The coronary dilation effect of Shen Fu injection was mediated through NO

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Li, Yu Hong ^a   Yu, Bin ^a   Duan, Zhen Zhen ^a   Akinyi, Olunga Mary ^a   Yu, Jia Hui ^a   Zhou, Kun ^a   Zhang, Yue ^a   Gao, Xiu Mei ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE TRIPHOSPHATE; GINSENOSIDE; GLIBENCLAMIDE; NITRIC OXIDE; SHEN FU; TETRYLAMMONIUM CHLORIDE; THROMBOXANE A2; UNCLASSIFIED DRUG; VASODILATOR AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HERBACEOUS AGENT; SHEN-FU;

ACONITE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; CORONARY HEMODYNAMICS; DRUG EFFECT; DRUG MECHANISM; GINSENG; GUINEA PIG; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART PERFORMANCE; HEART PROTECTION; IN VITRO STUDY; ISOLATED HEART; MALE; NONHUMAN; RESTING HEART RATE; UPREGULATION; VASODILATATION; ANIMAL; CHEMISTRY; CORONARY BLOOD VESSEL; DRUG EFFECTS; HEART; HUMAN; INJECTION; METABOLISM; PANAX; PERFUSION; PHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL;

ACONITUM; ANIMALS; CORONARY CIRCULATION; CORONARY VESSELS; DRUGS, CHINESE HERBAL; GUINEA PIGS; HEART; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INJECTIONS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PANAX; PERFUSION; UP-REGULATION; VASODILATION;

EID: 84899748898     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092415     Document Type: Article

References (48)

1. Luo XY, Zhang FR, He RM (2009) Efficacy of shenfu injection as adjuvant therapy in treating patients of ischemic cardiomyopathy with heart insufficiency. Zhongguo Zhong Xi Yi Jie He Za Zhi. 29(8):685-7.
2. Zheng CD, Min S, Chin J (2008) Cardioprotection of Shenfu Injection against myocardial ischemia/reperfusion injury in open heart surgery. Integr Med. 14(1):10-6. (Pubitemid 351488143)
3. Wen-Ting S, Fa-Feng C, Li X, Cheng-Ren L, Jian-Xun L (2012) Chinese medicine shenfu injection for heart failure: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2012:713149.
4. Cao J, Zheng CD, Zhang GX, Zhang YJ, Min S (2005) Protective effect of Shenfu injection on myocardial mitochondria injured by ischemia-reperfusion in rabbits. Chin Med J (Engl). 118 (6):505-7. (Pubitemid 40468147)
5. KT Choi (2008) Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacologica Sinica, 29(9):1109-1118.
6. Han JY, Ahn SY, Oh EH, Nam SY, Hong JT, et al (2012) Red ginseng extract attenuates kainate-induced excitotoxicity by antioxidative effects. Evid Based Complement Alternat Med. 2012: 479016.
7. Bak MJ, Hong SG, Lee JW, Jeong WS (2012) Red ginseng marc oil inhibits iNOS and COX-2 via NFκB and p38 pathways in LPS-stimulated RAW 264.7 macrophages. Molecules. 17(12):13769-86.
8. Chen IJ, Chang MY, Chiao SL, Chen JL, Yu CC, et al (2012). Korean red ginseng improves blood pressure stability in patients with intradialytic hypotension. Evid Based Complement Alternat Med. 2012:595271.
9. Li HX, Han SY, Ma X, Zhang K, Wang L, et al (2012) The saponin of red ginseng protects the cardiac myocytes against ischemic injury in vitro and in vivo. Phytomedicine. 19(6):477-83.
10. Shibata S, Fujita M, Itokawa H, Tanaka O, Ishii T (1963) Studies on the constituents of Japanese and Chinese crude drugs. Xi. Panaxadiol, a Sapogenin of Ginseng Roots. Chemical & Pharmaceutical Bulletin. 11:762-765.
11. Yoshizaki K, Yahara S (2012) New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1). Chem Pharm Bull (Tokyo). 60(3):354-62.
12. Popovich DG, Yeo CR, Zhang W (2011) Ginsenosides Derived from Asian (Panax ginseng), American Ginseng (Panax quinquefolius) and potential cytoactivity. International Journal of Biomedical and Pharmaceutical sciences. 56-62.
13. Chen X (1996) Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clin Exp Pharmacol Physiol. 23(8):728-32.
14. Deng J, Wang YW, Chen WM, Wu Q, Huang XN (2010) Role of nitric oxide in ginsenoside Rg(1)-induced protection against left ventricular hypertrophy produced by abdominal aorta coarctation in rats. Biol Pharm Bull 33(4):631-5.
15. Peng L, Sun S, Xie LH, Wicks SM, Xie JT (2012) Ginsenoside Re: pharmacological effects on cardiovascular system. Cardiovasc Ther. 30(4):e183-8.
16. Zhao D, Wang J, Cui Y, Wu X (2012) Pharmacological effects of Chinese herb aconite (fuzi) on cardiovascular system. J Tradit Chin Med. 32(3):308-13.
17. Ji XF, Yang L, Zhang MY, Li CS, Wang S, et al (2011) Shen-Fu injection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest. Shock. 35(5): 530-536.
18. Zhou SJ, Du GY (2003) Effects of higenamine on the cardio-circulatory system. Zhongguo Zhong Yao Za Zhi. 28(10):910-3.
19. Morrison RR, Teng B, Oldenburg PJ, Katwa LC, Schnermann JB, et al (2006) Effects of targeted deletion of A1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes. Am J Physiol Heart Circ Physiol. 291(4):H1875-H1882. (Pubitemid 44497695)
20. Skrzypiec-Spring M, Grotthus B, Szelag A, Schulz R (2007) Isolated heart perfusion according to Langendorff-Still viable in the new millennium. Journal of Pharmacological and Toxicological Methods 55, 113-126. (Pubitemid 46227990)
21. Meng X, Ao L, Brown JM, Fullerton DA, Banerjee A, et al (1997) Nitric oxide synthase is not involved in cardiac contractile dysfunction in a rat model of endotoxemia without shock. Shock. 7, 111-118. (Pubitemid 127654257)
22. 15O] water: effect in occasional and chronic users. Journal of Clinical Pharmacology. 44; 751-766.
23. Stowe DF, Graf BM, Fujita S, Gross GJ (1996) One-day cold perfusion of bimakalim and butanedione monoxime restores ex situ cardiac function. American Journal of Physiology. 271; 1884-1892.
24. McLean PG, Aston D, Sarkar D, Ahluwalia A (2002) Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers. Circulation Research. 90; 465-472. (Pubitemid 34633917)
25. Guo L, Dong Z, Guthrie H (2009) Validation of a guinea pig Langendorff heart model for assessing potential cardiovascular liability of drug candidates. J Pharmacol Toxicol Methods. 60(2):130-51.
26. García-Villalón AL, Fernández N, Monge L, Diéguez G (2011) Coronary response to diadenosine tetraphosphate after ischemia-reperfusion in the isolated rat heart. Eur J Pharmacol. 660(2-3):394-401.
27. Montoya JJ, Fernández N, Monge L, Diéguez G, Villalón AL (2011) Nitric oxide-mediated relaxation to lactate of coronary circulation in the isolated perfused rat heart. J Cardiovasc Pharmacol. 58(4):392-8.
28. Favaloro JL, Kemp-Harper BK (2007) The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature. Cardiovasc Res. 73(3):587-96. (Pubitemid 46073951)
29. Liao R, Podesser BK, Lim CC (2012) The continuing evolution of the Langendorff and ejecting murine heart: new advances in cardiac phenotyping. Am J Physiol Heart Circ Physiol. 303(2): H156-H167.
30. Mishra RC, Belke D, Wulff H, Braun AP (2013) SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts. Cardiovasc Res. 97(2):339-48.
31. Liu CH, Chen MF, Tseng TL, Chen LG, Kuo JS, et al (2012) Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats. Evid Based Complement Alternat Med. 2012:408187.
32. Gregg DE (1963) Effect of coronary perfusion pressure or coronary flow on oxygen usage of the myocardium. Circulation Research. 13: 497-500.
33. Arnold G, Kosche F, Miessner E, Neitzert A, Lochner W (1968) The importance of the perfusion pressure in the coronary arteries for the contractility and the oxygen consumption of the heart. Pflugers Arch Gesamte Physiol Menschen Tiere, 299(4):339-56.
34. Yang FJ, Wang ZR, Lin DP, Qu Y, Yin HH, et al (2003) The influence on hemodynamics of myocardial ischemic dogs and blood pressure of animals with shenfu injection. Zhongguo Zhong Yao Za Zhi. 28(3):259-62.
35. Sakuma I, Gross SS, Levi R (1989) Positive inotropic effect of the thromboxane analog U-46619 on guinea pig left atrium: mediation by specific receptors and association with increased phosphoinositide turnover. Can J Physiol Pharmacol. 67(8):943-949. (Pubitemid 19276573)
36. Mantelli L, Amerini S, Rubino A, Ledda F (1992) Effects of thromboxane agonists on cardiac adrenergic neurotransmission. Eur J Pharmacol. 213(1):79-85.
37. Dubé GP, Jakubowski JA, Brune KA, Bemis KG, Kurtz WL (1995) In vivo effects of a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) partial agonist (+) 5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]-bicyclohept-2-exo-yl]- heptenoic acid [(+)-S-145], on vascular, platelet and cardiac function. J Pharmacol Exp Ther. 272(2):799-807.
38. Yu J, Eto M, Akishita M, Kaneko A, Ouchi Y, et al (2007) Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor. Biochem Biophys Res Commun. 353(3):764-9. (Pubitemid 46048736)
39. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, et al (2005) Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 41(5):861-8. (Pubitemid 40693810)
40. Yi XQ, Li T, Wang JR, Wong VK, Luo P, et al (2010) Total ginsenosides increase coronary perfusion flow in isolated rat hearts through activation of PI3K/Akt-eNOS signaling. Phytomedicine. 17(13):1006-15.
41. Chong WS, Lee YS, Kang YJ (1998) Comparison of Inodilator Effect of Higemanine, YS-49, YS-51,Tetrahydroisoquinoline Analogs, and Dobutamine in the Rat. Korean J Physiol Pharmacol; 2(3): 323-330.
42. Niu CQ, Zhang TX, Xu HQ, Qin XM (2004) Research of vasodilation effect of aconite decoction on the rabbit aorta in vitro. Zhong Yao Yao Li Yu Lin Chuang 20(4): 23-25.
43. Zhu J, Kang L, Ye Q, Fan G, Liang Y, et al. (2013) Effects of shenfu injection and its main components on the contraction of isolated rat thoracic aortic rings. PLoS One. 30; 8 (10)
44. Yoshimura M, Yasue H, Nakayama M, Shimasaki Y, Sumida H, et al. (1998) A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum Genet. 103(1):65-9. (Pubitemid 28398388)
45. Shouyuan T, Zhijia G, Jiangang W, Jie ZW, Fang HC, et al. (2009) The Protective Effects of Pretreatment with Shenfu Injection on Myocardial Ischemia/reperfusion Injury in Dogs. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease. 7 (11): 1317-1319.
46. ZeLong H, WeiHong Y, XiaoLing Z (2001) Effect and mechanism of Shen Fu Injection on hemodynamics of congestive heart failure patient. Chinese Journal of Integrative Medicine. 21 (5):386.
47. Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, et al (2003) Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation. 107(25):3152-8. (Pubitemid 36793084)
48. Nishida M, Carley WW, Gerritsen ME, Ellingsen O, Kelly RA, et al (1993) Isolation and characterization of human and rat cardiac microvascular endothelial cells. Am J Physiol. 264(2 Pt 2):H639-52. (Pubitemid 23081144)