Use of probiotics in the treatment of severe acute pancreatitis: A systematic review and meta-analysis of randomized controlled trials

Critical Care

Volumn 18, Issue 2, 2014, Pages

  Gou, Shanmiao ^a   Yang, Zhiyong ^a   Liu, Tao ^a   Wu, Heshui ^a   Wang, Chunyou ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; PLACEBO; PROBIOTIC AGENT;

ACUTE HEMORRHAGIC PANCREATITIS; ACUTE PANCREATITIS; APACHE; ARTICLE; BIFIDOBACTERIUM LONGUM; DISEASE SEVERITY; DRUG EFFECT; ENTEROCOCCUS FAECALIS; GLASGOW OUTCOME SCALE; HUMAN; INFECTION RATE; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS BULGARICUS; LACTOBACILLUS CASEI; LACTOBACILLUS PARACASEI; LACTOBACILLUS PLANTARUM; LACTOBACILLUS SALIVARIUS; LENGTH OF STAY; LEUCONOSTOC MESENTEROIDES; META ANALYSIS; MORTALITY; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PANCREAS NECROSIS; PANCREAS SURGERY; PEDIOCOCCUS PENTOSACEUS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); STREPTOCOCCUS THERMOPHILUS; SURGERY; SYSTEMATIC REVIEW; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TREATMENT DURATION; DIET THERAPY; PANCREATITIS; PROCEDURES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

HUMANS; PANCREATITIS; PROBIOTICS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84899758742     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13809     Document Type: Article

References (60)

1. Peery AF, Dellon ES, Lund J, Crockett SD, McGowan CE, Bulsiewicz WJ, Gangarosa LM, Thiny MT, Stizenberg K, Morgan DR, Ringel Y, Kim HP, Dibonaventura MD, Carroll CF, Allen JK, Cook SF, Sandler RS, Kappelman MD, Shaheen NJ. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology 2012, 143:1179-1187. e3, 10.1053/j.gastro.2012.08.002, 3480553, 22885331.
2. UK Working Party on Acute Pancreatitis UK guidelines for the management of acute pancreatitis. Gut 2005, 54:iii1-iii9. 1867800, 15831893, UK Working Party on Acute Pancreatitis.
3. Beger HG, Rau B, Isenmann R. Natural history of necrotizing pancreatitis. Pancreatology 2003, 3:93-101.
4. Bradley EL, Dexter ND. Management of severe acute pancreatitis: a surgical odyssey. Ann Surg 2010, 251:6-17. 10.1097/SLA.0b013e3181c72b79, 20009748.
5. Dervenis C, Smailis D, Hatzitheoklitos E. Bacterial translocation and its prevention in acute pancreatitis. J Hepatobiliary Pancreat Surg 2003, 10:415-418. 10.1007/s00534-002-0727-5, 14714160.
6. Van Felius ID, Akkermans LM, Bosscha K, Verheem A, Harmsen W, Visser MR, Gooszen HG. Interdigestive small bowel motility and duodenal bacterial overgrowth in experimental acute pancreatitis. Neurogastroenterol Motil 2003, 15:267-276. 10.1046/j.1365-2982.2003.00410.x, 12787336.
7. van Minnen LP, Nieuwenhuijs VB, de Bruijn MT, Verheem A, Visser MR, van Dijk JE, Akkermans LM, Gooszen HG. Effects of subtotal colectomy on bacterial translocation during experimental acute pancreatitis. Pancreas 2006, 32:110-114. 10.1097/01.mpa.0000191650.24796.89, 16340752.
8. van Minnen LP, Timmerman HM, Lutgendorff F, Verheem A, Harmsen W, Konstantinov SR, Smidt H, Visser MR, Rijkers GT, Gooszen HG, Akkermans LM. Modification of intestinal flora with multispecies probiotics reduces bacterial translocation and improves clinical course in a rat model of acute pancreatitis. Surgery 2007, 141:470-480. 10.1016/j.surg.2006.10.007, 17383524.
9. Akyol S, Mas MR, Comert B, Ateskan T, Yasar M, Aydogan H, Deveci S, Akay C, Mas N, Yener N, Kocar IH. The effect of antibiotic and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis. Pancreas 2003, 26:363-367. 10.1097/00006676-200305000-00009, 12717269.
10. Muftuoglu MAT, Isikgor S, Tosun S, Saglam A. Effects of probiotics on the severity of experimental acute pancreatitis. Eur J Clin Nutr 2006, 60:464-468. 10.1038/sj.ejcn.1602338, 16340953.
11. Karen M, Yuksel O, Akyürek N, Ofluoǧlu E, Çaǧlar K, Şahin TT, Paşaoǧlu H, Memiş L, Akyürek N, Bostanci H. Probiotic agent Saccharomyces boulardii reduces the incidence of lung injury in acute necrotizing pancreatitis induced rats. J Surg Res 2010, 160:139-144. 10.1016/j.jss.2009.02.008, 19375719.
12. Shimizu K, Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Matsushima A, Tasaki O, Fujita K, Hosotsubo H, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H. Synbiotics decrease the incidence of septic complications in patients with severe SIRS: a preliminary report. Dig Dis Sci 2009, 54:1071-1078. 10.1007/s10620-008-0460-2, 18726154.
13. Giamarellos-Bourboulis EJ, Bengmark S, Kanellakopoulou K, Kotzampassi K. Pro- and synbiotics to control inflammation and infection in patients with multiple injuries. J Trauma 2009, 67:815-821. 10.1097/TA.0b013e31819d979e, 19820590.
14. Knight DJ, Gardiner D, Banks A, Snape SE, Weston VC, Bengmark S, Girling KJ. Effect of synbiotic therapy on the incidence of ventilator associated pneumonia in critically ill patients: a randomised, double-blind, placebo-controlled trial. Intensive Care Med 2009, 35:854-861. 10.1007/s00134-008-1368-1, 19083199.
15. Frohmader TJ, Chaboyer WP, Robertson IK, Gowardman J. Decrease in frequency of liquid stool in enterally fed critically ill patients given the multispecies probiotic VSL#3: a pilot trial. Am J Crit Care 2010, 19:e1-e11. 10.4037/ajcc2010976, 20436058.
16. Alberda C, Gramlich L, Meddings J, Field C, McCargar L, Kutsogiannis D, Fedorak R, Madsen K. Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2007, 85:816-823.
17. Kotzampassi K, Giamarellos-Bourboulis EJ, Voudouris A, Kazamias P, Eleftheriadis E. Benefits of a synbiotic formula (Synbiotic 2000Forte) in critically Ill trauma patients: early results of a randomized controlled trial. World J Surg 2006, 30:1848-1855. 10.1007/s00268-005-0653-1, 16983476.
18. Barraud D, Bollaert PE, Gibot S. Impact of the administration of probiotics on mortality in critically ill adult patients: a meta-analysis of randomized controlled trials. Chest 2013, 143:646-655.
19. Möndel M, Schroeder BO, Zimmermann K, Huber H, Nuding S, Beisner J, Fellermann K, Stange EF, Wehkamp J. Probiotic E. coli treatment mediates antimicrobial human β-defensin synthesis and fecal excretion in humans. Mucosal Immunol 2009, 2:166-172. 10.1038/mi.2008.77, 19129752.
20. Duquesne S, Petit V, Peduzzi J, Rebuffat S. Structural and functional diversity of microcins, gene-encoded antibacterial peptides from enterobacteria. J Mol Microbiol Biotechnol 2007, 13:200-209. 10.1159/000104748, 17827970.
21. Rea MC, Clayton E, O'Connor PM, Shanahan F, Kiely B, Ross RP, Hill C. Antimicrobial activity of lacticin 3147 against clinical Clostridium difficile strains. J Med Microbiol 2007, 56:940-946. 10.1099/jmm.0.47085-0, 17577060.
22. Kabeerdoss J, Devi RS, Mary RR, Prabhavathi D, Vidya R, Mechenro J, Mahendri NV, Pugazhendhi S, Ramakrishna BS. Effect of yoghurt containing Bifidobacterium lactis Bb12 on faecal excretion of secretory immunoglobulin A and human β-defensin 2 in healthy adult volunteers. Nutr J 2011, 10:138. 10.1186/1475-2891-10-138, 3265429, 22196482.
23. Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJ, Rosman C, Ploeg RJ, Brink MA, Schaapherder AF, Dejong CH, Wahab PJ, van Laarhoven CJ, van der Harst E, van Eijck CH, Cuesta MA, Akkermans LM, Gooszen HG, . the Dutch Acute Pancreatitis Study Group Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008, 371:651-659. 10.1016/S0140-6736(08)60207-X, 18279948, the Dutch Acute Pancreatitis Study Group.
24. Cui LH, Wang XH, Peng LH, Yu L, Yang YS. The effects of early enteral nutrition with addition of probiotics on the prognosis of patients suffering from severe acute pancreatitis [in Chinese]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2013, 25:224-228.
25. Li Y. Adjuvant therapy for probiotics in patients with severe acute pancreatitis: an analysis of 14 cases [in Chinese]. Shijie Huaren Xiaohua Zazhi 2007, 15:302-304.
26. Oláh A, Belágyi T, Issekutz A, Gamal ME, Bengmark S. Randomized clinical trial of specific Lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg 2002, 89:1103-1107. 10.1046/j.1365-2168.2002.02189.x, 12190674.
27. Oláh A, Belágyi T, Pótó L, Romics L, Bengmark S. Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study. Hepatogastroenterology 2007, 54:590-594.
28. Plaudis H, Pupelis G, Zeiza K, Boka V. Early low volume oral synbiotic/prebiotic supplemented enteral stimulation of the gut in patients with severe acute pancreatitis: a prospective feasibility study. Acta Chir Belg 2012, 112:131-138.
29. Working Group IAP/APA Acute Pancreatitis Guidelines IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology 2013, 13:e1-e15. Working Group IAP/APA Acute Pancreatitis Guidelines.
30. Toouli J, Brooke-Smith M, Bassi C, Carr-Locke D, Telford J, Freeny P, Imrie C, Tandon R. Guidelines for the management of acute pancreatitis. J Gastroenterol Hepatol 2002, 17:S15-S39.
31. Meier R, Beglinger C, Layer P, Gullo L, Keim V, Laugier R, Friess H, Schweitzer M, MacFie J, . ESPEN Consensus Group ESPEN guidelines on nutrition in acute pancreatitis. Clin Nutr 2002, 21:173-183. ESPEN Consensus Group.
32. Nathens AB, Curtis JR, Beale RJ, Cook DJ, Moreno RP, Romand JA, Skerrett SJ, Stapleton RD, Ware LB, Waldmann CS. Management of the critically ill patient with severe acute pancreatitis. Crit Care Med 2004, 32:2524-2536. 10.1097/01.CCM.0000148222.09869.92, 15599161.
33. Banks PA, Freeman ML. Practice guidelines in acute pancreatitis. Am J Gastroenterol 2006, 101:2379-2400. 10.1111/j.1572-0241.2006.00856.x, 17032204.
34. Takeda K, Takada T, Kawarada Y, Hirata K, Mayumi T, Yoshida M, Sekimoto M, Hirota M, Kimura Y, Isaji S, Koizumi M, Otsuki M, Matsuno S. JPN Guidelines for the management of acute pancreatitis: medical management of acute pancreatitis. J Hepatobiliary Pancreat Surg 2006, 13:42-47. 10.1007/s00534-005-1050-8, 2779395, 16463210.
35. Otsuki M, Hirota M, Arata S, Koizumi M, Kawa S, Kamisawa T, Takeda K, Mayumi T, Kitagawa M, Ito T, Inui K, Shimosegawa T, Tanaka S, Kataoka K, Saisho H, Okazaki K, Kuroda Y, Sawabu N, Takeyama Y, . the Research Committee of Intractable Diseases of the Pancreas Consensus of primary care in acute pancreatitis in Japan. World J Gastroenterol 2006, 12:3314-3323. the Research Committee of Intractable Diseases of the Pancreas.
36. American Gastroenterological Association Institute (AGA) on " Management of Acute Pancreatitis" Clinical Practice and Economics Committee; AGA Institute Governing Board AGA Institute Medical Position Statement on Acute Pancreatitis. Gastroenterology 2007, 132:2019-2021. 10.1053/j.gastro.2007.03.066, 17484893, American Gastroenterological Association Institute (AGA) on " Management of Acute Pancreatitis" Clinical Practice and Economics Committee; AGA Institute Governing Board.
37. Pezzilli R, Uomo G, Zerbi A, Gabbrielli A, Frulloni L, De Rai P, Delle Fave G, Di Carlo V, . Italian Association for the Study of the Pancreas and ProInf AISP (Computerized Project on Acute Pancreatitis) Study Group Diagnosis and treatment of acute pancreatitis: the position statement of the Italian Association for the Study of the Pancreas. Dig Liver Dis 2008, 40:803-808. 10.1016/j.dld.2008.02.019, 18387862, Italian Association for the Study of the Pancreas and ProInf AISP (Computerized Project on Acute Pancreatitis) Study Group.
38. Mirtallo JM, Forbes A, McClave SA, Jensen GL, Waitzberg DL, Davies AR, . International Consensus Guideline Committee Pancreatitis Task Force International consensus guidelines for nutrition therapy in pancreatitis. JPEN J Parenter Enteral Nutr 2012, 36:284-291. 10.1177/0148607112440823, 22457421, International Consensus Guideline Committee Pancreatitis Task Force.
39. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: Is blinding necessary?. Control Clin Trials 1996, 17:1-12. 10.1016/0197-2456(95)00134-4, 8721797.
40. Ioannidis JP, Trikalinos TA. The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey. CMAJ 2007, 176:1091-1096. 10.1503/cmaj.060410, 1839799, 17420491.
41. Sun S, Yang K, He X, Tian J, Ma B, Jiang L. Probiotics in patients with severe acute pancreatitis: a meta-analysis. Langenbecks Arch Surg 2009, 394:171-177. 10.1007/s00423-008-0379-2, 18633636.
42. Macho Fernandez E, Valenti V, Rockel C, Hermann C, Pot B, Boneca IG, Grangette C. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Gut 2011, 60:1050-1059. 10.1136/gut.2010.232918, 21471573.
43. Meijerink M, van Hemert S, Taverne N, Wels M, de Vos P, Bron PA, Savelkoul HF, van Bilsen J, Kleerebezem M, Wells JM. Identification of genetic loci in Lactobacillus plantarum that modulate the immune response of dendritic cells using comparative genome hybridization. PLoS One 2010, 5:e10632. 10.1371/journal.pone.0010632, 2869364, 20498715.
44. Klarin B, Molin G, Jeppsson B, Larsson A. Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomised controlled open pilot study. Crit Care 2008, 12:R136. 10.1186/cc7109, 2646346, 18990201.
45. McNaught CE, Woodcock NP, Anderson ADG, MacFie J. A prospective randomised trial of probiotics in critically ill patients. Clin Nutr 2005, 24:211-219. 10.1016/j.clnu.2004.08.008, 15784480.
46. Oudhuis GJ, Bergmans DC, Dormans T, Zwaveling JH, Kessels A, Prins MH, Stobberingh EE, Verbon A. Probiotics versus antibiotic decontamination of the digestive tract: infection and mortality. Intensive Care Med 2011, 37:110-117. 10.1007/s00134-010-2002-6, 3020315, 20721536.
47. Rayes N, Hansen S, Seehofer D, Müller AR, Serke S, Bengmark S, Neuhaus P. Early enteral supply of fiber and lactobacilli versus conventional nutrition: a controlled trial in patients with major abdominal surgery. Nutrition 2002, 18:609-615. 10.1016/S0899-9007(02)00811-0, 12093440.
48. Rayes N, Seehofer D, Theruvath T, Schiller RA, Langrehr JM, Jonas S, Bengmark S, Neuhaus P. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation-a randomized, double-blind trial. Am J Transplant 2005, 5:125-130. 10.1111/j.1600-6143.2004.00649.x, 15636620.
49. Spindler-Vesel A, Bengmark S, Vovk I, Cerovic O, Kompan L. Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients. JPEN J Parenter Enteral Nutr 2007, 31:119-126. 10.1177/0148607107031002119, 17308252.
50. Tan M, Zhu JC, Du J, Zhang LM, Yin HH. Effects of probiotics on serum levels of Th1/Th2 cytokine and clinical outcomes in severe traumatic brain-injured patients: a prospective randomized pilot study. Crit Care 2011, 15:R290. 10.1186/cc10579, 3388628, 22136422.
51. Jain PK, McNaught CE, Anderson ADG, MacFie J, Mitchell CJ. Influence of synbiotic containing Lactobacillus acidophilus La5, Bifidobacterium lactis Bb 12, Streptococcus thermophilus, Lactobacillus bulgaricus and oligofructose on gut barrier function and sepsis in critically ill patients: a randomised controlled trial. Clin Nutr 2004, 23:467-475. 10.1016/j.clnu.2003.12.002, 15297081.
52. Barraud D, Blard C, Hein F, Marçon O, Cravoisy A, Nace L, Alla F, Bollaert PE, Gibot S. Probiotics in the critically ill patient: a double blind, randomized, placebo-controlled trial. Intensive Care Med 2010, 36:1540-1547. 10.1007/s00134-010-1927-0, 20502866.
53. Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Lin L, Yang X, Yuan L. High dose and low dose Lactobacillus acidophilus exerted differential immune modulating effects on T cell immune responses induced by an oral human rotavirus vaccine in gnotobiotic pigs. Vaccine 2012, 30:1198-1207. 10.1016/j.vaccine.2011.11.107, 3269528, 22178726.
54. Boyanova L, Mitov I. Coadministration of probiotics with antibiotics: Why, when and for how long?. Expert Rev Anti Infect Ther 2012, 10:407-409. 10.1586/eri.12.24, 22512748.
55. Sharma B, Srivastava S, Singh N, Sachdev V, Kapur S, Saraya A. Role of probiotics on gut permeability and endotoxemia in patients with acute pancreatitis: a double-blind randomized controlled trial. J Clin Gastroenterol 2011, 45:442-448. 10.1097/MCG.0b013e318201f9e2, 21135704.
56. Besselink MGH, van Santvoort HC, van der Heijden GJMG, Buskens E, Gooszen HG. New randomized trial of probiotics in pancreatitis needed? Caution advised. Langenbecks Arch Surg 2009, 394:191-194. 10.1007/s00423-008-0419-y, 18841384.
57. Capurso G, Marignani M, Piciucchi M, Merola E, Delle Fave G. Probiotics and severe acute pancreatitis [Addendum]. J Clin Gastroenterol 2008, 42:S152-S153.
58. Bower RH, Cerra FB, Bershadsky B, Licari JJ, Hoyt DB, Jensen GL, Van Buren CT, Rothkopf MM, Daly JM, Adelsberg BR. Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Crit Care Med 1995, 23:436-449. 10.1097/00003246-199503000-00006, 7874893.
59. Montejo JC, Zarazaga A, López-Martínez J, Urrútia G, Roqué M, Blesa AL, Celaya S, Conejero R, Galbán C, García de Lorenzo A, Grau T, Mesejo A, Ortiz-Leyba C, Planas M, Ordóñez J, Jiménez FJ, . for the Nutritional and Metabolic Working Group of the Spanish Society of Intensive Care Medicine and Coronary Units (SEMICYUC), Spain Immunonutrition in the intensive care unit: a systematic review and consensus statement. Clin Nutr 2003, 22:221-233. 10.1016/S0261-5614(03)00007-4, 12765660, for the Nutritional and Metabolic Working Group of the Spanish Society of Intensive Care Medicine and Coronary Units (SEMICYUC), Spain.
60. Wilhelm SM, Kale-Pradhan PB. Combination of arginine and ω-3 fatty acids enteral nutrition in critically ill and surgical patients: a meta-analysis. Expert Rev Clin Pharmacol 2010, 3:459-469. 10.1586/ecp.10.29, 22111677.