HDAC inhibitors induce apoptosis but not cellular senescence in Gadd45α-deficient E1A+Ras cells

International Journal of Biochemistry and Cell Biology

Volumn 51, Issue 1, 2014, Pages 102-110

  Igotti Abramova, M V ^a,b   Pojidaeva, A K ^c   Filippova, E A ^b   Gnedina, O O ^b   Svetlikova, S B ^a,b   Pospelov, V A ^a,b  

^a INSTITUTE OF CYTOLOGY   (Russian Federation)

^b ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Apoptosis; Gadd45 inactivation; HDAC inhibitors; Senescence; Transformed cells

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; GADD45ALPHA PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; E1A PROTEIN; GADD45A PROTEIN, HUMAN; NUCLEAR PROTEIN; RAS PROTEIN;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA REPAIR; EMBRYO; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE INACTIVATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SENESCENCE; SIGNAL TRANSDUCTION; SINGLE STRANDED DNA BREAK; WESTERN BLOTTING; WILD TYPE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; FIBROBLAST; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; ONCOGENE RAS; TRANSFORMED CELL LINE;

ADENOVIRUS E1A PROTEINS; APOPTOSIS; CELL AGING; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; FIBROBLASTS; G1 PHASE CELL CYCLE CHECKPOINTS; GENE KNOCKOUT TECHNIQUES; GENES, RAS; HISTONE DEACETYLASE INHIBITORS; HUMANS; NUCLEAR PROTEINS; RAS PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84899581220     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.03.031     Document Type: Article

References (34)

1. M.V. Abramova, E.A. Zatulovskiy, S.B. Svetlikova, and V.A. Pospelov HDAC inhibitor-induced activation of NF-κB prevents apoptotic response of E1A+Ras-transformed cells to proapoptotic stimuli Int J Biochem Cell Biol 42 2010 1847 1855
2. M.V. Abramova, S.B. Svetlikova, A.N. Kukushkin, N.D. Aksenov, T.V. Pospelova, and V.A. Pospelov HDAC inhibitor sodium butyrate sensitizes E1A+Ras-transformed cells to DNA damaging agents by facilitating formation and persistence of γH2AX foci Cancer Biol Ther 12 2011 1069 1077 10.4161/cbt.12.12.18365
3. M. Asada, T. Yamada, H. Ichijo, D. Delia, K. Miyazono, and K. Fukumuro et al. Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation EMBO J 18 1999 1223 1234
4. S. Banin, L. Moyal, S.Y. Shieh, Y. Taya, C.W. Anderson, and L. Chessa et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage Science 281 1998 1674 1677
5. D.V. Bulavin, O. Kovalsky, M.C. Hollander, and A.J. Fornace Jr. Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a Mol Cell Biol 23 2003 3859 3871
6. P. Campomenosi, and P.A. Hall Gadd45 mutations are uncommon in human tumour cell lines Cell Prolif 33 2000 301 306
7. F. Carrier, I. Bae, M.L. Smith, D.M. Ayers, and A.J. Fornace Jr. Characterization of the Gadd45 response to ionizing radiation in WI-L2-NS cells, a p53 mutant cell line Mutat Res 352 1996 79 86
8. F. Carrier, P.T. Georgel, P. Pourquier, M. Blake, H.U. Kontny, and M.J. Antinore et al. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin Mol Cell Biol 19 1999 1673 1685
9. J. Ghose, M. Sinha, E. Das, N.R. Jana, and N.P. Bhattacharyya Regulation of miR-146a by RelA/NF-B and p53 in STHdhQ111/HdhQ111 cells, a cell model of Huntington's disease PLoS ONE 6 8 2011 e23837 10.1371/journal.pone.0023837
10. M. Gupta, S.K. Gupta, A.G. Balliet, M.C. Hollander, A.J. Fornace, and B. Hoffman et al. Hematopoietic cells from Gadd- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis Oncogene 24 2005 7170 7179
11. M. Gupta, S.K. Gupta, B. Hoffman, and D.A. Liebermann Gadd45α and Gadd45β protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition J Biol Chem 281 2006 17552 17558
12. J. Hildesheim, and A.J. Fornace Jr. Gadd: an elusive yet attractive candidate gene in pancreatic cancer Clin Cancer Res 8 2002 2475 2479
13. M.C. Hollander, M.S. Sheikh, D.V. Bulavin, K. Lundgren, L. Augeri-Henmueller, and R. Shehee et al. Genomic instability in Gadd-deficient mice Nat Genet 23 1999 176 184
14. Y.T. Hsu, K.G. Wolter, and R.J. Youle Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis Proc Natl Acad Sci U S A 94 1997 3668 3672 10.1073/pnas.94.8.3668
15. S.J. Jeong, M. Radonovich, J.N. Brady, and C.A. Pise-Masison HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity Blood 104 2004 1490 1497
16. S.J. Jeong, A.A. Pise-Masison, M.F. Radonovich, H.U. Park, and J.N. Brady A novel NF-κB pathway involving IKK and p65/RelA Ser-536 phosphorylation results in p53 inhibition in the absence of NF-κB transcriptional activity J Biol Chem 280 2005 10326 10332
17. H. Jijon, B. Allard, and C. Jobin NF-κB inducing kinase (NIK) activates NF-κB transcriptional activity independently of IκB kinase γ (IKKγ) through a p38 MAPK dependent RelA phosphorylation pathway Cell Signal 16 2004 1023 1032
18. M. Karin, and A. Lin NF-kappaB at the crossroads of life and death Nat Immunol 3 2002 221 227
19. H.C. Kirch, S. Flaswinkel, H. Rumpf, D. Brockmann, and H. Esche Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max Oncogene 18 1999 2728 2738
20. J.H. Lee, and T.T. Paull Activation and regulation of ATM kinase activity in response to DNA double-strand breaks Oncogene 26 2007 7741 7748 10.1038/sj.onc.1210872
21. D.A. Liebermann, J.S. Tront, X. Sha, K. Mukherjee, A.M. Hadley, and B. Hoffman Gadd45 stress sensors in malignancy and leukemia Crit Rev Oncog 16 2011 129 140
22. T. Maeda, R.A. Espino, E.G. Chomey, L. Luong, A. Bano, and D. Meakins et al. Loss of p21WAF1/Cip1 in Gadd45-deficient keratinocytes restores DNA repair capacity Carcinogenesis 26 2005 1804 1810
23. A. Moskalev, E. Plyusnina, M. Shaposhnikov, L. Shilova, A. Kazachenok, and A. Zhavoronkov The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance Cell Cycle 11 2012 4222 4241 10.4161/cc 22545
24. C. Niehrs, and A. Schafer Active DNA demethylation by Gadd45 and DNA repair Trends Cell Biol 22 2012 220 227
25. P.L. Olive, and J.P. Banath The comet assay: a method to measure DNA damage in individual cells Nat Protoc 1 2006 23 29
26. T.V. Pospelova, A.V. Medvedev, A.N. Kukushkin, S.B. Svetlikova, A.J. van der Eb, and J.C. Dorsman et al. E1A+cHa-ras transformed rat embryo fibroblast cells are characterized by high and constitutive DNA binding activities of AP-1 dimers with significantly altered composition Gene Expr 8 1999 19 32
27. K.M. Ryan, M.K. Ernst, N.R. Rice, and K.H. Vousden Role of NF-κB in p53-mediated programmed cell death Nature 404 2000 892 896
28. K. Sakaguchi, J.E. Herrera, S. Saito, T. Miki, M. Bustin, and A. Vassilev et al. DNA damage activates p53 through a phosphorylation-acetylation cascade Genes Dev 12 1998 2831 2841
29. R.C. Scaduto Jr., and L.W. Grotyohann Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives Biophys J 76 1999 469 477
30. M.L. Smith, J.M. Ford, M.C. Hollander, R.A. Bortnick, S.A. Amundson, and Y.R. Seo et al. p53-mediated DNA responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes Mol Cell Biol 20 2000 3705 3714
31. R.E. Tamura, J.F. de Vasconcellos, D. Sarkar, T.A. Libermann, P.B. Fisher, and L.F. Zerbini Gadd45 proteins: central players in tumorigenesis Cur Mol Med 12 2012 634 651 10.2174/156652412800619978
32. K. Yamasawa, Y. Nio, M. Dong, K. Yamaguchi, and M. Itakura Clinicopathological significance of abnormalities in Gadd45 expression and its relationship to p53 in human pancreatic cancer Clin Cancer Res 8 2002 2563 2569
33. L.F. Zerbini, Y. Wang, A. Czibere, R.G. Correa, J.Y. Cho, and K. Ijiri et al. NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins alpha and gamma is essential for cancer cell survival Proc Natl Acad Sci U S A 101 2004 13618 13623
34. W. Zhang, B. Hoffman, and D.A. Liebermann Ectopic expression of MyD118/Gadd45/CR6 (Gadd45beta/alpha/gamma) sensitizes neoplastic cells to genotoxic stress-induced apoptosis Int J Oncol 18 2001 749 757