Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer's disease

Frontiers in Molecular Neuroscience

Volumn 7, Issue MAY, 2014, Pages

  Peter Giese, K ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; Cdk5; Memory; p25; p35; Synaptic degeneration; Synaptic plasticity

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALPAIN; CYCLIN DEPENDENT KINASE 5; ENZYME ACTIVATOR; GLYCOGEN SYNTHASE KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN P25; PROTEIN P35; PROTEOME; SEPTIN; TAU PROTEIN;

ALZHEIMER DISEASE; AUTOPSY; AUTOSOMAL DOMINANT OPTIC ATROPHY; CALCIUM SIGNALING; EMBRYO DEVELOPMENT; HIPPOCAMPAL CA1 REGION; LONG TERM POTENTIATION; MEMORY DISORDER; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; REVIEW; SPATIAL MEMORY; SYNAPTOGENESIS; UPREGULATION;

EID: 84899693792     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2014.00036     Document Type: Review

References (30)

1. Angelo, M., Plattner, F., and Giese, K. P. (2006). Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory. J. Neurochem. 99, 353-370. doi: 10.1111/j.1471-4159.2006.04040.x
2. Angelo, M., Plattner, F., Irvine, E. E., and Giese, K. P. (2003). Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression. Eur. J. Neurosci. 18, 423-431. doi: 10.1046/j.1460-9568.2003.02746.x
3. Arendt, T. (2009). Synaptic degeneration in Alzheimer's disease. Acta Neuropathol. 118, 167-179. doi: 10.1007/s00401-009-0536-x
4. Cipolat, S., Martins de Brito, O., Dal Zilio, B., and Scorrano, L. (2004). OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc. Natl. Acad. Sci. U.S.A. 101, 15927-15932. doi: 10.1073/pnas.0407043101
5. Engmann, O., and Giese, K. P. (2009). Crosstalk between Cdk5 and GSK3β: implications for Alzheimer's disease. Front. Mol. Neurosci. 2:2. doi: 10.3389/neuro.02.002.2009
6. Engmann, O., Campbell, J., Ward, M., Giese, K. P., and Thompson, A. J. (2010). Comparison of a protein-level and peptide-level labeling strategy for quantitative proteomics of synaptosomes using isobaric tags. J. Proteome Res. 9, 2725-2733. doi: 10.1021/pr900627e
7. Engmann, O., Hortobagyi, T., Thompson, A. J., Guadagno, J., Troakes, C., Soriano, S., et al. (2011a). Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease. Biol. Psychiatry 70, 159-168. doi: 10.1016/j.biopsych.2011.04.011
8. Engmann, O., Hortobagyi, T., Pidsley, R., Troakes, C., Bernstein, H. G., Kreutz, M. R., et al. (2011b). Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain134, 2408-2421. doi: 10.1093/brain/awr155
9. Fischer, A., Sananbenesi, F., Pang, P. T., Lu, B., and Tsai, L. H. (2005). Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 48, 825-838. doi: 10.1016/j.neuron.2005.10.033
10. Giese, K. P., Ris, L., and Plattner, F. (2005). Is there a role of the cyclin-dependent kinase 5 activator p25 in Alzheimer's disease? Neuroreport 16, 1725-1730. doi: 10.1097/01.wnr.0000185019.67434.d2
11. Hooper, C., Killick, R., and Lovestone, S. (2008). The GSK3 hypothesis of Alzheimer's disease. J. Neurochem. 104, 1433-1439. doi: 10.1111/j.1471-4159.2007.05194.x
12. Kawahara, M. (2010). Neurotoxicity of β-amyloid protein: oligomerization, channel formation, and calcium dyshomeostasis. Curr. Pharm. Des. 16, 2779-2789. doi: 10.2174/138161210793176545
13. Koffie, R. M., Hashimoto, T., Tai, H. C., Kay, K. R., Serrano-Pozo, A., Joyner, D., et al. (2012). Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain 135, 2155-2168. doi: 10.1093/brain/aws127
14. Kusakawa, G., Saito, T., Onuki, R., Ishiguro, K., Kishimoto, T., and Hisanaga, S. (2000). Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J. Biol. Chem. 275, 17166-17172. doi: 10.1074/jbc.M907757199
15. O'Hare, M. J., Kushwaha, N., Zhang, Y., Aleyasin, H., Callaghan, S. M., Slack, R. S., et al. (2005). Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptosis and excitotoxic neuronal death. J. Neurosci. 25, 8954-8966. doi: 10.1523/JNEUROSCI.2899-05.2005
16. Palop, J., and Mucke, L. (2010). Amyloid-β-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat. Neurosci. 13, 812-818. doi: 10.1038/nn.2583
17. Patrick, G. N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., and Tsai, L. H. (1999). Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402, 615-622. doi: 10.1038/45159
18. Paula-Lima, A. C., Brito-Moreira, J., and Ferreira, S. T. (2013). Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease. J. Neurochem. 126, 191-202. doi: 10.1111/jnc.12304
19. Plattner, F., Angelo, M., and Giese, K. P. (2006). The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. J. Biol. Chem. 281, 25457-25465. doi: 10.1074/jbc.M603469200
20. Ris, L., Angelo, M., Plattner, F., Capron, B., Errington, M. L., Bliss, T. V., et al. (2005). Sexual dimorphisms in the effect of low-level p25 expression on synaptic plasticity and memory. Eur. J. Neurosci. 21, 3023-3033. doi: 10.1111/j.1460-9568.2005.04137.x
21. Selkoe, D. J. (2002). Alzheimer's disease is a synaptic failure. Science 298, 789-791. doi: 10.1126/science.1074069
22. Serrano-Pozo, A., Frosch, M. P., Masliah, E., and Hyman, B. T. (2012). "Neuropathological alterations in Alzheimer disease, " in The Biology of Alzheimer's Disease, eds D. J. Selkoe, E. Mandelkow, and D. M. Holtzman (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press), 43-65.
23. Tada, T., Simonetta, A., Batterton, M., Kinoshita, M., Edbauer, D., and Sheng, M. (2007). Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons. Curr. Biol. 17, 1752-1178. doi: 10.1016/j.cub.2007.09.039
24. Tandon, A., Yu, H., Wang, L., Rogaeva, E., Sato, C., Chishti, M. A., et al. (2003). Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles. J. Neurochem.86, 572-581. doi: 10.1046/j.1471-4159.2003.01865.x
25. Taniguchi, S., Fujita, Y., Hayashi, S., Kakita, A., Takahashi, H., Murayama, S., et al. (2001). Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. FEBS Lett. 489, 46-50. doi: 10.1016/S0014-5793(00)02431-5
26. Tseng, H. C., Zhou, Y., Shen, Y., and Tsai, L. H. (2002). A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains. FEBS Lett. 523, 58-62. doi: 10.1016/S0014-5793(02)02934-4
27. Wang, X., Su, B., Lee, H. G., Li, X., Perry, G., Smith, M. A., et al. (2009). Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J. Neurosci. 29, 9090-9103. doi: 10.1523/JNEUROSCI.1357-09.2009
28. Wen, Y., Planel, E., Herman, M., Figueroa, H. Y., Wang, L., Liu, L., et al. (2008). Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3β mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J. Neurosci. 28, 2624-2632. doi: 10.1523/JNEUROSCI.5245-07.2008
29. Xie, Y., Vessey, J. P., Konecna, A., Dahm, R., Macchi, P., and Kiebler, M. A. (2007). The GTP-binding protein Septin 7 is critical for dendrite branching and dendritic-spine morphology. Curr. Biol. 17, 1746-1751. doi: 10.1016/j.cub.2007.08.042
30. Yoo, B. C., and Lubec, G. (2001). p25 protein in neurodegeneration. Nature 411, 763-764; discussion 764-765. doi: 10.1038/35081146