Global gene expression of methicillin-resistant staphylococcus aureus USA300 during human and mouse infection

Journal of Infectious Diseases

Volumn 209, Issue 10, 2014, Pages 1542-1550

  Date, Shailesh V ^a   Modrusan, Zora ^a   Lawrence, Michael ^a   Morisaki, J Hiroshi ^a   Toy, Karen ^a   Shah, Ishita M ^a   Kim, Janice ^a   Park, Summer ^a   Xu, Min ^a   Basuino, Li ^b   Chan, Liana ^b   Zeitschel, Deborah ^b   Chambers, Henry F ^b   Tan, Man Wah ^a   Brown, Eric J ^a   Diep, Binh An ^b   Hazenbos, Wouter L W ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

accessory gene regulator; gene regulation; infection; methicillin resistant Staphylococcus aureus (MRSA); S. aureus exoprotein expression.; transcriptome

Indexed keywords

TRANSCRIPTOME;

AGR GENE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CONTROLLED STUDY; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION; HUMAN; KIDNEY ABSCESS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SAE PROTEIN; SKIN ABSCESS; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION REGULATION; UPREGULATION;

ACCESSORY GENE REGULATOR; GENE REGULATION; INFECTION; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA); S. AUREUS EXOPROTEIN EXPRESSION; TRANSCRIPTOME;

ABSCESS; ANIMALS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; PROTEIN ARRAY ANALYSIS; RNA, BACTERIAL; SKIN DISEASES, BACTERIAL; TRANSCRIPTOME; VIRULENCE;

EID: 84899542544     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jit668     Document Type: Article

References (26)

1. Chambers HF, DeLeo FR.Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol 2009; 7:629-41.
2. DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Communityassociated methicillin-resistant Staphylococcus aureus. Lancet 2010; 375:1557-68.
3. Lowy FD. Staphylococcus aureus infections. N Engl J Med 1998; 339: 520-32.
4. Conway T, Schoolnik GK. Microarray expression profiling: capturing a genome-wide portrait of the transcriptome. Mol Microbiol 2003; 47: 879-89.
5. Malachowa N, Whitney AR, Kobayashi SD, et al. Global changes in Staphylococcus aureus gene expression in human blood. PLOS One 2011; 6:e18617.
6. Muthaiyan A, Silverman JA, Jayaswal RK,Wilkinson BJ. Transcriptional profiling reveals that daptomycin induces the Staphylococcus aureus cell wall stress stimulon and genes responsive to membrane depolarization. Antimicrob Agents Chemother 2008; 52:980-90.
7. Palazzolo-Ballance AM, Reniere ML, Braughton KR, et al. Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus. J Immunol 2008; 180:500-9.
8. Loughman JA, Fritz SA, Storch GA, Hunstad DA. Virulence gene expression in human community-acquired Staphylococcus aureus infection. J Infect Dis 2009; 199:294-301.
9. Chambers HF. Pathogenesis of staphylococcal infection: a manner of expression. J Infect Dis 2009; 199:291-3.
10. Song J, Lays C, Vandenesch F, et al. The expression of small regulatory RNAs in clinical samples reflects the different life styles of Staphylococcus aureus in colonization vs. infection. PLOS One 2012; 7:e37294.
11. Monk IR, Shah IM, Xu M, Tan MW, Foster TJ. Transforming the untransformable: application of direct transformation to manipulate genetically Staphylococcus aureus and Staphylococcus epidermidis. MBio 2012; 3:pii: e00277-11.
12. Diep BA, Chambers HF, Graber CJ, et al. Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med 2008; 148:249-57.
13. Kauffmann A, Gentleman R, Huber W. arrayQualityMetrics-a bioconductor package for quality assessment of microarray data. Bioinformatics 2009; 25:415-6.
14. Otto M. Basis of virulence in community-associated methicillinresistant Staphylococcus aureus. Annu Rev Microbiol 2010; 64:143-62.
15. Dubin G. Extracellular proteases of Staphylococcus spp. Biol Chem 2002; 383:1075-86.
16. Hiron A, Borezee-Durant E, Piard JC, Juillard V. Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus. J Bacteriol 2007; 189:5119-29.
17. Coulter SN, Schwan WR, Ng EY, et al. Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments. Mol Microbiol 1998; 30:393-404.
18. Hammer ND, Skaar EP. Molecular mechanisms of Staphylococcus aureus iron acquisition. Annu Rev Microbiol 2011; 65:129-47.
19. Wang R, Braughton KR, Kretschmer D, et al. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 2007; 13:1510-4.
20. Cheng AG, DeDent AC, Schneewind O, Missiakas D. A play in four acts: Staphylococcus aureus abscess formation. Trends Microbiol 2011; 19:225-32.
21. Bronner S, Monteil H, Prevost G. Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. FEMS Microbiol Rev 2004; 28:183-200.
22. Novick RP. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 2003; 48:1429-49.
23. Dunman PM, Murphy E, Haney S, et al. Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci. J Bacteriol 2001; 183:7341-53.
24. Torres VJ, Attia AS, Mason WJ, et al. Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia. Infect Immun 2010; 78:1618-28.
25. Montgomery CP, Boyle-Vavra S, Daum RS. Importance of the global regulators Agr and SaeRS in the pathogenesis of CA-MRSA USA300 infection. PLOS One 2010; 5:e15177.
26. Kiser KB, Cantey-Kiser JM, Lee JC. Development and characterization of a Staphylococcus aureus nasal colonization model in mice. Infect Immun 1999; 67:5001-6.