메뉴 건너뛰기




Volumn 100, Issue 1, 2009, Pages 145-152

Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients

Author keywords

Biomarkers; CMET; EGFR pathway; KRAS; NSCLC; Prognosis

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR MARKER; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SCATTER FACTOR RECEPTOR; STAT3 PROTEIN; STAT5 PROTEIN; UVOMORULIN; VIMENTIN;

EID: 58149216409     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604781     Document Type: Article
Times cited : (41)

References (49)
  • 1
    • 3042785708 scopus 로고    scopus 로고
    • Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: Variation in staining intensity due to choice of fixative and storage time of tissue sections
    • Atkins D, Reiffen KA, Tegtmeier CL, Winther H, Bonato MS, Storkel S (2004) Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: Variation in staining intensity due to choice of fixative and storage time of tissue sections. J Histochem Cytochem 52: 893-901
    • (2004) J Histochem Cytochem , vol.52 , pp. 893-901
    • Atkins, D.1    Reiffen, K.A.2    Tegtmeier, C.L.3    Winther, H.4    Bonato, M.S.5    Storkel, S.6
  • 3
    • 0037093230 scopus 로고    scopus 로고
    • High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer
    • Bremnes RM, Veve R, Gabrielson E, Hirsch FR, Baron A, Bemis L, Gemmill RM, Drabkin HA, Franklin WA (2002) High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol 20: 2417-2428
    • (2002) J Clin Oncol , vol.20 , pp. 2417-2428
    • Bremnes, R.M.1    Veve, R.2    Gabrielson, E.3    Hirsch, F.R.4    Baron, A.5    Bemis, L.6    Gemmill, R.M.7    Drabkin, H.A.8    Franklin, W.A.9
  • 5
    • 4043064216 scopus 로고    scopus 로고
    • Subcellular localization of immunohistochemical signals.Knowledge of the ultrastructural or biologic features of the antigens helps predict the signal localization and proper interpretation of immunostains
    • Cheuk W, Chan JKC (2004) Subcellular localization of immunohistochemical signals.Knowledge of the ultrastructural or biologic features of the antigens helps predict the signal localization and proper interpretation of immunostains. Int J Surg Pathol 12: 185-206
    • (2004) Int J Surg Pathol , vol.12 , pp. 185-206
    • Cheuk, W.1    Chan, J.K.C.2
  • 6
    • 0000336139 scopus 로고
    • Regression models and life tables
    • Cox D (1972) Regression models and life tables. J Royal Stat Soc (B) 34: 187-202
    • (1972) J Royal Stat Soc (B) , vol.34 , pp. 187-202
    • Cox, D.1
  • 7
    • 6044230919 scopus 로고    scopus 로고
    • Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage
    • David O, Jett J, LeBeau H, Dy G, Hughes J, Friedman M, Brody AR (2004) Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clin Cancer Res 10: 6865-6871
    • (2004) Clin Cancer Res , vol.10 , pp. 6865-6871
    • David, O.1    Jett, J.2    LeBeau, H.3    Dy, G.4    Hughes, J.5    Friedman, M.6    Brody, A.R.7
  • 8
    • 4644278868 scopus 로고    scopus 로고
    • Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer: A study utilizing high-density tissue microarray and immunohistochemistry
    • Deeb G, Wang JM, Ramnath N, Slocum HK, Wiseman S, Beck A, Tan DF (2004) Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry. Mod Pathol 17: 430-439
    • (2004) Mod Pathol , vol.17 , pp. 430-439
    • Deeb, G.1    Wang, J.M.2    Ramnath, N.3    Slocum, H.K.4    Wiseman, S.5    Beck, A.6    Tan, D.F.7
  • 9
    • 35949000487 scopus 로고    scopus 로고
    • Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain
    • deGunst MM, Gallegos Ruiz MI, Giaccone G, Rodriguez JA (2007) Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain. Mol Cancer 6: 56
    • (2007) Mol Cancer , vol.6 , pp. 56
    • deGunst, M.M.1    Gallegos Ruiz, M.I.2    Giaccone, G.3    Rodriguez, J.A.4
  • 12
    • 34249789581 scopus 로고    scopus 로고
    • EGFR and K-ras mutation analysis in non-small cell lung cancer: Comparison of paraffin embedded versus frozen specimens
    • Gallegos Ruiz MI, Floor K, Rijmen F, Grunberg K, Rodriguez JA, Giaccone G (2007a) EGFR and K-ras mutation analysis in non-small cell lung cancer: comparison of paraffin embedded versus frozen specimens. Cell Oncol 29: 257-264
    • (2007) Cell Oncol , vol.29 , pp. 257-264
    • Gallegos Ruiz, M.I.1    Floor, K.2    Rijmen, F.3    Grunberg, K.4    Rodriguez, J.A.5    Giaccone, G.6
  • 13
    • 35348847786 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) gene copy number detection in non-small-cell lung cancer; a comparison of fluorescence in situ hybridization and chromogenic in situ hybridization
    • Gallegos Ruiz MI, Floor K, Vos W, Rijmen F, Grunberg K, Meijer GA, Rodriguez JA, Giaccone G (2007b) Epidermal growth factor receptor (EGFR) gene copy number detection in non-small-cell lung cancer; a comparison of fluorescence in situ hybridization and chromogenic in situ hybridization. Histopathology 51: 631-637
    • (2007) Histopathology , vol.51 , pp. 631-637
    • Gallegos Ruiz, M.I.1    Floor, K.2    Vos, W.3    Rijmen, F.4    Grunberg, K.5    Meijer, G.A.6    Rodriguez, J.A.7    Giaccone, G.8
  • 14
    • 19844362355 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer
    • Giaccone G (2005) Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer. J Clin Oncol 23: 3235-3242
    • (2005) J Clin Oncol , vol.23 , pp. 3235-3242
    • Giaccone, G.1
  • 15
    • 28544438023 scopus 로고    scopus 로고
    • Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer
    • Haura EB, Zheng Z, Song L, Cantor A, Bepler G (2005) Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clin Cancer Res 11: 8288-8294
    • (2005) Clin Cancer Res , vol.11 , pp. 8288-8294
    • Haura, E.B.1    Zheng, Z.2    Song, L.3    Cantor, A.4    Bepler, G.5
  • 16
    • 20144377465 scopus 로고    scopus 로고
    • HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells
    • Hirata A, Hosoi F, Miyagawa N, Ueda S, Naito S, Fujii T, Kuwano N, Ono M (2005) HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. Cancer Res 65: 4253-4260
    • (2005) Cancer Res , vol.65 , pp. 4253-4260
    • Hirata, A.1    Hosoi, F.2    Miyagawa, N.3    Ueda, S.4    Naito, S.5    Fujii, T.6    Kuwano, N.7    Ono, M.8
  • 17
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch FR, Varella-Garcia M, Bunn PA, Di Maria MV, Veve R, Bremnes RM, Baron AE, Zeng C, Franklin WA (2003) Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 21: 3798-3807
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn, P.A.3    Di Maria, M.V.4    Veve, R.5    Bremnes, R.M.6    Baron, A.E.7    Zeng, C.8    Franklin, W.A.9
  • 18
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study
    • Hirsch FR, Varella-Garcia M, Mccoy J, West H, Xavier AC, Gumerlock P, Bunn PA, Franklin WA, Crowley J, Gandara DR (2005) Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J Clin Oncol 23: 6838-6845
    • (2005) J Clin Oncol , vol.23 , pp. 6838-6845
    • Hirsch, F.R.1    Varella-Garcia, M.2    Mccoy, J.3    West, H.4    Xavier, A.C.5    Gumerlock, P.6    Bunn, P.A.7    Franklin, W.A.8    Crowley, J.9    Gandara, D.R.10
  • 19
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA (2005) ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5: 341-354
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 20
    • 33645690408 scopus 로고    scopus 로고
    • Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells. (vol 118, pg 209, 2006)
    • Janmaat ML, Rodriguez JA, Gallegos-Ruiz M, Kruyt FAE, Giaccone G (2006) Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells. (vol 118, pg 209, 2006). Int J Cancer 118: 2370
    • (2006) Int J Cancer , vol.118 , pp. 2370
    • Janmaat, M.L.1    Rodriguez, J.A.2    Gallegos-Ruiz, M.3    Kruyt, F.A.E.4    Giaccone, G.5
  • 23
    • 33845382806 scopus 로고
    • Non-parametric estimation from incomplete observations
    • Kaplan E, Meier P (1958) Non-parametric estimation from incomplete observations. J Am Stat Assoc 53: 457-481
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.1    Meier, P.2
  • 24
    • 0031899634 scopus 로고    scopus 로고
    • Tracing the origin of adenocarcinomas with unknown primary using immunohistochemistry: Differential diagnosis between colonic and ovarian carcinomas as primary sites
    • Lagendijk JH, Mullink H, Van Diest PJ, Meijer GA, Meijer CJLM (1998) Tracing the origin of adenocarcinomas with unknown primary using immunohistochemistry: differential diagnosis between colonic and ovarian carcinomas as primary sites. Hum Pathol 29: 491-497
    • (1998) Hum Pathol , vol.29 , pp. 491-497
    • Lagendijk, J.H.1    Mullink, H.2    Van Diest, P.J.3    Meijer, G.A.4    Meijer, C.J.L.M.5
  • 25
    • 36949007159 scopus 로고    scopus 로고
    • Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1 alpha
    • Lu Y, Liang K, Li X, Fan Z (2007) Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1 alpha. Mol Cancer 6: 63
    • (2007) Mol Cancer , vol.6 , pp. 63
    • Lu, Y.1    Liang, K.2    Li, X.3    Fan, Z.4
  • 27
    • 0013886333 scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel N (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chem Rep 50: 163-170
    • (1966) Cancer Chem Rep , vol.50 , pp. 163-170
    • Mantel, N.1
  • 29
    • 34249810645 scopus 로고    scopus 로고
    • KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Massarelli E, Varella-Garcia M, Tang XM, Xavier AC, Ozburn NC, Liu DD, Bekele BN, Herbst RS, Wistuba II (2007) KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 13: 2890-2896
    • (2007) Clin Cancer Res , vol.13 , pp. 2890-2896
    • Massarelli, E.1    Varella-Garcia, M.2    Tang, X.M.3    Xavier, A.C.4    Ozburn, N.C.5    Liu, D.D.6    Bekele, B.N.7    Herbst, R.S.8    Wistuba II9
  • 30
    • 2442513981 scopus 로고    scopus 로고
    • The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients
    • Masuya D, Huang C, Liu D, Nakashima T, Kameyama K, Haba R, Ueno M, Yokomise H (2004b) The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients. Br J Cancer 90: 1555-1562
    • (2004) Br J Cancer , vol.90 , pp. 1555-1562
    • Masuya, D.1    Huang, C.2    Liu, D.3    Nakashima, T.4    Kameyama, K.5    Haba, R.6    Ueno, M.7    Yokomise, H.8
  • 31
    • 2442513981 scopus 로고    scopus 로고
    • The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients
    • Masuya D, Huang C, Liu D, Nakashima T, Kameyama K, Haba R, Ueno M, Yokomise H (2004a) The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients. Br J Cancer 90: 1555-1562
    • (2004) Br J Cancer , vol.90 , pp. 1555-1562
    • Masuya, D.1    Huang, C.2    Liu, D.3    Nakashima, T.4    Kameyama, K.5    Haba, R.6    Ueno, M.7    Yokomise, H.8
  • 34
    • 0035476803 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
    • Moasser MM, Basso A, Averbuch SD, Rosen N (2001) The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res 61: 7184-7188
    • (2001) Cancer Res , vol.61 , pp. 7184-7188
    • Moasser, M.M.1    Basso, A.2    Averbuch, S.D.3    Rosen, N.4
  • 39
    • 0035863302 scopus 로고    scopus 로고
    • Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: A Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy
    • Schiller JH, Adak S, Feins RH, Keller SM, Fry WA, Livingston RB, Hammond ME, Wolf B, Sabatini L, Jett J, Kohman L, Johnson DH (2001) Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: a Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy. J Clin Oncol 19: 448-457
    • (2001) J Clin Oncol , vol.19 , pp. 448-457
    • Schiller, J.H.1    Adak, S.2    Feins, R.H.3    Keller, S.M.4    Fry, W.A.5    Livingston, R.B.6    Hammond, M.E.7    Wolf, B.8    Sabatini, L.9    Jett, J.10    Kohman, L.11    Johnson, D.H.12
  • 41
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J (2004) Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305: 1163-1167
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 42
    • 0026654238 scopus 로고
    • ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis
    • Sugio K, Ishida T, Yokoyama H, Inoue T, Sugimachi K, Sasazuki T (1992) ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis. Cancer Res 52: 2903-2906
    • (1992) Cancer Res , vol.52 , pp. 2903-2906
    • Sugio, K.1    Ishida, T.2    Yokoyama, H.3    Inoue, T.4    Sugimachi, K.5    Sasazuki, T.6
  • 43
    • 0029790384 scopus 로고    scopus 로고
    • Hepatocyte growth factor and c-met/hepatocyte growth factor receptor in pulmonary adenocarcinomas: An evaluation of their expression as prognostic markers
    • Takanami I, Tanana F, Hashizume T, Kikuchi K, Yamamoto Y, Yamamoto T, Kodaira S (1996) Hepatocyte growth factor and c-met/hepatocyte growth factor receptor in pulmonary adenocarcinomas: an evaluation of their expression as prognostic markers. Oncology 53: 392-397
    • (1996) Oncology , vol.53 , pp. 392-397
    • Takanami, I.1    Tanana, F.2    Hashizume, T.3    Kikuchi, K.4    Yamamoto, Y.5    Yamamoto, T.6    Kodaira, S.7
  • 44
    • 27144477683 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
    • Thomson S, Buck E, Petti F, Griffin G, Brown E, Ramnarine N, Iwata KK, Gibson N, Haley JD (2005) Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 65: 9455-9462
    • (2005) Cancer Res , vol.65 , pp. 9455-9462
    • Thomson, S.1    Buck, E.2    Petti, F.3    Griffin, G.4    Brown, E.5    Ramnarine, N.6    Iwata, K.K.7    Gibson, N.8    Haley, J.D.9
  • 46
    • 0029036245 scopus 로고
    • Prognostic factors in NSCLC. Recent experiences
    • Van Zandwijk N, Mooi WJ, Rodenhuis S (1995) Prognostic factors in NSCLC. Recent experiences. Lung Cancer 12(Suppl 1): S27-S33
    • (1995) Lung Cancer , vol.12 , Issue.SUPPL. 1
    • Van Zandwijk, N.1    Mooi, W.J.2    Rodenhuis, S.3
  • 47
    • 1842830208 scopus 로고    scopus 로고
    • TNM classification for lung cancer
    • Watanabe Y (2003) TNM classification for lung cancer. Ann Thorac Cardiovasc Surg 9: 343-350
    • (2003) Ann Thorac Cardiovasc Surg , vol.9 , pp. 343-350
    • Watanabe, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.