Infection and Inflammation Leading to Clozapine Toxicity and Intensive Care: A Case Series

Annals of Pharmacotherapy

Volumn 48, Issue 6, 2014, Pages 801-805

  Leung, Jonathan G ^a   Nelson, Sarah ^a   Takala, Christopher R ^a   Gören, Jessica L ^b,c,d  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c CAMBRIDGE HEALTH ALLIANCE   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

antipsychotics (atypical); psychiatry; psychotropics; schizophrenia; toxicity

Indexed keywords

ACETYLSALICYLIC ACID; ARIPIPRAZOLE; AZITHROMYCIN; CEFTRIAXONE; CLONAZEPAM; CLOZAPINE; ERTAPENEM; ESCITALOPRAM; FLUMAZENIL; FLUTICASONE; IPRATROPIUM BROMIDE PLUS SALBUTAMOL; MIRTAZAPINE; NALOXONE; NORCLOZAPINE; OXYBUTYNIN; PSYCHOTROPIC AGENT; SALBUTAMOL; SALMETEROL; STEROID; THEOPHYLLINE; VALPROATE SEMISODIUM; VANCOMYCIN; NEUROLEPTIC AGENT;

ADULT; ARTHRITIS; ARTICLE; ARTIFICIAL VENTILATION; CASE REPORT; CELLULITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMMUNICATING HYDROCEPHALUS; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG METABOLISM; DRUG SAFETY; DRUG WITHDRAWAL; EVENING DOSAGE; FEMALE; FEVER; HIP FRACTURE; HIP SURGERY; HOSPITAL ADMISSION; HUMAN; HYPERCAPNIA; HYPERSALIVATION; HYPOTENSION; INFECTION; INFLAMMATION; INTENSIVE CARE; INTENSIVE CARE UNIT; MALE; MEDICATION COMPLIANCE; MENTAL DISEASE; MENTAL HEALTH; MENTAL PATIENT; MIDDLE AGED; MODERATE RENAL IMPAIRMENT; MORNING DOSAGE; MYOCLONUS; NARANJO ADR PROBABILITY SCALE; NEUROLEPTIC MALIGNANT SYNDROME; NEUROLOGIC EXAMINATION; NEUROLOGICAL COMPLICATION; OPIATE ADDICTION; PARALYTIC ILEUS; PNEUMONIA; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RATING SCALE; RESPIRATORY ACIDOSIS; RISK FACTOR; SCHIZOPHRENIA; SMOKING CESSATION; SOMNOLENCE; STEROID THERAPY; SUBARACHNOID HEMORRHAGE; SYMPTOM; URINARY TRACT INFECTION; BACTERIAL INFECTION; COMPLICATION;

ANTIPSYCHOTIC AGENTS; BACTERIAL INFECTIONS; CLOZAPINE; FEMALE; HUMANS; INFLAMMATION; INTENSIVE CARE; MALE; MIDDLE AGED; SCHIZOPHRENIA;

EID: 84899722019     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028014526701     Document Type: Article

References (21)

1. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2013:.
2. Darling P,Huthwaite MA.Infection-associated clozapine toxicity.Clin Schizophr Relat Psychoses. 2011;5:159-160.
3. de Leon J,Diaz FJ.Serious respiratory infections can increase clozapine levels and contribute to side effects: a case report.Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:1059-1063.
4. Espnes KA,Heimdal KO,Spigset O.A puzzling case of increased serum clozapine levels in a patient with inflammation and infection.Ther Drug Monit. 2012;34:489-492.
5. Abou Farha K,van Vliet A,Knegtering H,Bruggeman R.The value of desmethylclozapine and serum CRP in clozapine toxicity: a case report.Case Rep Psychiatry. 2012;2012:592784.
6. Haack MJ,Bak ML,Beurskens R,Maes M,Stolk LM,Delespaul PA.Toxic rise of clozapine plasma concentrations in relation to inflammation.Eur Neuropsychopharmacol. 2003;13:381-385.
7. Liang CS,Hsieh TH.Myoclonus as an indicator of infection in patients with schizophrenia treated with clozapine.J Psychiatry Neurosci. 2011;36:E1-E2.
8. Jecel J,Michel TM,Gutknecht L,Schmidt D,Pfuhlmann B,Jabs BE.Clozapine serum levels during acute urinary tract infection: a case report.Eur J Clin Pharmacol. 2005;60:909-910.
9. Raaska K,Raitasuo V,Arstila M,Neuvonen PJ.Bacterial pneumonia can increase serum concentration of clozapine.Eur J Clin Pharmacol. 2002;58:321-322.
10. Reith D,Monteleone JP,Whyte IM,Ebelling W,Holford NH,Carter GL.Features and toxicokinetics of clozapine in overdose.Ther Drug Monit. 1998;20:92-97.
11. Nahata M.Drug interactions with azithromycin and the macrolides: an overview.J Antimicrob Chemother. 1996;37:133-142.
12. von Rosensteil NA,Adam D.Macrolide antibacterials. Drug interactions of clinical significance.Drug Saf. 1995;13:105-122.
13. Naranjo CA,Busto U,Sellers EM,et al.A method for estimating the probability of adverse drug reactions.Clin Pharmacol Ther. 1981;30:239-245.
14. Levin TT,Barrett J,Mendelowitz A.Death from clozapine-induced constipation: case report and literature review.Psychosomatics. 2002;43:71-73.
15. Brouwers EE,Sohne M,Kuipers S,et al.Ciprofloxacin strongly inhibits clozapine metabolism: two case reports.Clin Drug Investig. 2009;29:59-63.
16. Procyshyn RM,Vila-Rodriguez F,Honer WG,Barr AM.Clozapine administered once versus twice daily: does it make a difference?.Med Hypotheses:.
17. Israili ZH,Dayton PG.Human α-1-glycoprotein and its interactions with drugs.Drug Metab Rev. 2001;33:161-235.
18. Stuhec M.Clozapine-induced elevated C-reactive protein and fever mimic infection.Gen Hosp Psychiatry. 2013;35:680.e5-680.e6.
19. Visitsunthorn N,Udomittipong K,Punnakan L.Theophylline toxicity in Thai children.Asian Pac J Allergy Immunol. 2001;19:177-182.
20. de Leon J.Respiratory infections rather than antibiotics may increase clozapine levels: a critical review of the literature.J Clin Psychiatry. 2004;65:1144-1145.
21. Legare N,Gregoire CA,De Benedictis L,Dumais A.Increasing the clozapine: norclozapine ratio with co-administration of fluvoxamine to enhance efficacy and minimize side effects of clozapine therapy.Med Hypotheses. 2013;80:689-691.