Sex difference in the neurochemical and functional effects of MDMA in Sprague-Dawley rats. Psychopharmacology 189 (2007) 435-445
43. Wiechman B.E., and Borowitz J.L. Effect of steroid hormones and diethylstilbestrol on adrenomedullary catecholamine secretion. Pharmacology 18 (1979) 195-201
44. Ye J., Clark M., and Colquhoun E. Constant-pressure perfusion of rat hindlimb shows alpha- and beta-adrenergic stimulation of oxygen consumption. Am. J. Physiol 269 (5 Pt 1) (1995) E960-E968