Respiratory infections rather than antibiotics may increase clozapine levels: A critical review of the literature

Journal of Clinical Psychiatry

Volumn 65, Issue 8, 2004, Pages 1144-1145

  De Jose Leon, M D ^a  

^a Eastern State Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CLOZAPINE; CYTOCHROME P450 1A2; NEUROLEPTIC AGENT;

BLOOD; COMORBIDITY; DRUG ADMINISTRATION; DRUG ANTAGONISM; DRUG INTERACTION; HUMAN; LETTER; MENTAL DISEASE; METABOLISM; RESPIRATORY TRACT INFECTION;

ANTI-BACTERIAL AGENTS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; COMORBIDITY; CYTOCHROME P-450 CYP1A2; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; HUMANS; MENTAL DISORDERS; RESPIRATORY TRACT INFECTIONS;

EID: 4544247630     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (17)

1. Bertilsson L, Carrillo JA, Dahl M, et al. Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test. Br J Clin Pharmacol 1994;38:471-473 (Pubitemid 24344037)
2. Chang KC, Bell TD, Lauer BA, et al. Altered theophylline pharmacokinetics during acute respiratory viral illness [letter]. Lancet 1978;1: 1132-1133 (Pubitemid 8356442)
3. Shilalukey K, Robieux I, Spino M, et al. Are current pediatric dose recommendations for intravenous theophylline appropriate? J Asthma 1993;30:109-121
4. Clark CJ, Boyd G. Theophylline pharmacokinetics during respiratory viral infections [letter]. Lancet 1979;1:492 (Pubitemid 9127251)
5. Abdel-Razzak Z, Loyer P, Fautrel A, et al. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 1993;44:707-715 (Pubitemid 23317282)
6. Raaska K, Raitasuo V, Arstila M, et al. Bacterial pneumonia can increase serum concentration of clozapine. Eur J Clin Pharmacol 2002;58:321-322 (Pubitemid 34983922)
7. de Leon J, Diaz FJ. Serious respiratory infections can increase clozapine levels and contribute to side effects: a case report. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:1059-1063 (Pubitemid 37141394)
8. Funderburg LG, Vertrees JE, True JE, et al. Seizure following addition of erythromycin to clozapine treatment [letter]. Am J Psychiatry 1994;151:1840-1841 (Pubitemid 24370912)
9. Cohen LG, Chesley S, Eugenio L, et al. Erythromycin-induced clozapine toxic reaction. Arch Intern Med 1996;156:675-677 (Pubitemid 26095019)
10. Csik V, Molnar J. Possible adverse interaction between clozapine and ampicillin in an adolescent with schizophrenia. J Child Adolesc Psychopharmacol 1994;4:123-128 (Pubitemid 24253444)
11. Gillum JG, Israel DS, Polk RE. Pharmacokinetic drug interactions with antimicrobial agents. Clin Pharmacokinetics 1993;25:450-482 (Pubitemid 23358033)
12. Hagg S, Spigset O, Mjorndal T, et al. Absence of interaction between erythromycin and a single dose of clozapine. Eur J Clin Pharmacol 1999;55:221-226 (Pubitemid 29244650)
13. Raaska K, Neuvonen PJ. Serum concentration of clozapine and N-desmethylclozapine are unaffected by the potent CYP3A4 inhibitor itraconazole. Eur J Clin Pharmacol 1998;54:167-170
14. Choc MG, Lehr RG, Hsuan F, et al. Multiple-dose pharmacokinetics of clozapine in patients. Pharm Res 1987;4:402-405 (Pubitemid 18010569)
15. Raaska K, Neuvonen PJ. Ciprofloxacin increases serum clozapine and N-desmethylclozapine: a study in patients with schizophrenia. Eur J Clin Pharmacol 2000;56:585-589
16. Zullino DF, Delessert D, Eap CB, et al. Tobacco and cannabis smoking cessation can lead to intoxication with clozapine or olanzapine. Int Clin Psychopharmacol 2002;17:141-143 (Pubitemid 34442196)
17. Alvir JMJ, Lieberman JA, Safferman AZ, et al. Clozapine-induced agranulocytosis: incidence and risk factors in the United States. N Engl J Med 1993;329:162-167 (Pubitemid 23195736)