메뉴 건너뛰기




Volumn 6, Issue 3, 2014, Pages 249-259

Alemtuzumab for the treatment of relapsing-remitting multiple sclerosis

Author keywords

alemtuzumab; autoimmune adverse events; CD52; monoclonal antibody; relapsing remitting multiple sclerosis

Indexed keywords

ALEMTUZUMAB; ANTIHISTAMINIC AGENT; BETA1A INTERFERON; CORTICOSTEROID; ANTIRHEUMATIC AGENT; BETA INTERFERON; CD52 ANTIGEN; GLYCOPROTEIN; IMMUNOLOGIC FACTOR; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

EID: 84899569012     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.14.7     Document Type: Article
Times cited : (20)

References (47)
  • 1
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet 372, 1502-1517 (2008).
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 2
    • 27644552194 scopus 로고    scopus 로고
    • Cortical demyelination and diffuse white matter injury in multiple sclerosis
    • Kutzelnigg A, Lucchinetti CF, Stadelmann C et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 128, 2705-2712 (2005).
    • (2005) Brain , vol.128 , pp. 2705-2712
    • Kutzelnigg, A.1    Lucchinetti, C.F.2    Stadelmann, C.3
  • 3
    • 0034765063 scopus 로고    scopus 로고
    • Immunopathology of secondary-progressive multiple sclerosis
    • Prineas J, Kwon E, Cho E et al. Immunopathology of secondary-progressive multiple sclerosis. Ann. Neurol. 50, 646-657 (2001).
    • (2001) Ann. Neurol. , vol.50 , pp. 646-657
    • Prineas, J.1    Kwon, E.2    Cho, E.3
  • 5
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, O'Connor PW, Hardova E et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 354, 899-910 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Hardova, E.3
  • 6
    • 33644608613 scopus 로고    scopus 로고
    • Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    • Rudick RA, Stuart WH, Calabresi PA et al. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N. Engl. J. Med. 354, 911-923 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 911-923
    • Rudick, R.A.1    Stuart, W.H.2    Calabresi, P.A.3
  • 7
    • 76149093586 scopus 로고    scopus 로고
    • A placebocontrolled trial of oral fingolimod in relapsing multiple sclerosis
    • Kappos L, Radue E-W, O'Connor P et al. A placebocontrolled trial of oral fingolimod in relapsing multiple sclerosis. N. Engl. J. Med. 362, 387-401 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 387-401
    • Kappos, L.1    Radue, E.-W.2    Oconnor, P.3
  • 8
    • 76149140914 scopus 로고    scopus 로고
    • Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
    • Cohen JA, Barkhof F, Comi G et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N. Engl. J. Med. 362, 402-415 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 402-415
    • Cohen, J.A.1    Barkhof, F.2    Comi, G.3
  • 9
    • 80053533877 scopus 로고    scopus 로고
    • Randomized trial of oral teriflunomide for relapsing multiple sclerosis
    • O'Connor P, Wolinsky JS, Confavreux C et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N. Engl. J. Med. 365, 1293-1303 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1293-1303
    • O'Connor, P.1    Wolinsky, J.S.2    Confavreux, C.3
  • 10
    • 54149116366 scopus 로고    scopus 로고
    • Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomized, double-blind, placebo-controlled Phase IIb study
    • Kappos L, Gold R, Miller DH et al. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomized, double-blind, placebo-controlled Phase IIb study. Lancet 372, 1463-1472 (2008).
    • (2008) Lancet , vol.372 , pp. 1463-1472
    • Kappos, L.1    Gold, R.2    Miller, D.H.3
  • 11
    • 84866355653 scopus 로고    scopus 로고
    • Placebo-controlled Phase 3 study of oral bg-12 or glatiramer in multiple sclerosis
    • Fox R, Miller D, Phillips JT et al. Placebo-controlled Phase 3 study of oral bg-12 or glatiramer in multiple sclerosis. N. Engl. J. Med. 367, 1087-1097 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1087-1097
    • Fox, R.1    Miller, D.2    Phillips, J.T.3
  • 12
    • 0034765991 scopus 로고    scopus 로고
    • The CD52 antigen and development of the CAMPATH antibodies
    • Hale G. The CD52 antigen and development of the CAMPATH antibodies. Cytotherapy 3, 137-143 (2001).
    • (2001) Cytotherapy , vol.3 , pp. 137-143
    • Hale, G.1
  • 14
    • 27944439639 scopus 로고    scopus 로고
    • Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis
    • Cox AL, Thompson SA, Jones JL et al. Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis. Eur. J. Immunol. 35, 3332-3342 (2005).
    • (2005) Eur. J. Immunol. , vol.35 , pp. 3332-3342
    • Cox, A.L.1    Thompson, S.A.2    Jones, J.L.3
  • 15
    • 68849084141 scopus 로고    scopus 로고
    • IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)
    • Jones JL, Phuah CL, Cox AL et al. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J. Clin. Investig.119, 2052-2061 (2009).
    • (2009) J. Clin. Investig. , vol.119 , pp. 2052-2061
    • Jones, J.L.1    Phuah, C.L.2    Cox, A.L.3
  • 16
    • 77249114139 scopus 로고    scopus 로고
    • B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis
    • Thompson SA, Jones JL, Cox AL, Compston DAS, Coles AJ. B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis. J. Clin. Immunol. 30, 99-105 (2010).
    • (2010) J. Clin. Immunol. , vol.30 , pp. 99-105
    • Thompson, S.A.1    Jones, J.L.2    Cox, A.L.3    Compston, D.A.S.4    Coles, A.J.5
  • 17
    • 0032553334 scopus 로고    scopus 로고
    • Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart
    • Cheetham GM, Hale G, Waldmann H, Bloomer AC. Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart. J. Mol. Biol. 284, 85-99 (1998).
    • (1998) J. Mol. Biol. , vol.284 , pp. 85-99
    • Cheetham, G.M.1    Hale, G.2    Waldmann, H.3    Bloomer, A.C.4
  • 18
    • 0027386707 scopus 로고
    • A major mRNA of the human epididymal principal cells, HE5, encodes the leukocyte differentiation CDw52 antigen peptide backbone
    • Kirchhoff C, Krull N, Pera I, Ivell R. A major mRNA of the human epididymal principal cells, HE5, encodes the leukocyte differentiation CDw52 antigen peptide backbone. Mol. Reprod. Dev. 34, 8-15 (1993).
    • (1993) Mol. Reprod. Dev. , vol.34 , pp. 8-15
    • Kirchhoff, C.1    Krull, N.2    Pera, I.3    Ivell, R.4
  • 19
    • 69949120991 scopus 로고    scopus 로고
    • Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model
    • Hu Y, Turner MJ, Shields J et al. Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model. Immunology 128, 260-270 (2009).
    • (2009) Immunology , vol.128 , pp. 260-270
    • Hu, Y.1    Turner, M.J.2    Shields, J.3
  • 20
    • 0030453977 scopus 로고    scopus 로고
    • Mechanism of first-dose cytokine-release syndrome by campath 1-h: Involvement of cd16 (fcgammariii) and cd11a/cd18 (lfa-1) on nk cells
    • Wing mg, Moreau T, Greenwood J et al. Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: Involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells. J. Clin. Investig. 98, 2819-2826 (1996).
    • (1996) J. Clin. Investig. , vol.98 , pp. 2819-2826
    • Wing, M.G.1    Moreau, T.2    Greenwood, J.3
  • 21
    • 0029869119 scopus 로고    scopus 로고
    • Tranisent increase in symptoms associated with cytokine release in patients with multiple sclerosis
    • Moreau T, Coles A, Wing mg, Isaacs J, Waldmann H, Compston A. Tranisent increase in symptoms associated with cytokine release in patients with multiple sclerosis. Brain 119, 225-237 (1996).
    • (1996) Brain , vol.119 , pp. 225-237
    • Moreau, T.1    Coles, A.2    Wing, M.G.3    Isaacs, J.4    Waldmann, H.5    Compston, A.6
  • 22
    • 84890400796 scopus 로고    scopus 로고
    • Differential reconstitution of t cell subsets following immunodepleting treatment with alemtuzumab (anti-cd52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis
    • Zhang X, Tao Y, Chopra M et al. Differential reconstitution of t cell subsets following immunodepleting treatment with alemtuzumab (anti-cd52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis. J. Immunol. 191, 5867-5874 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 5867-5874
    • Zhang, X.1    Tao, Y.2    Chopra, M.3
  • 23
    • 77957044257 scopus 로고    scopus 로고
    • Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity
    • Jones JL, Anderson JM, Phuah CL et al. Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain 133, 2232-2247 (2010).
    • (2010) Brain , vol.133 , pp. 2232-2247
    • Jones, J.L.1    Anderson, J.M.2    Phuah, C.L.3
  • 24
    • 84869507357 scopus 로고    scopus 로고
    • Alemtuzumab for patients with relapsing multiple sclerosis after diseasemodifying therapy: A randomised controlled Phase 3 trial
    • Coles AJ, Twyman CL, Arnold DL et al. Alemtuzumab for patients with relapsing multiple sclerosis after diseasemodifying therapy: A randomised controlled Phase 3 trial. Lancet 380(9856), 1829-1839 (2012).
    • (2012) Lancet , vol.380 , Issue.9856 , pp. 1829-1839
    • Coles, A.J.1    Twyman, C.L.2    Arnold, D.L.3
  • 25
    • 84869492471 scopus 로고    scopus 로고
    • Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: A randomised controlled Phase 3 trial
    • Cohen JA, Coles AJ, Arnold DL et al. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: A randomised controlled Phase 3 trial. Lancet 380(9856), 1819-1828 (2012).
    • (2012) Lancet , vol.380 , Issue.9856 , pp. 1819-1818
    • Cohen, J.A.1    Coles, A.J.2    Arnold, D.L.3
  • 26
    • 84878638136 scopus 로고    scopus 로고
    • Drugs in development for relapsing multiple sclerosis
    • Ali R, Nicholas RSJ, Muraro PA. Drugs in development for relapsing multiple sclerosis. Drugs 73, 625-650 (2013).
    • (2013) Drugs , vol.73 , pp. 625-650
    • Ali, R.1    Nicholas, R.S.J.2    Muraro, P.A.3
  • 27
    • 37749016994 scopus 로고    scopus 로고
    • Mitoxantrone as induction treatment in aggressive relapsing remitting multiple sclerosis: Treatment response factors in a 5 year follow-up observational study of 100 consecutive patients
    • Le Page E, Leray E, Taurin G et al. Mitoxantrone as induction treatment in aggressive relapsing remitting multiple sclerosis: Treatment response factors in a 5 year follow-up observational study of 100 consecutive patients. J. Neurol. Neurosurg. Psychiatry 79, 52-56 (2008).
    • (2008) J. Neurol. Neurosurg. Psychiatry , vol.79 , pp. 52-56
    • Le Page, E.1    Leray, E.2    Taurin, G.3
  • 29
    • 0036470439 scopus 로고    scopus 로고
    • Pharmacokinetics of campath-1h: Assay development and validation
    • Rebello P, Hale G. Pharmacokinetics of CAMPATH-1H: Assay development and validation. J. Immuno. Methods 260, 285-302 (2002).
    • (2002) J. Immuno. Methods , vol.260 , pp. 285-302
    • Rebello, P.1    Hale, G.2
  • 30
    • 84899544187 scopus 로고    scopus 로고
    • Immunogenicity of alemtuzumab treatment in relapsing-remitting multiple sclerosis (rrms) patients in the care-ms ii study
    • Abstract 1 P07.101
    • Sørensen PS, Arnold DL, Cohen JA et al. Immunogenicity of Alemtuzumab Treatment in relapsing-remitting multiple sclerosis (RRMS) patients in the CARE-MS II study. Neurology 80(Abstract 1), P07.101 (2013).
    • (2013) Neurology , vol.80
    • Sørensen, P.S.1    Arnold, D.L.2    Cohen, J.A.3
  • 31
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-497 (1975).
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 32
    • 0021723276 scopus 로고
    • Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo
    • Cobbold SP, Jayasuriy A, Nash A, Prospero TD, Waldmann H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312, 548-551 (1984).
    • (1984) Nature , vol.312 , pp. 548-551
    • Cobbold, S.P.1    Jayasuriy, A.2    Nash, A.3    Prospero, T.D.4    Waldmann, H.5
  • 33
    • 0024566393 scopus 로고
    • Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype
    • Dyer MJ, Hale G, Hayhoe HG, Waldmann H. Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype. Blood 73, 1431-1439 (1989).
    • (1989) Blood , vol.73 , pp. 1431-1439
    • Dyer, M.J.1    Hale, G.2    Hayhoe, H.G.3    Waldmann, H.4
  • 35
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study. Blood 99, 3554-3561 (2002).
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 36
    • 0028346432 scopus 로고
    • Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis
    • Moreau T, Thorpe J, Miller D et al. Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis. Lancet 344, 298-301 (1994).
    • (1994) Lancet , vol.344 , pp. 298-301
    • Moreau, T.1    Thorpe, J.2    Miller, D.3
  • 37
    • 0033552391 scopus 로고    scopus 로고
    • Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis
    • Coles AJ, Wing MG, Smith S et al. Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis. Lancet 354, 1691-1695 (1999).
    • (1999) Lancet , vol.354 , pp. 1691-1695
    • Coles, A.J.1    Wing, M.G.2    Smith, S.3
  • 38
    • 0032882173 scopus 로고    scopus 로고
    • Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis
    • Coles AJ, Wing mg, Molyneux P et al. Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis. Ann. Neurol. 46, 296-304 (1999).
    • (1999) Ann. Neurol. , vol.46 , pp. 296-304
    • Coles, A.J.1    Wing, M.G.2    Molyneux, P.3
  • 39
    • 31544467633 scopus 로고    scopus 로고
    • The window of therapeutic opportunity in multiple sclerosis Evidence from monoclonal antibody therapy
    • Coles AJ, Cox A, Le Page E et al. The window of therapeutic opportunity in multiple sclerosis. Evidence from monoclonal antibody therapy. J. Neurol. 253, 98-108 (2006).
    • (2006) J. Neurol. , vol.253 , pp. 98-108
    • Coles, A.J.1    Cox, A.2    Le Page, E.3
  • 40
    • 54949143968 scopus 로고    scopus 로고
    • Alemtuzumab vs interferon beta-1a in early MS
    • Coles A, Group CS. Alemtuzumab vs. interferon beta-1a in early MS. N. Engl. J. Med. 359, 1786-1801 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1786-1801
    • Coles, A.1    Group, C.S.2
  • 41
    • 84860780657 scopus 로고    scopus 로고
    • Alemtuzumab more effective than interferon β-1a at 5-year follow-up of CAMMS223 clinical trial
    • Coles AJ, Fox E, Vladic A et al. Alemtuzumab more effective than interferon β-1a at 5-year follow-up of CAMMS223 clinical trial. Neurology 78, 1069-1078 (2012).
    • (2012) Neurology , vol.78 , pp. 1069-1078
    • Coles, A.J.1    Fox, E.2    Vladic, A.3
  • 42
    • 85067732448 scopus 로고    scopus 로고
    • Efficacy of Alemtuzumab in relapsing-remitting multiple sclerosis patients who relapsed on prior therapy (CARE-MS II): Subgroup analysis by previous DMT use
    • Abstract 1) P07.111
    • Freedman MS, Arnold DL, Cohen JA et al. Efficacy of Alemtuzumab in relapsing-remitting multiple sclerosis patients who relapsed on prior therapy (CARE-MS II): Subgroup analysis by previous DMT use. Neurology 80(Abstract 1), P07.111 (2013).
    • (2013) Neurology , vol.80
    • Freedman, M.S.1    Arnold, D.L.2    Cohen, J.A.3
  • 43
    • 85067731993 scopus 로고    scopus 로고
    • Anti-ifnb-1a antibody status was not a factor influencing efficacy of alemtuzumab vs ifnb-1a in relapsing-remitting multiple sclerosis patients who experienced disease activity while on prior therapy (care-ms ii)
    • Abstract 1) P07.125
    • Khan O, Arnold DL, Cohen JA et al. Anti-IFNB-1a antibody status was not a factor influencing efficacy of Alemtuzumab vs. IFNB-1a in relapsing-remitting multiple sclerosis patients who experienced disease activity while on prior therapy (CARE-MS II). Neurology 80(Abstract 1), P07.125 (2013).
    • (2013) Neurology , vol.80
    • Khan, O.1    Arnold, D.L.2    Cohen, J.A.3
  • 44
    • 84866686643 scopus 로고    scopus 로고
    • Case report of anti-glomerular basement membrane disease following alemtuzumab treatment of relapsing-remitting multiple sclerosis
    • Meyer D, Coles A, Oyuela P, Purvis A, Margolin DH. Case report of anti-glomerular basement membrane disease following alemtuzumab treatment of relapsing-remitting multiple sclerosis. Mult. Scler. Relat. Disord. 2, 60-63 (2013).
    • (2013) Mult. Scler. Relat. Disord. , vol.2 , pp. 60-63
    • Meyer, D.1    Coles, A.2    Oyuela, P.3    Purvis, A.4    Margolin, D.H.5
  • 45
    • 85067735979 scopus 로고    scopus 로고
    • Detection, incidence and management of glomerulonephritis in the alemtuzumab clinical development programme
    • 2-5 October
    • Wynn D Arnold DL Cohen JA et al. Detection, incidence and management of glomerulonephritis in the alemtuzumab clinical development programme. Presented at: ECTRIMS Copenhagen, Denmark, 2-5 October 2013.
    • (2013) Presented at: ECTRIMS Copenhagen, Denmark
    • Wynn, D.1    Arnold, D.L.2    Cohen, J.A.3
  • 46
    • 84873150369 scopus 로고    scopus 로고
    • Alemtuzumab therapy for multiple sclerosis
    • Coles A. Alemtuzumab therapy for multiple sclerosis. Neurotherapeutics 10, 29-33 (2013).
    • (2013) Neurotherapeutics , vol.10 , pp. 29-33
    • Coles, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.