Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase

Antiviral Research

Volumn 102, Issue 1, 2014, Pages 23-28

  Tarantino, Delia ^a   Pezzullo, Margherita ^a,b   Mastrangelo, Eloise ^a,b   Croci, Romina ^a   Rohayem, Jacques ^c,d   Robel, Ivonne ^d   Bolognesi, Martino ^a   Milani, Mario ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b CNR   (Italy)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d Riboxx GmbH   (Germany)

Author keywords

Antiviral discovery; Caliciviridae; Naphthalene sulfonate; Norovirus; RNA dependent RNA polymerase; X ray crystallography

Indexed keywords

ANTIVIRUS AGENT; NAPHTHALENE DI SULFONATE; NF 023; PYRIDOXAL 5' PHOSPHATE 6 (2' NAPHTHYLAZO 6' NITRO 4' ,8' DISULFONATE) TETRASODIUM SALT; RNA DIRECTED RNA POLYMERASE; SURAMIN; UNCLASSIFIED DRUG; NAPHTHALENE DISULFONATE; NAPHTHALENESULFONIC ACID DERIVATIVE; POLYCYTIDYLIC ACID; PYRIDOXAL 5' PHOSPHATE 6 (2' NAPHTHYLAZO 6' NITRO 4,8' DISULFONATE)TETRASODIUM SALT; RNA DIRECTED RNA POLYMERASE INHIBITOR; ENZYME INHIBITOR; PHORBOL DIBUTYRATE;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG STRUCTURE; ENZYMATIC ASSAY; HYDROGEN BOND; IC 50; NOROVIRUS; PRIORITY JOURNAL; R FACTOR; X RAY CRYSTALLOGRAPHY; DRUG BINDING SITE; DRUG PROTEIN BINDING; ENZYME INHIBITION; ENZYME INHIBITION ASSAY; ENZYME STRUCTURE; INHIBITION KINETICS; NONHUMAN; PROTEIN DOMAIN; ANTIVIRAL DISCOVERY; CALICIVIRUS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HNV; HUMAN NOROVIRUS; MNV; MURINE NOROVIRUS; NAF2; NAPHTHALENE-1,5-DISULFONIC ACID; NAPHTHALENE-SULFONATE; PPNDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DATA BANK; PYRIDOXAL-5′-PHOSPHATE-6-(2′-NAPHTHYLAZO-6′-NITRO-4′,8′-DISULFONATE) TETRASODIUM SALT; RDRP; RNA-DEPENDENT RNA POLYMERASE; RNA-DEPENDENT RNA-POLYMERASE; X-RAY CRYSTALLOGRAPHY;

ANTIVIRAL DISCOVERY; CALICIVIRIDAE; HNV; HUMAN NOROVIRUS; MNV; MURINE NOROVIRUS; NAF2; NAPHTHALENE-1,5-DISULFONIC ACID; NAPHTHALENE-SULFONATE; NOROVIRUS; PDB; PPNDS; PROTEIN DATA BANK; PYRIDOXAL-5′-PHOSPHATE-6-(2′-NAPHTHYLAZO-6′-NITRO-4′,8′-DISULFONATE) TETRASODIUM SALT; RDRP; RNA-DEPENDENT RNA POLYMERASE; RNA-DEPENDENT RNA-POLYMERASE; X-RAY CRYSTALLOGRAPHY;

ANTIVIRAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NAPHTHALENESULFONATES; NOROVIRUS; PROTEIN BINDING; PROTEIN CONFORMATION; RNA REPLICASE;

EID: 84890492915     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2013.11.016     Document Type: Article

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