UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster

EMBO Reports

Volumn 15, Issue 5, 2014, Pages 586-591

  Da Ré, Caterina ^a   De Pittà, Cristiano ^a   Zordan, Mauro A ^a   Teza, Giordano ^a   Nestola, Fabrizio ^a   Zeviani, Massimo ^b   Costa, Rodolfo ^a   Bernardi, Paolo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Drosophila melanogaster; energy dissipation; mitochondria; respiration; uncoupling proteins

Indexed keywords

GUANOSINE DIPHOSPHATE; OLIGOMYCIN; PALMITIC ACID; UCP 4C; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; CARRIER PROTEIN; DROSOPHILA PROTEIN; ENZYME INHIBITOR; PALMITIC ACID DERIVATIVE; UCP4C PROTEIN, DROSOPHILA;

ARTICLE; CONTROLLED STUDY; DEVELOPMENT; DROSOPHILA MELANOGASTER; ENERGY; GENE SILENCING; INFRARED PHOTOGRAPHY; LARVA; LOW TEMPERATURE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; ANIMAL; BREATHING; CELL CULTURE; COLD; DRUG EFFECTS; EMBRYOLOGY; GENE INACTIVATION; GENETICS; METABOLISM; MITOCHONDRION; PHYSIOLOGY; THERMOGENESIS;

ANIMALS; CELLS, CULTURED; COLD TEMPERATURE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENZYME INHIBITORS; GENE KNOCKOUT TECHNIQUES; GUANOSINE DIPHOSPHATE; LARVA; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; OLIGOMYCINS; OXYGEN CONSUMPTION; PALMITATES; RESPIRATION; THERMOGENESIS; UNCOUPLING AGENTS;

EID: 84899817296     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1002/embr.201337972     Document Type: Article

References (38)

1. Stephan W, Li H, (2007) The recent demographic and adaptive history of Drosophila melanogaster. Heredity (Edinb) 98: 65-68
2. Hoffmann AA, (2010) Physiological climatic limits in Drosophila: patterns and implications. J Exp Biol 213: 870-880
3. Hanak P, Jezek P, (2001) Mitochondrial uncoupling proteins and phylogenesis-UCP4 as the ancestral uncoupling protein. FEBS Lett 495: 137-141
4. Sokolova IM, Sokolov EP, (2005) Evolution of mitochondrial uncoupling proteins: novel invertebrate UCP homologues suggest early evolutionary divergence of the UCP family. FEBS Lett 579: 313-317
5. Nicholls DG, (2006) The physiological regulation of uncoupling proteins. Biochim Biophys Acta 1757: 459-466
6. Ledesma A, de Lacoba MG, Rial E, (2002) The mitochondrial uncoupling proteins. Genome Biol 3: 3015.1-3015.9.
7. Cannon B, Nedergaard J, (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84: 277-359
8. Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, et al (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150: 366-376
9. Wu J, Cohen P, Spiegelman BM, (2013) Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev 27: 234-250
10. Fedorenko A, Lishko PV, Kirichok Y, (2012) Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 151: 400-413
11. Ricquier D, Bouillaud F, (2000) The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J 345 (Pt 2): 161-179
12. Laloi M, Klein M, Riesmeier JW, Muller-Rober B, Fleury C, Bouillaud F, Ricquier D, (1997) A plant cold-induced uncoupling protein. Nature 389: 135-136
13. Slocinska M, Antos-Krzeminska N, Rosinski G, Jarmuszkiewicz W, (2011) Identification and characterization of uncoupling protein 4 in fat body and muscle mitochondria from the cockroach Gromphadorhina cocquereliana. J Bioenerg Biomembr 43: 717-727
14. Slocinska M, Antos-Krzeminska N, Rosinski G, Jarmuszkiewicz W, (2012) Molecular identification and functional characterisation of uncoupling protein 4 in larva and pupa fat body mitochondria from the beetle Zophobas atratus. Comp Biochem Physiol B Biochem Mol Biol 162: 126-133
15. Ji C, Guo W, Zhang M, Lu X, Ni Y, Guo X, (2012) Caenorhabditis elegans ucp-4 regulates fat metabolism: suppression of ucp-4 expression induced obese phenotype and caused impairment of insulin like pathway. Gene 491: 158-164
16. Keller PA, Lehr L, Giacobino JP, Charnay Y, Assimacopoulos-Jeannet F, Giovannini N, (2005) Cloning, ontogenesis, and localization of an atypical uncoupling protein 4 in Xenopus laevis. Physiol Genomics 22: 339-345
17. Fridell YW, Sanchez-Blanco A, Silvia BA, Helfand SL, (2004) Functional characterization of a Drosophila mitochondrial uncoupling protein. J Bioenerg Biomembr 36: 219-228
18. Sanchez-Blanco A, Fridell YW, Helfand SL, (2006) Involvement of Drosophila uncoupling protein 5 in metabolism and aging. Genetics 172: 1699-1710
19. Schneider I, (1972) Cell lines derived from late embryonic stages of Drosophila melanogaster. J Embryol Exp Morphol 27: 353-365
20. Brand AH, Perrimon N, (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415
21. Dietzl G, Chen D, Schnorrer F, Su KC, Barinova Y, Fellner M, Gasser B, Kinsey K, Oppel S, Scheiblauer S, et al (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448: 151-156
22. Angelin A, Bonaldo P, Bernardi P, (2008) Altered threshold of the mitochondrial permeability transition pore in Ullrich congenital muscular dystrophy. Biochim Biophys Acta 1777: 893-896
23. Vinogradov A, Scarpa A, Chance B, (1972) Calcium and pyridine nucleotide interaction in mitochondrial membranes. Arch Biochem Biophys 152: 646-654
24. + and is a causative event in the death of myocytes in postischemic reperfusion of the heart. J Biol Chem 276: 2571-2575
25. Schiesari L, Kyriacou CP, Costa R, (2011) The hormonal and circadian basis for insect photoperiodic timing. FEBS Lett 585: 1450-1460
26. Andreyev AY, Bondareva TO, Dedukhova VI, Mokhova EN, Skulachev VP, Tsofina LM, Volkov NI, Vygodina TV, (1989) The ATP/ADP-antiporter is involved in the uncoupling effect of fatty acids on mitochondria. Eur J Biochem 182: 585-592
27. Iser WB, Kim D, Bachman E, Wolkow C, (2005) Examination of the requirement for ucp-4, a putative homolog of mammalian uncoupling proteins, for stress tolerance and longevity in C. Elegans. Mech Ageing Dev 126: 1090-1096
28. Grönke S, Mildner A, Fellert S, Tennagels N, Petry S, Müller G, Jäckle H, Kühnlein RP, (2005) Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab 1: 323-330
29. Carvalho M, Sampaio JL, Palm W, Brankatschk M, Eaton S, Shevchenko A, (2012) Effects of diet and development on the Drosophila lipidome. Mol Syst Biol 8: 600
30. Kaun KR, Heberlein U, (2009) Too fat to fly? New brain circuits regulate obesity in Drosophila. Neuron 63: 279-281
31. Allen MJ, (2007) What makes a fly enter diapause? Fly (Austin) 1: 307-310
32. Saunders DS, Bertossa RC, (2011) Deciphering time measurement: the role of circadian 'clock' genes and formal experimentation in insect photoperiodism. J Insect Physiol 57: 557-566
33. David J, Clavel MF, (1967) Influence de la température subie au cours du développement sur divers caractères biométriques des adultes de Drosophila melanogaster Meigen. J Insect Physiol 13: 717-729
34. Skulachev VP, (1996) Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q Rev Biophys 29: 169-202
35. Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, et al (2007) Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292: C125-C136
36. Ghezzi D, Arzuffi P, Zordan M, Da Ré C, Lamperti C, Benna C, D'Adamo P, Diodato D, Costa R, Mariotti C, et al (2011) Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. Nat Genet 43: 259-263
37. 2+ transport in mitochondria of Drosophila melanogaster. J Biol Chem 286: 41163-41170
38. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt Method. Methods 25: 402-408