Does p63RhoGEF, a new key mediator of angiotensin II signalling, play a role in blood pressure regulation and cardiovascular remodelling in humans?

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 12, Issue 4, 2011, Pages 634-636

  Calò, Lorenzo A ^a   Davis, Paul A ^b   Pessina, Achille C ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; RGS2 PROTEIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

BARTTER SYNDROME; BLOOD PRESSURE REGULATION; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR REMODELLING; CELL PROLIFERATION; DOWN REGULATION; ENZYME ACTIVATION; GITELMAN SYNDROME; HUMAN; LETTER; LOSS OF FUNCTION MUTATION; NONHUMAN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION; VASOCONSTRICTION;

ANGIOTENSIN II; BLOOD PRESSURE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; NITRIC OXIDE; RECEPTOR, ANGIOTENSIN, TYPE 1; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; VENTRICULAR REMODELING;

EID: 83455195514     PISSN: 14703203     EISSN: 17528976     Source Type: Journal    
DOI: 10.1177/1470320311407232     Document Type: Letter

References (31)

1. Mehta PK, Griendling KK. Angiotensin II Cell Signaling. Physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 2007 ; 92: C82 - C97
2. Berridge MJ. Inositol trisphosphate and calcium signalling. Nature. 1993 ; 361: 315-325 (Pubitemid 23041621)
3. Touyz RM. Role of angiotensin II in regulating vascular structural and functional changes in hypertension. Curr Hypertens Rep. 2003 ; 5: 155-164 (Pubitemid 38898946)
4. Ushio-Fukai M, Griendling KK, Akers M, Lyons PR, Alexander RW. Temporal dispersion of activation of phospholipase C-beta1 and -gamma isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, alpha12, and beta gamma G protein subunits. J Biol Chem. 1998 ; 273: 19772-19777 (Pubitemid 28367037)
5. Tabet F, Schiffrin EL, Callera GE, et al. Redox-sensitive signaling by angiotensin ii involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR. Circ Res. 2008 ; 103: 149-158
6. Loirand G, Guerin P, Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology. Circ Res. 2006 ; 98: 322-334
7. Calò LA, Pessina AC. RhoA/Rho-kinase pathway: much more than just a modulation of vascular tone. Evidence from studies in humans. J Hypertens. 2007 ; 25: 259-264 (Pubitemid 46071919)
8. Wennerberg K, Der CJ. Rho-family GTPases: it's not only Rac and Rho (and I like it). J. Cell Sci. 2004 ; 117: 1301-1312 (Pubitemid 38559808)
9. Siderovski D P, Willard FS. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci. 2005 ; 1: 51-66
10. Wuertz MC, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S. p63RhoGEF-a key mediator of angiotensin II dependent signaling and processes in vascular smooth muscle cells. FASEB J. 2010 ; 24: 4865-4876
11. Shankaranarayanan A, Boguth CA, Lutz S, et al. Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF. Cell Signal. 2010 ; 22: 1114-1123
12. Guilluy C, Brégeon J, Toumaniantz G, et al. The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med. 2010 ; 16: 183-190
13. Naesens M, Steels P, Verberckmoes R, Vanrenterghem Y, Kuypers D. Bartter's and Gitelman's Syndromes: From gene to clinic. Nephron Physiol. 2004 ; 96: 65-78
14. Calò LA. Vascular tone control in humans: the utility of studies in Bartter's/Gitelman's syndromes. Kidney Int. 2006 ; 69: 963-966 (Pubitemid 43372169)
15. Calò LA, Pagnin E, Davis PA, et al. Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter's/Gitelman's syndrome. A role in the control of vascular tone and implication for hypertension. J Clin Endocrinol Metab. 2004 ; 89: 4153-4157 (Pubitemid 39071528)
16. Wieland T, Lutz S, Chidiac P. Regulators of G protein signaling: a spotlight on emerging functions in the cardiovascular system. Curr Opin Pharmacol. 2007 ; 7: 1-7
17. Shankaranarayanan A, Thal DM, Tesmer VM, et al. Assembly of high order G alpha q-effector complexes with RGS proteins. J Biol Chem. 2008 ; 283: 34923-34934
18. Calò LA, Pagnin E, Ceolotto G, et al. Silencing regulator of G protein signaling-2 (RGS-2) increases angiotensin II signaling: insights into hypertension from findings in Bartter's/Gitelman's syndromes. J Hypertens. 2008 ; 26: 938-945 (Pubitemid 351520981)
19. Semplicini A, Lenzini L, Sartori M, et al. Reduced expression of regulator of G protein signaling-2 in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II. J Hypertens. 2006 ; 24: 1115-1124 (Pubitemid 43772320)
20. Calò LA, Schiavo S, Davis PA, et al. Angiotensin II signaling via type 2 receptors in a human model of vascular hyporeactivity: implications for hypertension. J Hypertens. 2010 ; 28: 111-118
21. Pagnin E, Semplicini A, Sartori M, Pessina AC, Calò LA. Reduced mRNA and protein content of Rho guanine nucleotide exchange factor (RhoGEF) in Bartter's and Gitelman's syndromes: relevance for the pathophysiology of hypertension. Am J Hypertens. 2005 ; 18: 1200-1205 (Pubitemid 41337973)
22. Pagnin E, Davis PA, Sartori M, Semplicini A, Pessina AC, Calò LA. Rho kinase and PAI-1 in Bartter's/Gitelman's syndromes: relationship to angiotensin II signaling. J Hypertens. 2004 ; 22: 1963-1969 (Pubitemid 39336679)
23. Calò L, Sartore G, Bassi A, et al. Reduced susceptibility of low density lipoprotein to oxidation in patients with overproduction of nitric oxide (Bartter's and Gitelman's syndrome). J Hypertens. 1998 ; 16: 1001-1008 (Pubitemid 28367955)
24. Calò LA, Pagnin E, Davis PA, Sartori M, Semplicini A. Oxidative stress related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling. Nephrol Dial Transplant. 2003 ; 18: 1518-1525 (Pubitemid 36939623)
25. Calò LA, Puato M, Schiavo S, et al. Absence of vascular remodelling in a high angiotensin-II state (Bartter's and Gitelman's syndromes): implications for angiotensin IIsignalling pathways. Nephrol Dial Transplant. 2008 ; 23: 2804-2809
26. Calò LA, Montisci R, Scognamiglio R, et al. High angiotensin II state without cardiac remodeling (Bartter's and Gitelman's syndromes). Are angiotensin II type 2 receptors involved?. J Endocrinol Invest. 2009 ; 32: 832-836
27. Mogi M, Iwai M, Horiuchi M. Emerging concepts of regulation of angiotensin II receptors: new players and targets for traditional receptors. Arterioscler Thromb Vasc Biol. 2007 ; 27: 2532-2539 (Pubitemid 350158902)
28. Nouet S, Nahmias C. Signal transduction from the angiotensin II AT2 receptor. Trends Endocrinol Metab. 2000 ; 11: 1-6 (Pubitemid 30395452)
29. Carey RM. Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age. Hypertension. 2005 ; 45: 840-844 (Pubitemid 40628923)
30. Savoia C, Tabet F, Yao G, Schiffrin EL, Touyz RM. Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats. J Hypertens. 2005 ; 23: 1037-1045 (Pubitemid 40637923)
31. Siragy HM. Evidence for benefits of angiotensin receptor blockade beyond blood pressure control. Curr Hypertens Rep. 2008 ; 10: 261-267