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Volumn 30, Issue 4, 2012, Pages

Ginsenoside Re: Pharmacological Effects on Cardiovascular System

Author keywords

Cardiovascular system; Chemistry; Electrophysiology; Ginseng; Ginsenoside Re; Pharmacological effect

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RC; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 1; PROTEIN BAX; PROTEIN BCL 2; VERAPAMIL;

EID: 84863434733     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2011.00271.x     Document Type: Review
Times cited : (80)

References (58)
  • 1
    • 69149110615 scopus 로고    scopus 로고
    • Ginseng compounds: An update on their molecular mechanisms and medical applications
    • Lu JM, Yao Q, Chen C. Ginseng compounds: An update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol 2009;7:293-302.
    • (2009) Curr Vasc Pharmacol , vol.7 , pp. 293-302
    • Lu, J.M.1    Yao, Q.2    Chen, C.3
  • 2
    • 51749113105 scopus 로고    scopus 로고
    • Antihyperglycemic effects of ginseng and possible mechanisms
    • Peng DC, Chen WP, Xie JT. Antihyperglycemic effects of ginseng and possible mechanisms. Drugs Future 2008;33:507-514.
    • (2008) Drugs Future , vol.33 , pp. 507-514
    • Peng, D.C.1    Chen, W.P.2    Xie, J.T.3
  • 3
    • 84863422062 scopus 로고    scopus 로고
    • Ginseng, Panax ginseng CA Meyer
    • Awaad AS, Singh VK, Govil JN, editors. Houston, USA: Studium Press LLC
    • Cho WC. Ginseng, Panax ginseng CA Meyer. In: Awaad AS, Singh VK, Govil JN, editors. Recent Progress in Medicinal Plants, Volume 28, Drug Plants II. Houston, USA: Studium Press LLC, 2010;19-30.
    • (2010) Recent Progress in Medicinal Plants, Volume 28, Drug Plants II , pp. 19-30
    • Cho, W.C.1
  • 5
    • 0017602451 scopus 로고
    • A contribution to our knowledge of ginseng
    • Hu SY. A contribution to our knowledge of ginseng. Am J Chin Med 1977;5:1-23.
    • (1977) Am J Chin Med , vol.5 , pp. 1-23
    • Hu, S.Y.1
  • 6
    • 0344549853 scopus 로고    scopus 로고
    • Multiple pharmacological effects of ginseng
    • Attele AS, Wu JA, Yuan CS. Multiple pharmacological effects of ginseng. Biochem Pharmacol 1999;58:1685-1693.
    • (1999) Biochem Pharmacol , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 7
    • 0036266324 scopus 로고    scopus 로고
    • Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component
    • Attele AS, Zhou YP, Xie JT, et al. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51:1851-1858.
    • (2002) Diabetes , vol.51 , pp. 1851-1858
    • Attele, A.S.1    Zhou, Y.P.2    Xie, J.T.3
  • 8
    • 4644356962 scopus 로고    scopus 로고
    • Cancer prevention and therapeutics: Panax ginseng
    • Helms S. Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev 2004;9:259-274.
    • (2004) Altern Med Rev , vol.9 , pp. 259-274
    • Helms, S.1
  • 10
    • 20444417081 scopus 로고    scopus 로고
    • Anti-diabetic effect of ginsenoside Re in ob/ob mice
    • Xie JT, Mehendale SR, Li X, et al. Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta 2005;1740:319-325.
    • (2005) Biochim Biophys Acta , vol.1740 , pp. 319-325
    • Xie, J.T.1    Mehendale, S.R.2    Li, X.3
  • 11
    • 33749997319 scopus 로고    scopus 로고
    • Altered expression of serum protein in ginsenoside Re-treated diabetic rats detected by SELDI-TOF MS
    • Cho WC, Yip TT, Chung WS, Lee SK, Leung AW, Cheng CH, Yue KK. Altered expression of serum protein in ginsenoside Re-treated diabetic rats detected by SELDI-TOF MS. J Ethnopharmacol 2006;108:272-279.
    • (2006) J Ethnopharmacol , vol.108 , pp. 272-279
    • Cho, W.C.1    Yip, T.T.2    Chung, W.S.3    Lee, S.K.4    Leung, A.W.5    Cheng, C.H.6    Yue, K.K.7
  • 12
    • 33749990092 scopus 로고    scopus 로고
    • Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats
    • Cho WC, Chung WS, Lee SK, Leung AW, Cheng CH, Yue KK. Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. Eur J Pharmacol 2006;550:173-179.
    • (2006) Eur J Pharmacol , vol.550 , pp. 173-179
    • Cho, W.C.1    Chung, W.S.2    Lee, S.K.3    Leung, A.W.4    Cheng, C.H.5    Yue, K.K.6
  • 13
    • 33644544121 scopus 로고    scopus 로고
    • Antioxidant effects of ginsenoside Re in cardiomyocytes
    • Xie JT, Shao ZH, Vanden Hoek TL, et al. Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol 2006;532:201-207.
    • (2006) Eur J Pharmacol , vol.532 , pp. 201-207
    • Xie, J.T.1    Shao, Z.H.2    Vanden Hoek, T.L.3
  • 14
    • 0030757369 scopus 로고    scopus 로고
    • Panax ginseng pharmacology: A nitric oxide link?
    • Gillis CN. Panax ginseng pharmacology: A nitric oxide link?Biochem Pharmacol 1997;54:1-8.
    • (1997) Biochem Pharmacol , vol.54 , pp. 1-8
    • Gillis, C.N.1
  • 15
    • 3142628179 scopus 로고    scopus 로고
    • Proof of the mysterious efficacy of ginseng: basic and clinical trials: Suppression of adrenal medullary function in vitro by ginseng
    • Tachikawa E, Kudo K. Proof of the mysterious efficacy of ginseng: basic and clinical trials: Suppression of adrenal medullary function in vitro by ginseng. J Pharmacol Sci 2004;95:140-144.
    • (2004) J Pharmacol Sci , vol.95 , pp. 140-144
    • Tachikawa, E.1    Kudo, K.2
  • 16
    • 13444293396 scopus 로고    scopus 로고
    • Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action
    • Cheng Y, Shen LH, Zhang JT. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacol Sin 2005;26:143-149.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 143-149
    • Cheng, Y.1    Shen, L.H.2    Zhang, J.T.3
  • 17
    • 50349101675 scopus 로고    scopus 로고
    • Chapter 1 Ginsenosides: Chemistry, Biosynthesis, Analysis, and Potential Health Effects
    • Christensen LP. Chapter 1 Ginsenosides: Chemistry, Biosynthesis, Analysis, and Potential Health Effects. Adv Food Nutr Res 2008;55:1-99.
    • (2008) Adv Food Nutr Res , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 18
    • 24744467359 scopus 로고    scopus 로고
    • Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng
    • Xie JT, Wang CZ, Wang AB, Wu JA, Basila D, Yuan CS. Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng. Acta Pharmacol Sin 2005;26:1104-1110.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1104-1110
    • Xie, J.T.1    Wang, C.Z.2    Wang, A.B.3    Wu, J.A.4    Basila, D.5    Yuan, C.S.6
  • 19
    • 70349451559 scopus 로고    scopus 로고
    • Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method
    • Joo KM, Lee JH, Jeon HY, et al. Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method. J Pharm Biomed Anal 2010;51:278-283.
    • (2010) J Pharm Biomed Anal , vol.51 , pp. 278-283
    • Joo, K.M.1    Lee, J.H.2    Jeon, H.Y.3
  • 20
    • 0142169482 scopus 로고    scopus 로고
    • Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes
    • Bai CX, Sunami A, Namiki T, Sawanobori T, Furukawa T. Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes. Eur J Pharmacol 2003;476:35-44.
    • (2003) Eur J Pharmacol , vol.476 , pp. 35-44
    • Bai, C.X.1    Sunami, A.2    Namiki, T.3    Sawanobori, T.4    Furukawa, T.5
  • 22
    • 0031597590 scopus 로고    scopus 로고
    • 2+ channels and membrane capacitance in rat adrenal chromaffin cells
    • 2+ channels and membrane capacitance in rat adrenal chromaffin cells. Brain Res Bull 1998;46:245-251.
    • (1998) Brain Res Bull , vol.46 , pp. 245-251
    • Kim, H.S.1    Lee, J.H.2    Goo, Y.S.3    Nah, S.Y.4
  • 23
    • 0028045204 scopus 로고
    • Effect of ginsenoside Re on the electrophysiological activity of the heart
    • Jin ZQ, Liu CM. Effect of ginsenoside Re on the electrophysiological activity of the heart. Planta Med 1994;60:192-193.
    • (1994) Planta Med , vol.60 , pp. 192-193
    • Jin, Z.Q.1    Liu, C.M.2
  • 24
    • 0029779265 scopus 로고    scopus 로고
    • The action of ginsenoside Re on inotropy and chronotropy of isolated atria prepared from guinea pigs
    • Jin ZQ. The action of ginsenoside Re on inotropy and chronotropy of isolated atria prepared from guinea pigs. Planta Med 1996;62:314-316.
    • (1996) Planta Med , vol.62 , pp. 314-316
    • Jin, Z.Q.1
  • 25
    • 0038393172 scopus 로고    scopus 로고
    • Effects of ginseng saponin administered intraperitoneally on the hypothalamo-pituitary-adrenal axis in mice
    • Suppl
    • Kim DH, Moon YS, Jung JS, Min SK, Son BK, Suh HW, Song DK. Effects of ginseng saponin administered intraperitoneally on the hypothalamo-pituitary-adrenal axis in mice. Neurosci Lett 2003;343(Suppl):62-66.
    • (2003) Neurosci Lett , vol.343 , pp. 62-66
    • Kim, D.H.1    Moon, Y.S.2    Jung, J.S.3    Min, S.K.4    Son, B.K.5    Suh, H.W.6    Song, D.K.7
  • 26
    • 84863480711 scopus 로고    scopus 로고
    • Ginsenoside Re experts anti-arrhythmic effects in cat ventricle myocytes
    • Wang Y, Yuan CS, Lipsius S. Ginsenoside Re experts anti-arrhythmic effects in cat ventricle myocytes. Exp Biol Abstr A277.
    • Exp Biol Abstr A277
    • Wang, Y.1    Yuan, C.S.2    Lipsius, S.3
  • 29
    • 26444489991 scopus 로고    scopus 로고
    • Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect
    • Bae EA, Shin JE, Kim DH. Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect. Biol Pharm Bull 2005;28:1903-1908.
    • (2005) Biol Pharm Bull , vol.28 , pp. 1903-1908
    • Bae, E.A.1    Shin, J.E.2    Kim, D.H.3
  • 30
    • 51749111854 scopus 로고    scopus 로고
    • Ginseng: beneficial and potential adverse effects
    • Yuan C-S, Beiber E, Bauer BA, editors. Boca Raton, London, New York, Washington, D.C .: CRC Press Company
    • Xie JT, Attele AS, Yuan C-S. Ginseng: beneficial and potential adverse effects. In: Yuan C-S, Beiber E, Bauer BA, editors. A textbook of complementary and alternative therapies. Boca Raton, London, New York, Washington, D.C .: CRC Press Company, 2006;71-89.
    • (2006) A textbook of complementary and alternative therapies , pp. 71-89
    • Xie, J.T.1    Attele, A.S.2    Yuan, C.-S.3
  • 35
    • 0002913007 scopus 로고
    • Essex : Longman Scientific and Technical
    • Banthorpe DV. Natural products. Essex : Longman Scientific and Technical, 1994.
    • (1994) Natural products
    • Banthorpe, D.V.1
  • 36
    • 77953307436 scopus 로고    scopus 로고
    • Pharmacology of ginsenosides: A literature review
    • doi:.
    • Leung KW, Wong AS. Pharmacology of ginsenosides: A literature review. Chin Med 2010; doi:.
    • (2010) Chin Med
    • Leung, K.W.1    Wong, A.S.2
  • 37
    • 79953655743 scopus 로고    scopus 로고
    • Study on the hemolytic and anti-hemolytic actions of individual ginsenosides
    • 26.
    • Cheng D, Fu R, Dou D, Kang T. Study on the hemolytic and anti-hemolytic actions of individual ginsenosides. Zhongguo Xiandai Zhongyao 2007;94:19-23, 26.
    • (2007) Zhongguo Xiandai Zhongyao , vol.94 , pp. 19-23
    • Cheng, D.1    Fu, R.2    Dou, D.3    Kang, T.4
  • 38
    • 0028914837 scopus 로고
    • Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta
    • Kang SY, Schini-Kerth VB, Kim ND. Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta. Life Sci 1995;56:1577-1586.
    • (1995) Life Sci , vol.56 , pp. 1577-1586
    • Kang, S.Y.1    Schini-Kerth, V.B.2    Kim, N.D.3
  • 39
    • 0023220303 scopus 로고
    • Plant-glycoside modulation of cell surface related to control of differentiation in cultured B16 melanoma cells
    • Ota T, Fujikawa-Yamamoto K, Zong ZP, et al. Plant-glycoside modulation of cell surface related to control of differentiation in cultured B16 melanoma cells. Cancer Res 1987;47:3863-3867.
    • (1987) Cancer Res , vol.47 , pp. 3863-3867
    • Ota, T.1    Fujikawa-Yamamoto, K.2    Zong, Z.P.3
  • 40
    • 0012397405 scopus 로고    scopus 로고
    • Effects of American ginseng berry extract on blood glucose levels in ob/ob mice
    • Xie JT, Aung HH, Wu JA, Attele AS, Yuan CS. Effects of American ginseng berry extract on blood glucose levels in ob/ob mice. Am J Chin Med 2002;30:187-194.
    • (2002) Am J Chin Med , vol.30 , pp. 187-194
    • Xie, J.T.1    Aung, H.H.2    Wu, J.A.3    Attele, A.S.4    Yuan, C.S.5
  • 42
    • 70450278777 scopus 로고    scopus 로고
    • Ginseng leaf-stem: Bioactive constituents and pharmacological functions
    • Wang H, Peng D, Xie JT. Ginseng leaf-stem: Bioactive constituents and pharmacological functions. Chin Med 2009;4:20-27.
    • (2009) Chin Med , vol.4 , pp. 20-27
    • Wang, H.1    Peng, D.2    Xie, J.T.3
  • 45
    • 27744539639 scopus 로고    scopus 로고
    • Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium)
    • Lim W, Mudge KW, Vermeylen F. Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium). J Agric Food Chem 2005;53:8498-8505.
    • (2005) J Agric Food Chem , vol.53 , pp. 8498-8505
    • Lim, W.1    Mudge, K.W.2    Vermeylen, F.3
  • 46
    • 67650729744 scopus 로고    scopus 로고
    • Quantitative analysis of ginsenosides Rb1, Rg1, and Re in American ginseng berry and flower samples by ELISA using monoclonal antibodies
    • Sritularak B, Morinaga O, Yuan CS, Shoyama Y, Tanaka H. Quantitative analysis of ginsenosides Rb1, Rg1, and Re in American ginseng berry and flower samples by ELISA using monoclonal antibodies. J Nat Med (Tokyo) 2009;63:360-363.
    • (2009) J Nat Med (Tokyo) , vol.63 , pp. 360-363
    • Sritularak, B.1    Morinaga, O.2    Yuan, C.S.3    Shoyama, Y.4    Tanaka, H.5
  • 47
    • 77950518981 scopus 로고    scopus 로고
    • Evaluation of a new eastern blotting technique for the analysis of ginsenoside Re in American ginseng berry pulp extracts
    • Morinaga O, Uto T, Yuan CS, Tanaka H, Shoyama Y. Evaluation of a new eastern blotting technique for the analysis of ginsenoside Re in American ginseng berry pulp extracts. Fitoterapia 2010;81:284-288.
    • (2010) Fitoterapia , vol.81 , pp. 284-288
    • Morinaga, O.1    Uto, T.2    Yuan, C.S.3    Tanaka, H.4    Shoyama, Y.5
  • 49
    • 65749102789 scopus 로고    scopus 로고
    • Protective effect of ginsenoside Re on isoproterenol-induced triggered ventricular arrhythmia in rabbits
    • Chen CX, Zhang HY. Protective effect of ginsenoside Re on isoproterenol-induced triggered ventricular arrhythmia in rabbits. Zhongguo Dang Dai Er Ke Za Zhi 2009;11:384-388.
    • (2009) Zhongguo Dang Dai Er Ke Za Zhi , vol.11 , pp. 384-388
    • Chen, C.X.1    Zhang, H.Y.2
  • 50
    • 0142258911 scopus 로고    scopus 로고
    • Effect of ginsenoside Re on cardiomyocyte apoptosis and expression of Bcl-2/Bax gene after ischemia and reperfusion in rats
    • Liu Z, Li Z, Liu X. Effect of ginsenoside Re on cardiomyocyte apoptosis and expression of Bcl-2/Bax gene after ischemia and reperfusion in rats. J Huazhong Univ Sci Technolog Med Sci 2002;22:305-309.
    • (2002) J Huazhong Univ Sci Technolog Med Sci , vol.22 , pp. 305-309
    • Liu, Z.1    Li, Z.2    Liu, X.3
  • 51
    • 45849093732 scopus 로고    scopus 로고
    • Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats
    • Chen LM, Zhou XM, Cao YL, Hu WX. Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats. J Asian Nat Prod Res 2008;10:439-445.
    • (2008) J Asian Nat Prod Res , vol.10 , pp. 439-445
    • Chen, L.M.1    Zhou, X.M.2    Cao, Y.L.3    Hu, W.X.4
  • 52
    • 0034747182 scopus 로고    scopus 로고
    • Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: role of nitric oxide
    • Scott GI, Colligan PB, Ren BH, Ren J. Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: role of nitric oxide. Br J Pharmacol 2001;134:1159-1165.
    • (2001) Br J Pharmacol , vol.134 , pp. 1159-1165
    • Scott, G.I.1    Colligan, P.B.2    Ren, B.H.3    Ren, J.4
  • 53
    • 18044385758 scopus 로고    scopus 로고
    • A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration
    • Huang YC, Chen CT, Chen SC, et al. A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration. Pharm Res 2005;22:636-646.
    • (2005) Pharm Res , vol.22 , pp. 636-646
    • Huang, Y.C.1    Chen, C.T.2    Chen, S.C.3
  • 54
    • 33845385343 scopus 로고    scopus 로고
    • Stability of angiogenic agents, ginsenoside Rg1 and Re, isolated from Panax ginseng: in vitro and in vivo studies
    • Yu LC, Chen SC, Chang WC, Huang YC, Lin KM, Lai PH, Sung HW. Stability of angiogenic agents, ginsenoside Rg1 and Re, isolated from Panax ginseng: in vitro and in vivo studies. Int J Pharm 2007;328:168-176.
    • (2007) Int J Pharm , vol.328 , pp. 168-176
    • Yu, L.C.1    Chen, S.C.2    Chang, W.C.3    Huang, Y.C.4    Lin, K.M.5    Lai, P.H.6    Sung, H.W.7
  • 55
    • 33846446729 scopus 로고    scopus 로고
    • Dynamic origin of spatially discordant alternans in cardiac tissue
    • Hayashi H, Shiferaw Y, Sato D, et al. Dynamic origin of spatially discordant alternans in cardiac tissue. Biophys J 2007;92:448-460.
    • (2007) Biophys J , vol.92 , pp. 448-460
    • Hayashi, H.1    Shiferaw, Y.2    Sato, D.3
  • 57
    • 55549132972 scopus 로고    scopus 로고
    • Intracellular Ca alternans: Coordinated regulation by sarcoplasmic reticulum release, uptake, and leak
    • Xie LH, Sato D, Garfinkel A, Qu Z, Weiss JN. Intracellular Ca alternans: Coordinated regulation by sarcoplasmic reticulum release, uptake, and leak. Biophys J 2008;95:3100-3110.
    • (2008) Biophys J , vol.95 , pp. 3100-3110
    • Xie, L.H.1    Sato, D.2    Garfinkel, A.3    Qu, Z.4    Weiss, J.N.5
  • 58
    • 33751119582 scopus 로고    scopus 로고
    • Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones
    • Furukawa T, Bai CX, Kaihara A, et al. Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones. Mol Pharmacol 2006;70:1916-192.
    • (2006) Mol Pharmacol , vol.70 , pp. 1916-1192
    • Furukawa, T.1    Bai, C.X.2    Kaihara, A.3


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