PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases

FEBS Letters

Volumn 588, Issue 9, 2014, Pages 1720-1725

  Croci, Romina ^a   Tarantino, Delia ^a   Milani, Mario ^a,b   Pezzullo, Margherita ^a,b   Rohayem, Jacques ^c,d   Bolognesi, Martino ^a   Mastrangelo, Eloise ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b CNR   (Italy)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d Riboxx GmbH   (Germany)

Author keywords

Antiviral discovery; In silico docking; Norovirus; PPNDS; RNA dependent RNA polymerase; X ray crystallography

Indexed keywords

ANTIVIRUS AGENT; PYRIDOXAL 5' PHOSPHATE 6 (2' NAPHTHYLAZO 6' NITRO 4',8' DISULFONATE)TETRASODIUM SALT; RNA DIRECTED RNA POLYMERASE; RNA DIRECTED RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIPARALLEL RNA STACKING INTERACTION; ARTICLE; BIOASSAY; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; COMPLEX FORMATION; COMPUTER MODEL; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR INTERACTION; MURINE NOROVIRUS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERMOFLUORIMETRIC ASSAY;

MURINAE; MURINE NOROVIRUS; NOROVIRUS;

ANTIVIRAL DISCOVERY; IN SILICO-DOCKING; NOROVIRUS; PPNDS; RNA-DEPENDENT-RNA-POLYMERASE; X-RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIVIRAL AGENTS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MICE; MODELS, MOLECULAR; NOROVIRUS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PYRIDOXAL PHOSPHATE; RNA REPLICASE; SULFONIC ACIDS; VIRAL PROTEINS;

EID: 84899656586     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.03.021     Document Type: Article

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