Virulence gene expression in human community-acquired Staphylococcus aureus infection

Journal of Infectious Diseases

Volumn 199, Issue 3, 2009, Pages 294-301

  Loughman, Jennifer A ^a   Fritz, Stephanie A ^a   Storch, Gregory A ^a   Hunstad, David A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; METICILLIN; PANTON VALENTINE LEUKOCIDIN; PROTEIN A;

ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CHILD; COMMUNITY; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; ENVIRONMENT; FEMALE; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HOST; HUMAN; HUMAN TISSUE; LABORATORY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAMPLE; STAPHYLOCOCCUS INFECTION;

ABSCESS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CHILD; CHILD, PRESCHOOL; COMMUNITY-ACQUIRED INFECTIONS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; INFANT; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; NEUTROPHILS; PREVALENCE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE;

EID: 58849131103     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/595982     Document Type: Article

References (25)

1. Lowy FD. Staphylococcus aureus infections. N Engl J Med 1998; 339:520-32.
2. Cheung AL, Bayer AS, Zhang G, Gresham H, Xiong YQ. Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Immunol Med Microbiol 2004; 40:1-9.
3. Novick RP. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 2003; 48:1429-49.
4. Novick RP, Ross HF, Projan SJ, Kornblum J, Kreiswirth B, Moghazeh S. Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J 1993; 12:3967-75.
5. Lyon GJ, Mayville P, Muir TW, Novick RP. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proc Natl Acad Sci U S A 2000; 97:13330-5.
6. Lina G, Jarraud S, Ji G, et al. Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus. Mol Microbiol 1998; 28:655-62.
7. Novick RP, Jiang D. The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing. Microbiology 2003; 149:2709-17.
8. - mutant of Staphylococcus aureus in the rabbit model of endocarditis. J Clin Invest 1994; 94:1815-22.
9. Abdelnour A, Arvidson S, Bremell T, Ryden C, Tarkowski A. The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect Immun 1993; 61:3879-85.
10. Wang R, Braughton KR, Kretschmer D, et al. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 2007; 13:1510-4.
11. Voyich JM, Otto M, Mathema B, et al. Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis 2006; 194:1761-70.
12. Labandeira-Rey M, Couzon F, Boisset S, et al. Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science 2007; 315:1130-3.
13. Parkos CA, Delp C, Arnaout MA, Madara JL. Neutrophil migration across a cultured intestinal epithelium: dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction. J Clin Invest 1991; 88:1605-12.
14. Anderson KL, Roberts C, Disz T, et al. Characterization of the Staphylococcus aureus heat shock, cold shock, stringent, and SOS responses and their effects on log-phase mRNA turnover. J Bacteriol 2006; 188:6739-56.
15. -Δ(ΔCT) method. Methods 2001; 25:402-8.
16. Lina G, Boutite F, Tristan A, Bes M, Etienne J, Vandenesch F. Bacterial competition for human nasal cavity colonization: role of staphylococcal agr alleles. Appl Environ Microbiol 2003; 69:18-23.
17. Diep BA, Gill SR, Chang RF, et al. Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus. Lancet 2006; 367:731-9.
18. Elizur A, Orscheln RC, Ferkol TW, et al. Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus lung infection in patients with cystic fibrosis. Chest 2007; 131:1718-25.
19. Cho KH, Caparon MG. Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes. Mol Microbiol 2005; 57:1545-56.
20. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 2006; 355:666-74.
21. Sahl HG, Bierbaum G. Lantibiotics: biosynthesis and biological activities of uniquely modified peptides from gram-positive bacteria. Annu Rev Microbiol 1998; 52:41-79.
22. Voyich JM, Braughton KR, Sturdevant DE, et al. Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol 2005; 175:3907-19.
23. Ferry T, Thomas D, Perpoint T, et al. Analysis of superantigenic toxin Vβ T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock. Clin Microbiol Infect 2008; 14:546-54.
24. Gomez MI, Lee A, Reddy B, et al. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat Med 2004; 10:842-8.
25. Loughman JA, Caparon M. Regulation of SpeB in Streptococcus pyogenes by pH and NaCl: a model for in vivo gene expression. J Bacteriol 2006; 188:399-408.