Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 4, 2014, Pages 1606-1615

  Sun, Chao ^a   Liu, Chunxia ^a   Li, Shugang ^a   Li, Hongan ^a   Wang, Yuanyuan ^a   Xie, Yuwen ^a   Li, Bingcheng ^a   Cui, Xiaobin ^a   Chen, Yunzhao ^a   Zhang, Wenjie ^a   Li, Feng ^a  

^a SHIHEZI UNIVERSITY   (China)

Author keywords

Guanine nucleotide exchange factor; Overexpression; Prognosis; Rhabdomyosarcoma

Indexed keywords

GEFT PROTEIN, HUMAN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; TUMOR MARKER;

ADOLESCENT; ADULT; AGED; CANCER STAGING; CASE CONTROL STUDY; CHILD; FEMALE; HUMAN; INFANT; KAPLAN MEIER METHOD; MALE; METABOLISM; MIDDLE AGED; MORTALITY; PREDICTIVE VALUE; PRESCHOOL CHILD; PROGNOSIS; RHABDOMYOSARCOMA; SOFT TISSUE NEOPLASMS; SURVIVAL RATE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INFANT; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RHABDOMYOSARCOMA; SOFT TISSUE NEOPLASMS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84899577821     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Amankwah EK, Conley AP, Reed DR. Epidemiology and therapies for metastatic sarcoma. Clin Epidemiol 2013; 5: 147-162.
2. Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proli-feration, transformation, and migration. J Biol Chem 2003; 278: 13207-15.
3. Liu C, Li D, Hu J, Jiang J, Zhang W, Chen Y, Cui X, Qi Y, Zou H, Zhang W, Li F. Chromosomal and genetic imbalances in Chinese patients with rhabdomyosarcoma detected by high-resolu-tion array comparative genomic hybridization. Int J Clin Exp Pathol 2014; 7: 690-698.
4. Paulson V, Chandler G, Rakheja D, Galindo RL, Wilson K, Amatruda JF, Cameron S. High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis. Genes Chromosomes Can-cer 2011; 50: 397-408.
5. Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M. Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. Mol Cell Biol 2005; 25: 11089-101.
6. Cherfils J and Zeghouf M. Rho, regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev 2013; 93: 269-309.
7. Cook D, Rossman K, Der C. Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene 2013; 1-15.
8. Barrio-Real L, Kazanietz MG. Rho GEFs and cancer: linking gene expression and metastatic dissemination. Sci Signal 2012; 5: pe43.
9. Lazer G, Idelchuk Y, Schapira V, Pikarsky E, Katzav S. The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis. J Pathol 2009; 219: 25-34.
10. Leabu M, Uniyal S, Xie J, Xu YQ, Vladau C, Morris VL, Chan BM. Integrin a2β1 modulates EGF stimulation of Rho GTPase-dependent morphological changes in adherent human rhabdomyosarcoma RD cells. J Cell Physiol 2005; 202: 754-66.
11. q-Mediated Activation of Smooth Muscle. Trends Cardiovasc Med 2012; 22: 122-27.
12. Smith TK, Hager HA, Francis R, Kilkenny DM, Lo CW, Bader DM. Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity. Proc Natl Acad Sci U S A 2008; 105: 8298-303.
13. Mitchell DC, Bryan BA, Liu L, Hu XH, Huang XQ, Ji WK, Chen PC, Hu WF, Liu JP, Zhang J, Liu M, Li DW. GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism. Curr Mol Med 2011; 11: 465-80.
14. Aittaleb M, Boguth CA, Tesmer JJ. Structure of Gaq-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs. Science 2007; 318: 1922-27.
15. Swenson-Fields KI, Sandquist JC, Rossol-Allison J, Blat IC, Wennerberg K, Burridge K, Means AR. MLK3 limits activated Gaq signaling to Rho by binding to p63RhoGEF. Mol Cell 2008; 32: 43-56.
16. Momotani K, Artamonov MV, Utepbergenov D, Derewenda U, Derewenda ZS, Somlyo AV. p63RhoGEF Couples Gaq/11-Mediated Signaling to Ca2+ Sensitization of Vascular Smooth Muscle Contractility. Circ Res 2011; 109: 993-1002.
17. Yono M, Yoshida M, Yamamoto Y, Imanishi A, Fukagawa A, Latifpour J, Eto M. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. BJU Int 2010; 105: 877-83.
18. Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M. GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation. J Biol Chem 2004; 279: 45824-32.
19. Bryan BA, Cai Y, Liu M. The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid-and cAMP-induced neurite outgrowth. J Neurosci Res 2006; 83: 1151-9.
20. Tang X, Jin R, Qu G, Wang X, Li Z, Yuan Z, Zhao C, Siwko S, Shi T, Wang P, Xiao J, Liu M, Luo J. GPR116, an Adhesion G-Protein-Coupled Receptor, Promotes Breast Cancer Metastasis via the G aq-p63RhoGEF-Rho GTPase Pathway. Cancer Res 2013; 73: 6206-6218.
21. Hayashi A, Hiatari R, Tsuji T, Ohashi K, Mizuno K. p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells. FEBS Lett 2013; 587: 698-705.
22. Qi Y, Wang CC, He YL, Zou H, Liu CX, Pang LJ, Hu JM, Jiang JF, Zhang WJ, Li F. The correlation between morphology and the expression of TGF-β signaling pathway proteins and epithelial-mesenchymal transition-related proteins in synovial sarcomas. Int J Clin Exp Pathol 2013; 6: 2787-2799.
23. Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S. p63RhoGEF-a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. FASEB J 2010; 24: 4865-76.
24. Calò LA, Davis PA, Pessina AC. Does p63RhoGEF, a new key mediator of angiotensin II signalling, play a role in blood pressure regulation and cardiovascular remodelling in humans?. J Renin Angiotensin Aldosterone Syst 2011; 12: 634-6.
25. Xin H, Zhen YJ, Han ZG, Wang WZ. Effect of endothelial Rho and Rho kinase in extravasation migration of sarcoma cell. Chinese Journal of Pathophysiology 2004; 20: 950-953.
26. Saito S, Liu XF, Kamijo K, Raziuddin R, Tatsumoto T, Okamoto I, Chen X, Lee CC, Lorenzi MV, Ohara N, Miki T. Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation. J Biol Chem 2004; 279: 7169-79.
27. Justilien V, Fields AP. Ect2 links the PKCl-Par6α complex to Rac1 activation and cellular transformation. Oncogene 2009; 28: 3597-607.
28. Citterio C, Menacho-Márquez M, García-Escudero R, Larive RM, Barreiro O, Sánchez-Madrid F, Paramio JM, Bustelo XR. The Rho exchange factors Vav2 and Vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. Sci Signal 2012; 5: ra71.
29. Bennett G, Sadlier D, Doran PP, Macmathuna P, Murray DW. A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer. BMC Cancer; 2011: 11: 50.
30. Wang H, Li Y, Wang Y, Han ZG, Cai B. C9orf100, a new member of the Dbl-family guanine nucleotide exchange factors, promotes cell proliferation and migration in hepatocellular carcinoma. Mol Med Rep 2012; 5: 1169-74.
31. Jin H, Li T, Ding Y, Deng Y, Zhang W, Yang H, Zhou J, Liu C, Lin J, Ding Y. Methylation status of T-lymphoma invasion and metastasis 1 promoter and its overexpression in colorectal cancer. Human Pathology 2011; 42: 541-51.
32. Ayala I, Giacchetti G, Caldieri G, Attanasio F, Mariggiò S, Tetè S, Polishchuk R, Castronovo V, Buccione R. Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is up-regulated in prostate and breast cancer. Cancer Res 2009; 69: 747-52.