Influence of synbiotic containing Lactobacillus acidophilus La5, Bifidobacterium lactis Bb 12, Streptococcus thermophilus, Lactobacillus bulgaricus and oligofructose on gut barrier function and sepsis in critically ill patients: A randomised controlled trial

Clinical Nutrition

Volumn 23, Issue 4, 2004, Pages 467-475

  Jain, Prashant K ^a   McNaught, Clare E ^a   Anderson, Alexander D G ^a   MacFie, John ^a   Mitchell, Charles J ^a  

^a SCARBOROUGH HOSPITAL   (United Kingdom)

Author keywords

Critical illness; Prebiotic; Probiotic; Synbiotic

Indexed keywords

ANTIBIOTIC AGENT; FRUCTOSE; HISTAMINE H2 RECEPTOR ANTAGONIST; INOTROPIC AGENT; PLACEBO; PREBIOTIC AGENT; PROBIOTIC AGENT; PROTON PUMP INHIBITOR; RAFLITOSE; TREVIS;

ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; BIFIDOBACTERIUM ANIMALIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INTENSIVE CARE UNIT; INTESTINE FUNCTION; INTESTINE MUCOSA PERMEABILITY; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS BULGARICUS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NASOGASTRIC TUBE; PERMEABILITY BARRIER; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEPSIS; SPECIES DIFFERENCE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STREPTOCOCCUS THERMOPHILUS;

AGED; AGED, 80 AND OVER; BACTERIAL TRANSLOCATION; BIFIDOBACTERIUM; CRITICAL ILLNESS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTESTINAL MUCOSA; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS; MALE; MIDDLE AGED; OLIGOSACCHARIDES; PERMEABILITY; PROBIOTICS; SEPSIS; STREPTOCOCCUS THERMOPHILUS;

EID: 2942538737     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2003.12.002     Document Type: Article

References (39)

1. Simon G.L. Gorbach S.L. Intestinal flora in health and disease Gastroenterology 86 1984 174-193
2. Botterill I. Macfie J. Bacterial translocation in the critically ill: a review of the evidence Care Crit Ill 16 2000 6-10
3. Marshall J.C. Christou N.V. Horn R. Meakins J.L. The microbiology of multiple organ failure: the proximal gastrointestinal tract as an occult reservoir of pathogens Arch Surg 123 1988 309-315
4. Marshall J.C. Gastrointestinal flora and its alterations in critical illness Curr Opin Clin Nutr Metab Care 2 1999 405-411
5. Vincent J.L. Bihari D.J. Suter P.M. et al. The prevalence of nosocomial infection in intensive care units in Europe: results of the European prevalence of infection in intensive care (EPIC) study J Am Med Assoc 274 1995 639-644
6. Richards M.J. Edwards J.R. Culver D.H. Gaynes R.P. Nosocomial infections in medical intensive care units in the United States Crit Care Med 27 1999 887-892
7. Hillman K.M. Riordan T. O'Farrell S.M. Colonization of the gastric contents in critically ill patients Crit Care Med 10 1982 444-447
8. du Moulin G.C. Paterson D.G. Hedley-Whyte J. Lisbon A. Aspiration of gastric bacteria in antacid-treated patients: a frequent cause of postoperative colonisation of he airway Lancet 1 1982 242-245
9. Marshall J.C. The gastrointestinal tract: the "undrained abscess" of multiple organ failure Ann Surg 218 1993 111-119
10. Schrezenmeir J. de Vrese M. Probiotics, prebiotics and synbiotics-approaching a definition Am J Clin Nutr 73 suppl 2001 361S-364S
11. Gorbach S.L. Plaut A.G. Nahas L. et al. Studies of intestinal microflora II. Micro-organisms of the small intestine and their relations to oral and faecal flora Gastroenterology 53 1967 856-867
12. Barrow G.I. Feltham R.K. Cowan and steel's manual for identification of medical bacteria 3rd ed 1993 Cambridge University Press Cambridge
13. Sorenson S.H. Proud F.J. Adam A. Rutgers H.C. Batt R.M. A novel HPLC method for the simultaneous quantification of monosaccharides and disaccharides used in tests of intestinal function and permeability Clin Chim Acta 221 1993 115-125
14. Knaus W.A. Draper E.A. Wagner D.P. Zimmerman J.E. APACHE II: a severity of disease classification system Crit Care Med 13 1985 818-829
15. Copeland G.P. Jones D. Walters M. POSSUM: a scoring system for surgical audit Br J Surg 78 1991 355-360
16. Landow L. Andersen L.W. Splanchnic ischaemia and its role in multiple organ failure Acta Anaesthesiol Scand 38 1994 626-639
17. Conejero R. Bonet A. Grau T. et al. Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study Nutrition 18 2002 716-721
18. Van der Waaij D. Colonization resistance of the digestive tract-mechanism and clinical consequences Nahrung 31 1987 507-517
19. Schiffrin E.J. Rochat F. Link-Amster H. Aeschlimann J.M. Donnet-Hughes A. Immunomodulation of human blood cells following the ingestion of lactic acid bacteria J Dairy Sci 78 1994 491-497
20. Bengmark S. Gut microbial ecology in critical illness: is there a role for prebiotics, probiotics and synbiotics? Curr Opin Crit Care 8 2002 145-151
21. Collins M.D. Glenn R.G. Probiotics, prebiotics and synbiotics: approaches for modulating the microbial ecology of the gut Am J Clin Nutr 69 suppl 1999 1052S-1057S
22. Isolauri E. Probiotics in human disease Am J Clin Nutr 73 suppl 2001 1142S-1146S
23. Bengmark S. Pre-, pro and synbiotics Curr Opin Clin Nutr Metab Care 4 2001 571-579
24. Kolida S. Tuohy K. Gibson G.R. Prebiotic effect of inulin and oligofructose Br J Nutr 87 2002 S193-S197
25. Adawi D. Ahrne S. Molin G. Effect of different probiotic strains of Lactobacillus and Bifidobacterium on bacterial translocation and liver injury in acute liver injury model Int J Food Microbiol 70 2001 213-220
26. Mattar A.F. Drongowski R.A. Coran A.G. Harmon C.M. Effect of probiotics on enterocyte bacterial translocation in vitro Pediatr Surg Int 17 2001 265-268
27. Olah A. Belagyi T. Issekutz A. Gamal M.E. Benkmark S. Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis Br J Surg 89 2002 1103-1107
28. Rayes N. Hansen S. Seehofer D. et al. Early enteral supply of fiber and Lactobacilli versus conventional nutrition: a controlled trial in patients with major abdominal surgery Nutrition 18 2002 609-615
29. Rayes N. Seehofer D. Hansen S. et al. Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients Transplantation 74 2002 123-128
30. MacFie J. O'Boyle C. Mitchell C.J. et al. Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora and septic morbidity Gut 45 1999 223-228
31. Reid G. Charbonneau D. Erb J. et al. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women FEMS Immunol Med Microbiol 35 2003 131-134
32. Glück U. Olaf Gebbers J. Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and β-hemolytic streptococci) Am J Clin Nutr 77 2003 517-520
33. Perdigon G. Vintini E. Alvarez S. Medina M. Medici M. Study of the possible mechanisms involved in the mucosal immune system activation by lactic acid bacteria J Dairy Sci 82 1999 1108-1114
34. Gill H.S. Rutherfurd K.J. Cross M.L. Gopal P.K. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019 Am J Clin Nutr 74 2001 833-839
35. Harris C.E. Griffiths R.D. Freestone N. et al. Intestinal permeability in the critically ill Intensive Care Med 18 1 1992 38-41
36. Mangell P. Nejdfors P. Wang M. et al. Lactobacillus plantarum 299v inhibits Escherichia coli-induced intestinal permeability Digestive Dis Sci 47 2002 511-516
37. McNaught C.E. Woodcock N.P. MacFie J. Mitchell C.J. A prospective randomised study of the probiotic Lactobacillus plantarum 299V on indices of gut barrier function in elective surgical patients Gut 51 2002 827-831
38. O'Boyle C.J. MacFie J. Dave K. Sagar P.S. Poon P. Mitchell C.J. Alterations in intestinal barrier function do not predispose to translocation of enteric bacteria in gastroenterologic patients Nutrition 14 1998 358-362
39. Walter J. Hertel C. Tannock G.W. Lis C.M. Munro K. Hammes W.P. Detection of Lactobacillus, Pediococcus, Leuconostoc, and Weissella species in human feces by using group-specific PCR primers and denaturing gradient gel electrophoresis Appl Environ Microbiol 67 2001 2578-2585