AFF4 binding to TAT-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter

eLife

Volumn 2014, Issue 3, 2014, Pages

  Schulze Gahmen, Ursula ^a   Lu, Huasong ^a   Zhou, Qiang ^a   Alber, Tom ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Crystal structure; Tat AFF4 cyclint1 interface; Tat TAR recognition motif; Transcriptional elongation

Indexed keywords

CYCLIN DEPENDENT KINASE; MEDIATOR COMPLEX; P TEFB KINASE; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; RNA POLYMERASE II; SUPER ELONGATION COMPLEX; TRANSACTIVATOR PROTEIN; TRANSCRIPTION ELONGATION FACTOR; UNCLASSIFIED DRUG; AFF4 PROTEIN, HUMAN; PROTEIN BINDING; REPRESSOR PROTEIN; VIRAL PROTEIN; VIRUS RNA;

ARTICLE; CRYSTALLIZATION; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOPRECIPITATION; LUCIFERASE ASSAY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STRUCTURE ANALYSIS; TRANSACTIVATION; TRANSCRIPTION ELONGATION; VIRUS GENOME; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; LONG TERMINAL REPEAT; METABOLISM; PROMOTER REGION; PROTEIN CONFORMATION;

GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAT; GENOME, VIRAL; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; REPRESSOR PROTEINS; RNA, VIRAL; TRANSCRIPTIONAL ELONGATION FACTORS; VIRAL PROTEINS;

EID: 84899659444     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02375     Document Type: Article

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