Energetics of intermolecular hydrogen bonds in a hydrophobic protein cavity

Journal of the American Society for Mass Spectrometry

Volumn 25, Issue 5, 2014, Pages 742-750

  Liu, Lan ^a   Baergen, Alyson ^a   Michelsen, Klaus ^b   Kitova, Elena N ^a   Schnier, Paul D ^b   Klassen, John S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b AMGEN INC   (United States)

Author keywords

Hydrogen bonds; Hydrophobic; Kinetics energetics; Protein ligand complexes

Indexed keywords

ACTIVATION ENERGY; HYDROGEN BONDS; HYDROPHOBICITY; IONS; LIGANDS; MOLECULAR DYNAMICS; PROTEINS;

ASSOCIATION CONSTANT; GAS-PHASE MEASUREMENT; HYDROPHOBIC; HYDROPHOBIC CAVITIES; HYDROPHOBIC PROTEIN; INTERMOLECULAR HYDROGEN BONDS; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN-LIGAND COMPLEXES;

COMPLEXATION;

16 HYDROXYPALMITIC ACID; 3 HYDROXYPALMITIC ACID; 7 HYDROXYPALMITIC ACID; BETA LACTOGLOBULIN; OXYGEN; PALMITIC ACID DERIVATIVE; UNCLASSIFIED DRUG; 16-HYDROXYPALMITIC ACID; 3-HYDROXYPALMITIC ACID; LACTOGLOBULIN; LIGAND; PALMITIC ACID;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENERGY TRANSFER; HYDROGEN BOND; KINETICS; MASS SPECTROMETRY; MEASUREMENT; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PROTEIN LIPID INTERACTION; REACTION TIME; SURFACE PLASMON RESONANCE; ANIMAL; BINDING SITE; BOVINE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; PROTEIN CONFORMATION; PROTEIN STABILITY; VOLATILIZATION;

ANIMALS; BINDING SITES; CATTLE; ENERGY TRANSFER; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; LACTOGLOBULINS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PALMITIC ACID; PALMITIC ACIDS; PROTEIN CONFORMATION; PROTEIN STABILITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SURFACE PLASMON RESONANCE; VOLATILIZATION;

EID: 84899561205     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-014-0833-z     Document Type: Article

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