Differential expression of the anterior gradient protein-2 is a conserved feature during morphogenesis and carcinogenesis of the biliary tree

Liver International

Volumn 31, Issue 3, 2011, Pages 322-328

  Lepreux, Sébastien ^a,b   Bioulac Sage, Paulette ^a,b   Chevet, Eric ^a  

^a INSERM   (France)

^b BORDEAUX UNIVERSITY HOSPITAL   (France)

Author keywords

AGR2; Biliary tree; Cholangiocarcinoma; Extrahepatic; Hilar; Intrahepatic; Liver

Indexed keywords

ANTERIOR GRADIENT PROTEIN 2; THIOREDOXIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CARCINOGENESIS; CLINICAL ARTICLE; FEMALE; GALLBLADDER; HEPATOBILIARY SYSTEM; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MORPHOGENESIS; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CARCINOMA, HEPATOCELLULAR; CHOLANGIOCARCINOMA; EPITHELIAL CELLS; FEMALE; FETAL DEVELOPMENT; FETUS; GALLBLADDER; GESTATIONAL AGE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROTEINS;

EID: 79551553022     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02438.x     Document Type: Article

References (29)

1. Lillig CH, Holmgren A. Thioredoxin and related molecules - from biology to health and disease. Antioxid Redox Signal 2007; 9: 25-47.
2. Komiya T, Tanigawa Y, Hirohashi S. Cloning of the gene gob-4, which is expressed in intestinal goblet cells in mice. Biochim Biophys Acta 1999; 1444: 434-8.
3. Park SW, Zhen G, Verhaeghe C, et al. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci USA 2009; 106: 6950-5.
4. Zhao L, Lee BY, Brown DA, et al. Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling. Cancer Res 2009; 69: 7696-703.
5. Barraclough DL, Platt-Higgins A, De Silva Rudland S, et al. The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients. Am J Pathol 2009; 175: 1848-57.
6. Fritzsche FR, Dahl E, Dankof A, et al. Expression of AGR2 in non small cell lung cancer. Histol Histopathol 2007; 22: 703-8.
7. Innes HE, Liu D, Barraclough R, et al. Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients. Br J Cancer 2006; 94: 1057-65.
8. Kristiansen G, Pilarsky C, Wissmann C, et al. Expression profiling of microdissected matched prostate cancer samples reveals CD166/MEMD and CD24 as new prognostic markers for patient survival. J Pathol 2005; 205: 359-76.
9. Ramachandran V, Arumugam T, Wang H, Logsdon CD. Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival. Cancer Res 2008; 68: 7811-8.
10. Wang Z, Hao Y, Lowe AW. The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. Cancer Res 2008; 68: 492-7.
11. Zhang Y, Forootan SS, Liu D, et al. Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients. Prostate Cancer Prostatic Dis 2007; 10: 293-300.
12. Zhao F, Edwards R, Dizon D, et al. Disruption of paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol 2009; 338: 270-9.
13. Pohler E, Craig AL, Cotton J, et al. The barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage. Mol Cell Proteomics 2004; 3: 534-47.
14. Lee S, Bang S, Song K, Lee I. Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon. Oncol Rep 2006; 16: 747-54.
15. Vivekanandan P, Micchelli ST, Torbenson M. Anterior gradient-2 is overexpressed by fibrolamellar carcinomas. Hum Pathol 2009; 40: 293-9.
16. Hadlock FP, Harrist RB, Sharman RS, et al. Estimation of fetal weight with the use of head, body, and femur measurements - a prospective study. Am J Obstet Gynecol 1985; 151: 333-7.
17. Roskams T, Desmet V. Embryology of extra- and intrahepatic bile ducts, the ductal plate. Anat Rec (Hoboken) 2008; 291: 628-35.
18. Aberger F, Weidinger G, Grunz H, Richter K. Anterior specification of embryonic ectoderm: the role of the Xenopus cement gland-specific gene XAG-2. Mech Dev 1998; 72: 115-30.
19. Fritzsche FR, Dahl E, Pahl S, et al. Prognostic relevance of AGR2 expression in breast cancer. Clin Cancer Res 2006; 12: 1728-34.
20. Smirnov DA, Zweitzig DR, Foulk BW, et al. Global gene expression profiling of circulating tumor cells. Cancer Res 2005; 65: 4993-7.
21. Valladares-Ayerbes M, Diaz-Prado S, Reboredo M, et al. Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer. Cancer Detect Prev 2008; 32: 236-50.
22. Sasaki M, Ikeda H, Nakanuma Y. Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: physiological distribution and pathological significance. Prog Histochem Cytochem 2007; 42: 61-110.
23. Ward SC, Huang J, Tickoo SK, et al. Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation. Mod Pathol 2010; 23: 1180-90.
24. Torbenson M. Review of the clinicopathologic features of fibrolamellar carcinoma. Adv Anat Pathol 2007; 14: 217-23.
25. Guedj N, Zhan Q, Perigny M, et al. Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas. J Hepatol 2009; 51: 93-101.
26. Dos Santos A, Court M, Thiers V, et al. Identification of cellular targets in human intrahepatic cholangiocarcinoma using laser microdissection and accurate mass and time tag proteomics. Mol Cell Proteomics 2010; 9: 1991-2004.
27. Hughes NR, Pairojkul C, Royce SG, et al. Liver fluke-associated and sporadic cholangiocarcinoma: an immunohistochemical study of bile duct, peribiliary gland and tumour cell phenotypes. J Clin Pathol 2006; 59: 1073-8.
28. Riener MO, Pilarsky C, Gerhardt J, et al. Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma. Histol Histopathol 2009; 24: 1121-8.
29. Zhang JS, Gong A, Cheville JC, et al. AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. Genes Chromosomes Cancer 2005; 43: 249-59.