-
1
-
-
38849152398
-
Targeted therapies: A new generation of cancer treatments
-
Gerber, D. E. Targeted therapies: a new generation of cancer treatments. Am. Fam. Physician, 2008, 77(3), 311-319.
-
(2008)
Am. Fam. Physician
, vol.77
, Issue.3
, pp. 311-319
-
-
Gerber, D.E.1
-
2
-
-
84859440747
-
The APL paradigm and the co-clinical trial project
-
Nardella, C.; Lunardi, A.; Patnaik, A.; Cantley, L. C.; Pandolfi, P. P. The APL paradigm and the co-clinical trial project. Cancer Discov., 2011, 1(2), 108-116.
-
(2011)
Cancer Discov.
, vol.1
, Issue.2
, pp. 108-116
-
-
Nardella, C.1
Lunardi, A.2
Patnaik, A.3
Cantley, L.C.4
Pandolfi, P.P.5
-
3
-
-
77954542260
-
Eradication of acute promyelocytic leukemiainitiating cells by PML/RARA-targeting
-
Nasr, R.; de The, H. Eradication of acute promyelocytic leukemiainitiating cells by PML/RARA-targeting. Int. J. Hematol., 2010, 91(5), 742-747.
-
(2010)
Int. J. Hematol.
, vol.91
, Issue.5
, pp. 742-747
-
-
Nasr, R.1
De The, H.2
-
4
-
-
78650382003
-
Biologically targeted cancer therapy and marginal benefits: Are we making too much of too little or are we achieving too little by giving too much?
-
Fojo, T.; Parkinson, D. R. Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much? Clin. Cancer Res., 2010, 16(24), 5972-5980.
-
(2010)
Clin. Cancer Res.
, vol.16
, Issue.24
, pp. 5972-5980
-
-
Fojo, T.1
Parkinson, D.R.2
-
5
-
-
2442482627
-
Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme
-
Learn, C. A.; Hartzell, T. L.; Wikstrand, C. J.; Archer, G. E.; Rich, J. N.; Friedman, A. H.; Friedman, H. S.; Bigner, D. D.; Sampson, J. H. Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme. Clin. Cancer Res., 2004, 10(9), 3216-3224.
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.9
, pp. 3216-3224
-
-
Learn, C.A.1
Hartzell, T.L.2
Wikstrand, C.J.3
Archer, G.E.4
Rich, J.N.5
Friedman, A.H.6
Friedman, H.S.7
Bigner, D.D.8
Sampson, J.H.9
-
6
-
-
0037616593
-
Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
-
Bianco, R.; Shin, I.; Ritter, C. A.; Yakes, F. M.; Basso, A.; Rosen, N.; Tsurutani, J.; Dennis, P. A.; Mills, G. B.; Arteaga, C. L. Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene, 2003, 22(18), 2812-2822.
-
(2003)
Oncogene
, vol.22
, Issue.18
, pp. 2812-2822
-
-
Bianco, R.1
Shin, I.2
Ritter, C.A.3
Yakes, F.M.4
Basso, A.5
Rosen, N.6
Tsurutani, J.7
Dennis, P.A.8
Mills, G.B.9
Arteaga, C.L.10
-
7
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata, Y.; Lan, K. H.; Zhou, X.; Tan, M.; Esteva, F. J.; Sahin, A. A.; Klos, K. S.; Li, P.; Monia, B. P.; Nguyen, N. T.; Hortobagyi, G. N.; Hung, M. C.; Yu, D. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell, 2004, 6(2), 117-127.
-
(2004)
Cancer Cell
, vol.6
, Issue.2
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
Tan, M.4
Esteva, F.J.5
Sahin, A.A.6
Klos, K.S.7
Li, P.8
Monia, B.P.9
Nguyen, N.T.10
Hortobagyi, G.N.11
Hung, M.C.12
Yu, D.13
-
8
-
-
25844481618
-
Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy
-
Bianco, R.; Troiani, T.; Tortora, G.; Ciardiello, F. Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy. Endocr. Relat. Cancer, 2005, 12 Suppl 1, S159-S171.
-
(2005)
Endocr. Relat. Cancer
, vol.12
, Issue.SUPPL. 1
-
-
Bianco, R.1
Troiani, T.2
Tortora, G.3
Ciardiello, F.4
-
9
-
-
84871262033
-
Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules
-
Efferth, T. Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules. Curr. Med. Chem., 2012, 19(33), 5735-5744.
-
(2012)
Curr. Med. Chem.
, vol.19
, Issue.33
, pp. 5735-5744
-
-
Efferth, T.1
-
10
-
-
36048974574
-
Primary and acquired resistance to anti-EGFR targeted drugs in cancer therapy
-
Morgillo, F.; Bareschino, M. A.; Bianco, R.; Tortora, G.; Ciardiello, F. Primary and acquired resistance to anti-EGFR targeted drugs in cancer therapy. Differentiation, 2007, 75(9), 788-799.
-
(2007)
Differentiation
, vol.75
, Issue.9
, pp. 788-799
-
-
Morgillo, F.1
Bareschino, M.A.2
Bianco, R.3
Tortora, G.4
Ciardiello, F.5
-
11
-
-
73349105243
-
Resistance to targeted therapies: Refining Anticancer therapy in the era of molecular oncology. Clin
-
Ellis, L. M.; Hicklin, D. J. Resistance to Targeted Therapies: Refining Anticancer Therapy in the Era of Molecular Oncology. Clin. Cancer Res., 2009, 15(24), 7471-7478.
-
(2009)
Cancer Res.
, vol.15
, Issue.24
, pp. 7471-7478
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
12
-
-
41649099467
-
Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR
-
Michalczyk, A.; Kluter, S.; Rode, H. B.; Simard, J. R.; Grutter, C.; Rabiller, M.; Rauh, D. Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg. Med. Chem., 2008, 16(7), 3482-3488.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, Issue.7
, pp. 3482-3488
-
-
Michalczyk, A.1
Kluter, S.2
Rode, H.B.3
Simard, J.R.4
Grutter, C.5
Rabiller, M.6
Rauh, D.7
-
13
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
Van Cutsem, E.; Peeters, M.; Siena, S.; Humblet, Y.; Hendlisz, A.; Neyns, B.; Canon, J. L.; Van Laethem, J. L.; Maurel, J.M; Richardson, G.; Wolf, M.; Amado, R. G. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer. J. Clin. Oncol., 2007, 25(13), 1658-1664.
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.13
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
Canon, J.L.7
Van Laethem, J.L.8
Maurel, J.M.9
Richardson, G.10
Wolf, M.11
Amado, R.G.12
-
14
-
-
49649127657
-
Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in nonsmall cell lung cancer
-
Engelman, J. A.; Janne, P. A. Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in nonsmall cell lung cancer. Clin. Cancer Res., 2008, 14(10), 2895-2899.
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.10
, pp. 2895-2899
-
-
Engelman, J.A.1
Janne, P.A.2
-
15
-
-
79959935268
-
Overcoming the drug resistance problem with second-generation tyrosine kinase inhibitors: From enzymology to structural models
-
Crespan, E.; Zucca, E.; Maga, G. Overcoming the drug resistance problem with second-generation tyrosine kinase inhibitors: from enzymology to structural models. Curr. Med. Chem., 2011, 18(19), 2836-2847.
-
(2011)
Curr. Med. Chem.
, vol.18
, Issue.19
, pp. 2836-2847
-
-
Crespan, E.1
Zucca, E.2
Maga, G.3
-
16
-
-
80054873093
-
The role of antiangiogenetic agents in the treatment of breast cancer
-
Bareschino, M. A.; Schettino, C.; Colantuoni, G.; Rossi, E.; Rossi, A.; Maione, P.; Ciardiello, F.; Gridelli, C. The role of antiangiogenetic agents in the treatment of breast cancer. Curr. Med. Chem., 2011, 18(33), 5022-5032.
-
(2011)
Curr. Med. Chem.
, vol.18
, Issue.33
, pp. 5022-5032
-
-
Bareschino, M.A.1
Schettino, C.2
Colantuoni, G.3
Rossi, E.4
Rossi, A.5
Maione, P.6
Ciardiello, F.7
Gridelli, C.8
-
17
-
-
79959958353
-
Inhibition of tumor angiogenesis by antibodies, synthetic small molecules and natural products
-
Wahl, O.; Oswald, M.; Tretzel, L.; Herres, E.; Arend, J.; Efferth, T. Inhibition of tumor angiogenesis by antibodies, synthetic small molecules and natural products. Curr. Med. Chem., 2011, 18(21), 3136-3155.
-
(2011)
Curr. Med. Chem.
, vol.18
, Issue.21
, pp. 3136-3155
-
-
Wahl, O.1
Oswald, M.2
Tretzel, L.3
Herres, E.4
Arend, J.5
Efferth, T.6
-
18
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers, G.; Hanahan, D. Modes of resistance to anti-angiogenic therapy. Nat. Rev. Cancer, 2008, 8(8), 592-603.
-
(2008)
Nat. Rev. Cancer
, vol.8
, Issue.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
19
-
-
84876563391
-
Genomics of Drug Sensitivity in Cancer (GDSC): A resource for therapeutic biomarker discovery in cancer cells
-
Yang, W.; Soares, J.; Greninger, P.; Edelman, E. J.; Lightfoot, H.: Forbes, S.: Bindal, N.; Beare, D.; Smith, J. A.; Thompson, I. R.; Ramaswamy, S.; Futreal, P. A.; Haber, D. A.; Stratton, M. R.; Benes, C.; McDermott, U.; Garnett, M. J. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res., 2012, 41(D1), D955-961.
-
(2012)
Nucleic Acids Res.
, vol.41
, Issue.1
-
-
Yang, W.1
Soares, J.2
Greninger, P.3
Edelman, E.J.4
Lightfoot, H.5
Forbes, S.6
Bindal, N.7
Beare, D.8
Smith, J.A.9
Thompson, I.R.10
Ramaswamy, S.11
Futreal, P.A.12
Haber, D.A.13
Stratton, M.R.14
Benes, C.15
McDermott, U.16
Garnett, M.J.17
-
20
-
-
78651330430
-
COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
-
Forbes, S. A.; Bindal, N.; Bamford, S.; Cole, C.; Kok, C. Y.; Beare, D.; Jia, M.; Shepherd, R.; Leung, K.; Menzies, A.; Teague, J. W.; Campbell, P. J.; Stratton, M. R.; Futreal, P. A. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res., 2010, 39(Database issue), D945-950.
-
(2010)
Nucleic Acids Res.
, vol.39
-
-
Forbes, S.A.1
Bindal, N.2
Bamford, S.3
Cole, C.4
Kok, C.Y.5
Beare, D.6
Jia, M.7
Shepherd, R.8
Leung, K.9
Menzies, A.10
Teague, J.W.11
Campbell, P.J.12
Stratton, M.R.13
Futreal, P.A.14
-
21
-
-
84859187259
-
Systematic identification of genomic markers of drug sensitivity in cancer cells
-
Garnett, M. J.; Edelman, E. J.; Heidorn, S. J.; Greenman, C. D.; Dastur, A.; Lau, K. W.; Greninger, P.; Thompson, I. R.; Luo, X.; Soares, J.; Liu, Q.; Iorio, F.; Surdez, D.; Chen, L.; Milano, R. J.; Bignell, G. R.; Tam, A. T.; Davies, H.; Stevenson, J. A.; Barthorpe, S.; Lutz, S. R.; Kogera, F.; Lawrence, K.; McLaren-Douglas, A.; Mitropoulos, X.; Mironenko, T.; Thi, H.; Richardson, L.; Zhou, W.; Jewitt, F.; Zhang, T.; O'Brien, P.; Boisvert, J. L.; Price, S.; Hur, W.; Yang, W.; Deng, X.; Butler, A.; Choi, H. G.; Chang, J. W.; Baselga, J.; Stamenkovic, I.; Engelman, J. A.; Sharma, S. V.; Delattre, O.; Saez-Rodriguez, J.; Gray, N. S.; Settleman, J.; Futreal, P. A.; Haber, D. A.; Stratton, M. R.; Ramaswamy, S.; McDermott, U.; Benes, C. H. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature, 2012, 483(7391), 570-575.
-
(2012)
Nature
, vol.483
, Issue.7391
, pp. 570-575
-
-
Garnett, M.J.1
Edelman, E.J.2
Heidorn, S.J.3
Greenman, C.D.4
Dastur, A.5
Lau, K.W.6
Greninger, P.7
Thompson, I.R.8
Luo, X.9
Soares, J.10
Liu, Q.11
Iorio, F.12
Surdez, D.13
Chen, L.14
Milano, R.J.15
Bignell, G.R.16
Tam, A.T.17
Davies, H.18
Stevenson, J.A.19
Barthorpe, S.20
Lutz, S.R.21
Kogera, F.22
Lawrence, K.23
McLaren-Douglas, A.24
Mitropoulos, X.25
Mironenko, T.26
Thi, H.27
Richardson, L.28
Zhou, W.29
Jewitt, F.30
Zhang, T.31
O'Brien, P.32
Boisvert, J.L.33
Price, S.34
Hur, W.35
Yang, W.36
Deng, X.37
Butler, A.38
Choi, H.G.39
Chang, J.W.40
Baselga, J.41
Stamenkovic, I.42
Engelman, J.A.43
Sharma, S.V.44
Delattre, O.45
Saez-Rodriguez, J.46
Gray, N.S.47
Settleman, J.48
Futreal, P.A.49
Haber, D.A.50
Stratton, M.R.51
Ramaswamy, S.52
McDermott, U.53
Benes, C.H.54
more..
-
22
-
-
84859169877
-
The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina, J.; Caponigro, G.; Stransky, N.; Venkatesan, K.; Margolin, A. A.; Kim, S.; Wilson, C. J.; Lehar, J.; Kryukov, G. V.; Sonkin, D.; Reddy, A.; Liu, M.; Murray, L.; Berger, M. F.; Monahan, J. E.; Morais, P.; Meltzer, J.; Korejwa, A.; Jane-Valbuena, J.; Mapa, F. A.; Thibault, J.; Bric-Furlong, E.; Raman, P.; Shipway, A.; Engels, I. H.; Cheng, J.; Yu, G. K.; Yu, J.; Aspesi, P., Jr.; de Silva, M.; Jagtap, K.; Jones, M. D.; Wang, L.; Hatton, C.; Palescandolo, E.; Gupta, S.; Mahan, S.; Sougnez, C.; Onofrio, R. C.; Liefeld, T.; MacConaill, L.; Winckler, W.; Reich, M.; Li, N.; Mesirov, J. P.;Gabriel, S. B.; Getz, G.; Ardlie, K.; Chan, V.; Myer, V. E.; Weber, B. L.; Porter, J.; Warmuth, M.; Finan, P.; Harris, J. L.; Meyerson, M.; Golub, T. R.; Morrissey, M. P.; Sellers, W. R.; Schlegel, R.; Garraway, L. A. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 2012, 483(7391), 603-607.
-
(2012)
Nature
, vol.483
, Issue.7391
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
Venkatesan, K.4
Margolin, A.A.5
Kim, S.6
Wilson, C.J.7
Lehar, J.8
Kryukov, G.V.9
Sonkin, D.10
Reddy, A.11
Liu, M.12
Murray, L.13
Berger, M.F.14
Monahan, J.E.15
Morais, P.16
Meltzer, J.17
Korejwa, A.18
Jane-Valbuena, J.19
Mapa, F.A.20
Thibault, J.21
Bric-Furlong, E.22
Raman, P.23
Shipway, A.24
Engels, I.H.25
Cheng, J.26
Yu, G.K.27
Yu, J.28
Aspesi Jr., P.29
De Silva, M.30
Jagtap, K.31
Jones, M.D.32
Wang, L.33
Hatton, C.34
Palescandolo, E.35
Gupta, S.36
Mahan, S.37
Sougnez, C.38
Onofrio, R.C.39
Liefeld, T.40
Macconaill, L.41
Winckler, W.42
Reich, M.43
Li, N.44
Mesirov, J.P.45
Gabriel, S.B.46
Getz, G.47
Ardlie, K.48
Chan, V.49
Myer, V.E.50
Weber, B.L.51
Porter, J.52
Warmuth, M.53
Finan, P.54
Harris, J.L.55
Meyerson, M.56
Golub, T.R.57
Morrissey, M.P.58
Sellers, W.R.59
Schlegel, R.60
Garraway, L.A.61
more..
-
23
-
-
12344302247
-
Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer
-
Tanner, M.; Kapanen, A. I.; Junttila, T.; Raheem, O.; Grenman, S.; Elo, J.; Elenius, K.; Isola, J. Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer. Mol. Cancer Ther., 2004, 3(12), 1585-1592.
-
(2004)
Mol. Cancer Ther.
, vol.3
, Issue.12
, pp. 1585-1592
-
-
Tanner, M.1
Kapanen, A.I.2
Junttila, T.3
Raheem, O.4
Grenman, S.5
Elo, J.6
Elenius, K.7
Isola, J.8
-
24
-
-
12544250996
-
Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line
-
Nagy, P.; Friedlander, E.; Tanner, M.; Kapanen, A. I.; Carraway, K. L.; Isola, J.; Jovin, T. M. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res., 2005, 65(2), 473-482.
-
(2005)
Cancer Res.
, vol.65
, Issue.2
, pp. 473-482
-
-
Nagy, P.1
Friedlander, E.2
Tanner, M.3
Kapanen, A.I.4
Carraway, K.L.5
Isola, J.6
Jovin, T.M.7
-
25
-
-
0032532950
-
NH2-terminally truncated HER-2/neu protein: Relationship with shedding of the extracellular domain and with prognostic factors in breast cancer
-
Christianson, T. A.; Doherty, J. K.; Lin, Y. J.; Ramsey, E. E.; Holmes, R.; Keenan, E. J.; Clinton, G. M. NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancer. Cancer Res., 1998, 58(22), 5123-5129.
-
(1998)
Cancer Res.
, vol.58
, Issue.22
, pp. 5123-5129
-
-
Christianson, T.A.1
Doherty, J.K.2
Lin, Y.J.3
Ramsey, E.E.4
Holmes, R.5
Keenan, E.J.6
Clinton, G.M.7
-
26
-
-
0033002270
-
Isolation and characterization of a new human breast cancer cell line, KPL-4, expressing the Erb B family receptors and interleukin-6
-
Kurebayashi, J.; Otsuki, T.; Tang, C. K.; Kurosumi, M.; Yamamoto, S.; Tanaka, K.; Mochizuki, M.; Nakamura, H.; Sonoo, H. Isolation and characterization of a new human breast cancer cell line, KPL-4, expressing the Erb B family receptors and interleukin-6. Br. J. Cancer, 1999, 79(5-6), 707-717.
-
(1999)
Br. J. Cancer
, vol.79
, Issue.5-6
, pp. 707-717
-
-
Kurebayashi, J.1
Otsuki, T.2
Tang, C.K.3
Kurosumi, M.4
Yamamoto, S.5
Tanaka, K.6
Mochizuki, M.7
Nakamura, H.8
Sonoo, H.9
-
27
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch, T. J.; Bell, D. W.; Sordella, R.; Gurubhagavatula, S.; Okimoto, R. A.; Brannigan, B. W.; Harris, P. L.; Haserlat, S. M.; Supko, J. G.; Haluska, F. G.; Louis, D. N.; Christiani, D. C.; Settleman, J.; Haber, D. A. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med., 2004, 350(21), 2129-2139.
-
(2004)
N. Engl. J. Med.
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
28
-
-
84863756482
-
The role of EGFR tyrosine kinase inhibitors in the first-line treatment of advanced non small cell lung cancer patients harboring EGFR mutation
-
Sgambato, A.; Casaluce, F.; Maione, P.; Rossi, A.; Rossi, E.; Napolitano, A.; Palazzolo, G.; Bareschino, M. A.; Schettino, C.; Sacco, P. C.; Ciadiello, F.; Gridelli, C. The role of EGFR tyrosine kinase inhibitors in the first-line treatment of advanced non small cell lung cancer patients harboring EGFR mutation. Curr. Med. Chem., 2012, 19(20), 3337-3352.
-
(2012)
Curr. Med. Chem.
, vol.19
, Issue.20
, pp. 3337-3352
-
-
Sgambato, A.1
Casaluce, F.2
Maione, P.3
Rossi, A.4
Rossi, E.5
Napolitano, A.6
Palazzolo, G.7
Bareschino, M.A.8
Schettino, C.9
Sacco, P.C.10
Ciadiello, F.11
Gridelli, C.12
-
29
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
Shigematsu, H.; Lin, L.; Takahashi, T.; Nomura, M.; Suzuki, M.; Wistuba,, II; Fong, K. M.; Lee, H.; Toyooka, S.; Shimizu, N.; Fujisawa, T.; Feng, Z.; Roth, J. A.; Herz, J.; Minna, J. D.; Gazdar, A. F. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J. Natl. Cancer Inst., 2005, 97(5), 339-346.
-
(2005)
J. Natl. Cancer Inst.
, vol.97
, Issue.5
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
Nomura, M.4
Suzuki, M.5
Wistuba, I.I.6
Fong, K.M.7
Lee, H.8
Toyooka, S.9
Shimizu, N.10
Fujisawa, T.11
Feng, Z.12
Roth, J.A.13
Herz, J.14
Minna, J.D.15
Gazdar, A.F.16
-
30
-
-
84870507634
-
Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment
-
Orzaez, M.; Guevara, T.; Sancho, M.; Perez-Paya, E. Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment. Cell Death Dis., 2012, 3, e415.
-
(2012)
Cell Death Dis.
, vol.3
-
-
Orzaez, M.1
Guevara, T.2
Sancho, M.3
Perez-Paya, E.4
-
31
-
-
68049118826
-
The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells
-
Milligan, S. A.; Burke, P.; Coleman, D. T.; Bigelow, R. L.; Steffan, J. J.; Carroll, J. L.; Williams, B. J.; Cardelli, J. A. The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells. Clin. Cancer Res., 2009, 15(15), 4885-4894.
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.15
, pp. 4885-4894
-
-
Milligan, S.A.1
Burke, P.2
Coleman, D.T.3
Bigelow, R.L.4
Steffan, J.J.5
Carroll, J.L.6
Williams, B.J.7
Cardelli, J.A.8
-
32
-
-
80051699683
-
Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: A beneficial strategy to combat non-small cell lung cancer
-
Gorzalczany, Y.; Gilad, Y.; Amihai, D.; Hammel, I.; Sagi-Eisenberg, R.; Merimsky, O. Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: a beneficial strategy to combat non-small cell lung cancer. Cancer Lett., 2012, 310(2), 207-215.
-
(2012)
Cancer Lett.
, vol.310
, Issue.2
, pp. 207-215
-
-
Gorzalczany, Y.1
Gilad, Y.2
Amihai, D.3
Hammel, I.4
Sagi-Eisenberg, R.5
Merimsky, O.6
-
33
-
-
80054095608
-
Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers
-
Rosa, R.; Melisi, D.; Damiano, V.; Bianco, R.; Garofalo, S.; Gelardi, T.; Agrawal, S.; Di Nicolantonio, F.; Scarpa, A.; Bardelli, A.; Tortora, G. Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers. Clin. Cancer Res., 2011, 17(20), 6531-6541.
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.20
, pp. 6531-6541
-
-
Rosa, R.1
Melisi, D.2
Damiano, V.3
Bianco, R.4
Garofalo, S.5
Gelardi, T.6
Agrawal, S.7
Di Nicolantonio, F.8
Scarpa, A.9
Bardelli, A.10
Tortora, G.11
-
34
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag, G.; Hirth, P.; Tsai, J.; Zhang, J.; Ibrahim, P. N.; Cho, H.; Spevak, W.; Zhang, C.; Zhang, Y.; Habets, G.; Burton, E. A.; Wong, B.; Tsang, G.; West, B. L.; Powell, B.; Shellooe, R.; Marimuthu, A.; Nguyen, H.; Zhang, K. Y.; Artis, D. R.; Schlessinger, J.; Su, F.; Higgins, B.; Iyer, R.; D'Andrea, K.; Koehler, A.; Stumm, M.; Lin, P. S.; Lee, R. J.; Grippo, J. ; Puzanov, I.; Kim, K. B.; Ribas, A.; McArthur, G. A.; Sosman, J. A.; Chapman, P. B.; Flaherty, K. T.; Xu, X.; Nathanson, K. L.; Nolop, K. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature, 2010, 467(7315), 596-599.
-
(2010)
Nature
, vol.467
, Issue.7315
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
Zhang, J.4
Ibrahim, P.N.5
Cho, H.6
Spevak, W.7
Zhang, C.8
Zhang, Y.9
Habets, G.10
Burton, E.A.11
Wong, B.12
Tsang, G.13
West, B.L.14
Powell, B.15
Shellooe, R.16
Marimuthu, A.17
Nguyen, H.18
Zhang, K.Y.19
Artis, D.R.20
Schlessinger, J.21
Su, F.22
Higgins, B.23
Iyer, R.24
D'Andrea, K.25
Koehler, A.26
Stumm, M.27
Lin, P.S.28
Lee, R.J.29
Grippo, J.30
Puzanov, I.31
Kim, K.B.32
Ribas, A.33
McArthur, G.A.34
Sosman, J.A.35
Chapman, P.B.36
Flaherty, K.T.37
Xu, X.38
Nathanson, K.L.39
Nolop, K.40
more..
-
35
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad, A.; Sun, C.; Huang, S.; Di Nicolantonio, F.; Salazar, R.; Zecchin, D.; Beijersbergen, R. L.; Bardelli, A.; Bernards, R. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature, 2012, 483(7387), 100-103.
-
(2012)
Nature
, vol.483
, Issue.7387
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
Di Nicolantonio, F.4
Salazar, R.5
Zecchin, D.6
Beijersbergen, R.L.7
Bardelli, A.8
Bernards, R.9
-
36
-
-
33947401129
-
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor
-
Yeh, T. C.; Marsh, V.; Bernat, B. A.; Ballard, J.; Colwell, H.; Evans, R. J.; Parry, J.; Smith, D.; Brandhuber, B. J.; Gross, S.; Marlow, A.; Hurley, B.; Lyssikatos, J.; Lee, P. A.; Winkler, J. D.; Koch, K.; Wallace, E. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin. Cancer Res., 2007, 13(5), 1576-1583.
-
(2007)
Clin. Cancer Res.
, vol.13
, Issue.5
, pp. 1576-1583
-
-
Yeh, T.C.1
Marsh, V.2
Bernat, B.A.3
Ballard, J.4
Colwell, H.5
Evans, R.J.6
Parry, J.7
Smith, D.8
Brandhuber, B.J.9
Gross, S.10
Marlow, A.11
Hurley, B.12
Lyssikatos, J.13
Lee, P.A.14
Winkler, J.D.15
Koch, K.16
Wallace, E.17
-
37
-
-
70349878470
-
Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines
-
Balmanno, K.; Chell, S. D.; Gillings, A. S.; Hayat, S.; Cook, S. J. Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. Int. J. Cancer, 2009, 125(10), 2332-2341.
-
(2009)
Int. J. Cancer
, vol.125
, Issue.10
, pp. 2332-2341
-
-
Balmanno, K.1
Chell, S.D.2
Gillings, A.S.3
Hayat, S.4
Cook, S.J.5
-
38
-
-
64249106832
-
Mouse xenograft models vs GEM models for human cancer therapeutics
-
Richmond, A.; Su, Y. Mouse xenograft models vs GEM models for human cancer therapeutics. Dis. Model Mech., 2008, 1(2-3), 78-82.
-
(2008)
Dis. Model Mech.
, vol.1
, Issue.2-3
, pp. 78-82
-
-
Richmond, A.1
Su, Y.2
-
39
-
-
79957936388
-
How genetically engineered mouse tumor models provide insights into human cancers
-
Politi, K.; Pao, W. How genetically engineered mouse tumor models provide insights into human cancers. J. Clin. Oncol., 2011, 29(16), 2273-2281.
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.16
, pp. 2273-2281
-
-
Politi, K.1
Pao, W.2
-
41
-
-
34547820876
-
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
-
Shojaei, F.; Wu, X.; Malik, A. K.; Zhong, C.; Baldwin, M. E.; Schanz, S.; Fuh, G.; Gerber, H. P.; Ferrara, N. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat. Biotechnol., 2007, 25(8), 911-920.
-
(2007)
Nat. Biotechnol.
, vol.25
, Issue.8
, pp. 911-920
-
-
Shojaei, F.1
Wu, X.2
Malik, A.K.3
Zhong, C.4
Baldwin, M.E.5
Schanz, S.6
Fuh, G.7
Gerber, H.P.8
Ferrara, N.9
-
42
-
-
48649107126
-
Refractoriness to antivascular endothelial growth factor treatment: Role of myeloid cells
-
Shojaei, F.; Ferrara, N. Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells. Cancer Res., 2008, 68(14), 5501-5504.
-
(2008)
Cancer Res.
, vol.68
, Issue.14
, pp. 5501-5504
-
-
Shojaei, F.1
Ferrara, N.2
-
43
-
-
77953973648
-
Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
-
Ulanet, D. B.; Ludwig, D. L.; Kahn, C. R.; Hanahan, D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc. Natl. Acad. Sci. U S A, 2010, 107(24), 10791-10798.
-
(2010)
Proc. Natl. Acad. Sci. U S A
, vol.107
, Issue.24
, pp. 10791-10798
-
-
Ulanet, D.B.1
Ludwig, D.L.2
Kahn, C.R.3
Hanahan, D.4
-
44
-
-
0034076307
-
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
-
Clynes, R. A.; Towers, T. L.; Presta, L. G.; Ravetch, J. V. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat. Med., 2000, 6(4), 443-446.
-
(2000)
Nat. Med.
, vol.6
, Issue.4
, pp. 443-446
-
-
Clynes, R.A.1
Towers, T.L.2
Presta, L.G.3
Ravetch, J.V.4
-
45
-
-
84862777541
-
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
-
Chen, Z.; Cheng, K.; Walton, Z.; Wang, Y.; Ebi, H.; Shimamura, T.; Liu, Y.; Tupper, T.; Ouyang, J.; Li, J.; Gao, P.; Woo, M. S.; Xu, C.; Yanagita, M.; Altabef, A.; Wang, S.; Lee, C.; Nakada, Y.; Pena, C. G.; Sun, Y.; Franchetti, Y.; Yao, C.; Saur, A.; Cameron, M. D.; Nishino, M.; Hayes, D. N.; Wilkerson, M. D.; Roberts, P. J.; Lee, C. B.; Bardeesy, N.; Butaney, M.; Chirieac, L. R.; Costa, D. B.; Jackman, D.; Sharpless, N. E.; Castrillon, D. H.; Demetri, G. D.; Janne, P. A.; Pandolfi, P. P.; Cantley, L. C.; Kung, A. L.; Engelman, J. A.; Wong, K. K. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature, 2012, 483(7391), 613-617.
-
(2012)
Nature
, vol.483
, Issue.7391
, pp. 613-617
-
-
Chen, Z.1
Cheng, K.2
Walton, Z.3
Wang, Y.4
Ebi, H.5
Shimamura, T.6
Liu, Y.7
Tupper, T.8
Ouyang, J.9
Li, J.10
Gao, P.11
Woo, M.S.12
Xu, C.13
Yanagita, M.14
Altabef, A.15
Wang, S.16
Lee, C.17
Nakada, Y.18
Pena, C.G.19
Sun, Y.20
Franchetti, Y.21
Yao, C.22
Saur, A.23
Cameron, M.D.24
Nishino, M.25
Hayes, D.N.26
Wilkerson, M.D.27
Roberts, P.J.28
Lee, C.B.29
Bardeesy, N.30
Butaney, M.31
Chirieac, L.R.32
Costa, D.B.33
Jackman, D.34
Sharpless, N.E.35
Castrillon, D.H.36
Demetri, G.D.37
Janne, P.A.38
Pandolfi, P.P.39
Cantley, L.C.40
Kung, A.L.41
Engelman, J.A.42
Wong, K.K.43
more..
-
46
-
-
0033989990
-
DEAE-dextran transfection of mammalian cultured cells
-
Schenborn, E. T.; Goiffon, V. DEAE-dextran transfection of mammalian cultured cells. Methods Mol. Biol., 2000, 130, 147-153.
-
(2000)
Methods Mol. Biol.
, vol.130
, pp. 147-153
-
-
Schenborn, E.T.1
Goiffon, V.2
-
47
-
-
77956058093
-
Mammalian cell transfection: The present and the future
-
Kim, T. K.; Eberwine, J. H. Mammalian cell transfection: the present and the future. Anal. Bioanal. Chem., 2010, 397(8), 3173-3178.
-
(2010)
Anal. Bioanal. Chem.
, vol.397
, Issue.8
, pp. 3173-3178
-
-
Kim, T.K.1
Eberwine, J.H.2
-
48
-
-
56449111358
-
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
-
Eichhorn, P. J.; Gili, M.; Scaltriti, M.; Serra, V.; Guzman, M.; Nijkamp, W.; Beijersbergen, R. L.; Valero, V.; Seoane, J.; Bernards, R.; Baselga, J. Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res., 2008, 68(22), 9221-9230.
-
(2008)
Cancer Res.
, vol.68
, Issue.22
, pp. 9221-9230
-
-
Eichhorn, P.J.1
Gili, M.2
Scaltriti, M.3
Serra, V.4
Guzman, M.5
Nijkamp, W.6
Beijersbergen, R.L.7
Valero, V.8
Seoane, J.9
Bernards, R.10
Baselga, J.11
-
49
-
-
77949848665
-
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
-
Li, J.; Rix, U.; Fang, B.; Bai, Y.; Edwards, A.; Colinge, J.; Bennett, K. L.; Gao, J.; Song, L.; Eschrich, S.; Superti-Furga, G.; Koomen, J.; Haura, E. B. A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat. Chem. Biol., 2010, 6(4), 291-299.
-
(2010)
Nat. Chem. Biol.
, vol.6
, Issue.4
, pp. 291-299
-
-
Li, J.1
Rix, U.2
Fang, B.3
Bai, Y.4
Edwards, A.5
Colinge, J.6
Bennett, K.L.7
Gao, J.8
Song, L.9
Eschrich, S.10
Superti-Furga, G.11
Koomen, J.12
Haura, E.B.13
-
50
-
-
80052803473
-
DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo
-
Li, J. L.; Sainson, R. C.; Oon, C. E.; Turley, H.; Leek, R.; Sheldon, H.; Bridges, E.; Shi, W.; Snell, C.; Bowden, E. T.; Wu, H.; Chowdhury, P. S.; Russell, A. J.; Montgomery, C. P.; Poulsom, R.; Harris, A. L. DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo . Cancer Res., 2011, 71(18), 6073-6083.
-
(2011)
Cancer Res.
, vol.71
, Issue.18
, pp. 6073-6083
-
-
Li, J.L.1
Sainson, R.C.2
Oon, C.E.3
Turley, H.4
Leek, R.5
Sheldon, H.6
Bridges, E.7
Shi, W.8
Snell, C.9
Bowden, E.T.10
Wu, H.11
Chowdhury, P.S.12
Russell, A.J.13
Montgomery, C.P.14
Poulsom, R.15
Harris, A.L.16
-
51
-
-
84864300017
-
MicroRNA involvement in human cancer
-
Iorio, M. V.; Croce, C. M. microRNA involvement in human cancer. Carcinogenesis, 2012, 33(6), 1126-1133.
-
(2012)
Carcinogenesis
, vol.33
, Issue.6
, pp. 1126-1133
-
-
Iorio, M.V.1
Croce, C.M.2
-
52
-
-
84855543629
-
EGFR and MET receptor tyrosine kinasealtered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers
-
Garofalo, M.; Romano, G.; Di Leva, G.; Nuovo, G.; Jeon, Y. J.; Ngankeu, A.; Sun, J.; Lovat, F.; Alder, H.; Condorelli, G.; Engelman, J. A.; Ono, M.; Rho, J. K.; Cascione, L.; Volinia, S.; Nephew, K. P.; Croce, C. M. EGFR and MET receptor tyrosine kinasealtered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat. Med., 2011, 18(1), 74-82.
-
(2011)
Nat. Med.
, vol.18
, Issue.1
, pp. 74-82
-
-
Garofalo, M.1
Romano, G.2
Di Leva, G.3
Nuovo, G.4
Jeon, Y.J.5
Ngankeu, A.6
Sun, J.7
Lovat, F.8
Alder, H.9
Condorelli, G.10
Engelman, J.A.11
Ono, M.12
Rho, J.K.13
Cascione, L.14
Volinia, S.15
Nephew, K.P.16
Croce, C.M.17
-
53
-
-
84862999938
-
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
-
Misale, S.; Yaeger, R.; Hobor, S.; Scala, E.; Janakiraman, M.; Liska, D.; Valtorta, E.; Schiavo, R.; Buscarino, M.; Siravegna, G.; Bencardino, K.; Cercek, A.; Chen, C. T.; Veronese, S.; Zanon, C.; Sartore-Bianchi, A.; Gambacorta, M.; Gallicchio, M.; Vakiani, E.; Boscaro, V.; Medico, E.; Weiser, M.; Siena, S.; Di Nicolantonio, F.; Solit, D.; Bardelli, A. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature, 2012, 486(7404), 532-536.
-
(2012)
Nature
, vol.486
, Issue.7404
, pp. 532-536
-
-
Misale, S.1
Yaeger, R.2
Hobor, S.3
Scala, E.4
Janakiraman, M.5
Liska, D.6
Valtorta, E.7
Schiavo, R.8
Buscarino, M.9
Siravegna, G.10
Bencardino, K.11
Cercek, A.12
Chen, C.T.13
Veronese, S.14
Zanon, C.15
Sartore-Bianchi, A.16
Gambacorta, M.17
Gallicchio, M.18
Vakiani, E.19
Boscaro, V.20
Medico, E.21
Weiser, M.22
Siena, S.23
Di Nicolantonio, F.24
Solit, D.25
Bardelli, A.26
more..
-
54
-
-
74549135338
-
Isogenic mutant human cells: A new tool for personalized cancer medicine
-
Di Nicolantonio, F.; Arena, S.; Gallicchio, M.; Bardelli, A. Isogenic mutant human cells: a new tool for personalized cancer medicine. Cell Cycle, 2009, 9(1), 20-21.
-
(2009)
Cell Cycle
, vol.9
, Issue.1
, pp. 20-21
-
-
Di Nicolantonio, F.1
Arena, S.2
Gallicchio, M.3
Bardelli, A.4
-
55
-
-
58549095879
-
Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses
-
Di Nicolantonio, F.; Arena, S.; Gallicchio, M.; Zecchin, D.; Martini, M.; Flonta, S. E.; Stella, G. M.; Lamba, S.; Cancelliere, C.; Russo, M.; Geuna, M.; Appendino, G.; Fantozzi, R.; Medico, E.; Bardelli, A. Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses. Proc. Natl. Acad. Sci. U S A, 2008, 105(52), 20864-20869.
-
(2008)
Proc. Natl. Acad. Sci. U S A
, vol.105
, Issue.52
, pp. 20864-20869
-
-
Di Nicolantonio, F.1
Arena, S.2
Gallicchio, M.3
Zecchin, D.4
Martini, M.5
Flonta, S.E.6
Stella, G.M.7
Lamba, S.8
Cancelliere, C.9
Russo, M.10
Geuna, M.11
Appendino, G.12
Fantozzi, R.13
Medico, E.14
Bardelli, A.15
-
56
-
-
78049341541
-
Association of KRAS p. G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
-
De Roock, W.; Jonker, D. J.; Di Nicolantonio, F.; Sartore-Bianchi, A.; Tu, D.; Siena, S.; Lamba, S.; Arena, S.; Frattini, M.; Piessevaux, H.; Van Cutsem, E.; O'Callaghan, C. J.; Khambata-Ford, S.; Zalcberg, J. R.; Simes, J.; Karapetis, C. S.; Bardelli, A.; Tejpar, S. Association of KRAS p. G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA, 2010, 304(16), 1812-1820.
-
(2010)
JAMA
, vol.304
, Issue.16
, pp. 1812-1820
-
-
De Roock, W.1
Jonker, D.J.2
Di Nicolantonio, F.3
Sartore-Bianchi, A.4
Tu, D.5
Siena, S.6
Lamba, S.7
Arena, S.8
Frattini, M.9
Piessevaux, H.10
Van Cutsem, E.11
O'Callaghan, C.J.12
Khambata-Ford, S.13
Zalcberg, J.R.14
Simes, J.15
Karapetis, C.S.16
Bardelli, A.17
Tejpar, S.18
-
57
-
-
77955288855
-
Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
-
Di Nicolantonio, F.; Arena, S.; Tabernero, J.; Grosso, S.; Molinari, F.; Macarulla, T.; Russo, M.; Cancelliere, C.; Zecchin, D.; Mazzucchelli, L.; Sasazuki, T.; Shirasawa, S.; Geuna, M.; Frattini, M.; Baselga, J.; Gallicchio, M.; Biffo, S.; Bardelli, A. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J. Clin. Invest., 2010, 120(8), 2858-2866.
-
(2010)
J. Clin. Invest.
, vol.120
, Issue.8
, pp. 2858-2866
-
-
Di Nicolantonio, F.1
Arena, S.2
Tabernero, J.3
Grosso, S.4
Molinari, F.5
Macarulla, T.6
Russo, M.7
Cancelliere, C.8
Zecchin, D.9
Mazzucchelli, L.10
Sasazuki, T.11
Shirasawa, S.12
Geuna, M.13
Frattini, M.14
Baselga, J.15
Gallicchio, M.16
Biffo, S.17
Bardelli, A.18
-
58
-
-
70349385645
-
Resistance to targeted therapy in renalcell carcinoma
-
Rini, B. I.; Atkins, M. B. Resistance to targeted therapy in renalcell carcinoma. Lancet Oncol., 2009, 10(10), 992-1000.
-
(2009)
Lancet Oncol.
, vol.10
, Issue.10
, pp. 992-1000
-
-
Rini, B.I.1
Atkins, M.B.2
-
59
-
-
76249133170
-
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
-
Huang, D.; Ding, Y.; Zhou, M.; Rini, B. I.; Petillo, D.; Qian, C. N.; Kahnoski, R.; Futreal, P. A.; Furge, K. A.; Teh, B. T. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res., 2010, 70(3), 1063-1071.
-
(2010)
Cancer Res.
, vol.70
, Issue.3
, pp. 1063-1071
-
-
Huang, D.1
Ding, Y.2
Zhou, M.3
Rini, B.I.4
Petillo, D.5
Qian, C.N.6
Kahnoski, R.7
Futreal, P.A.8
Furge, K.A.9
Teh, B.T.10
-
60
-
-
0842289982
-
Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy
-
Ciardiello, F.; Bianco, R.; Caputo, R.; Damiano, V.; Troiani, T.; Melisi, D.; De Vita, F.; De Placido, S.; Bianco, A. R.; Tortora, G. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin. Cancer Res., 2004, 10(2), 784-793.
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.2
, pp. 784-793
-
-
Ciardiello, F.1
Bianco, R.2
Caputo, R.3
Damiano, V.4
Troiani, T.5
Melisi, D.6
De Vita, F.7
De Placido, S.8
Bianco, A.R.9
Tortora, G.10
-
61
-
-
52649143725
-
Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
-
Bianco, R.; Rosa, R.; Damiano, V.; Daniele, G.; Gelardi, T.; Garofalo, S.; Tarallo, V.; De Falco, S.; Melisi, D.; Benelli, R.; Albini, A.; Ryan, A.; Ciardiello, F.; Tortora, G. Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells. Clin. Cancer Res., 2008, 14(16), 5069-5080.
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.16
, pp. 5069-5080
-
-
Bianco, R.1
Rosa, R.2
Damiano, V.3
Daniele, G.4
Gelardi, T.5
Garofalo, S.6
Tarallo, V.7
De Falco, S.8
Melisi, D.9
Benelli, R.10
Albini, A.11
Ryan, A.12
Ciardiello, F.13
Tortora, G.14
-
62
-
-
84871982124
-
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models
-
Rosa, R.; Marciano, R.; Malapelle, U.; Formisano, L.; Nappi, L.; D'Amato, C.; D'Amato, V.; Damiano, V.; Marfe, G.; Del Vecchio, S.; Zannetti, A.; Greco, A.; De Stefano, A.; Carlomagno, C.; Veneziani, B. M.; Troncone, G.; De Placido, S.; Bianco, R. Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models. Clin. Cancer Res., 2011, 19(1), 138-147.
-
(2011)
Clin. Cancer Res.
, vol.19
, Issue.1
, pp. 138-147
-
-
Rosa, R.1
Marciano, R.2
Malapelle, U.3
Formisano, L.4
Nappi, L.5
D'Amato, C.6
D'Amato, V.7
Damiano, V.8
Marfe, G.9
Del Vecchio, S.10
Zannetti, A.11
Greco, A.12
De Stefano, A.13
Carlomagno, C.14
Veneziani, B.M.15
Troncone, G.16
De Placido, S.17
Bianco, R.18
-
63
-
-
80052453669
-
Anti-VEGF treatmentresistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype
-
Carbone, C.; Moccia, T.; Zhu, C.; Paradiso, G.; Budillon, A.; Chiao, P. J.; Abbruzzese, J. L.; Melisi, D. Anti-VEGF treatmentresistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype. Clin. Cancer Res., 2011, 17(17), 5822-5832.
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.17
, pp. 5822-5832
-
-
Carbone, C.1
Moccia, T.2
Zhu, C.3
Paradiso, G.4
Budillon, A.5
Chiao, P.J.6
Abbruzzese, J.L.7
Melisi, D.8
-
64
-
-
85027940454
-
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
-
Rexer, B. N.; Ham, A. J.; Rinehart, C.; Hill, S.; Granja-Ingram Nde, M.; Gonzalez-Angulo, A. M.; Mills, G. B.; Dave, B.; Chang, J. C.; Liebler, D. C.; Arteaga, C. L. Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition. Oncogene, 2011, 30(40), 4163-4174.
-
(2011)
Oncogene
, vol.30
, Issue.40
, pp. 4163-4174
-
-
Rexer, B.N.1
Ham, A.J.2
Rinehart, C.3
Hill, S.4
Granja-Ingram Nde, M.5
Gonzalez-Angulo, A.M.6
Mills, G.B.7
Dave, B.8
Chang, J.C.9
Liebler, D.C.10
Arteaga, C.L.11
-
65
-
-
79953745096
-
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
-
Zhang, S.; Huang, W. C.; Li, P.; Guo, H.; Poh, S. B.; Brady, S. W.; Xiong, Y.; Tseng, L. M.; Li, S. H.; Ding, Z.; Sahin, A. A.; Esteva, F. J.; Hortobagyi, G. N.; Yu, D. Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat. Med., 2011, 17(4), 461-469.
-
(2011)
Nat. Med.
, vol.17
, Issue.4
, pp. 461-469
-
-
Zhang, S.1
Huang, W.C.2
Li, P.3
Guo, H.4
Poh, S.B.5
Brady, S.W.6
Xiong, Y.7
Tseng, L.M.8
Li, S.H.9
Ding, Z.10
Sahin, A.A.11
Esteva, F.J.12
Hortobagyi, G.N.13
Yu, D.14
-
66
-
-
79954620289
-
Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer
-
Donev, I. S.; Wang, W.; Yamada, T.; Li, Q.; Takeuchi, S.; Matsumoto, K.; Yamori, T.; Nishioka, Y.; Sone, S.; Yano, S. Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer. Clin. Cancer Res., 2011, 17(8), 2260-2269.
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.8
, pp. 2260-2269
-
-
Donev, I.S.1
Wang, W.2
Yamada, T.3
Li, Q.4
Takeuchi, S.5
Matsumoto, K.6
Yamori, T.7
Nishioka, Y.8
Sone, S.9
Yano, S.10
-
67
-
-
84869211206
-
Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer
-
Tanizaki, J.; Okamoto, I.; Okabe, T.; Sakai, K.; Tanaka, K.; Hayashi, H.; Kaneda, H.; Takezawa, K.; Kuwata, K.; Yamaguchi, H.; Hatashita, E.; Nishio, K.; Nakagawa, K. Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer. Clin. Cancer Res., 2012, 18(22), 6219-6226.
-
(2012)
Clin. Cancer Res.
, vol.18
, Issue.22
, pp. 6219-6226
-
-
Tanizaki, J.1
Okamoto, I.2
Okabe, T.3
Sakai, K.4
Tanaka, K.5
Hayashi, H.6
Kaneda, H.7
Takezawa, K.8
Kuwata, K.9
Yamaguchi, H.10
Hatashita, E.11
Nishio, K.12
Nakagawa, K.13
-
68
-
-
40849140848
-
Imatinib-resistant K562 cells are more sensitive to celecoxib, a selective COX-2 inhibitor: Role of COX-2 and MDR-1
-
Arunasree, K. M.; Roy, K. R.; Anilkumar, K.; Aparna, A.; Reddy, G. V.; Reddanna, P. Imatinib-resistant K562 cells are more sensitive to celecoxib, a selective COX-2 inhibitor: role of COX-2 and MDR-1. Leuk. Res., 2008, 32(6), 855-864.
-
(2008)
Leuk. Res.
, vol.32
, Issue.6
, pp. 855-864
-
-
Arunasree, K.M.1
Roy, K.R.2
Anilkumar, K.3
Aparna, A.4
Reddy, G.V.5
Reddanna, P.6
-
69
-
-
79956274055
-
Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells
-
e656
-
Marfe, G.; Di Stefano, C.; Gambacurta, A.; Ottone, T.; Martini, V.; Abruzzese, E.; Mologni, L.; Sinibaldi-Salimei, P.; de Fabritis, P.; Gambacorti-Passerini, C.; Amadori, S.; Birge, R. B. Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells. Exp. Hematol., 2011, 39(6), 653-665 e656.
-
(2011)
Exp. Hematol.
, vol.39
, Issue.6
, pp. 653-665
-
-
Marfe, G.1
Di Stefano, C.2
Gambacurta, A.3
Ottone, T.4
Martini, V.5
Abruzzese, E.6
Mologni, L.7
Sinibaldi-Salimei, P.8
De Fabritis, P.9
Gambacorti-Passerini, C.10
Amadori, S.11
Birge, R.B.12
-
70
-
-
84865386963
-
Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562
-
Liu, L.; Wang, S.; Chen, R.; Wu, Y.; Zhang, B.; Huang, S.; Zhang, J.; Xiao, F.; Wang, M.; Liang, Y. Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562. Biochem. Biophys. Res. Commun., 2012, 425(2), 368-373.
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.425
, Issue.2
, pp. 368-373
-
-
Liu, L.1
Wang, S.2
Chen, R.3
Wu, Y.4
Zhang, B.5
Huang, S.6
Zhang, J.7
Xiao, F.8
Wang, M.9
Liang, Y.10
-
71
-
-
84874810369
-
Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody
-
Monteleone, F.; Rosa, R.; Vitale, M.; D'Ambrosio, C.; Succoio, M.; Formisano, L.; Nappi, L.; Romano, M. F.; Scaloni, A.; Tortora, G.; Bianco, R.; Zambrano, N. Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody. Proteomics, 2013.
-
(2013)
Proteomics
-
-
Monteleone, F.1
Rosa, R.2
Vitale, M.3
D'Ambrosio, C.4
Succoio, M.5
Formisano, L.6
Nappi, L.7
Romano, M.F.8
Scaloni, A.9
Tortora, G.10
Bianco, R.11
Zambrano, N.12
-
72
-
-
84862772839
-
A molecularly annotated platform of patient-derived xenografts (xenopatients) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
-
Bertotti, A.; Migliardi, G.; Galimi, F.; Sassi, F.; Torti, D.; Isella, C.; Cora, D.; Di Nicolantonio, F.; Buscarino, M.; Petti, C.; Ribero, D.; Russolillo, N.; Muratore, A.; Massucco, P.;Pisacane, A.; Molinaro, L.; Valtorta, E.; Sartore-Bianchi, A.; Risio, M.; Capussotti, L.; Gambacorta, M.; Siena, S.; Medico, E.; Sapino, A.; Marsoni, S.; Comoglio, P. M.; Bardelli, A.; Trusolino, L. A molecularly annotated platform of patient-derived xenografts (xenopatients) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov., 2012, 1(6), 508-523.
-
(2012)
Cancer Discov.
, vol.1
, Issue.6
, pp. 508-523
-
-
Bertotti, A.1
Migliardi, G.2
Galimi, F.3
Sassi, F.4
Torti, D.5
Isella, C.6
Cora, D.7
Di Nicolantonio, F.8
Buscarino, M.9
Petti, C.10
Ribero, D.11
Russolillo, N.12
Muratore, A.13
Massucco, P.14
Pisacane, A.15
Molinaro, L.16
Valtorta, E.17
Sartore-Bianchi, A.18
Risio, M.19
Capussotti, L.20
Gambacorta, M.21
Siena, S.22
Medico, E.23
Sapino, A.24
Marsoni, S.25
Comoglio, P.M.26
Bardelli, A.27
Trusolino, L.28
more..
|