Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: Through regulation of NR2B-containing NMDA receptor-ERK pathway

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Huo, Xin Long ^a   Min, Jing Jing ^a   Pan, Cai Yu ^a   Zhao, Cui Cui ^a   Pan, Lu Lu ^a   Gui, Fei Fei ^a   Jin, Lu ^a   Wang, Xiao Tong ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; IFENPRODIL; MEMBRANE PROTEIN; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; SYNAPSE ASSOCIATED PROTEIN 102; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR BLOCKING AGENT; DLGH3 PROTEIN, RAT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPEPTIDE; NOOTROPIC AGENT; NR2B NMDA RECEPTOR; PIPERIDINE DERIVATIVE; SYNGAP1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC INTERMITTENT HYPOXIA; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ELECTRON MICROSCOPY; ENZYME INACTIVATION; ENZYME REGULATION; HIPPOCAMPUS; HYPERCAPNIA; LEARNING DISORDER; MALE; MEMORY DISORDER; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPATIAL LEARNING; SYNAPSE; TREATMENT DURATION; ANIMAL; ANOXIA; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL MEMBRANE; CHRONIC DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LEARNING DISORDERS; MAZE TEST; MEMORY DISORDERS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT; SYNAPTOSOME; ULTRASTRUCTURE;

ANIMALS; ANOXIA; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; GTPASE-ACTIVATING PROTEINS; HIPPOCAMPUS; HYPERCAPNIA; LEARNING DISORDERS; LOVASTATIN; MALE; MAP KINASE SIGNALING SYSTEM; MAZE LEARNING; MEMBRANE MICRODOMAINS; MEMORY DISORDERS; NEUROPEPTIDES; NOOTROPIC AGENTS; PIPERIDINES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SPATIAL LEARNING; SYNAPTOSOMES;

EID: 84899497105     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094278     Document Type: Article

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