Antidepressant and neuroprotective effect of the chinese herb kaixinsan against lentiviral shRNA knockdown brain-derived neurotrophic factor-induced injury in vitro and in vivo

Neuropsychobiology

Volumn 69, Issue 3, 2014, Pages 129-139

  Hu, Yuan ^a,d   Zhou, Xiao Jiang ^a   Liu, Ping ^a,b   Dong, Xian Zhe ^a   Mu, Li Hua ^a   Chen, Yi Bang ^b,d   Liu, Ming Yue ^a,c   Yu, Bing Ying ^a,c  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c HEBEI NORTH UNIVERSITY   (China)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Antidepressant like effects; Brain derived neurotrophic factor; Kaixinsan; Knockdown

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CHINESE DRUG; HERBACEOUS AGENT; KAIXINSAN; NEUROPROTECTIVE AGENT; SHORT HAIRPIN RNA; SUCROSE; UNCLASSIFIED DRUG; CYCLIC AMP; LENTIVIRUS VECTOR; KAI XIN SAN; SMALL INTERFERING RNA;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DEATH; CELL VIABILITY; CHINESE HERB; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; GENE SILENCING; HIPPOCAMPAL NEURONAL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; LENTIVIRUS INFECTION; MORRIS WATER MAZE TEST; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUCROSE PREFERENCE TEST; SUGAR INTAKE; WESTERN BLOTTING; ANTIDEPRESSANT ACTIVITY; BRAIN NERVE CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; NERVE CELL NECROSIS; NEUROPROTECTION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; FOOD PREFERENCE; GENE VECTOR; GENETICS; MAZE TEST; METABOLISM; MOTOR ACTIVITY; PRIMARY CELL CULTURE;

ANIMALS; ANTIDEPRESSIVE AGENTS; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE; CELL SURVIVAL; DEPRESSION; DRUGS, CHINESE HERBAL; FOOD PREFERENCES; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HIPPOCAMPUS; IN VITRO TECHNIQUES; LENTIVIRUS; MAZE LEARNING; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; PRIMARY CELL CULTURE; RATS; RNA, SMALL INTERFERING;

EID: 84899596766     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000358089     Document Type: Article

References (36)

1. Gass P, Riva MA: CREB, neurogenesis and depression. Bioessays 2007; 29: 957-961. (Pubitemid 47522836
2. Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM: Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 2008; 63: 642-649. (Pubitemid 351329281
3. Ansorge MS, Hen R, Gingrich JA: Neurodevelopmental origins of depressive disorders. Curr Opin Pharmacol 2007; 7: 8-17. (Pubitemid 46238045
4. Duman RS, Monteggia LM: A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006; 59: 1116-1127
5. Kang H, Schuman EM: Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 1995; 267: 1658-1662
6. Ma YL, Wang HL, Wu HC, Wei CL, Lee EH: Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-Term potentiation in rats. Neuroscience 1998; 82: 957-967. (Pubitemid 27502041
7. Xu H, Chen Z, He J, Haimanot S, Li X, Dyck L, Li XM: Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus 2006; 16: 551-559. (Pubitemid 43942103
8. Kendler KS, Karkowski LM, Prescott CA: Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 1999; 156: 837-841. (Pubitemid 29260336
9. McGonagle KA, Kessler RC: Chronic stress, acute stress, and depressive symptoms. Am J Community Psychol 1990; 18: 681-706
10. Smith MA, Makino S, Kvetnansky R, Post RM: Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 1995; 15: 1768-1777
11. Zhang ZJ: Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders. Life Sci 2004; 75: 1659-1699
12. Ping HY, Guo D-H: Behavioural and biochemical effects of KaiXin-San, a traditional Chinese medicinal empirical formula. Drug Dev Res 2008; 69: 267-271
13. Nishiyama N, Zhou Y, Saito H: Beneficial effects of DX-9386, a traditional Chinese prescription, on memory disorder produced by lesioning the amygdala in mice. Biol Pharm Bull 1994; 17: 1679-1681
14. Nishiyama N, Zhou Y, Saito H: Ameliorative effects of chronic treatment using DX-9386, a traditional Chinese prescription, on learning performance and lipid peroxide content in senescence accelerated mouse. Biol Pharm Bull 1994; 17: 1481-1484. (Pubitemid 24368071
15. Hu Y, Liao HB, Dai-Hong G, Liu P, Wang YY, Rahman K: Antidepressant-like effects of 3,6'-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats. Neurochem Int 2010; 56: 461-465
16. Hu Y, Liao HB, Liu P, Guo DH, Rahman K: A bioactive compound from Polygala tenuifolia regulates efficiency of chronic stress on hypothalamic-pituitary-Adrenal axis. Pharmazie 2009; 64: 605-608
17. Mu LH, Huang ZX, Liu P, Hu Y, Gao Y: Acute and subchronic oral toxicity assessment of the herbal formula Kai-Xin-San. J Ethnopharmacol 2011; 138: 351-357
18. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R: Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 1987; 93: 358-364. (Pubitemid 17160661
19. Coyle JT, Duman RS: Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 2003; 38: 157-160. (Pubitemid 36555643
20. Einat H, Manji HK: Cellular plasticity cascades: Genes-To-behaviours pathways in animal models of bipolar disorder. Biol Psychiatry 2006; 59: 1160-1171. (Pubitemid 43949143
21. Einat H, Yuan P, Gould TD, Li J, Du J, Zhang L, Manji HK, Chen G: The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. J Neurosci 2003; 23: 7311-7316. (Pubitemid 36999520
22. Manji HK, Duman RS: Impairments of neuroplasticity and cellular resilience in severe mood disorders: Implications for the development of novel therapeutics. Psychopharmacol Bull 2001; 35: 5-49
23. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS: Brain-derived neurotrophic factor produces antidepressant effects in behavioural models of depression. J Neurosci 2002; 22: 3251-3261. (Pubitemid 35379212
24. Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM: Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 1997; 56: 131-137. (Pubitemid 27016116
25. Nawa H, Carnahan J, Gall C: BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: Partial disagreement with mRNA levels. Eur J Neurosci 1995; 7: 1527-1535
26. Mizuno K, Giese KP: Hippocampus-dependent memory formation: Do memory typespecific mechanisms exist?. J Pharmacol Sci 2005; 98: 191-197
27. Kalueff AV, Gallagher PS, Murphy DL: Are serotonin transporter knockout mice 'depressed'?: Hypoactivity but no anhedonia. Neuroreport 2006; 17: 1347-1351
28. Taliaz D, Stall N, Dar DE, Zangen A: Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviours associated with depression and reduces neurogenesis. Mol Psychiatry 2010; 15: 80-92
29. Wang JL LP, Wang DX, Tu HH, Chen GY: Effects of Kai-Xin-San on behavior and expression of p-CREB in hippocampus of chronic stress rats. Zhongquo Zhong Yao Za Zhi 2007; 32: 1555-1558
30. Dang H, Sun L, Liu X, Peng B, Wang Q, Jia W, Chen Y, Pan A, Xiao P: Preventive action of Kai Xin San aqueous extract on Depressivelike symptoms and cognition Deficit induced by chronic mild stress. Exp Biol Med (Maywood) 2009; 234: 785-793
31. Surget A, Wang Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G, Belzung C, Sibille E: Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharmacology 2009; 34: 1363-1380
32. Vancassel S, Leman S, Hanonick L, Denis S, Roger J, Nollet M, Bodard S, Kousignian I, Belzung C, Chalon S: N-3 polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice. J Lipid Res 2008; 49: 340-348. (Pubitemid 351213618
33. Ibarguen-Vargas Y, Surget A, Touma C, Palme R, Belzung C: Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal. Psychoneuroendocrinology 2008; 33: 1357-1368
34. Mutlu O, Ulak G, Laugeray A, Belzung C: Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole (TRIM) in unpredictable chronic mild stress procedure in mice. Pharmacol Biochem Behav 2009; 92: 82-87
35. Wang L, Kisaalita WS: Administration of BDNF/ginsenosides combination enhanced synaptic development in human neural stem cells. J Neurosci Methods 2011; 194: 274-282
36. Xue W, Hu JF, Yuan YH, Sun JD, Li BY, Zhang DM, Li CJ, Chen NH: Polygalasaponin XXXII from polygala tenuifolia root improves hippocampal-dependent learning and memory. Acta Pharmacol Sin 2009; 30: 1211-1219.