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Volumn 62, Issue 5, 2014, Pages 335-346

Profiling of Phospho-AKT, Phospho-mTOR, Phospho-MAPK and EGFR in Non-small Cell Lung Cancer

Author keywords

AKT; EGFR; Image analysis; Immunohistochemistry; MAPK; mTOR; Non small cell lung cancer; Survival analysis; Tissue microarray

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B;

EID: 84899682848     PISSN: 00221554     EISSN: 15515044     Source Type: Journal    
DOI: 10.1369/0022155414523022     Document Type: Article
Times cited : (37)

References (66)
  • 2
    • 60149096824 scopus 로고    scopus 로고
    • Prognostic significance of Akt, phospho-Akt and BAD expression in primary breast cancer
    • Al-Bazz YO,Underwood JC,Brown BL,Dobson PR.Prognostic significance of Akt, phospho-Akt and BAD expression in primary breast cancer.Eur J Cancer. 2009;45:694-704.
    • (2009) Eur J Cancer , vol.45 , pp. 694-704
    • Al-Bazz, Y.O.1    Underwood, J.C.2    Brown, B.L.3    Dobson, P.R.4
  • 6
    • 59449103646 scopus 로고    scopus 로고
    • The Expression of Phospho-AKT, Phospho-mTOR, and PTEN in Extrahepatic Cholangiocarcinoma
    • Chung JY,Hong SM,Choi BY,Cho H,Yu E,Hewitt SM.The Expression of Phospho-AKT, Phospho-mTOR, and PTEN in Extrahepatic Cholangiocarcinoma.Clin Cancer Res. 2009;15:660-667.
    • (2009) Clin Cancer Res , vol.15 , pp. 660-667
    • Chung, J.Y.1    Hong, S.M.2    Choi, B.Y.3    Cho, H.4    Yu, E.5    Hewitt, S.M.6
  • 9
    • 84858984798 scopus 로고    scopus 로고
    • The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches
    • De Luca A,Maiello MR,D'Alessio A,Pergameno M,Normanno N.The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches.Expert Opin Ther Targets. 2012;16:S17-27.
    • (2012) Expert Opin Ther Targets , vol.16
    • de Luca, A.1    Maiello, M.R.2    D'Alessio, A.3    Pergameno, M.4    Normanno, N.5
  • 11
    • 11144343679 scopus 로고    scopus 로고
    • Therapeutic potential of target of rapamycin inhibitors
    • Easton JB,Houghton PJ.Therapeutic potential of target of rapamycin inhibitors.Expert Opin Ther Targets. 2004;8:551-564.
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 551-564
    • Easton, J.B.1    Houghton, P.J.2
  • 14
    • 54949144410 scopus 로고    scopus 로고
    • mTOR inhibitors in the treatment of cancer
    • Fasolo A,Sessa C.mTOR inhibitors in the treatment of cancer.Expert Opin Investig Drugs. 2008;17:1717-1734.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1717-1734
    • Fasolo, A.1    Sessa, C.2
  • 15
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: downstream AKTion blocks apoptosis
    • Franke TF,Kaplan DR,Cantley LC.PI3K: downstream AKTion blocks apoptosis.Cell. 1997;88:435-437.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 19
    • 56049094836 scopus 로고    scopus 로고
    • Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer
    • Guo RX,Qiao YH,Zhou Y,Li LX,Shi HR,Chen KS.Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer.Pathol Int. 2008;58:749-756.
    • (2008) Pathol Int , vol.58 , pp. 749-756
    • Guo, R.X.1    Qiao, Y.H.2    Zhou, Y.3    Li, L.X.4    Shi, H.R.5    Chen, K.S.6
  • 23
    • 84858227016 scopus 로고    scopus 로고
    • Impact of preanalytic factors on the design and application of integral biomarkers for directing patient therapy
    • Hewitt SM,Badve SS,True LD.Impact of preanalytic factors on the design and application of integral biomarkers for directing patient therapy.Clin Cancer Res. 2012;18:1524-1530.
    • (2012) Clin Cancer Res , vol.18 , pp. 1524-1530
    • Hewitt, S.M.1    Badve, S.S.2    True, L.D.3
  • 27
    • 8444241119 scopus 로고    scopus 로고
    • Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer
    • Howard BA,Zheng Z,Campa MJ,Wang MZ,Sharma A,Haura E,Herndon JE,Fitzgerald MC,Bepler G,Patz EF.Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer.Lung Cancer. 2004;46:313-323.
    • (2004) Lung Cancer , vol.46 , pp. 313-323
    • Howard, B.A.1    Zheng, Z.2    Campa, M.J.3    Wang, M.Z.4    Sharma, A.5    Haura, E.6    Herndon, J.E.7    Fitzgerald, M.C.8    Bepler, G.9    Patz, E.F.10
  • 28
    • 0037499945 scopus 로고    scopus 로고
    • Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways
    • Janmaat ML,Kruyt FA,Rodriguez JA,Giaccone G.Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways.Clin Cancer Res. 2003;9:2316-2326.
    • (2003) Clin Cancer Res , vol.9 , pp. 2316-2326
    • Janmaat, M.L.1    Kruyt, F.A.2    Rodriguez, J.A.3    Giaccone, G.4
  • 29
    • 84871370178 scopus 로고    scopus 로고
    • Alternative dosing of dual PI3K and MEK inhibition in cancer therapy
    • Jokinen E,Laurila N,Koivunen JP.Alternative dosing of dual PI3K and MEK inhibition in cancer therapy.BMC Cancer. 2012;12:612.
    • (2012) BMC Cancer , vol.12 , pp. 612
    • Jokinen, E.1    Laurila, N.2    Koivunen, J.P.3
  • 33
    • 33750573063 scopus 로고    scopus 로고
    • Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway
    • Krishnan K,Bruce B,Hewitt S,Thomas D,Khanna C,Helman LJ.Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway.Clin Exp Metastasis. 2006;23:227-236.
    • (2006) Clin Exp Metastasis , vol.23 , pp. 227-236
    • Krishnan, K.1    Bruce, B.2    Hewitt, S.3    Thomas, D.4    Khanna, C.5    Helman, L.J.6
  • 36
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
    • LoPiccolo J,Blumenthal GM,Bernstein WB,Dennis PA.Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.Drug Resist Updat. 2008;11:32-50.
    • (2008) Drug Resist Updat , vol.11 , pp. 32-50
    • LoPiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 41
    • 35848959875 scopus 로고    scopus 로고
    • A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: a trial of the Eastern Cooperative Oncology Group (E1500)
    • Pandya KJ,Dahlberg S,Hidalgo M,Cohen RB,Lee MW,Schiller JH,Johnson DH.A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: a trial of the Eastern Cooperative Oncology Group (E1500).J Thorac Oncol. 2007;2:1036-1041.
    • (2007) J Thorac Oncol , vol.2 , pp. 1036-1041
    • Pandya, K.J.1    Dahlberg, S.2    Hidalgo, M.3    Cohen, R.B.4    Lee, M.W.5    Schiller, J.H.6    Johnson, D.H.7
  • 43
    • 84858169566 scopus 로고    scopus 로고
    • Leveling the playing field: bringing development of biomarkers and molecular diagnostics up to the standards for drug development
    • Poste G,Carbone DP,Parkinson DR,Verweij J,Hewitt SM,Jessup JM.Leveling the playing field: bringing development of biomarkers and molecular diagnostics up to the standards for drug development.Clin Cancer Res. 2012;18:1515-1523.
    • (2012) Clin Cancer Res , vol.18 , pp. 1515-1523
    • Poste, G.1    Carbone, D.P.2    Parkinson, D.R.3    Verweij, J.4    Hewitt, S.M.5    Jessup, J.M.6
  • 48
    • 40949118437 scopus 로고    scopus 로고
    • Temsirolimus, an inhibitor of mammalian target of rapamycin
    • Rini BI.Temsirolimus, an inhibitor of mammalian target of rapamycin.Clin Cancer Res. 2008;14:1286-1290.
    • (2008) Clin Cancer Res , vol.14 , pp. 1286-1290
    • Rini, B.I.1
  • 50
    • 33646706052 scopus 로고    scopus 로고
    • Oncogenic PI3K and its role in cancer
    • Samuels Y,Ericson K.Oncogenic PI3K and its role in cancer.Curr Opin Oncol. 2006;18:77-82.
    • (2006) Curr Opin Oncol , vol.18 , pp. 77-82
    • Samuels, Y.1    Ericson, K.2
  • 52
    • 0344063370 scopus 로고    scopus 로고
    • Will mTOR inhibitors make it as cancer drugs?
    • Sawyers CL.Will mTOR inhibitors make it as cancer drugs?.Cancer Cell. 2003;4:343-348.
    • (2003) Cancer Cell , vol.4 , pp. 343-348
    • Sawyers, C.L.1
  • 54
    • 0035742095 scopus 로고    scopus 로고
    • Current standards of care in small-cell and non-small-cell lung cancer
    • Schiller JH.Current standards of care in small-cell and non-small-cell lung cancer.Oncology 61 Suppl. 2001;1:3-13.
    • (2001) Oncology 61 Suppl , vol.1 , pp. 3-13
    • Schiller, J.H.1
  • 55
    • 33847117662 scopus 로고    scopus 로고
    • Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations
    • Schmitz KJ,Wohlschlaeger J,Alakus H,Bohr J,Stauder MA,Worm K,Winde G,Schmid KW,Baba HA.Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations.Virchows Arch. 2007;450:151-159.
    • (2007) Virchows Arch , vol.450 , pp. 151-159
    • Schmitz, K.J.1    Wohlschlaeger, J.2    Alakus, H.3    Bohr, J.4    Stauder, M.A.5    Worm, K.6    Winde, G.7    Schmid, K.W.8    Baba, H.A.9
  • 56
    • 36549013178 scopus 로고    scopus 로고
    • Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
    • Schmitz KJ,Wohlschlaeger J,Lang H,Sotiropoulos GC,Malago M,Steveling K,Reis H,Cicinnati VR,Schmid KW,Baba HA.Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection.J Hepatol. 2008;48:83-90.
    • (2008) J Hepatol , vol.48 , pp. 83-90
    • Schmitz, K.J.1    Wohlschlaeger, J.2    Lang, H.3    Sotiropoulos, G.C.4    Malago, M.5    Steveling, K.6    Reis, H.7    Cicinnati, V.R.8    Schmid, K.W.9    Baba, H.A.10
  • 57
    • 33745075558 scopus 로고    scopus 로고
    • Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
    • Smalley KS,Haass NK,Brafford PA,Lioni M,Flaherty KT,Herlyn M.Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.Mol Cancer Ther. 2006;5:1136-1144.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1136-1144
    • Smalley, K.S.1    Haass, N.K.2    Brafford, P.A.3    Lioni, M.4    Flaherty, K.T.5    Herlyn, M.6
  • 58
    • 33846285373 scopus 로고    scopus 로고
    • Influence of epidermal growth factor receptor (EGFR) gene mutations on the expression of EGFR, phosphoryl-Akt, and phosphoryl-MAPK, and on the prognosis of patients with non-small cell lung cancer
    • Sonobe M,Nakagawa M,Takenaka K,Katakura H,Adachi M,Yanagihara K,Otake Y,Wada H,Tanaka F.Influence of epidermal growth factor receptor (EGFR) gene mutations on the expression of EGFR, phosphoryl-Akt, and phosphoryl-MAPK, and on the prognosis of patients with non-small cell lung cancer.J Surg Oncol. 2007;95:63-69.
    • (2007) J Surg Oncol , vol.95 , pp. 63-69
    • Sonobe, M.1    Nakagawa, M.2    Takenaka, K.3    Katakura, H.4    Adachi, M.5    Yanagihara, K.6    Otake, Y.7    Wada, H.8    Tanaka, F.9
  • 59
    • 0141570766 scopus 로고    scopus 로고
    • The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status
    • Suzuki T,Nakagawa T,Endo H,Mitsudomi T,Masuda A,Yatabe Y,Sugiura T,Takahashi T,Hida T.The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status.Lung Cancer. 2003;42:35-41.
    • (2003) Lung Cancer , vol.42 , pp. 35-41
    • Suzuki, T.1    Nakagawa, T.2    Endo, H.3    Mitsudomi, T.4    Masuda, A.5    Yatabe, Y.6    Sugiura, T.7    Takahashi, T.8    Hida, T.9
  • 61
    • 31344479312 scopus 로고    scopus 로고
    • Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
    • Tang JM,He QY,Guo RX,Chang XJ.Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis.Lung Cancer. 2006;51:181-191.
    • (2006) Lung Cancer , vol.51 , pp. 181-191
    • Tang, J.M.1    He, Q.Y.2    Guo, R.X.3    Chang, X.J.4
  • 62
    • 0033853015 scopus 로고    scopus 로고
    • The total test approach to standardization of immunohistochemistry
    • Taylor CR.The total test approach to standardization of immunohistochemistry.Arch Pathol Lab Med. 2000;124:945-951.
    • (2000) Arch Pathol Lab Med , vol.124 , pp. 945-951
    • Taylor, C.R.1
  • 66
    • 50949104555 scopus 로고    scopus 로고
    • Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy
    • Yu K,Toral-Barza L,Shi C,Zhang WG,Zask A.Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy.Cancer Biol Ther. 2008;7:307-315.
    • (2008) Cancer Biol Ther , vol.7 , pp. 307-315
    • Yu, K.1    Toral-Barza, L.2    Shi, C.3    Zhang, W.G.4    Zask, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.