Structure-guided mutation of the conserved G3-box glycine in rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR)

Journal of Biological Chemistry

Volumn 289, Issue 18, 2014, Pages 12195-12201

  Mazhab Jafari, Mohammad T ^a   Marshall, Christopher B ^a   Ho, Jason ^a   Ishiyama, Noboru ^a   Stambolic, Vuk ^a   Ikura, Mitsuhiko ^a  

^a University of Toronto   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS;

BOUND STATE; CELLULAR SIGNALING; GTPASES; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); RESEARCH TOOLS;

ANTIBIOTICS;

ADENINE; ALANINE; ENZYME VARIANT; G3 BOX GLYCINE; GLYCINE; GUANINE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NUCLEOTIDE; PHOSPHATE; RHEB PROTEIN; S6 KINASE; TUBERIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFECT; ENZYME STRUCTURE; ENZYME SUBSTRATE; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN HYDROLYSIS; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

CONSTITUTIVELY ACTIVE; CRYSTAL STRUCTURE; ENZYME CATALYSIS; G3-BOX; MTOR COMPLEX (MTORC); PROTEIN ENGINEERING; RHEB; SMALL GTPASES; TSC2GAP;

ALANINE; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; GLYCINE; GUANOSINE TRIPHOSPHATE; HELA CELLS; HUMANS; HYDROLYSIS; MICE; MODELS, MOLECULAR; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; MUTATION; NEUROPEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84899746263     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C113.543736     Document Type: Article

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