An unexpected role for serum uric acid as a biomarker for severity of asthma exacerbation

Asian Pacific Journal of Allergy and Immunology

Volumn 32, Issue 1, 2014, Pages 93-99

  Li, Lin ^a   Wan, Chun ^a   Wen, Fuqiang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Asthma exacerbation; Event severity; Lung function; Serum uric acid; Smoking

Indexed keywords

BIOLOGICAL MARKER; URIC ACID;

ADULT; ARTICLE; ASTHMA; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PEAK EXPIRATORY FLOW; RETROSPECTIVE STUDY; SMOKING; URIC ACID BLOOD LEVEL; BLOOD; LUNG; PATHOPHYSIOLOGY;

ASTHMA; BIOLOGICAL MARKERS; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; URIC ACID;

EID: 84899699437     PISSN: 0125877X     EISSN: 22288694     Source Type: Journal    
DOI: 10.12932/AP0337.32.1.2014     Document Type: Article

References (18)

1. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, Firzgerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31:143- 78.
2. Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008;8:183-92.
3. Shi Y, Evans JE, Rock KL. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature. 2003;425:516-21.
4. Kobayashi T, Kouzaki H, Kita H. Human eosinophils recognize endogenous danger signal crystalline uric acid and produce proinflammatory cytokines mediated by autocrine ATP. J Immunol. 2010;184:6350-8.
5. Kool M, Willart MA, van Nimwegen M, Bergen I, Pouliot P, Virchow JC, et al. An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity. 2011;34:527-40.
6. Gasse P, Riteau N, Charron S, Girre S, Fick L, Pétrilli V, et al. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med. 2009;179:903-13.
7. Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Goutassociated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440:237-41.
8. Kool M, Soullié T, van Nimwegen M, Willart MA, Muskens F, Jung S, et al. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med. 2008;205:869-82.
9. Nakamura Y, Miyata M, Ohba T, Ando T, Hatsushika K, Suenaga F, et al. Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T(H)2-type immune responses and airway inflammation. J Allergy Clin Immunol. 2008;122:1208-14.
10. Liam CK, Goh CT, Isahak M, Lim KH, Wong CM. Relationship between symptoms and objective measures of airway obstruction in asthmatic patients. Asian Pac J Allergy Immunol. 2001;19:79- 83.
11. Seo WH, Ahn SH, Park SH, Kim J, Ahn KM, Ko BJ, et al. The standard range of peak expiratory flow rates of Korean children. Asian Pac J Allergy Immunol. 2011;29:143-9.
12. Aida Y, Shibata Y, Osaka D, Abe S, Inoue S, Fukuzaki K, et al. The relationship between serum uric acid and spirometric values in participants in a health check: the Takahata study. Int J Med Sci. 2011;8:470-8.
13. Garcia-Pachon E, Padilla-Navas I, Shum C. Serum uric acid to creatinine ratio in patients with chronic obstructive pulmonary disease. Lung. 2007;185:21-4.
14. Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G. Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the apolipoprotein mortality risk study (AMORIS). J Intern Med. 2009;266:558-70.
15. Obermayr RP, Temml C, Gutjahr G, Knechtelsdorfer M, Oberbauer R, Klauser-Braun R. Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol. 2008;19:2407-13.
16. Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, et al. Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. J Mol Cell Cardiol. 2007;43:437-44.
17. Chen L, Sun BB, Wang T, Wang X, Li JQ, Wang HX, et al. Cigarette smoke enhances {beta}-defensin 2 expression in rat airways via nuclear factor-{kappa}B activation. Eur Respir J. 2010;36:638-45.
18. Ruggiero C, Cherubini A, Miller E, Maggio M, Najjar SS, Lauretani F, et al. Usefulness of uric acid to predict changes in Creactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years. Am J Cardiol. 2007;100:115-21.