메뉴 건너뛰기




Volumn 33, Issue 5, 2014, Pages 1236-1242

Inactivation of von Hippel-Lindau increases ovarian cancer cell aggressiveness through the HIF1α/miR-210/VMP1 signaling pathway

Author keywords

MicroRNA 210; Ovarian cancer; Von Hippel Lindau

Indexed keywords

GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIFICIGUAT; MEMBRANE PROTEIN; MICRORNA 210; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VACUOLE MEMBRANE PROTEIN 1; VON HIPPEL LINDAU PROTEIN; 3-(5'-HYDROXYMETHYL-2'-FURYL)-1-BENZYLINDAZOLE; INDAZOLE DERIVATIVE; MICRORNA; MIRN210 MICRORNA, HUMAN;

EID: 84899570199     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1661     Document Type: Article
Times cited : (26)

References (40)
  • 2
    • 84872080485 scopus 로고    scopus 로고
    • Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
    • Vanharanta S, Shu W, Brenet F, et al: Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat Med 19: 50-56, 2013.
    • (2013) Nat Med , vol.19 , pp. 50-56
    • Vanharanta, S.1    Shu, W.2    Brenet, F.3
  • 3
    • 40949136438 scopus 로고    scopus 로고
    • The VHL tumor suppressor and HIF: Insights from genetic studies in mice
    • DOI 10.1038/sj.cdd.4402313, PII 4402313, The biology of Hypoxia-inducible factors
    • Kapitsinou PP and Haase VH: The VHL tumor suppressor and HIF: insights from genetic studies in mice. Cell Death Differ 15: 650-659, 2008. (Pubitemid 351405068)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.4 , pp. 650-659
    • Kapitsinou, P.P.1    Haase, V.H.2
  • 4
    • 78649921834 scopus 로고    scopus 로고
    • The relationship of erythropoietin overexpression with von Hippel-Lindau tumour suppressor gene mutations between hypoxia-inducible factor-1α and -2α in sporadic clear cell renal carcinoma
    • Gong K, Zhang N, Zhang K and Na Y: The relationship of erythropoietin overexpression with von Hippel-Lindau tumour suppressor gene mutations between hypoxia-inducible factor-1α and -2α in sporadic clear cell renal carcinoma. Int J Mol Med 26: 907-912, 2010.
    • (2010) Int J Mol Med , vol.26 , pp. 907-912
    • Gong, K.1    Zhang, N.2    Zhang, K.3    Na, Y.4
  • 5
    • 0034145215 scopus 로고    scopus 로고
    • Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis
    • (Review)
    • Minet E, Michel G, Remacle J and Michiels C: Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (Review). Int J Mol Med 5: 253-259, 2000.
    • (2000) Int J Mol Med , vol.5 , pp. 253-259
    • Minet, E.1    Michel, G.2    Remacle, J.3    Michiels, C.4
  • 8
    • 77953483108 scopus 로고    scopus 로고
    • MicroRNA-210: A unique and pleiotropic hypoxamir
    • Chan SY and Loscalzo J: MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle 9: 1072-1083, 2010.
    • (2010) Cell Cycle , vol.9 , pp. 1072-1083
    • Chan, S.Y.1    Loscalzo, J.2
  • 10
    • 84862781979 scopus 로고    scopus 로고
    • Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro
    • Yang W, Sun T, Cao J, Liu F, Tian Y and Zhu W: Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro. Exp Cell Res 318: 944-954, 2012.
    • (2012) Exp Cell Res , vol.318 , pp. 944-954
    • Yang, W.1    Sun, T.2    Cao, J.3    Liu, F.4    Tian, Y.5    Zhu, W.6
  • 11
    • 71749100911 scopus 로고    scopus 로고
    • An integrated approach for experimental target identification of hypoxia-induced miR-210
    • Fasanaro P, Greco S, Lorenzi M, et al: An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem 284: 35134-35143, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 35134-35143
    • Fasanaro, P.1    Greco, S.2    Lorenzi, M.3
  • 12
    • 78650944900 scopus 로고    scopus 로고
    • MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1)
    • Tsuchiya S, Fujiwara T, Sato F, et al: MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1). J Biol Chem 286: 420-428, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 420-428
    • Tsuchiya, S.1    Fujiwara, T.2    Sato, F.3
  • 13
    • 82455162648 scopus 로고    scopus 로고
    • Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma
    • Ying Q, Liang L, Guo W, et al: Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology 54: 2064-2075, 2011.
    • (2011) Hepatology , vol.54 , pp. 2064-2075
    • Ying, Q.1    Liang, L.2    Guo, W.3
  • 14
    • 37549012209 scopus 로고    scopus 로고
    • The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells
    • Ropolo A, Grasso D, Pardo R, et al: The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells. J Biol Chem 282: 37124-37133, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 37124-37133
    • Ropolo, A.1    Grasso, D.2    Pardo, R.3
  • 17
    • 34547838192 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: Nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma
    • DOI 10.1016/j.humpath.2007.02.010, PII S0046817707000998
    • Osada R, Horiuchi A, Kikuchi N, et al: Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma. Hum Pathol 38: 1310-1320, 2007. (Pubitemid 47247486)
    • (2007) Human Pathology , vol.38 , Issue.9 , pp. 1310-1320
    • Osada, R.1    Horiuchi, A.2    Kikuchi, N.3    Yoshida, J.4    Hayashi, A.5    Ota, M.6    Katsuyama, Y.7    Mellilo, G.8    Konishi, I.9
  • 18
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • Semenza GL: HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8 (Suppl 4): S62-S67, 2002.
    • (2002) Trends Mol Med , vol.8 , Issue.SUPPL. 4
    • Semenza, G.L.1
  • 19
    • 79959637929 scopus 로고    scopus 로고
    • Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer
    • Rothe F, Ignatiadis M, Chaboteaux C, et al: Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer. PLoS One 6: e20980, 2011.
    • (2011) PLoS One , vol.6
    • Rothe, F.1    Ignatiadis, M.2    Chaboteaux, C.3
  • 20
    • 84872765715 scopus 로고    scopus 로고
    • MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma
    • Redova M, Poprach A, Besse A, et al: MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma. Tumour Biol 34: 481-491, 2013.
    • (2013) Tumour Biol , vol.34 , pp. 481-491
    • Redova, M.1    Poprach, A.2    Besse, A.3
  • 22
    • 84870699436 scopus 로고    scopus 로고
    • Novel roles of Vmp1: Inhibition metastasis and proliferation of hepatocellular carcinoma
    • Guo L, Yang LY, Fan C, Chen GD and Wu F: Novel roles of Vmp1: inhibition metastasis and proliferation of hepatocellular carcinoma. Cancer Sci 103: 2110-2119, 2012.
    • (2012) Cancer Sci , vol.103 , pp. 2110-2119
    • Guo, L.1    Yang, L.Y.2    Fan, C.3    Chen, G.D.4    Wu, F.5
  • 23
    • 84874912807 scopus 로고    scopus 로고
    • Expression of vacuole membrane protein 1 and its prognostic value in invasive ductal carcinoma of the breast
    • (In Chinese)
    • Liu F, Niu Y, Liu N, et al: Expression of vacuole membrane protein 1 and its prognostic value in invasive ductal carcinoma of the breast. Zhonghua Bing Li Xue Za Zhi 42: 86-89, 2013 (In Chinese).
    • (2013) Zhonghua Bing Li Xue Za Zhi , vol.42 , pp. 86-89
    • Liu, F.1    Niu, Y.2    Liu, N.3
  • 24
    • 57449091118 scopus 로고    scopus 로고
    • Von-Hippel-Lindau (VHL) protein function by initiation and progression of renal cancer
    • (In German)
    • Moch H: Von-Hippel-Lindau (VHL) protein function by initiation and progression of renal cancer. Pathologe 29 (Suppl 2): 149-152, 2008 (In German).
    • (2008) Pathologe , vol.29 , Issue.SUPPL. 2 , pp. 149-152
    • Moch, H.1
  • 25
    • 43049113104 scopus 로고    scopus 로고
    • Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors
    • Ivanov SV, Ivanova AV, Salnikow K, Timofeeva O, Subramaniam M and Lerman MI: Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors. Biochem Biophys Res Commun 370: 536-540, 2008.
    • (2008) Biochem Biophys Res Commun , vol.370 , pp. 536-540
    • Ivanov, S.V.1    Ivanova, A.V.2    Salnikow, K.3    Timofeeva, O.4    Subramaniam, M.5    Lerman, M.I.6
  • 27
    • 27544477748 scopus 로고    scopus 로고
    • The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing
    • Kaelin WG Jr: The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing. Biochem Biophys Res Commun 338: 627-638, 2005.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 627-638
    • Kaelin Jr., W.G.1
  • 28
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 29
    • 38449111737 scopus 로고    scopus 로고
    • The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells
    • Zia MK, Rmali KA, Watkins G, Mansel RE and Jiang WG: The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells. Int J Mol Med 20: 605-611, 2007.
    • (2007) Int J Mol Med , vol.20 , pp. 605-611
    • Zia, M.K.1    Rmali, K.A.2    Watkins, G.3    Mansel, R.E.4    Jiang, W.G.5
  • 30
    • 84884583240 scopus 로고    scopus 로고
    • The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma
    • Choueiri TK, Fay AP, Gagnon R, et al: The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma. Clin Cancer Res 19: 5218-5226, 2013.
    • (2013) Clin Cancer Res , vol.19 , pp. 5218-5226
    • Choueiri, T.K.1    Fay, A.P.2    Gagnon, R.3
  • 32
    • 59149091637 scopus 로고    scopus 로고
    • MicroRNA regulation of DNA repair gene expression in hypoxic stress
    • Crosby ME, Kulshreshtha R, Ivan M and Glazer PM: MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 69: 1221-1229, 2009.
    • (2009) Cancer Res , vol.69 , pp. 1221-1229
    • Crosby, M.E.1    Kulshreshtha, R.2    Ivan, M.3    Glazer, P.M.4
  • 34
    • 84892164223 scopus 로고    scopus 로고
    • A robust TALENs system for highly efficient mammalian genome editing
    • Feng Y, Zhang S and Huang X: A robust TALENs system for highly efficient mammalian genome editing. Sci Rep 4: 3632, 2014.
    • (2014) Sci Rep , vol.4 , pp. 3632
    • Feng, Y.1    Zhang, S.2    Huang, X.3
  • 35
    • 84871292051 scopus 로고    scopus 로고
    • Synthetic miRNA-mowers targeting miR-183-96-182 cluster or miR-210 inhibit growth and migration and induce apoptosis in bladder cancer cells
    • Liu Y, Han Y, Zhang H, et al: Synthetic miRNA-mowers targeting miR-183-96-182 cluster or miR-210 inhibit growth and migration and induce apoptosis in bladder cancer cells. PLoS One 7: e52280, 2012.
    • (2012) PLoS One , vol.7
    • Liu, Y.1    Han, Y.2    Zhang, H.3
  • 36
    • 84866161987 scopus 로고    scopus 로고
    • On the prometastatic stress response to cancer therapies: Evidence for a positive co-operation between TIMP-1, HIF-1á, and miR-210
    • Cui H, Grosso S, Schelter F, Mari B and Kruger A: On the prometastatic stress response to cancer therapies: evidence for a positive co-operation between TIMP-1, HIF-1á, and miR-210. Front Pharmacol 3: 134, 2012.
    • (2012) Front Pharmacol , vol.3 , pp. 134
    • Cui, H.1    Grosso, S.2    Schelter, F.3    Mari, B.4    Kruger, A.5
  • 37
    • 70349168446 scopus 로고    scopus 로고
    • Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation
    • Huang X, Ding L, Bennewith KL, et al: Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell 35: 856-867, 2009.
    • (2009) Mol Cell , vol.35 , pp. 856-867
    • Huang, X.1    Ding, L.2    Bennewith, K.L.3
  • 39
    • 33645748171 scopus 로고    scopus 로고
    • Regulation of E-cadherin expression by VHL and hypoxia-inducible factor
    • Esteban MA, Tran MG, Harten SK, et al: Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res 66: 3567-3575, 2006.
    • (2006) Cancer Res , vol.66 , pp. 3567-3575
    • Esteban, M.A.1    Tran, M.G.2    Harten, S.K.3
  • 40
    • 84861192691 scopus 로고    scopus 로고
    • Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization
    • Zhou Q, Chen T, Ibe JC, Raj JU and Zhou G: Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization. FEBS Lett 586: 1510-1515, 2012.
    • (2012) FEBS Lett , vol.586 , pp. 1510-1515
    • Zhou, Q.1    Chen, T.2    Ibe, J.C.3    Raj, J.U.4    Zhou, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.