Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart

Journal of Molecular Biology

Volumn 284, Issue 1, 1998, Pages 85-99

  Cheetham, Graham M T ^a,c   Hale, Geoffrey ^b   Waldmann, Herman ^b   Bloomer, Anne C ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c YALE UNIVERSITY   (United States)

Author keywords

Antibody humanization; CD52; Molecular replacement; Protein crystallography; Therapeutic antibodies

Indexed keywords

ALEMTUZUMAB; DIMER; IMMUNOGLOBULIN F(AB) FRAGMENT;

ANTIBODY COMBINING SITE; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CRYSTAL STRUCTURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; RAT;

EID: 0032553334     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2157     Document Type: Article

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