Peptide:Lipid ratio and membrane surface charge determine the mechanism of action of the antimicrobial peptide BP100. Conformational and functional studies

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 7, 2014, Pages 1985-1999

  Manzini, Mariana C ^a   Perez, Katia R ^b   Riske, Karin A ^b   Bozelli, José C ^a   Santos, Talita L ^c   Da Silva, Marcia A ^a   Saraiva, Greice K V ^a   Politi, Mario J ^a   Valente, Ana P ^c   Almeida, Fábio C L ^c   Chaimovich, Hernan ^a   Rodrigues, Magali A ^d   Bemquerer, Marcelo P ^d   Schreier, Shirley ^a   Cuccovia, Iolanda M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d EMBRAPA RECURSOS GENÉTICOS E BIOTECNOLOGIA   (Brazil)

Author keywords

Antimicrobial peptide; BP100; CD; Model membrane leakage; NMR; Zeta potential

Indexed keywords

BP100 PROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CELL VACUOLE; CHEMICAL PARAMETERS; CIRCULAR DICHROISM; HYDROPHOBICITY; ION EXCHANGE; LIGHT SCATTERING; MEMBRANE DAMAGE; MICROSCOPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE LIPID RATIO; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; STATIC ELECTRICITY; SURFACE CHARGE; UNILAMELLAR VESICLE; ZETA POTENTIAL;

NEGIBACTERIA;

ANTIMICROBIAL PEPTIDE; BP100; CD; MODEL MEMBRANE LEAKAGE; NMR; ZETA POTENTIAL;

ANTIMICROBIAL CATIONIC PEPTIDES; CELL MEMBRANE; GRAM-NEGATIVE BACTERIA; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPID BILAYERS; MEMBRANE LIPIDS; OLIGOPEPTIDES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS; PROTEIN STRUCTURE, SECONDARY; STATIC ELECTRICITY;

EID: 84899616422     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2014.04.004     Document Type: Article

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