Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma

Experimental and Molecular Pathology

Volumn 96, Issue 3, 2014, Pages 375-381

  Brychtova, Veronika ^a   Zampachova, Vita ^b   Hrstka, Roman ^a   Fabian, Pavel ^a   Novak, Jiri ^a   Hermanova, Marketa ^b   Vojtesek, Borivoj ^a  

^a MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

^b ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

Author keywords

AGR3; GPC 3; Hepatocellular carcinoma; Immunohistochemistry; Intrahepatic cholangiocarcinoma; Mucopolysaccharides

Indexed keywords

ACID GLYCOSAMINOGLYCAN; ANTERIOR GRADIENT 3 PROTEIN; GLYPICAN 3; MEMBRANE PROTEIN; PROTEIN DISULFIDE ISOMERASE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER CLASSIFICATION; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE MARKER; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MUCUS SECRETION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SENSITIVITY AND SPECIFICITY;

AGR3; GPC-3; HEPATOCELLULAR CARCINOMA; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC CHOLANGIOCARCINOMA; MUCOPOLYSACCHARIDES;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BILE DUCTS, INTRAHEPATIC; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CHOLANGIOCARCINOMA; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENETIC MARKERS; GLYPICANS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84899821341     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2014.04.002     Document Type: Article

References (21)

1. Adam P.J., Boyd R., Tyson K.L., Fletcher G.C., Stamps A., Hudson L., Poyser H.R., Redpath N., Griffiths M., Steers G., Harris A.L., Patel S., Berry J., Loader J.A., Townsend R.R., Daviet L., Legrain P., Parekh R., Terrett J.A. Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. J. Biol. Chem. 2003, 278:6482-6489.
2. Bosman F.T., Carneiro F., Hruban R.H., Theisem N.D. WHO Classification of Tumors of the Digestive System 2010, 159-181. IARC, Lyon.
3. Brychtova V., Vojtesek B., Hrstka R. Anterior gradient 2: a novel player in tumor cell biology. Cancer Lett. 2011, 304:1-7.
4. Brychtova V., Hermanova M., Karasek P., Lenz J., Selingerova I., Vojtesek B., Kala Z., Hrstka R. Anterior gradient 2 and mucin 4 expression mirrors tumor cell differentiation in pancreatic adenocarcinomas, but aberrant anterior gradient 2 expression predicts worse patient outcome in poorly differentiated tumors. Pancreas 2014, 43:75-81.
5. El-Serag H.B., Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132:2557-2576.
6. Fatima S., Lee N.P., Luk J.M. Dickkopfs and Wnt/beta-catenin signalling in liver cancer. World J. Clin. Oncol. 2011, 2:311-325.
7. Fletcher G.C., Patel S., Tyson K., Adam P.J., Schenker M., Loader J.A., Daviet L., Legrain P., Parekh R., Harris A.L., Terrett J.A. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br. J. Cancer 2003, 88:579-585.
8. Gray T.A., MacLaine N.J., Michie C.O., Bouchalova P., Murray E., Howie J., Hrstka R., Maslon M.M., Nenutil R., Vojtesek B., Langdon S., Hayward L., Gourley C., Hupp T.R. Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models. J. Immunol. Methods 2012, 378:20-32.
9. Hrstka R., Nenutil R., Fourtouna A., Maslon M.M., Naughton C., Langdon S., Murray E., Larionov A., Petrakova K., Muller P., Dixon M.J., Hupp T.R., Vojtesek B. The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers. Oncogene 2010, 29:4838-4847.
10. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J. Clin. 2011, 61:69-90.
11. Kakar S., Gown A.M., Goodman Z.D., Ferrell L.D. Best practices in diagnostic immunohistochemistry: hepatocellular carcinoma versus metastatic neoplasms. Arch. Pathol. Lab. Med. 2007, 131:1648-1654.
12. Lepreux S., Bioulac-Sage P., Chevet E. Differential expression of the anterior gradient protein-2 is a conserved feature during morphogenesis and carcinogenesis of the biliary tree. Liver Int. 2011, 31:322-328.
13. Marzioni M., Glaser S.S., Francis H., Phinizy J.L., LeSage G., Alpini G. Functional heterogeneity of cholangiocytes. Semin. Liver Dis. 2002, 22:227-240.
14. Nakanuma Y., Sato Y., Harada K., Sasaki M., Xu J., Ikeda H. Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. World J. Hepatol. 2010, 2:419-427.
15. Nakanuma Y., Curado M.-P., Franceschi S., Gores G., Paradis V., Sripa B. Intrahepatic cholangiocarcinoma. WHO Classification of Tumors of the Digestive System 2010, 173-180. IARC, Lyon.
16. Norris A.M., Gore A., Balboni A., Young A., Longnecker D.S., Korc M. AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia. Oncogene 2013, 32:3867-3876.
17. Park S.W., Zhen G., Verhaeghe C., Nakagami Y., Nguyenvu L.T., Barczak A.J., Killeen N., Erle D.J. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:6950-6955.
18. Schroeder B.W., Verhaeghe C., Park S.W., et al. AGR2 is induced in asthma and promotes allergen-induced mucin overproduction. Am. J. Respir. Cell Mol. Biol. 2012, 47:178-185.
19. Tremosini S., Forner A., Boix L., et al. Prospective validation of an immunohistochemical panel (glypican 3, heat shock protein 70 and glutamine synthetase) in liver biopsies for diagnosis of very early hepatocellular carcinoma. Gut 2012, 61:1481-1487.
20. Vivekanandan P., Micchelli S.T., Torbenson M. Anterior gradient-2 is overexpressed by fibrolamellar carcinomas. Hum. Pathol. 2009, 40:293-299.
21. Zhang J.S., Gong A., Cheville J.C., Smith D.I., Young C.Y. AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. Genes Chromosomes Cancer 2005, 43:249-259.