Anti-cancer effect and the underlying mechanisms of gypenosides on human colorectal cancer SW-480 cells

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Yan, Han ^a   Wang, Xiaobing ^a   Niu, Junfeng ^a   Wang, Yaqin ^a   Wang, Pan ^a   Liu, Quanhong ^a  

^a SHAANXI NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GYPENOSIDE; REACTIVE OXYGEN METABOLITE; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MEMBRANE DAMAGE; MICROFILAMENT; MICROVILLUS; MITOCHONDRIAL MEMBRANE POTENTIAL; ACTIN FILAMENT; CELL MEMBRANE; CELL MOTION; CELL NUCLEUS; CELL SHAPE; CELL SURVIVAL; CHEMISTRY; COLORECTAL NEOPLASMS; DRUG EFFECTS; DRUG SCREENING; FLOW CYTOMETRY; GYNOSTEMMA; METABOLISM; PATHOLOGY; TUMOR CELL LINE; ULTRASTRUCTURE;

ACETYLCYSTEINE; ACTIN CYTOSKELETON; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; CELL NUCLEUS; CELL SHAPE; CELL SURVIVAL; COLORECTAL NEOPLASMS; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; GYNOSTEMMA; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES;

EID: 84899690091     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095609     Document Type: Article

References (40)

1. Ferlay J, Parkin DM, Steliarova-Foucher E (2010) Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 46: 765-781.
2. Weitz J, Koch M, Debus J, Höhler T, Galle PR, et al. (2005) Colorectal cancer. Lancet 365: 153-165. (Pubitemid 40091806)
3. Gerber M (2009) Background review paper on total fat, fatty acid intake and cancers. Ann Nutr Metab 55: 140-161.
4. Van Duijnhoven FJ, Bueno-De-Mesquita HB, Ferrari P, Jenab M, Boshuizen HC, et al. (2009) Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 89: 1441-1452.
5. Cragg GM, Newman DJ (2005) Plants as a source of anti-cancer agents. J Ethnopharmacol 100: 72-79. (Pubitemid 41073525)
6. Lin CC, Huang PC, Lin JM (2000) Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum. Am J Chin Med 28: 87-96.
7. La Cour B, Molgaard P, Yi Z (1995) Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol 46: 125-129.
8. Purmová J, Opletal L (1995) Phytotherapeutic aspects of diseases of the cardiovascular system.5. Saponins and possibilities of their use in prevention and therapy. Ceska Slov Farm 44: 246-251.
9. Li L, Jiao L, Lau BH (1993) Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes. Cancer Biother 8: 263-272. (Pubitemid 23321994)
10. Lin JM, Lin CC, Chiu HF, Yang JJ, Lee SG (1993) Evaluation of the anti-inflammatory and liver-protective effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats. Am J Chin Med 21: 59-69.
11. Tan H, Liu ZL, Liu MJ (1993) Antithrombotic effect of Gynostemma pentaphyllum. Zhongguo Zhong Xi Yi Jie He Za Zhi 13: 278-280, 261.
12. Wang QF, Chen JC, Hsieh SJ, Cheng CC, Hsu SL (2002) Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells. Cancer Lett 183: 169-178.
13. Cheng X, Xiao Y, Wang X, Wang P, Li H, et al. (2012) Anti-tumor and proapoptotic activity of ethanolic extract and its various fractions from Polytrichum commune L.ex Hedw in L1210 cells. J Ethnopharmacol 143: 49-56.
14. Krysko DV, Berghe TV, D'Herde K (2008) Apoptosis and necrosis: detection, discrimination and phagocytosis. Methods 44: 205-221. (Pubitemid 351296447)
15. Wang ZB, Liu YQ, Zhang Y, Li Y, An XX, et al. (2007) Reactive oxygen species, but not mitochondrial membrane potential, is associated with radiation-induced apoptosis of AHH-1 human lymphoblastoid cells. Cell Biol Int 31: 1353-1358. (Pubitemid 47361872)
16. Verma M, Singh SK, Bhushan S, Sharma VK, Datt P, et al. (2008) In vitro cytotoxic potential of polyalthia longifolia on human cancer cell lines and induction of apoptosis through mitochondrial-dependent pathway in HL60 cells. Chem Biol Interact 171: 45-56. (Pubitemid 350191842)
17. Mclnroy L, Määttä A (2007) Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion. Biochem Biophys Res Commun 360: 109-114.
18. Yamada KM, Geiger B (1997) Molecular interactions in cell adhesion complexes. Curr Opin Cell Biol 9: 76-85. (Pubitemid 27065112)
19. Kekre N, Griffin C, McNulty J, Pandey S (2005) Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidylserine followed by rapid apoptosis specifically in human lymphoma cells. Cancer Chemother Pharmacol 56: 29-38. (Pubitemid 41201753)
20. Hsu HY, Yang JS, Lu KW, Yu CS, Chou ST, et al. (2011) An experimental study on the antileukemia effects of gypenosides in vitro and in vivo. Integr Cancer Ther 10: 101-112.
21. Qian X, Wang Y, Tang X (1998) Effects of Gynostemma pentaphllum Makino polysaccharide (PGP) on immunefunction. Journal of China Pharmaceutical University 30: 51-53.
22. Tanner MA, Bu X, Steimle JA, Myers PR (1999) The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum. Nitric Oxide 3: 359-365. (Pubitemid 29531862)
23. Yan H, Wang X, Wang Y, Wang P, Xiao Y (2014) Antiproliferation and antimigration induced by gypenosides in human colon cancer SW620 and esophageal cancer Eca-109 cells. Hum Exp Toxicol 33: 522-533.
24. Leibovitz A, Stinson JC, McCombs WB 3rd, McCoy CE, Mazur KC, et al. (1976) Classification of human colorectal adenocarcinoma cell lines. Cancer Res 36: 4562-4569.
25. Lu KW, Chen JC, Lai TY, Yang JS, Weng SW, et al. (2011) Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways. Hum Exp Toxicol 30: 406-415.
26. Khaitlina SY (2001) Functional specificity of actin isoforms. Int Rev Cytol 202: 35-98.
27. Cooper JA (1991) The role of actin polymerization in cell motility. Annu Rev Physiol 53: 585-605.
28. Kerr JF, Winterford CM, Harnon BV (1994) Apoptosis-its significance in cancer and cancer therapy. Cancer 73: 2013-2026.
29. Liu YL, Tang LH, Liang ZQ, You BG, Yang SL (2010) Growth inhibitory and apoptosis inducing by effects of total flavonoids from Lysimachia clethroides Duby in human chronic myeloid leukemia K562 cells. J Ethnopharmacol 131: 1-9.
30. Abbott RG, Forrest S, Pienta KJ (2006) Simulating the hallmarks of cancer. Artif Life 12: 617-634. (Pubitemid 44356027)
31. Lipponen P (1999) Apoptosis in breast cancer: relationship with other pathological parameters. Endocr Relat Cancer 6: 13-16.
32. Engel N, Oppermann C, Falodunb A, Falodun A, Kragl U (2011) Proliferative effects of five traditional Nigerian medicinal plant extracts on human breast and bone cancer cell lines. J Ethnopharmacol 137: 1003-1010.
33. Li H, Wang P, Liu Q, Cheng X, Zhou Y, et al. (2012) Cell cycle arrest and cell apoptosis induced by Equisetum hyemale extract in murine leukemia L1210 cells. J Ethnopharmacol 144: 322-327.
34. Ndozangue-Touriguine O, Hamelin J, Bréard J (2008) Cytoskeleton and apoptosis. Biochem Pharmacol 76: 11-18.
35. Rello S, Stockert JC, Moreno V, Gámez A, Pacheco M, et al. (2005) Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments. Apoptosis 10: 201-208. (Pubitemid 40558128)
36. Sanchez M, Torres JV, Tormos C, Iradi A, Muñiz P, et al. (2006) Impairment of antioxidant enzymes, lipid peroxidation and 8-oxo-29- deoxyguanosine in advanced epithelial ovarian carcinoma of a Spanish community. Cancer Lett 233: 28-35. (Pubitemid 43214561)
37. Carew JS, Giles FJ, Nawrocki ST (2008) Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy. Cancer Lett 269: 7-17.
38. Razmovski-Naumovski V, Huang THW, Tran VH, Li GQ, Duke CC, et al. (2005) Chemistry and Pharmacology of Gynostemma pentaphyllum. Phytochem Rev 4: 197-219. (Pubitemid 41752177)
39. Antosiewicz J, Herman-Antosiewicz A, Marynowski SW, Singh SV (2006) c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells. Cancer Res 66: 5379-5386. (Pubitemid 43844964)
40. Su YT, Chang HL, Shyue SK, Hsu SL (2005) Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochem Pharmacol 70: 229-241.